Envelope glycoprotein - Human immunodeficiency virus 1

Preferred order of sections

Names and origin

Protein names

Submitted name:
Envelope glycoprotein EMBL AAY20506.1

Gene names

Name:

env EMBL AAY20506.1

Organism

Human immunodeficiency virus 1 EMBL AAY20506.1

Taxonomic identifier

11676 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	208 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

Ontologies

Keywords
Biological process	Fusion of virus membrane with host membrane SAAS SAAS000777 Host-virus interaction Viral attachment to host cell SAAS SAAS000777 Viral penetration into host cytoplasm Virus entry into host cell
Cellular component	Viral envelope protein EMBL AAY20506.1 Virion
PTM	Disulfide bond SAAS SAAS000777
Technical term	3D-structure PDB 2NXY
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Amino acid modifications

Glycosylation

18

1

N-linked (GlcNAc...) PDB 2NXY

Glycosylation

24

1

N-linked (GlcNAc...) PDB 2NXY

Glycosylation

111

1

N-linked (GlcNAc...) PDB 2NXY

Glycosylation

117

1

N-linked (GlcNAc...) PDB 2NXY

Glycosylation

173

1

N-linked (GlcNAc...) PDB 2NXY

Experimental info

Non-terminal residue

Non-terminal residue

1

Sequences

Sequence

Length

Mass (Da)

Tools

Q49DS8 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: EEEDDE925D7E6C39
Show »

FASTA

208

23,212

        10         20         30         40         50         60 
IRSENITNNA KIIIVQLNES VIINCTRPYN NTRRSTHVGP GQALFTTEII GDIRQAHCNI 

        70         80         90        100        110        120 
SGTSWNKTLQ QVTAKLKNLF NKTIVFKSPS GGDPEITTHS FNCGGEFFYC NTTNLFNNRE 

       130        140        150        160        170        180 
TVNNRTITLP CRIKQIINMW QGVGKAMYAP PIAGRINCSS NITGLLLTRD GGNGSQQNET 

       190        200 
FRPGGGDMRD NWRSELYKYK VVKIEPLG

« Hide

References

[1]	"Transmission of cell-free and cell-associated HIV-1 through breast-feeding." Koulinska I.N., Villamor E., Chaplin B., Msamanga G., Fawzi W., Renjifo B., Essex M. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 41:93-99(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: TZMDE732-11-10 EMBL AAY20506.1.
[2]	"Risk of HIV-1 transmission by breastfeeding among mothers infected with recombinant and non-recombinant HIV-1 genotypes." Koulinska I.N., Villamor E., Msamanga G., Fawzi W., Blackard J., Renjifo B., Essex M. Virus Res. 120:191-198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: TZMDE732-11-10 EMBL AAY20506.1.
[3]	"Structural definition of a conserved neutralization epitope on HIV-1 gp120." Zhou T., Xu L., Dey B., Hessell A.J., Van Ryk D., Xiang S.H., Yang X., Zhang M.Y., Zwick M.B., Arthos J., Burton D.R., Dimitrov D.S., Sodroski J., Wyatt R., Nabel G.J., Kwong P.D. Nature 445:732-737(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 14-205, GLYCOSYLATION AT ASN-18; ASN-24; ASN-111; ASN-117 AND ASN-173.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY932129 Genomic DNA. Translation: AAY20506.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2NXY	X-ray	2.00	A	14-205	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.170.40.20. 1 hit.

InterPro

IPR000777. HIV1_GP160.
[Graphical view]

Pfam

PF00516. GP120. 1 hit.
[Graphical view]

SUPFAM

SSF56502. GP120. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q49DS8.

Entry information

Entry name

Q49DS8_9HIV1

Accession

Primary (citable) accession number: Q49DS8

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	May 29, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)