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Q49B96

- COX19_HUMAN

UniProt

Q49B96 - COX19_HUMAN

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Protein
Cytochrome c oxidase assembly protein COX19
Gene
COX19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be required for the assembly of mitochondrial cytochrome c oxidase By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX19
Short name:
hCOX19
Gene namesi
Name:COX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28074. COX19.

Subcellular locationi

Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 9089Cytochrome c oxidase assembly protein COX19
PRO_0000273151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ49B96.
PaxDbiQ49B96.
PeptideAtlasiQ49B96.
PRIDEiQ49B96.

PTM databases

PhosphoSiteiQ49B96.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ49B96.
BgeeiQ49B96.
CleanExiHS_COX19.
GenevestigatoriQ49B96.

Organism-specific databases

HPAiHPA021226.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342015.

Structurei

3D structure databases

ProteinModelPortaliQ49B96.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 6442CHCH
Add
BLAST

Sequence similaritiesi

Belongs to the COX19 family.
Contains 1 CHCH domain.

Phylogenomic databases

eggNOGiNOG302199.
HOGENOMiHOG000208239.
HOVERGENiHBG081305.
InParanoidiQ49B96.
KOiK18183.
OMAiECRMERK.
PhylomeDBiQ49B96.
TreeFamiTF321525.

Family and domain databases

InterProiIPR010625. CHCH.
IPR009069. Cys_alpha_HP_mot_SF.
[Graphical view]
PfamiPF06747. CHCH. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49B96-1 [UniParc]FASTAAdd to Basket

« Hide

MSTAMNFGTK SFQPRPPDKG SFPLDHLGEC KSFKEKFMKC LHNNNFENAL   50
CRKESKEYLE CRMERKLMLQ EPLEKLGFGD LTSGKSEAKK 90
Length:90
Mass (Da):10,394
Last modified:September 13, 2005 - v1
Checksum:i238A37E8A70EFA09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY957566 mRNA. Translation: AAY35062.1.
BC070383 mRNA. Translation: AAH70383.1.
BC103632 mRNA. Translation: AAI03633.1.
BC110420 mRNA. Translation: AAI10421.1.
CCDSiCCDS34582.1.
RefSeqiNP_001026788.1. NM_001031617.2.
UniGeneiHs.121593.

Genome annotation databases

EnsembliENST00000344111; ENSP00000342015; ENSG00000240230.
GeneIDi90639.
KEGGihsa:90639.
UCSCiuc003sjp.1. human.

Polymorphism databases

DMDMi121943561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY957566 mRNA. Translation: AAY35062.1 .
BC070383 mRNA. Translation: AAH70383.1 .
BC103632 mRNA. Translation: AAI03633.1 .
BC110420 mRNA. Translation: AAI10421.1 .
CCDSi CCDS34582.1.
RefSeqi NP_001026788.1. NM_001031617.2.
UniGenei Hs.121593.

3D structure databases

ProteinModelPortali Q49B96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000342015.

PTM databases

PhosphoSitei Q49B96.

Polymorphism databases

DMDMi 121943561.

Proteomic databases

MaxQBi Q49B96.
PaxDbi Q49B96.
PeptideAtlasi Q49B96.
PRIDEi Q49B96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344111 ; ENSP00000342015 ; ENSG00000240230 .
GeneIDi 90639.
KEGGi hsa:90639.
UCSCi uc003sjp.1. human.

Organism-specific databases

CTDi 90639.
GeneCardsi GC07M000972.
HGNCi HGNC:28074. COX19.
HPAi HPA021226.
MIMi 610429. gene.
neXtProti NX_Q49B96.
PharmGKBi PA145008561.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302199.
HOGENOMi HOG000208239.
HOVERGENi HBG081305.
InParanoidi Q49B96.
KOi K18183.
OMAi ECRMERK.
PhylomeDBi Q49B96.
TreeFami TF321525.

Miscellaneous databases

GenomeRNAii 90639.
NextBioi 76893.
PROi Q49B96.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q49B96.
Bgeei Q49B96.
CleanExi HS_COX19.
Genevestigatori Q49B96.

Family and domain databases

InterProi IPR010625. CHCH.
IPR009069. Cys_alpha_HP_mot_SF.
[Graphical view ]
Pfami PF06747. CHCH. 1 hit.
[Graphical view ]
SUPFAMi SSF47072. SSF47072. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX19_HUMAN
AccessioniPrimary (citable) accession number: Q49B96
Secondary accession number(s): A4FTX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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