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Q49AM3 (TTC31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetratricopeptide repeat protein 31

Short name=TPR repeat protein 31
Gene names
Name:TTC31
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 3 TPR repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
TPR repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q49AM3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q49AM3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     281-285: REERP → ATSPC
     286-519: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Tetratricopeptide repeat protein 31
PRO_0000281149

Regions

Repeat305 – 33834TPR 1
Repeat339 – 37234TPR 2
Repeat373 – 40634TPR 3
Coiled coil147 – 19751 Potential

Natural variations

Alternative sequence281 – 2855REERP → ATSPC in isoform 2.
VSP_023990
Alternative sequence286 – 519234Missing in isoform 2.
VSP_023991
Natural variant281A → V. Ref.3
Corresponds to variant rs6707475 [ dbSNP | Ensembl ].
VAR_047357
Natural variant2051T → P.
Corresponds to variant rs35852562 [ dbSNP | Ensembl ].
VAR_047358

Experimental info

Sequence conflict1411L → P in BAB14272. Ref.1
Sequence conflict2161P → T in AAH36017. Ref.3
Sequence conflict4131R → H in AAH36017. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: B618E043E0FBD78E

FASTA51957,105
        10         20         30         40         50         60 
MAPIPKTVGR IKLDCSLRPS CPLEVAAAPK LCKEFGPEDY GEEDIVDFLR RLVESDPQGL 

        70         80         90        100        110        120 
HRIHVDGSSG RLQLWHHDYL LGHLDDEGKS TGQSDRGKGA EGLGTYCGLR KSFLYPPQES 

       130        140        150        160        170        180 
EPCPQSPSAS ATFPSVSDSL LQVAMPQKLL VTEEEANRLA EELVAEEERM KQKAEKKRLK 

       190        200        210        220        230        240 
KKRQKERKRQ ERLEQYCGEP KASTTSDGDE SPPSSPGNPV QGQCGEEEDS LDLSSTFVSL 

       250        260        270        280        290        300 
ALRKVGDWPL SARREKGLNQ EPQGRGLALQ KMGQEEESPP REERPQQSPK VQASPGLLAA 

       310        320        330        340        350        360 
ALQQSQELAK LGTSFAQNGF YHEAVVLFTQ ALKLNPQDHR LFGNRSFCHE RLGQPAWALA 

       370        380        390        400        410        420 
DAQVALTLRP GWPRGLFRLG KALMGLQRFR EAAAVFQETL RGGSQPDAAR ELRSCLLHLT 

       430        440        450        460        470        480 
LQGQRGGICA PPLSPGALQP LPHAELAPSG LPSLRCPRST ALRSPGLSPL LHYPSCHRSH 

       490        500        510 
PNQPLSQTQS RRPHPLKPQD PSKGWDILGL GLQHLSQAR 

« Hide

Isoform 2 [UniParc].

Checksum: F8E931CF4B82D3AB
Show »

FASTA28531,450

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-28.
Tissue: Testis.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-369.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK022850 mRNA. Translation: BAB14272.1.
AC005041 Genomic DNA. No translation available.
BC036017 mRNA. Translation: AAH36017.1.
BC096709 mRNA. Translation: AAH96709.1.
AK223355 mRNA. Translation: BAD97075.1.
RefSeqNP_071937.4. NM_022492.4.
UniGeneHs.557709.

3D structure databases

ProteinModelPortalQ49AM3.
SMRQ49AM3. Positions 302-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000233623.

PTM databases

PhosphoSiteQ49AM3.

Polymorphism databases

DMDM215274203.

Proteomic databases

PaxDbQ49AM3.
PRIDEQ49AM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000233623; ENSP00000233623; ENSG00000115282. [Q49AM3-1]
GeneID64427.
KEGGhsa:64427.
UCSCuc002slt.2. human. [Q49AM3-1]

Organism-specific databases

CTD64427.
GeneCardsGC02P074710.
HGNCHGNC:25759. TTC31.
HPAHPA041783.
neXtProtNX_Q49AM3.
PharmGKBPA145147843.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG305435.
HOGENOMHOG000154705.
HOVERGENHBG086296.
InParanoidQ49AM3.
OMAKSFLYPP.
PhylomeDBQ49AM3.
TreeFamTF341776.

Gene expression databases

ArrayExpressQ49AM3.
BgeeQ49AM3.
CleanExHS_TTC31.
GenevestigatorQ49AM3.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi64427.
NextBio66433.
PROQ49AM3.

Entry information

Entry nameTTC31_HUMAN
AccessionPrimary (citable) accession number: Q49AM3
Secondary accession number(s): Q4KN40, Q53FD4, Q9H9F7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM