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Protein

UPF0489 protein C5orf22

Gene

C5orf22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0489 protein C5orf22
Gene namesi
Name:C5orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25639. C5orf22.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55322.
OpenTargetsiENSG00000082213.
PharmGKBiPA144596503.

Polymorphism and mutation databases

BioMutaiC5orf22.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050021 – 442UPF0489 protein C5orf22Add BLAST442

Proteomic databases

EPDiQ49AR2.
MaxQBiQ49AR2.
PaxDbiQ49AR2.
PeptideAtlasiQ49AR2.
PRIDEiQ49AR2.

PTM databases

iPTMnetiQ49AR2.
PhosphoSitePlusiQ49AR2.

Miscellaneous databases

PMAP-CutDBQ49AR2.

Expressioni

Gene expression databases

BgeeiENSG00000082213.
CleanExiHS_C5orf22.
ExpressionAtlasiQ49AR2. baseline and differential.
GenevisibleiQ49AR2. HS.

Organism-specific databases

HPAiHPA043062.

Interactioni

Protein-protein interaction databases

BioGridi120603. 6 interactors.
IntActiQ49AR2. 3 interactors.
MINTiMINT-1485452.
STRINGi9606.ENSP00000326879.

Structurei

3D structure databases

ProteinModelPortaliQ49AR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0489 family.Curated

Phylogenomic databases

eggNOGiENOG410IGS7. Eukaryota.
ENOG41109E9. LUCA.
GeneTreeiENSGT00390000001801.
HOGENOMiHOG000008429.
HOVERGENiHBG057060.
InParanoidiQ49AR2.
OMAiWIMPMVY.
OrthoDBiEOG091G0TRE.
PhylomeDBiQ49AR2.
TreeFamiTF324160.

Family and domain databases

InterProiIPR024131. UPF0489.
[Graphical view]
PANTHERiPTHR13225. PTHR13225. 1 hit.
PfamiPF12640. UPF0489. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49AR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSAGGRAG LRRYPKLPVW VVEDHQEVLP FIYRAIGSKH LPASNVSFLH
60 70 80 90 100
FDSHPDLLIP VNMPADTVFD KETLFGELSI ENWIMPAVYA GHFSHVIWFH
110 120 130 140 150
PTWAQQIREG RHHFLVGKDT STTTIRVTST DHYFLSDGLY VPEDQLENQK
160 170 180 190 200
PLQLDVIMVK PYKLCNNQEE NDAVSSAKKP KLALEDSENT ASTNCDSSSE
210 220 230 240 250
GLEKDTATQR SDQTCLEPSC SCSSENQECQ TAASTGEILE ILKKGKAFVL
260 270 280 290 300
DIDLDFFSVK NPFKEMFTQE EYKILQELYQ FKKPGTNLTE EDLVDIVDTR
310 320 330 340 350
IHQLEDLEAT FADLCDGDDE ETVQRWASNP GMESLVPLVQ SLKKRMEVPD
360 370 380 390 400
YEMVHQAGLT CDYSELPHHI STEQEIECLI QSVHYLLKNL PNPTLVTIAR
410 420 430 440
SSLDDYCPSD QVDTIQEKVL NMLRALYGNL DLQVYAAESP PS
Length:442
Mass (Da):49,967
Last modified:October 2, 2007 - v2
Checksum:iA79A014E358C7367
GO
Isoform 2 (identifier: Q49AR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,249
Checksum:i7703ABFA6BE14AA0
GO
Isoform 3 (identifier: Q49AR2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.
     280-353: QFKKPGTNLT...KRMEVPDYEM → MEVPDYEMFP...PVPKLLPHFQ

