Q49B96 (COX19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase assembly protein COX19
Short name=hCOX19

Gene names

Name:

COX19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be required for the assembly of mitochondrial cytochrome c oxidase By similarity.
Subcellular location	Cytoplasm › cytosol Ref.1.
Tissue specificity	Ubiquitously expressed. Highly expressed in skeletal muscle. Ref.1
Sequence similarities	Belongs to the COX19 family. Contains 1 CHCH domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	Cytochrome c oxidase assembly protein COX19		PRO_0000273151
Regions
	Domain	23 – 64	42	CHCH

Sequences

	Sequence		Length	Mass (Da)
	Q49B96 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 238A37E8A70EFA09	FASTA	90	10,394
	10 20 30 40 50 60 MSTAMNFGTK SFQPRPPDKG SFPLDHLGEC KSFKEKFMKC LHNNNFENAL CRKESKEYLE 70 80 90 CRMERKLMLQ EPLEKLGFGD LTSGKSEAKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly." Sacconi S., Trevisson E., Pistollato F., Baldoin M.C., Rezzonico R., Bourget I., Desnuelle C., Tenconi R., Basso G., DiMauro S., Salviati L. Biochem. Biophys. Res. Commun. 337:832-839(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY957566 mRNA. Translation: AAY35062.1. BC070383 mRNA. Translation: AAH70383.1. BC103632 mRNA. Translation: AAI03633.1. BC110420 mRNA. Translation: AAI10421.1.
IPI	IPI00413436.
RefSeq	NP_001026788.1. NM_001031617.2.
UniGene	Hs.121593.
3D structure databases
ProteinModelPortal	Q49B96.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000342015.
PTM databases
PhosphoSite	Q49B96.
Polymorphism databases
DMDM	121943561.
Proteomic databases
PaxDb	Q49B96.
PeptideAtlas	Q49B96.
PRIDE	Q49B96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344111; ENSP00000342015; ENSG00000240230.
GeneID	90639.
KEGG	hsa:90639.
UCSC	uc003sjp.1. human.
Organism-specific databases
CTD	90639.
GeneCards	GC07M000972.
HGNC	HGNC:28074. COX19.
HPA	HPA021226.
MIM	610429. gene.
neXtProt	NX_Q49B96.
PharmGKB	PA145008561.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302199.
HOGENOM	HOG000208239.
HOVERGEN	HBG081305.
InParanoid	Q49B96.
OMA	CKLEMLN.
PhylomeDB	Q49B96.
Gene expression databases
ArrayExpress	Q49B96.
Bgee	Q49B96.
CleanEx	HS_COX19.
Genevestigator	Q49B96.
Family and domain databases
InterPro	IPR010625. CHCH. [Graphical view]
Pfam	PF06747. CHCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90639.
NextBio	76893.
SOURCE	Search...

Entry information

Entry name

COX19_HUMAN

Accession

Primary (citable) accession number: Q49B96
Secondary accession number(s): A4FTX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	September 13, 2005
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.