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Q49AR2

- CE022_HUMAN

UniProt

Q49AR2 - CE022_HUMAN

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Protein
UPF0489 protein C5orf22
Gene
C5orf22
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0489 protein C5orf22
Gene namesi
Name:C5orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:25639. C5orf22.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442UPF0489 protein C5orf22
PRO_0000305002Add
BLAST

Proteomic databases

MaxQBiQ49AR2.
PaxDbiQ49AR2.
PeptideAtlasiQ49AR2.
PRIDEiQ49AR2.

Miscellaneous databases

PMAP-CutDBQ49AR2.

Expressioni

Gene expression databases

ArrayExpressiQ49AR2.
BgeeiQ49AR2.
CleanExiHS_C5orf22.
GenevestigatoriQ49AR2.

Organism-specific databases

HPAiHPA043062.

Interactioni

Protein-protein interaction databases

BioGridi120603. 5 interactions.
IntActiQ49AR2. 2 interactions.
MINTiMINT-1485452.
STRINGi9606.ENSP00000326879.

Structurei

3D structure databases

ProteinModelPortaliQ49AR2.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0489 family.

Phylogenomic databases

eggNOGiNOG71438.
HOGENOMiHOG000008429.
HOVERGENiHBG057060.
InParanoidiQ49AR2.
OMAiPHHVSTE.
OrthoDBiEOG7VTDQ0.
PhylomeDBiQ49AR2.
TreeFamiTF324160.

Family and domain databases

InterProiIPR024131. UPF0489.
[Graphical view]
PANTHERiPTHR13225. PTHR13225. 1 hit.
PfamiPF12640. UPF0489. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q49AR2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDSAGGRAG LRRYPKLPVW VVEDHQEVLP FIYRAIGSKH LPASNVSFLH    50
FDSHPDLLIP VNMPADTVFD KETLFGELSI ENWIMPAVYA GHFSHVIWFH 100
PTWAQQIREG RHHFLVGKDT STTTIRVTST DHYFLSDGLY VPEDQLENQK 150
PLQLDVIMVK PYKLCNNQEE NDAVSSAKKP KLALEDSENT ASTNCDSSSE 200
GLEKDTATQR SDQTCLEPSC SCSSENQECQ TAASTGEILE ILKKGKAFVL 250
DIDLDFFSVK NPFKEMFTQE EYKILQELYQ FKKPGTNLTE EDLVDIVDTR 300
IHQLEDLEAT FADLCDGDDE ETVQRWASNP GMESLVPLVQ SLKKRMEVPD 350
YEMVHQAGLT CDYSELPHHI STEQEIECLI QSVHYLLKNL PNPTLVTIAR 400
SSLDDYCPSD QVDTIQEKVL NMLRALYGNL DLQVYAAESP PS 442
Length:442
Mass (Da):49,967
Last modified:October 2, 2007 - v2
Checksum:iA79A014E358C7367
GO
Isoform 2 (identifier: Q49AR2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.

Note: No experimental confirmation available.

Show »
Length:177
Mass (Da):20,249
Checksum:i7703ABFA6BE14AA0
GO
Isoform 3 (identifier: Q49AR2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.
     280-353: QFKKPGTNLT...KRMEVPDYEM → MEVPDYEMFP...PVPKLLPHFQ

Note: No experimental confirmation available.

Show »
Length:163
Mass (Da):18,068
Checksum:iEC2BAF4545DD8097
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351T → P.
Corresponds to variant rs17410000 [ dbSNP | Ensembl ].
VAR_035149
Natural varianti405 – 4051D → E.
Corresponds to variant rs16901277 [ dbSNP | Ensembl ].
VAR_035150

