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Q49B96

- COX19_HUMAN

UniProt

Q49B96 - COX19_HUMAN

Protein

Cytochrome c oxidase assembly protein COX19

Gene

COX19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be required for the assembly of mitochondrial cytochrome c oxidase.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase assembly protein COX19
    Short name:
    hCOX19
    Gene namesi
    Name:COX19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:28074. COX19.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145008561.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 9089Cytochrome c oxidase assembly protein COX19PRO_0000273151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ49B96.
    PaxDbiQ49B96.
    PeptideAtlasiQ49B96.
    PRIDEiQ49B96.

    PTM databases

    PhosphoSiteiQ49B96.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highly expressed in skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ49B96.
    BgeeiQ49B96.
    CleanExiHS_COX19.
    GenevestigatoriQ49B96.

    Organism-specific databases

    HPAiHPA021226.

    Interactioni

    Protein-protein interaction databases

    BioGridi124748. 1 interaction.
    STRINGi9606.ENSP00000342015.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49B96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 6442CHCHAdd
    BLAST

    Sequence similaritiesi

    Belongs to the COX19 family.Curated
    Contains 1 CHCH domain.Curated

    Phylogenomic databases

    eggNOGiNOG302199.
    HOGENOMiHOG000208239.
    HOVERGENiHBG081305.
    InParanoidiQ49B96.
    KOiK18183.
    OMAiECRMERK.
    PhylomeDBiQ49B96.
    TreeFamiTF321525.

    Family and domain databases

    InterProiIPR010625. CHCH.
    IPR009069. Cys_alpha_HP_mot_SF.
    [Graphical view]
    PfamiPF06747. CHCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47072. SSF47072. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q49B96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTAMNFGTK SFQPRPPDKG SFPLDHLGEC KSFKEKFMKC LHNNNFENAL   50
    CRKESKEYLE CRMERKLMLQ EPLEKLGFGD LTSGKSEAKK 90
    Length:90
    Mass (Da):10,394
    Last modified:September 13, 2005 - v1
    Checksum:i238A37E8A70EFA09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY957566 mRNA. Translation: AAY35062.1.
    BC070383 mRNA. Translation: AAH70383.1.
    BC103632 mRNA. Translation: AAI03633.1.
    BC110420 mRNA. Translation: AAI10421.1.
    CCDSiCCDS34582.1.
    RefSeqiNP_001026788.1. NM_001031617.2.
    UniGeneiHs.121593.

    Genome annotation databases

    EnsembliENST00000344111; ENSP00000342015; ENSG00000240230.
    GeneIDi90639.
    KEGGihsa:90639.
    UCSCiuc003sjp.1. human.

    Polymorphism databases

    DMDMi121943561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY957566 mRNA. Translation: AAY35062.1 .
    BC070383 mRNA. Translation: AAH70383.1 .
    BC103632 mRNA. Translation: AAI03633.1 .
    BC110420 mRNA. Translation: AAI10421.1 .
    CCDSi CCDS34582.1.
    RefSeqi NP_001026788.1. NM_001031617.2.
    UniGenei Hs.121593.

    3D structure databases

    ProteinModelPortali Q49B96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124748. 1 interaction.
    STRINGi 9606.ENSP00000342015.

    PTM databases

    PhosphoSitei Q49B96.

    Polymorphism databases

    DMDMi 121943561.

    Proteomic databases

    MaxQBi Q49B96.
    PaxDbi Q49B96.
    PeptideAtlasi Q49B96.
    PRIDEi Q49B96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344111 ; ENSP00000342015 ; ENSG00000240230 .
    GeneIDi 90639.
    KEGGi hsa:90639.
    UCSCi uc003sjp.1. human.

    Organism-specific databases

    CTDi 90639.
    GeneCardsi GC07M000972.
    HGNCi HGNC:28074. COX19.
    HPAi HPA021226.
    MIMi 610429. gene.
    neXtProti NX_Q49B96.
    PharmGKBi PA145008561.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302199.
    HOGENOMi HOG000208239.
    HOVERGENi HBG081305.
    InParanoidi Q49B96.
    KOi K18183.
    OMAi ECRMERK.
    PhylomeDBi Q49B96.
    TreeFami TF321525.

    Miscellaneous databases

    GenomeRNAii 90639.
    NextBioi 76893.
    PROi Q49B96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q49B96.
    Bgeei Q49B96.
    CleanExi HS_COX19.
    Genevestigatori Q49B96.

    Family and domain databases

    InterProi IPR010625. CHCH.
    IPR009069. Cys_alpha_HP_mot_SF.
    [Graphical view ]
    Pfami PF06747. CHCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47072. SSF47072. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX19_HUMAN
    AccessioniPrimary (citable) accession number: Q49B96
    Secondary accession number(s): A4FTX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3