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Q49B96 (COX19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase assembly protein COX19

Short name=hCOX19
Gene names
Name:COX19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be required for the assembly of mitochondrial cytochrome c oxidase By similarity.

Subcellular location

Cytoplasmcytosol Ref.1.

Tissue specificity

Ubiquitously expressed. Highly expressed in skeletal muscle. Ref.1

Sequence similarities

Belongs to the COX19 family.

Contains 1 CHCH domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

cytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 9089Cytochrome c oxidase assembly protein COX19
PRO_0000273151

Regions

Domain23 – 6442CHCH

Amino acid modifications

Modified residue21N-acetylserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q49B96 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 238A37E8A70EFA09

FASTA9010,394
        10         20         30         40         50         60 
MSTAMNFGTK SFQPRPPDKG SFPLDHLGEC KSFKEKFMKC LHNNNFENAL CRKESKEYLE 

        70         80         90 
CRMERKLMLQ EPLEKLGFGD LTSGKSEAKK 

« Hide

References

« Hide 'large scale' references
[1]"hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly."
Sacconi S., Trevisson E., Pistollato F., Baldoin M.C., Rezzonico R., Bourget I., Desnuelle C., Tenconi R., Basso G., DiMauro S., Salviati L.
Biochem. Biophys. Res. Commun. 337:832-839(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY957566 mRNA. Translation: AAY35062.1.
BC070383 mRNA. Translation: AAH70383.1.
BC103632 mRNA. Translation: AAI03633.1.
BC110420 mRNA. Translation: AAI10421.1.
CCDSCCDS34582.1.
RefSeqNP_001026788.1. NM_001031617.2.
UniGeneHs.121593.

3D structure databases

ProteinModelPortalQ49B96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000342015.

PTM databases

PhosphoSiteQ49B96.

Polymorphism databases

DMDM121943561.

Proteomic databases

MaxQBQ49B96.
PaxDbQ49B96.
PeptideAtlasQ49B96.
PRIDEQ49B96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344111; ENSP00000342015; ENSG00000240230.
GeneID90639.
KEGGhsa:90639.
UCSCuc003sjp.1. human.

Organism-specific databases

CTD90639.
GeneCardsGC07M000972.
HGNCHGNC:28074. COX19.
HPAHPA021226.
MIM610429. gene.
neXtProtNX_Q49B96.
PharmGKBPA145008561.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302199.
HOGENOMHOG000208239.
HOVERGENHBG081305.
InParanoidQ49B96.
KOK18183.
OMAECRMERK.
PhylomeDBQ49B96.
TreeFamTF321525.

Gene expression databases

ArrayExpressQ49B96.
BgeeQ49B96.
CleanExHS_COX19.
GenevestigatorQ49B96.

Family and domain databases

InterProIPR010625. CHCH.
IPR009069. Cys_alpha_HP_mot_SF.
[Graphical view]
PfamPF06747. CHCH. 1 hit.
[Graphical view]
SUPFAMSSF47072. SSF47072. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi90639.
NextBio76893.
PROQ49B96.
SOURCESearch...

Entry information

Entry nameCOX19_HUMAN
AccessionPrimary (citable) accession number: Q49B96
Secondary accession number(s): A4FTX0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM