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Protein

Tetratricopeptide repeat protein 31

Gene

TTC31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 31
Short name:
TPR repeat protein 31
Gene namesi
Name:TTC31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25759. TTC31.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147843.

Polymorphism and mutation databases

BioMutaiTTC31.
DMDMi215274203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Tetratricopeptide repeat protein 31PRO_0000281149Add
BLAST

Proteomic databases

MaxQBiQ49AM3.
PaxDbiQ49AM3.
PRIDEiQ49AM3.

PTM databases

PhosphoSiteiQ49AM3.

Expressioni

Gene expression databases

BgeeiQ49AM3.
CleanExiHS_TTC31.
ExpressionAtlasiQ49AM3. baseline and differential.
GenevisibleiQ49AM3. HS.

Organism-specific databases

HPAiHPA041783.

Interactioni

Protein-protein interaction databases

BioGridi122175. 2 interactions.
STRINGi9606.ENSP00000233623.

Structurei

3D structure databases

ProteinModelPortaliQ49AM3.
SMRiQ49AM3. Positions 302-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati305 – 33834TPR 1Add
BLAST
Repeati339 – 37234TPR 2Add
BLAST
Repeati373 – 40634TPR 3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili147 – 19751Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG305435.
GeneTreeiENSGT00790000123104.
HOGENOMiHOG000154705.
HOVERGENiHBG086296.
InParanoidiQ49AM3.
OMAiLQLWHHD.
PhylomeDBiQ49AM3.
TreeFamiTF341776.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49AM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPIPKTVGR IKLDCSLRPS CPLEVAAAPK LCKEFGPEDY GEEDIVDFLR
60 70 80 90 100
RLVESDPQGL HRIHVDGSSG RLQLWHHDYL LGHLDDEGKS TGQSDRGKGA
110 120 130 140 150
EGLGTYCGLR KSFLYPPQES EPCPQSPSAS ATFPSVSDSL LQVAMPQKLL
160 170 180 190 200
VTEEEANRLA EELVAEEERM KQKAEKKRLK KKRQKERKRQ ERLEQYCGEP
210 220 230 240 250
KASTTSDGDE SPPSSPGNPV QGQCGEEEDS LDLSSTFVSL ALRKVGDWPL
260 270 280 290 300
SARREKGLNQ EPQGRGLALQ KMGQEEESPP REERPQQSPK VQASPGLLAA
310 320 330 340 350
ALQQSQELAK LGTSFAQNGF YHEAVVLFTQ ALKLNPQDHR LFGNRSFCHE
360 370 380 390 400
RLGQPAWALA DAQVALTLRP GWPRGLFRLG KALMGLQRFR EAAAVFQETL
410 420 430 440 450
RGGSQPDAAR ELRSCLLHLT LQGQRGGICA PPLSPGALQP LPHAELAPSG
460 470 480 490 500
LPSLRCPRST ALRSPGLSPL LHYPSCHRSH PNQPLSQTQS RRPHPLKPQD
510
PSKGWDILGL GLQHLSQAR
Length:519
Mass (Da):57,105
Last modified:November 25, 2008 - v3
Checksum:iB618E043E0FBD78E
GO
Isoform 2 (identifier: Q49AM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-285: REERP → ATSPC
     286-519: Missing.

Show »
Length:285
Mass (Da):31,450
Checksum:iF8E931CF4B82D3AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411L → P in BAB14272 (PubMed:14702039).Curated
Sequence conflicti216 – 2161P → T in AAH36017 (PubMed:15489334).Curated
Sequence conflicti413 – 4131R → H in AAH36017 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281A → V.1 Publication
Corresponds to variant rs6707475 [ dbSNP | Ensembl ].
VAR_047357
Natural varianti205 – 2051T → P.
Corresponds to variant rs35852562 [ dbSNP | Ensembl ].
VAR_047358

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei281 – 2855REERP → ATSPC in isoform 2. 2 PublicationsVSP_023990
Alternative sequencei286 – 519234Missing in isoform 2. 2 PublicationsVSP_023991Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022850 mRNA. Translation: BAB14272.1.
AC005041 Genomic DNA. No translation available.
BC036017 mRNA. Translation: AAH36017.1.
BC096709 mRNA. Translation: AAH96709.1.
AK223355 mRNA. Translation: BAD97075.1.
CCDSiCCDS42701.1. [Q49AM3-1]
RefSeqiNP_071937.4. NM_022492.4. [Q49AM3-1]
UniGeneiHs.557709.

Genome annotation databases

EnsembliENST00000233623; ENSP00000233623; ENSG00000115282.
ENST00000442235; ENSP00000416823; ENSG00000115282. [Q49AM3-2]
GeneIDi64427.
KEGGihsa:64427.
UCSCiuc002slt.2. human. [Q49AM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022850 mRNA. Translation: BAB14272.1.
AC005041 Genomic DNA. No translation available.
BC036017 mRNA. Translation: AAH36017.1.
BC096709 mRNA. Translation: AAH96709.1.
AK223355 mRNA. Translation: BAD97075.1.
CCDSiCCDS42701.1. [Q49AM3-1]
RefSeqiNP_071937.4. NM_022492.4. [Q49AM3-1]
UniGeneiHs.557709.

3D structure databases

ProteinModelPortaliQ49AM3.
SMRiQ49AM3. Positions 302-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122175. 2 interactions.
STRINGi9606.ENSP00000233623.

PTM databases

PhosphoSiteiQ49AM3.

Polymorphism and mutation databases

BioMutaiTTC31.
DMDMi215274203.

Proteomic databases

MaxQBiQ49AM3.
PaxDbiQ49AM3.
PRIDEiQ49AM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233623; ENSP00000233623; ENSG00000115282.
ENST00000442235; ENSP00000416823; ENSG00000115282. [Q49AM3-2]
GeneIDi64427.
KEGGihsa:64427.
UCSCiuc002slt.2. human. [Q49AM3-1]

Organism-specific databases

CTDi64427.
GeneCardsiGC02P074710.
HGNCiHGNC:25759. TTC31.
HPAiHPA041783.
neXtProtiNX_Q49AM3.
PharmGKBiPA145147843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG305435.
GeneTreeiENSGT00790000123104.
HOGENOMiHOG000154705.
HOVERGENiHBG086296.
InParanoidiQ49AM3.
OMAiLQLWHHD.
PhylomeDBiQ49AM3.
TreeFamiTF341776.

Miscellaneous databases

ChiTaRSiTTC31. human.
GenomeRNAii64427.
NextBioi66433.
PROiQ49AM3.

Gene expression databases

BgeeiQ49AM3.
CleanExiHS_TTC31.
ExpressionAtlasiQ49AM3. baseline and differential.
GenevisibleiQ49AM3. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-28.
    Tissue: Testis.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-369.
    Tissue: Testis.

Entry informationi

Entry nameiTTC31_HUMAN
AccessioniPrimary (citable) accession number: Q49AM3
Secondary accession number(s): Q4KN40, Q53FD4, Q9H9F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 25, 2008
Last modified: July 22, 2015
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.