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Protein

Tetratricopeptide repeat protein 31

Gene

TTC31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 31
Short name:
TPR repeat protein 31
Gene namesi
Name:TTC31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25759. TTC31.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115282.
PharmGKBiPA145147843.

Polymorphism and mutation databases

BioMutaiTTC31.
DMDMi215274203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811491 – 519Tetratricopeptide repeat protein 31Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ49AM3.
MaxQBiQ49AM3.
PaxDbiQ49AM3.
PeptideAtlasiQ49AM3.
PRIDEiQ49AM3.

PTM databases

iPTMnetiQ49AM3.
PhosphoSitePlusiQ49AM3.

Expressioni

Gene expression databases

BgeeiENSG00000115282.
CleanExiHS_TTC31.
ExpressionAtlasiQ49AM3. baseline and differential.
GenevisibleiQ49AM3. HS.

Organism-specific databases

HPAiHPA041783.

Interactioni

Protein-protein interaction databases

BioGridi122175. 13 interactors.
STRINGi9606.ENSP00000233623.

Structurei

3D structure databases

ProteinModelPortaliQ49AM3.
SMRiQ49AM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati305 – 338TPR 1Add BLAST34
Repeati339 – 372TPR 2Add BLAST34
Repeati373 – 406TPR 3Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili147 – 197Sequence analysisAdd BLAST51

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
GeneTreeiENSGT00840000129937.
HOGENOMiHOG000154705.
HOVERGENiHBG086296.
InParanoidiQ49AM3.
OMAiLQLWHHD.
OrthoDBiEOG091G0GVJ.
PhylomeDBiQ49AM3.
TreeFamiTF341776.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49AM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPIPKTVGR IKLDCSLRPS CPLEVAAAPK LCKEFGPEDY GEEDIVDFLR
60 70 80 90 100
RLVESDPQGL HRIHVDGSSG RLQLWHHDYL LGHLDDEGKS TGQSDRGKGA
110 120 130 140 150
EGLGTYCGLR KSFLYPPQES EPCPQSPSAS ATFPSVSDSL LQVAMPQKLL
160 170 180 190 200
VTEEEANRLA EELVAEEERM KQKAEKKRLK KKRQKERKRQ ERLEQYCGEP
210 220 230 240 250
KASTTSDGDE SPPSSPGNPV QGQCGEEEDS LDLSSTFVSL ALRKVGDWPL
260 270 280 290 300
SARREKGLNQ EPQGRGLALQ KMGQEEESPP REERPQQSPK VQASPGLLAA
310 320 330 340 350
ALQQSQELAK LGTSFAQNGF YHEAVVLFTQ ALKLNPQDHR LFGNRSFCHE
360 370 380 390 400
RLGQPAWALA DAQVALTLRP GWPRGLFRLG KALMGLQRFR EAAAVFQETL
410 420 430 440 450
RGGSQPDAAR ELRSCLLHLT LQGQRGGICA PPLSPGALQP LPHAELAPSG
460 470 480 490 500
LPSLRCPRST ALRSPGLSPL LHYPSCHRSH PNQPLSQTQS RRPHPLKPQD
510
PSKGWDILGL GLQHLSQAR
Length:519
Mass (Da):57,105
Last modified:November 25, 2008 - v3
Checksum:iB618E043E0FBD78E
GO
Isoform 2 (identifier: Q49AM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-285: REERP → ATSPC
     286-519: Missing.

Show »
Length:285
Mass (Da):31,450
Checksum:iF8E931CF4B82D3AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141L → P in BAB14272 (PubMed:14702039).Curated1
Sequence conflicti216P → T in AAH36017 (PubMed:15489334).Curated1
Sequence conflicti413R → H in AAH36017 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04735728A → V.1 PublicationCorresponds to variant rs6707475dbSNPEnsembl.1
Natural variantiVAR_047358205T → P.Corresponds to variant rs35852562dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023990281 – 285REERP → ATSPC in isoform 2. 2 Publications5
Alternative sequenceiVSP_023991286 – 519Missing in isoform 2. 2 PublicationsAdd BLAST234

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022850 mRNA. Translation: BAB14272.1.
AC005041 Genomic DNA. No translation available.
BC036017 mRNA. Translation: AAH36017.1.
BC096709 mRNA. Translation: AAH96709.1.
AK223355 mRNA. Translation: BAD97075.1.
CCDSiCCDS42701.1. [Q49AM3-1]
RefSeqiNP_071937.4. NM_022492.4. [Q49AM3-1]
UniGeneiHs.557709.

Genome annotation databases

EnsembliENST00000233623; ENSP00000233623; ENSG00000115282. [Q49AM3-1]
ENST00000442235; ENSP00000416823; ENSG00000115282. [Q49AM3-2]
GeneIDi64427.
KEGGihsa:64427.
UCSCiuc002slt.3. human. [Q49AM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022850 mRNA. Translation: BAB14272.1.
AC005041 Genomic DNA. No translation available.
BC036017 mRNA. Translation: AAH36017.1.
BC096709 mRNA. Translation: AAH96709.1.
AK223355 mRNA. Translation: BAD97075.1.
CCDSiCCDS42701.1. [Q49AM3-1]
RefSeqiNP_071937.4. NM_022492.4. [Q49AM3-1]
UniGeneiHs.557709.

3D structure databases

ProteinModelPortaliQ49AM3.
SMRiQ49AM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122175. 13 interactors.
STRINGi9606.ENSP00000233623.

PTM databases

iPTMnetiQ49AM3.
PhosphoSitePlusiQ49AM3.

Polymorphism and mutation databases

BioMutaiTTC31.
DMDMi215274203.

Proteomic databases

EPDiQ49AM3.
MaxQBiQ49AM3.
PaxDbiQ49AM3.
PeptideAtlasiQ49AM3.
PRIDEiQ49AM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233623; ENSP00000233623; ENSG00000115282. [Q49AM3-1]
ENST00000442235; ENSP00000416823; ENSG00000115282. [Q49AM3-2]
GeneIDi64427.
KEGGihsa:64427.
UCSCiuc002slt.3. human. [Q49AM3-1]

Organism-specific databases

CTDi64427.
GeneCardsiTTC31.
HGNCiHGNC:25759. TTC31.
HPAiHPA041783.
neXtProtiNX_Q49AM3.
OpenTargetsiENSG00000115282.
PharmGKBiPA145147843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
GeneTreeiENSGT00840000129937.
HOGENOMiHOG000154705.
HOVERGENiHBG086296.
InParanoidiQ49AM3.
OMAiLQLWHHD.
OrthoDBiEOG091G0GVJ.
PhylomeDBiQ49AM3.
TreeFamiTF341776.

Miscellaneous databases

ChiTaRSiTTC31. human.
GenomeRNAii64427.
PROiQ49AM3.

Gene expression databases

BgeeiENSG00000115282.
CleanExiHS_TTC31.
ExpressionAtlasiQ49AM3. baseline and differential.
GenevisibleiQ49AM3. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC31_HUMAN
AccessioniPrimary (citable) accession number: Q49AM3
Secondary accession number(s): Q4KN40, Q53FD4, Q9H9F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.