Q49AR2 (CE022_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0489 protein C5orf22

Gene names

Name:

C5orf22

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the UPF0489 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q49AR2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q49AR2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q49AR2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.
     280-353: QFKKPGTNLT...KRMEVPDYEM → MEVPDYEMFP...PVPKLLPHFQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	UPF0489 protein C5orf22		PRO_0000305002
Natural variations
	Alternative sequence	1 – 279	279	Missing in isoform 3.		VSP_028182
	Alternative sequence	1 – 265	265	Missing in isoform 2.		VSP_028183
	Alternative sequence	280 – 353	74	QFKKP…PDYEM → MEVPDYEMFPASSSSPSETT SAWISLSMSLSAFWSKPFNK SLGSSKLSNISLPSSEPSKL FQPLPVPKLLPHFQ in isoform 3.		VSP_028184
	Natural variant	235	1	T → P. Corresponds to variant rs17410000 [ dbSNP | Ensembl ].		VAR_035149
	Natural variant	405	1	D → E. Corresponds to variant rs16901277 [ dbSNP | Ensembl ].		VAR_035150
Experimental info
	Sequence conflict	199	1	S → P in BAA92060. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: A79A014E358C7367	FASTA	442	49,967
	10 20 30 40 50 60 MSDSAGGRAG LRRYPKLPVW VVEDHQEVLP FIYRAIGSKH LPASNVSFLH FDSHPDLLIP 70 80 90 100 110 120 VNMPADTVFD KETLFGELSI ENWIMPAVYA GHFSHVIWFH PTWAQQIREG RHHFLVGKDT 130 140 150 160 170 180 STTTIRVTST DHYFLSDGLY VPEDQLENQK PLQLDVIMVK PYKLCNNQEE NDAVSSAKKP 190 200 210 220 230 240 KLALEDSENT ASTNCDSSSE GLEKDTATQR SDQTCLEPSC SCSSENQECQ TAASTGEILE 250 260 270 280 290 300 ILKKGKAFVL DIDLDFFSVK NPFKEMFTQE EYKILQELYQ FKKPGTNLTE EDLVDIVDTR 310 320 330 340 350 360 IHQLEDLEAT FADLCDGDDE ETVQRWASNP GMESLVPLVQ SLKKRMEVPD YEMVHQAGLT 370 380 390 400 410 420 CDYSELPHHI STEQEIECLI QSVHYLLKNL PNPTLVTIAR SSLDDYCPSD QVDTIQEKVL 430 440 NMLRALYGNL DLQVYAAESP PS
	Isoform 2 [UniParc]. Checksum: 7703ABFA6BE14AA0	FASTA	177	20,249
	10 20 30 40 50 60 MFTQEEYKIL QELYQFKKPG TNLTEEDLVD IVDTRIHQLE DLEATFADLC DGDDEETVQR 70 80 90 100 110 120 WASNPGMESL VPLVQSLKKR MEVPDYEMVH QAGLTCDYSE LPHHISTEQE IECLIQSVHY 130 140 150 160 170 LLKNLPNPTL VTIARSSLDD YCPSDQVDTI QEKVLNMLRA LYGNLDLQVY AAESPPS
	Isoform 3 [UniParc]. Checksum: EC2BAF4545DD8097	FASTA	163	18,068
	10 20 30 40 50 60 MEVPDYEMFP ASSSSPSETT SAWISLSMSL SAFWSKPFNK SLGSSKLSNI SLPSSEPSKL 70 80 90 100 110 120 FQPLPVPKLL PHFQVHQAGL TCDYSELPHH ISTEQEIECL IQSVHYLLKN LPNPTLVTIA 130 140 150 160 RSSLDDYCPS DQVDTIQEKV LNMLRALYGN LDLQVYAAES PPS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Lymph node.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis and Uterus.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002055 mRNA. Translation: BAA92060.1. AL834427 mRNA. Translation: CAD39088.2. CH471118 Genomic DNA. Translation: EAX10771.1. CH471118 Genomic DNA. Translation: EAX10772.1. BC021215 mRNA. Translation: AAH21215.1. BC032845 mRNA. Translation: AAH32845.1.
IPI	IPI00019966. IPI00168444. IPI00867737.
RefSeq	NP_060826.2. NM_018356.2.
UniGene	Hs.519246.
3D structure databases
ProteinModelPortal	Q49AR2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q49AR2. 2 interactions.
MINT	MINT-1485452.
STRING	9606.ENSP00000326879.
Polymorphism databases
DMDM	158706466.
Proteomic databases
PaxDb	Q49AR2.
PeptideAtlas	Q49AR2.
PRIDE	Q49AR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325366; ENSP00000326879; ENSG00000082213. ENST00000355907; ENSP00000348171; ENSG00000082213.
GeneID	55322.
KEGG	hsa:55322.
UCSC	uc003jhj.4. human. uc003jhk.4. human. uc010iuj.3. human.
Organism-specific databases
CTD	55322.
GeneCards	GC05P031532.
H-InvDB	HIX0004781.
HGNC	HGNC:25639. C5orf22.
HPA	HPA043062.
neXtProt	NX_Q49AR2.
PharmGKB	PA144596503.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG71438.
HOGENOM	HOG000008429.
HOVERGEN	HBG057060.
InParanoid	Q49AR2.
OMA	ASNPGME.
OrthoDB	EOG4SBDZC.
PhylomeDB	Q49AR2.
Gene expression databases
ArrayExpress	Q49AR2.
Bgee	Q49AR2.
CleanEx	HS_C5orf22.
Genevestigator	Q49AR2.
Family and domain databases
InterPro	IPR024131. UPF0489. [Graphical view]
PANTHER	PTHR13225. PTHR13225. 1 hit.
Pfam	PF12640. UPF0489. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55322.
NextBio	59582.
PMAP-CutDB	Q49AR2.

Entry information

Entry name

CE022_HUMAN

Accession

Primary (citable) accession number: Q49AR2
Secondary accession number(s): Q8ND28, Q8WU61, Q9NUR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	April 3, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.