Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM135B

Gene

FAM135B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

ESTHERihuman-FAM135B. Duf_676.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM135B
Gene namesi
Name:FAM135B
Synonyms:C8orfK32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28029. FAM135B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386277.

Polymorphism and mutation databases

BioMutaiFAM135B.
DMDMi166233528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14061406Protein FAM135BPRO_0000314171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei777 – 7771PhosphoserineBy similarity
Modified residuei778 – 7781PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ49AJ0.
PaxDbiQ49AJ0.
PeptideAtlasiQ49AJ0.
PRIDEiQ49AJ0.

PTM databases

iPTMnetiQ49AJ0.
PhosphoSiteiQ49AJ0.

Expressioni

Gene expression databases

BgeeiQ49AJ0.
CleanExiHS_FAM135B.
ExpressionAtlasiQ49AJ0. baseline and differential.
GenevisibleiQ49AJ0. HS.

Organism-specific databases

HPAiHPA023911.
HPA023950.
HPA024815.

Interactioni

Protein-protein interaction databases

BioGridi119251. 2 interactions.
IntActiQ49AJ0. 2 interactions.
MINTiMINT-1408491.
STRINGi9606.ENSP00000378710.

Structurei

3D structure databases

ProteinModelPortaliQ49AJ0.
SMRiQ49AJ0. Positions 1140-1232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM135 family.Curated

Phylogenomic databases

eggNOGiKOG2205. Eukaryota.
ENOG410XQFK. LUCA.
GeneTreeiENSGT00390000007885.
HOGENOMiHOG000082668.
HOVERGENiHBG107866.
InParanoidiQ49AJ0.
OMAiRYVDCPA.
OrthoDBiEOG7C8GGG.
PhylomeDBiQ49AJ0.
TreeFamiTF314837.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022122. DUF3657.
IPR007751. DUF676_lipase-like.
[Graphical view]
PfamiPF12394. DUF3657. 1 hit.
PF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49AJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEIQGTVEF SVELHKFYNV DLFQRGYYQI RVTLKVSSRI PHRLSASIAG
60 70 80 90 100
QTESSSLHSA CVHDSTVHSR VFQILYRNEE VPINDAVVFR VHLLLGGERM
110 120 130 140 150
EDALSEVDFQ LKVDLHFTDS EQQLRDVAGA PMVSSRTLGL HFHPRNGLHH
160 170 180 190 200
QVPVMFDYFH LSVISVTVHA ALVALQQPLI SFTRPGRGSW LGKGGPDTGQ
210 220 230 240 250
EQSIISLENL VFGAGYCKPT SSEGSFYITS ENCMQHAHKW HRDLCLLLLH
260 270 280 290 300
AYRGLRLHFL VIMRDIPELP HTELEALAVE ETLSQLCSEL QMLNNPEKIA
310 320 330 340 350
EQISKDLAWL TSHMMTLWTQ FLDTVTLHSQ VTTYLTQEHH TLRVRRFSEA
360 370 380 390 400
FFYMEHQKLA VLTFQENLIQ THSQLSLDIR NSEYLTSMPP LPAECLDIDG
410 420 430 440 450
DWNTLPVIFE DRYVDCPATG HNLSVYPNFD VPVTSPTIMN LKDKEDNCMV
460 470 480 490 500
NSNLSFREDL VLSTIKPSQM DSDEEVIRCP EPGENVATQN HMDMCSESQV
510 520 530 540 550
YISIGEFQNK AGVPEDECWT GQTSDAGTYP VADVDTSRRS PGPEDGQAPV
560 570 580 590 600
LTYIDVKSSN KNPSRAEPLV AFNAQHESRS SRDKYGLDRT GLSKVVVGGS
610 620 630 640 650
HQNAISSDKT TLHELSTLGK GIDQEGKMVL LSLKLTPSEP CDPLSSTLRE
660 670 680 690 700
PLDIRSSLKD SHTEEQEELS VLSGVIKRSS SIISDSGIES EPSSVAWSEA
710 720 730 740 750
RSRALELPSD REVLHPFVRR HALHRNSLEG GHTESNTSLP SGIQASLTSI
760 770 780 790 800
SSLPFEEDER EVALTKLTKS VSAPHISSPE EAAEDADTKQ QDGGFAEPSD
810 820 830 840 850
MHSKSQGSPG SCSQLCGDSG TDAGADHPLV EIVLDADNQQ GPGYIDIPKG
860 870 880 890 900
KGKQFDAQGH CLPDGRTENT PGVETKGLNL KIPRVIALEN PRTRSLHRAL
910 920 930 940 950
EETPKGMPKD LNVGQQALSN SGISEVEGLS QHQVPELSCT SAADAINRNS
960 970 980 990 1000
TGQQSQSGSP CIMDDTAFNR GVNAFPEAKH KAGTVCPTVT HSVHSQVLKN
1010 1020 1030 1040 1050
QELKAGTSIM GSHLTSAETF TLDSLKAVEV VNLSVSCTAT CLPFSSVPKE
1060 1070 1080 1090 1100
TPARAGFSSK QTLFPITHQP LGSFGVVSTH SSTLDEEVSE RMFSFYQAKE
1110 1120 1130 1140 1150
KFKKELKIEG FLYSDLTVLA SDIPYFPPEE EEENLEDGIH LVVCVHGLDG
1160 1170 1180 1190 1200
NSADLRLVKT FIELGLPGGK LDFLMSEKNQ MDTFADFDTM TDRLLDEIIQ
1210 1220 1230 1240 1250
HIQLYNLSIS RISFIGHSLG NIIIRSVLTR PRFRYYLNKL HTFLSLSGPH
1260 1270 1280 1290 1300
LGTLYNNSTL VSTGLWLMQK LKKSGSLLQL TFRDNADLRK CFLYQLSQKT
1310 1320 1330 1340 1350
GLQYFKNVVL VASPQDRYVP FHSARIEMCK TALKDRHTGP VYAEMINNLL
1360 1370 1380 1390 1400
GPLVEAKDCT LIRHNVFHAL PNTANTLIGR AAHIAVLDSE LFLEKFFLVA

