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Protein

Cytochrome c oxidase assembly protein COX19

Gene

COX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be required for the assembly of mitochondrial cytochrome c oxidase.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33302-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX19
Short name:
hCOX19
Gene namesi
Name:COX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:28074. COX19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000240230.
PharmGKBiPA145008561.

Polymorphism and mutation databases

BioMutaiCOX19.
DMDMi121943561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002731512 – 90Cytochrome c oxidase assembly protein COX19Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Disulfide bondi30 ↔ 61PROSITE-ProRule annotation
Disulfide bondi40 ↔ 51PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiQ49B96.
MaxQBiQ49B96.
PaxDbiQ49B96.
PeptideAtlasiQ49B96.
PRIDEiQ49B96.

PTM databases

iPTMnetiQ49B96.
PhosphoSitePlusiQ49B96.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000240230.
CleanExiHS_COX19.
ExpressionAtlasiQ49B96. baseline and differential.
GenevisibleiQ49B96. HS.

Organism-specific databases

HPAiHPA021226.

Interactioni

Protein-protein interaction databases

BioGridi124748. 1 interactor.
STRINGi9606.ENSP00000342015.

Structurei

3D structure databases

ProteinModelPortaliQ49B96.
SMRiQ49B96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 69CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 40Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi51 – 61Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the COX19 family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3477. Eukaryota.
ENOG41121W4. LUCA.
GeneTreeiENSGT00390000016895.
HOGENOMiHOG000208239.
HOVERGENiHBG081305.
InParanoidiQ49B96.
KOiK18183.
OMAiQLMTKEP.
OrthoDBiEOG091G10VA.
PhylomeDBiQ49B96.
TreeFamiTF321525.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR010625. CHCH.
IPR009069. Cys_alpha_HP_mot_SF.
[Graphical view]
PfamiPF06747. CHCH. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49B96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAMNFGTK SFQPRPPDKG SFPLDHLGEC KSFKEKFMKC LHNNNFENAL
60 70 80 90
CRKESKEYLE CRMERKLMLQ EPLEKLGFGD LTSGKSEAKK
Length:90
Mass (Da):10,394
Last modified:September 13, 2005 - v1
Checksum:i238A37E8A70EFA09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY957566 mRNA. Translation: AAY35062.1.
BC070383 mRNA. Translation: AAH70383.1.
BC103632 mRNA. Translation: AAI03633.1.
BC110420 mRNA. Translation: AAI10421.1.
CCDSiCCDS34582.1.
RefSeqiNP_001026788.1. NM_001031617.2.
UniGeneiHs.121593.

Genome annotation databases

EnsembliENST00000344111; ENSP00000342015; ENSG00000240230.
GeneIDi90639.
KEGGihsa:90639.
UCSCiuc003sjp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY957566 mRNA. Translation: AAY35062.1.
BC070383 mRNA. Translation: AAH70383.1.
BC103632 mRNA. Translation: AAI03633.1.
BC110420 mRNA. Translation: AAI10421.1.
CCDSiCCDS34582.1.
RefSeqiNP_001026788.1. NM_001031617.2.
UniGeneiHs.121593.

3D structure databases

ProteinModelPortaliQ49B96.
SMRiQ49B96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124748. 1 interactor.
STRINGi9606.ENSP00000342015.

PTM databases

iPTMnetiQ49B96.
PhosphoSitePlusiQ49B96.

Polymorphism and mutation databases

BioMutaiCOX19.
DMDMi121943561.

Proteomic databases

EPDiQ49B96.
MaxQBiQ49B96.
PaxDbiQ49B96.
PeptideAtlasiQ49B96.
PRIDEiQ49B96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344111; ENSP00000342015; ENSG00000240230.
GeneIDi90639.
KEGGihsa:90639.
UCSCiuc003sjp.2. human.

Organism-specific databases

CTDi90639.
GeneCardsiCOX19.
HGNCiHGNC:28074. COX19.
HPAiHPA021226.
MIMi610429. gene.
neXtProtiNX_Q49B96.
OpenTargetsiENSG00000240230.
PharmGKBiPA145008561.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3477. Eukaryota.
ENOG41121W4. LUCA.
GeneTreeiENSGT00390000016895.
HOGENOMiHOG000208239.
HOVERGENiHBG081305.
InParanoidiQ49B96.
KOiK18183.
OMAiQLMTKEP.
OrthoDBiEOG091G10VA.
PhylomeDBiQ49B96.
TreeFamiTF321525.

Enzyme and pathway databases

BioCyciZFISH:G66-33302-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

GenomeRNAii90639.
PROiQ49B96.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240230.
CleanExiHS_COX19.
ExpressionAtlasiQ49B96. baseline and differential.
GenevisibleiQ49B96. HS.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR010625. CHCH.
IPR009069. Cys_alpha_HP_mot_SF.
[Graphical view]
PfamiPF06747. CHCH. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX19_HUMAN
AccessioniPrimary (citable) accession number: Q49B96
Secondary accession number(s): A4FTX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 13, 2005
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.