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Protein

Transcription termination factor 2, mitochondrial

Gene

MTERF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription, both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes and normal mitochondrial function (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 2, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 2
Short name:
mTERF2
Mitochondrial transcription termination factor-like protein
Short name:
mTERF-like
Short name:
mTERFL
mTERF domain-containing protein 3, mitochondrial
Gene namesi
Name:MTERF2
Synonyms:MTERFD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30779. MTERF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120832.
PharmGKBiPA142671311.

Polymorphism and mutation databases

DMDMi118595440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionAdd BLAST35
ChainiPRO_000025546436 – 385Transcription termination factor 2, mitochondrialAdd BLAST350

Proteomic databases

EPDiQ49AM1.
MaxQBiQ49AM1.
PaxDbiQ49AM1.
PeptideAtlasiQ49AM1.
PRIDEiQ49AM1.

PTM databases

iPTMnetiQ49AM1.
PhosphoSitePlusiQ49AM1.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, liver and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000120832.
CleanExiHS_MTERFD3.
ExpressionAtlasiQ49AM1. baseline and differential.
GenevisibleiQ49AM1. HS.

Organism-specific databases

HPAiHPA003526.

Interactioni

Subunit structurei

Monomer. Homodimer (By similarity).By similarity

Protein-protein interaction databases

BioGridi123214. 4 interactors.
STRINGi9606.ENSP00000240050.

Structurei

3D structure databases

ProteinModelPortaliQ49AM1.
SMRiQ49AM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1267. Eukaryota.
ENOG410XT49. LUCA.
GeneTreeiENSGT00530000063817.
HOGENOMiHOG000113677.
HOVERGENiHBG081991.
InParanoidiQ49AM1.
KOiK15031.
OMAiIRRLKGW.
OrthoDBiEOG091G0AQ5.
PhylomeDBiQ49AM1.
TreeFamiTF330821.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49AM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWKLLLRSQ SCRLCSFRKM RSPPKYRPFL ACFTYTTDKQ SSKENTRTVE
60 70 80 90 100
KLYKCSVDIR KIRRLKGWVL LEDETYVEEI ANILQELGAD ETAVASILER
110 120 130 140 150
CPEAIVCSPT AVNTQRKLWQ LVCKNEEELI KLIEQFPESF FTIKDQENQK
160 170 180 190 200
LNVQFFQELG LKNVVISRLL TAAPNVFHNP VEKNKQMVRI LQESYLDVGG
210 220 230 240 250
SEANMKVWLL KLLSQNPFIL LNSPTAIKET LEFLQEQGFT SFEILQLLSK
260 270 280 290 300
LKGFLFQLCP RSIQNSISFS KNAFKCTDHD LKQLVLKCPA LLYYSVPVLE
310 320 330 340 350
ERMQGLLREG ISIAQIRETP MVLELTPQIV QYRIRKLNSS GYRIKDGHLA
360 370 380
NLNGSKKEFE ANFGKIQAKK VRPLFNPVAP LNVEE
Length:385
Mass (Da):44,414
Last modified:October 31, 2006 - v2
Checksum:iFF6D948759681BBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140F → S in BAD96278 (Ref. 3) Curated1
Sequence conflicti171T → A in AAH36066 (PubMed:16541075).Curated1
Sequence conflicti236E → G in BAB14834 (PubMed:14702039).Curated1
Sequence conflicti383V → A in BAD96278 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03411314L → V.Corresponds to variant rs34238336dbSNPEnsembl.1
Natural variantiVAR_05378731A → V.Corresponds to variant rs35305400dbSNPEnsembl.1
Natural variantiVAR_03411481A → G.Corresponds to variant rs35548605dbSNPEnsembl.1
Natural variantiVAR_053788198V → I.Corresponds to variant rs1043157dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008301 mRNA. Translation: AAG22860.1.
AK024124 mRNA. Translation: BAB14834.1.
AK222558 mRNA. Translation: BAD96278.1.
AL832827 mRNA. Translation: CAI46173.1.
AC007541 Genomic DNA. No translation available.
BC025984 mRNA. Translation: AAH25984.1.
BC036066 mRNA. Translation: AAH36066.1.
CCDSiCCDS9111.1.
RefSeqiNP_001028222.1. NM_001033050.2.
NP_079474.2. NM_025198.4.
XP_011537069.1. XM_011538767.2.
XP_016875474.1. XM_017019985.1.
XP_016875475.1. XM_017019986.1.
XP_016875476.1. XM_017019987.1.
UniGeneiHs.5009.

Genome annotation databases

EnsembliENST00000240050; ENSP00000240050; ENSG00000120832.
ENST00000392830; ENSP00000376575; ENSG00000120832.
ENST00000552029; ENSP00000447651; ENSG00000120832.
GeneIDi80298.
KEGGihsa:80298.
UCSCiuc001tme.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008301 mRNA. Translation: AAG22860.1.
AK024124 mRNA. Translation: BAB14834.1.
AK222558 mRNA. Translation: BAD96278.1.
AL832827 mRNA. Translation: CAI46173.1.
AC007541 Genomic DNA. No translation available.
BC025984 mRNA. Translation: AAH25984.1.
BC036066 mRNA. Translation: AAH36066.1.
CCDSiCCDS9111.1.
RefSeqiNP_001028222.1. NM_001033050.2.
NP_079474.2. NM_025198.4.
XP_011537069.1. XM_011538767.2.
XP_016875474.1. XM_017019985.1.
XP_016875475.1. XM_017019986.1.
XP_016875476.1. XM_017019987.1.
UniGeneiHs.5009.

3D structure databases

ProteinModelPortaliQ49AM1.
SMRiQ49AM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123214. 4 interactors.
STRINGi9606.ENSP00000240050.

PTM databases

iPTMnetiQ49AM1.
PhosphoSitePlusiQ49AM1.

Polymorphism and mutation databases

DMDMi118595440.

Proteomic databases

EPDiQ49AM1.
MaxQBiQ49AM1.
PaxDbiQ49AM1.
PeptideAtlasiQ49AM1.
PRIDEiQ49AM1.

Protocols and materials databases

DNASUi80298.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240050; ENSP00000240050; ENSG00000120832.
ENST00000392830; ENSP00000376575; ENSG00000120832.
ENST00000552029; ENSP00000447651; ENSG00000120832.
GeneIDi80298.
KEGGihsa:80298.
UCSCiuc001tme.2. human.

Organism-specific databases

CTDi80298.
GeneCardsiMTERF2.
HGNCiHGNC:30779. MTERF2.
HPAiHPA003526.
MIMi616929. gene.
neXtProtiNX_Q49AM1.
OpenTargetsiENSG00000120832.
PharmGKBiPA142671311.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1267. Eukaryota.
ENOG410XT49. LUCA.
GeneTreeiENSGT00530000063817.
HOGENOMiHOG000113677.
HOVERGENiHBG081991.
InParanoidiQ49AM1.
KOiK15031.
OMAiIRRLKGW.
OrthoDBiEOG091G0AQ5.
PhylomeDBiQ49AM1.
TreeFamiTF330821.

Miscellaneous databases

GenomeRNAii80298.
PROiQ49AM1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120832.
CleanExiHS_MTERFD3.
ExpressionAtlasiQ49AM1. baseline and differential.
GenevisibleiQ49AM1. HS.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTEF2_HUMAN
AccessioniPrimary (citable) accession number: Q49AM1
Secondary accession number(s): Q53HM2, Q9H4L6, Q9H7Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.