Reviewed,
UniProtKB/Swiss-Prot Q49AH0 (ARMEL_HUMAN)
Last modified
November 4, 2008.
Version 17.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ARMET-like protein 1 Alternative name(s): Conserved dopamine neurotrophic factor Short name=CDNF | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 187 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra By similarity. |
| Subcellular location | |
| Tissue specificity | Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. |
| Sequence similarities | Belongs to the ARMET family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Alternative splicing |
| Domain | Signal |
| Molecular function | Growth factor |
Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q49AH0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q49AH0-2) The sequence of this isoform differs from the canonical sequence as follows: 1-102: Missing. | ||||||
| Notes: No experimental confirmation available. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis. |
| [2] | "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo." Lindholm P., Voutilainen M.H., Lauren J., Peraenen J., Leppaenen V.-M., Andressoo J.-O., Lindahl M., Janhunen S., Kalkkinen N., Timmusk T., Tuominen R.K., Saarma M. Nature 448:73-77(2007) [PubMed: 17611540] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| BC037872 mRNA. Translation: AAH37872.1. BC133042 mRNA. Translation: AAI33043.1. BC133044 mRNA. Translation: AAI33045.1. | |
| RefSeq | NP_001025125.2. |
| UniGene | Hs.559067 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q49AH0. |
Genome annotation databases | |
| Ensembl | ENSG00000185267. Homo sapiens. [Contig view] |
| GeneID | 441549. |
| KEGG | hsa:441549. |
Organism-specific databases | |
| HGNC | HGNC:24913. ARMETL1. |
| MIM | 611233. gene. |
| PharmGKB | PA134870440. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | Q49AH0. |
Gene expression databases | |
| ArrayExpress | Q49AH0. |
| CleanEx | HS_ARMETL1. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 110303. |
| SOURCE | Search... |
Entry information
| Entry name | ARMEL_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q49AH0 Secondary accession number(s): A2RUU0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