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,068
Checksum:iEC2BAF4545DD8097
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199S → P in BAA92060 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035149235T → P.Corresponds to variant rs17410000dbSNPEnsembl.1
Natural variantiVAR_035150405D → E.Corresponds to variant rs16901277dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0281821 – 279Missing in isoform 3. 1 PublicationAdd BLAST279
Alternative sequenceiVSP_0281831 – 265Missing in isoform 2. 1 PublicationAdd BLAST265
Alternative sequenceiVSP_028184280 – 353QFKKP…PDYEM → MEVPDYEMFPASSSSPSETT SAWISLSMSLSAFWSKPFNK SLGSSKLSNISLPSSEPSKL FQPLPVPKLLPHFQ in isoform 3. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002055 mRNA. Translation: BAA92060.1.
AL834427 mRNA. Translation: CAD39088.2.
CH471118 Genomic DNA. Translation: EAX10771.1.
CH471118 Genomic DNA. Translation: EAX10772.1.
BC021215 mRNA. Translation: AAH21215.1.
BC032845 mRNA. Translation: AAH32845.1.
CCDSiCCDS3895.1. [Q49AR2-1]
RefSeqiNP_060826.2. NM_018356.2. [Q49AR2-1]
XP_006714543.1. XM_006714480.3. [Q49AR2-2]
XP_016865102.1. XM_017009613.1. [Q49AR2-2]
XP_016865103.1. XM_017009614.1. [Q49AR2-2]
XP_016865104.1. XM_017009615.1. [Q49AR2-2]
XP_016865105.1. XM_017009616.1. [Q49AR2-2]
UniGeneiHs.519246.

Genome annotation databases

EnsembliENST00000325366; ENSP00000326879; ENSG00000082213. [Q49AR2-1]
GeneIDi55322.
KEGGihsa:55322.
UCSCiuc003jhj.4. human. [Q49AR2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002055 mRNA. Translation: BAA92060.1.
AL834427 mRNA. Translation: CAD39088.2.
CH471118 Genomic DNA. Translation: EAX10771.1.
CH471118 Genomic DNA. Translation: EAX10772.1.
BC021215 mRNA. Translation: AAH21215.1.
BC032845 mRNA. Translation: AAH32845.1.
CCDSiCCDS3895.1. [Q49AR2-1]
RefSeqiNP_060826.2. NM_018356.2. [Q49AR2-1]
XP_006714543.1. XM_006714480.3. [Q49AR2-2]
XP_016865102.1. XM_017009613.1. [Q49AR2-2]
XP_016865103.1. XM_017009614.1. [Q49AR2-2]
XP_016865104.1. XM_017009615.1. [Q49AR2-2]
XP_016865105.1. XM_017009616.1. [Q49AR2-2]
UniGeneiHs.519246.

3D structure databases

ProteinModelPortaliQ49AR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120603. 6 interactors.
IntActiQ49AR2. 3 interactors.
MINTiMINT-1485452.
STRINGi9606.ENSP00000326879.

PTM databases

iPTMnetiQ49AR2.
PhosphoSitePlusiQ49AR2.

Polymorphism and mutation databases

BioMutaiC5orf22.

Proteomic databases

EPDiQ49AR2.
MaxQBiQ49AR2.
PaxDbiQ49AR2.
PeptideAtlasiQ49AR2.
PRIDEiQ49AR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325366; ENSP00000326879; ENSG00000082213. [Q49AR2-1]
GeneIDi55322.
KEGGihsa:55322.
UCSCiuc003jhj.4. human. [Q49AR2-1]

Organism-specific databases

CTDi55322.
DisGeNETi55322.
GeneCardsiC5orf22.
H-InvDBHIX0004781.
HGNCiHGNC:25639. C5orf22.
HPAiHPA043062.
neXtProtiNX_Q49AR2.
OpenTargetsiENSG00000082213.
PharmGKBiPA144596503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGS7. Eukaryota.
ENOG41109E9. LUCA.
GeneTreeiENSGT00390000001801.
HOGENOMiHOG000008429.
HOVERGENiHBG057060.
InParanoidiQ49AR2.
OMAiWIMPMVY.
OrthoDBiEOG091G0TRE.
PhylomeDBiQ49AR2.
TreeFamiTF324160.

Miscellaneous databases

GenomeRNAii55322.
PMAP-CutDBQ49AR2.
PROiQ49AR2.

Gene expression databases

BgeeiENSG00000082213.
CleanExiHS_C5orf22.
ExpressionAtlasiQ49AR2. baseline and differential.
GenevisibleiQ49AR2. HS.

Family and domain databases

InterProiIPR024131. UPF0489.
[Graphical view]
PANTHERiPTHR13225. PTHR13225. 1 hit.
PfamiPF12640. UPF0489. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCE022_HUMAN
AccessioniPrimary (citable) accession number: Q49AR2
Secondary accession number(s): Q8ND28, Q8WU61, Q9NUR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.