GLNYFK
Length:1,406
Mass (Da):155,770
Last modified:January 15, 2008 - v2
Checksum:iE2C3831C53A6CA13
GO
Isoform 2 (identifier: Q49AJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.

Show »
Length:1,307
Mass (Da):144,486
Checksum:i9B78498264337737
GO
Isoform 3 (identifier: Q49AJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1094-1141: SFYQAKEKFK...EENLEDGIHL → RGRGRKFGRW...PWRKTGLPNV
     1142-1406: Missing.

Show »
Length:1,141
Mass (Da):125,562
Checksum:iAE306FE041CF6C5F
GO
Isoform 4 (identifier: Q49AJ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1213-1213: S → R
     1214-1406: Missing.

Note: No experimental confirmation available.
Show »
Length:1,213
Mass (Da):133,902
Checksum:iE04E7ED29303ECCE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti245 – 2451C → W in AAH37288 (PubMed:15489334).Curated
Sequence conflicti1020 – 10201F → V in AAD20030 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti477 – 4771I → V.1 Publication
Corresponds to variant rs7835830 [ dbSNP | Ensembl ].
VAR_053980
Natural varianti578 – 5781S → N.
Corresponds to variant rs57534956 [ dbSNP | Ensembl ].
VAR_062218
Natural varianti846 – 8461D → N.
Corresponds to variant rs2978180 [ dbSNP | Ensembl ].
VAR_053981
Natural varianti1142 – 11421V → I.
Corresponds to variant rs35765793 [ dbSNP | Ensembl ].
VAR_062219

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9999Missing in isoform 2. 1 PublicationVSP_030232Add
BLAST
Alternative sequencei1094 – 114148SFYQA…DGIHL → RGRGRKFGRWNSPGCLCPWP GWEQCRPPAGKDFHRTGAPW RKTGLPNV in isoform 3. 3 PublicationsVSP_030233Add
BLAST
Alternative sequencei1142 – 1406265Missing in isoform 3. 3 PublicationsVSP_030234Add
BLAST
Alternative sequencei1213 – 12131S → R in isoform 4. 1 PublicationVSP_030235
Alternative sequencei1214 – 1406193Missing in isoform 4. 1 PublicationVSP_030236Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196635 mRNA. Translation: BAE53437.1.
AC068467 Genomic DNA. No translation available.
AC087711 Genomic DNA. No translation available.
AC103777 Genomic DNA. No translation available.
BC037288 mRNA. Translation: AAH37288.1.
BC106912 mRNA. Translation: AAI06913.2.
BC106913 mRNA. Translation: AAI06914.2.
AF131744 mRNA. Translation: AAD20030.1.
CR457147 mRNA. Translation: CAG33428.1.
CCDSiCCDS6375.2. [Q49AJ0-1]
RefSeqiNP_056996.2. NM_015912.3. [Q49AJ0-1]
XP_011515366.1. XM_011517064.1. [Q49AJ0-1]
XP_011515370.1. XM_011517068.1. [Q49AJ0-2]
XP_011515373.1. XM_011517071.1. [Q49AJ0-4]
UniGeneiHs.126024.
Hs.662285.