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 279279Missing in isoform 3.
VSP_028182Add
BLAST
Alternative sequencei1 – 265265Missing in isoform 2.
VSP_028183Add
BLAST
Alternative sequencei280 – 35374QFKKP…PDYEM → MEVPDYEMFPASSSSPSETT SAWISLSMSLSAFWSKPFNK SLGSSKLSNISLPSSEPSKL FQPLPVPKLLPHFQ in isoform 3.
VSP_028184Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991S → P in BAA92060. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002055 mRNA. Translation: BAA92060.1.
AL834427 mRNA. Translation: CAD39088.2.
CH471118 Genomic DNA. Translation: EAX10771.1.
CH471118 Genomic DNA. Translation: EAX10772.1.
BC021215 mRNA. Translation: AAH21215.1.
BC032845 mRNA. Translation: AAH32845.1.
CCDSiCCDS3895.1. [Q49AR2-1]
RefSeqiNP_060826.2. NM_018356.2. [Q49AR2-1]
XP_005248376.1. XM_005248319.1. [Q49AR2-2]
XP_006714543.1. XM_006714480.1. [Q49AR2-2]
UniGeneiHs.519246.

Genome annotation databases

EnsembliENST00000325366; ENSP00000326879; ENSG00000082213. [Q49AR2-1]
ENST00000355907; ENSP00000348171; ENSG00000082213. [Q49AR2-3]
GeneIDi55322.
KEGGihsa:55322.
UCSCiuc003jhj.4. human. [Q49AR2-1]
uc003jhk.4. human. [Q49AR2-2]
uc010iuj.3. human. [Q49AR2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002055 mRNA. Translation: BAA92060.1 .
AL834427 mRNA. Translation: CAD39088.2 .
CH471118 Genomic DNA. Translation: EAX10771.1 .
CH471118 Genomic DNA. Translation: EAX10772.1 .
BC021215 mRNA. Translation: AAH21215.1 .
BC032845 mRNA. Translation: AAH32845.1 .
CCDSi CCDS3895.1. [Q49AR2-1 ]
RefSeqi NP_060826.2. NM_018356.2. [Q49AR2-1 ]
XP_005248376.1. XM_005248319.1. [Q49AR2-2 ]
XP_006714543.1. XM_006714480.1. [Q49AR2-2 ]
UniGenei Hs.519246.

3D structure databases

ProteinModelPortali Q49AR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120603. 5 interactions.
IntActi Q49AR2. 2 interactions.
MINTi MINT-1485452.
STRINGi 9606.ENSP00000326879.

Proteomic databases

MaxQBi Q49AR2.
PaxDbi Q49AR2.
PeptideAtlasi Q49AR2.
PRIDEi Q49AR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325366 ; ENSP00000326879 ; ENSG00000082213 . [Q49AR2-1 ]
ENST00000355907 ; ENSP00000348171 ; ENSG00000082213 . [Q49AR2-3 ]
GeneIDi 55322.
KEGGi hsa:55322.
UCSCi uc003jhj.4. human. [Q49AR2-1 ]
uc003jhk.4. human. [Q49AR2-2 ]
uc010iuj.3. human. [Q49AR2-3 ]

Organism-specific databases

CTDi 55322.
GeneCardsi GC05P031532.
H-InvDB HIX0004781.
HGNCi HGNC:25639. C5orf22.
HPAi HPA043062.
neXtProti NX_Q49AR2.
PharmGKBi PA144596503.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71438.
HOGENOMi HOG000008429.
HOVERGENi HBG057060.
InParanoidi Q49AR2.
OMAi PHHVSTE.
OrthoDBi EOG7VTDQ0.
PhylomeDBi Q49AR2.
TreeFami TF324160.

Miscellaneous databases

GenomeRNAii 55322.
NextBioi 59582.
PMAP-CutDB Q49AR2.

Gene expression databases

ArrayExpressi Q49AR2.
Bgeei Q49AR2.
CleanExi HS_C5orf22.
Genevestigatori Q49AR2.

Family and domain databases

InterProi IPR024131. UPF0489.
[Graphical view ]
PANTHERi PTHR13225. PTHR13225. 1 hit.
Pfami PF12640. UPF0489. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lymph node.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis and Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCE022_HUMAN
AccessioniPrimary (citable) accession number: Q49AR2
Secondary accession number(s): Q8ND28, Q8WU61, Q9NUR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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