ID   ARMEL_HUMAN             Reviewed;         187 AA.
AC   Q49AH0; A2RUU0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=ARMET-like protein 1;
DE   AltName: Full=Conserved dopamine neurotrophic factor;
DE            Short=CDNF;
DE   Flags: Precursor;
GN   Name=ARMETL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=17611540; DOI=10.1038/nature05957;
RA   Lindholm P., Voutilainen M.H., Lauren J., Peraenen J.,
RA   Leppaenen V.-M., Andressoo J.-O., Lindahl M., Janhunen S.,
RA   Kalkkinen N., Timmusk T., Tuominen R.K., Saarma M.;
RT   "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine
RT   neurons in vivo.";
RL   Nature 448:73-77(2007).
CC   -!- FUNCTION: Trophic factor for dopamine neurons. Prevents the 6-
CC       hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic
CC       neurons. When administered after 6-OHDA-lesioning, restores the
CC       dopaminergic function and prevents the degeneration of
CC       dopaminergic neurons in substantia nigra (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q49AH0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q49AH0-2; Sequence=VSP_023986;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Widely expressed in neuronal and non-neuronal
CC       tissues. In the brain, highest levels in the optic nerve and
CC       corpus callosum.
CC   -!- SIMILARITY: Belongs to the ARMET family.
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DR   EMBL; BC037872; AAH37872.1; -; mRNA.
DR   EMBL; BC133042; AAI33043.1; -; mRNA.
DR   EMBL; BC133044; AAI33045.1; -; mRNA.
DR   IPI; IPI00646351; -.
DR   IPI; IPI00647956; -.
DR   RefSeq; NP_001025125.2; -.
DR   UniGene; Hs.559067; -.
DR   PDB; 2W50; X-ray; 1.60 A; A/B=32-133.
DR   PDBsum; 2W50; -.
DR   PhosphoSite; Q49AH0; -.
DR   PRIDE; Q49AH0; -.
DR   Ensembl; ENSG00000185267; Homo sapiens.
DR   GeneID; 441549; -.
DR   KEGG; hsa:441549; -.
DR   GeneCards; GC10M014866; -.
DR   HGNC; HGNC:24913; ARMETL1.
DR   MIM; 611233; gene.
DR   PharmGKB; PA134870440; -.
DR   HOVERGEN; Q49AH0; -.
DR   OMA; Q49AH0; GADCEVC.
DR   NextBio; 110303; -.
DR   ArrayExpress; Q49AH0; -.
DR   Bgee; Q49AH0; -.
DR   CleanEx; HS_ARMETL1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019345; Armet_prot.
DR   Pfam; PF10208; Armet; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Growth factor; Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    187       ARMET-like protein 1.
FT                                /FTId=PRO_0000281137.
FT   VAR_SEQ       1    102       Missing (in isoform 2).
FT                                /FTId=VSP_023986.
SQ   SEQUENCE   187 AA;  20964 MW;  87460391592A10CA CRC64;
     MWCASPVAVV AFCAGLLVSH PVLTQGQEAG GRPGADCEVC KEFLNRFYKS LIDRGVNFSL
     DTIEKELISF CLDTKGKENR LCYYLGATKD AATKILSEVT RPMSVHMPAM KICEKLKKLD
     SQICELKYEK TLDLASVDLR KMRVAELKQI LHSWGEECRA CAEKTDYVNL IQELAPKYAA
     THPKTEL
//