Genome annotation databases

EnsembliENST00000276737; ENSP00000276737; ENSG00000147724. [Q49AJ0-3]
ENST00000395297; ENSP00000378710; ENSG00000147724. [Q49AJ0-1]
GeneIDi51059.
KEGGihsa:51059.
UCSCiuc003yuy.3. human. [Q49AJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196635 mRNA. Translation: BAE53437.1.
AC068467 Genomic DNA. No translation available.
AC087711 Genomic DNA. No translation available.
AC103777 Genomic DNA. No translation available.
BC037288 mRNA. Translation: AAH37288.1.
BC106912 mRNA. Translation: AAI06913.2.
BC106913 mRNA. Translation: AAI06914.2.
AF131744 mRNA. Translation: AAD20030.1.
CR457147 mRNA. Translation: CAG33428.1.
CCDSiCCDS6375.2. [Q49AJ0-1]
RefSeqiNP_056996.2. NM_015912.3. [Q49AJ0-1]
XP_011515366.1. XM_011517064.1. [Q49AJ0-1]
XP_011515370.1. XM_011517068.1. [Q49AJ0-2]
XP_011515373.1. XM_011517071.1. [Q49AJ0-4]
UniGeneiHs.126024.
Hs.662285.

3D structure databases

ProteinModelPortaliQ49AJ0.
SMRiQ49AJ0. Positions 1140-1232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119251. 2 interactions.
IntActiQ49AJ0. 2 interactions.
MINTiMINT-1408491.
STRINGi9606.ENSP00000378710.

Protein family/group databases

ESTHERihuman-FAM135B. Duf_676.

PTM databases

iPTMnetiQ49AJ0.
PhosphoSiteiQ49AJ0.

Polymorphism and mutation databases

BioMutaiFAM135B.
DMDMi166233528.

Proteomic databases

EPDiQ49AJ0.
PaxDbiQ49AJ0.
PeptideAtlasiQ49AJ0.
PRIDEiQ49AJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276737; ENSP00000276737; ENSG00000147724. [Q49AJ0-3]
ENST00000395297; ENSP00000378710; ENSG00000147724. [Q49AJ0-1]
GeneIDi51059.
KEGGihsa:51059.
UCSCiuc003yuy.3. human. [Q49AJ0-1]

Organism-specific databases

CTDi51059.
GeneCardsiFAM135B.
HGNCiHGNC:28029. FAM135B.
HPAiHPA023911.
HPA023950.
HPA024815.
neXtProtiNX_Q49AJ0.
PharmGKBiPA162386277.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2205. Eukaryota.
ENOG410XQFK. LUCA.
GeneTreeiENSGT00390000007885.
HOGENOMiHOG000082668.
HOVERGENiHBG107866.
InParanoidiQ49AJ0.
OMAiRYVDCPA.
OrthoDBiEOG7C8GGG.
PhylomeDBiQ49AJ0.
TreeFamiTF314837.

Miscellaneous databases

GeneWikiiFAM135B.
GenomeRNAii51059.
PROiQ49AJ0.

Gene expression databases

BgeeiQ49AJ0.
CleanExiHS_FAM135B.
ExpressionAtlasiQ49AJ0. baseline and differential.
GenevisibleiQ49AJ0. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022122. DUF3657.
IPR007751. DUF676_lipase-like.
[Graphical view]
PfamiPF12394. DUF3657. 1 hit.
PF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene on human chromosome 8."
    Shimizu N., Asakawa S., Shimizu A., Yamazaki S., Ishikawa S.K.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 756-1406 (ISOFORM 4), VARIANT VAL-477.
    Tissue: Testis.
  4. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 691-1406 (ISOFORM 3).
    Tissue: Brain.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 801-1406 (ISOFORM 3).

Entry informationi

Entry nameiF135B_HUMAN
AccessioniPrimary (citable) accession number: Q49AJ0
Secondary accession number(s): B5MDB3
, O95879, Q2WGJ7, Q3KP46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.