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Protein

Transcription termination factor 2, mitochondrial

Gene

MTERF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species.3 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • double-stranded DNA binding Source: InterPro
  • nucleic acid binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 2, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 2
Short name:
mTERF2
Mitochondrial transcription termination factor-like protein
Short name:
mTERF-like
Short name:
mTERFL1 Publication
mTERF domain-containing protein 3, mitochondrial
Gene namesi
Name:MTERF2
Synonyms:MTERFD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000120832.9
HGNCiHGNC:30779 MTERF2
MIMi616929 gene
neXtProtiNX_Q49AM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120832
PharmGKBiPA142671311

Polymorphism and mutation databases

DMDMi118595440

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35Mitochondrion1 PublicationAdd BLAST35
ChainiPRO_000025546436 – 385Transcription termination factor 2, mitochondrialAdd BLAST350

Proteomic databases

EPDiQ49AM1
MaxQBiQ49AM1
PaxDbiQ49AM1
PeptideAtlasiQ49AM1
PRIDEiQ49AM1
ProteomicsDBi62055

PTM databases

iPTMnetiQ49AM1
PhosphoSitePlusiQ49AM1

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, liver and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000120832
CleanExiHS_MTERFD3
ExpressionAtlasiQ49AM1 baseline and differential
GenevisibleiQ49AM1 HS

Organism-specific databases

HPAiHPA003526

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi123214, 4 interactors
STRINGi9606.ENSP00000240050

Structurei

3D structure databases

ProteinModelPortaliQ49AM1
SMRiQ49AM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1267 Eukaryota
ENOG410XT49 LUCA
GeneTreeiENSGT00530000063817
HOGENOMiHOG000113677
HOVERGENiHBG081991
InParanoidiQ49AM1
KOiK15031
OMAiIRRLKGW
OrthoDBiEOG091G0AQ5
PhylomeDBiQ49AM1
TreeFamiTF330821

Family and domain databases

Gene3Di1.25.70.10, 2 hits
InterProiView protein in InterPro
IPR003690 MTERF
IPR038538 MTERF_sf
PfamiView protein in Pfam
PF02536 mTERF, 1 hit
SMARTiView protein in SMART
SM00733 Mterf, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q49AM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWKLLLRSQ SCRLCSFRKM RSPPKYRPFL ACFTYTTDKQ SSKENTRTVE
60 70 80 90 100
KLYKCSVDIR KIRRLKGWVL LEDETYVEEI ANILQELGAD ETAVASILER
110 120 130 140 150
CPEAIVCSPT AVNTQRKLWQ LVCKNEEELI KLIEQFPESF FTIKDQENQK
160 170 180 190 200
LNVQFFQELG LKNVVISRLL TAAPNVFHNP VEKNKQMVRI LQESYLDVGG
210 220 230 240 250
SEANMKVWLL KLLSQNPFIL LNSPTAIKET LEFLQEQGFT SFEILQLLSK
260 270 280 290 300
LKGFLFQLCP RSIQNSISFS KNAFKCTDHD LKQLVLKCPA LLYYSVPVLE
310 320 330 340 350
ERMQGLLREG ISIAQIRETP MVLELTPQIV QYRIRKLNSS GYRIKDGHLA
360 370 380
NLNGSKKEFE ANFGKIQAKK VRPLFNPVAP LNVEE
Length:385
Mass (Da):44,414
Last modified:October 31, 2006 - v2
Checksum:iFF6D948759681BBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140F → S in BAD96278 (Ref. 3) Curated1
Sequence conflicti171T → A in AAH36066 (PubMed:16541075).Curated1
Sequence conflicti236E → G in BAB14834 (PubMed:14702039).Curated1
Sequence conflicti383V → A in BAD96278 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03411314L → V. Corresponds to variant dbSNP:rs34238336Ensembl.1
Natural variantiVAR_05378731A → V. Corresponds to variant dbSNP:rs35305400Ensembl.1
Natural variantiVAR_03411481A → G. Corresponds to variant dbSNP:rs35548605Ensembl.1
Natural variantiVAR_053788198V → I. Corresponds to variant dbSNP:rs1043157Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008301 mRNA Translation: AAG22860.1
AK024124 mRNA Translation: BAB14834.1
AK222558 mRNA Translation: BAD96278.1
AL832827 mRNA Translation: CAI46173.1
AC007541 Genomic DNA No translation available.
BC025984 mRNA Translation: AAH25984.1
BC036066 mRNA Translation: AAH36066.1
CCDSiCCDS9111.1
RefSeqiNP_001028222.1, NM_001033050.2
NP_079474.2, NM_025198.4
XP_011537069.1, XM_011538767.2
XP_016875474.1, XM_017019985.1
XP_016875475.1, XM_017019986.1
XP_016875476.1, XM_017019987.1
UniGeneiHs.5009

Genome annotation databases

EnsembliENST00000240050; ENSP00000240050; ENSG00000120832
ENST00000392830; ENSP00000376575; ENSG00000120832
ENST00000552029; ENSP00000447651; ENSG00000120832
GeneIDi80298
KEGGihsa:80298
UCSCiuc001tme.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTEF2_HUMAN
AccessioniPrimary (citable) accession number: Q49AM1
Secondary accession number(s): Q53HM2, Q9H4L6, Q9H7Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 20, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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