Reviewed, UniProtKB/Swiss-Prot Q49AH0 (ARMEL_HUMAN)

Names and origin

Protein names

Recommended name:
    ARMET-like protein 1
Alternative name(s):
    Conserved dopamine neurotrophic factor
      Short name=CDNF

Gene names

Name:

ARMETL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra By similarity.
Subcellular location	Secreted.
Tissue specificity	Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
Sequence similarities	Belongs to the ARMET family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Growth factor
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q49AH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q49AH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 187	163	ARMET-like protein 1		PRO_0000281137
Natural variations
	Alternative sequence	1 – 102	102	Missing in isoform 2.		VSP_023986

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 87460391592A10CA	FASTA	187	20,964
	10 20 30 40 50 60 MWCASPVAVV AFCAGLLVSH PVLTQGQEAG GRPGADCEVC KEFLNRFYKS LIDRGVNFSL 70 80 90 100 110 120 DTIEKELISF CLDTKGKENR LCYYLGATKD AATKILSEVT RPMSVHMPAM KICEKLKKLD 130 140 150 160 170 180 SQICELKYEK TLDLASVDLR KMRVAELKQI LHSWGEECRA CAEKTDYVNL IQELAPKYAA THPKTEL
	Isoform 2 [UniParc]. Checksum: 6DF6CCDF820C8838		85	9,806
	10 20 30 40 50 60 MSVHMPAMKI CEKLKKLDSQ ICELKYEKTL DLASVDLRKM RVAELKQILH SWGEECRACA 70 80 EKTDYVNLIQ ELAPKYAATH PKTEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[2]	"Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo." Lindholm P., Voutilainen M.H., Lauren J., Peraenen J., Leppaenen V.-M., Andressoo J.-O., Lindahl M., Janhunen S., Kalkkinen N., Timmusk T., Tuominen R.K., Saarma M. Nature 448:73-77(2007) [PubMed: 17611540] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC037872 mRNA. Translation: AAH37872.1. BC133042 mRNA. Translation: AAI33043.1. BC133044 mRNA. Translation: AAI33045.1.
RefSeq	NP_001025125.2.
UniGene	Hs.559067
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q49AH0.
Genome annotation databases
Ensembl	ENSG00000185267. Homo sapiens. [Contig view]
GeneID	441549.
KEGG	hsa:441549.
Organism-specific databases
HGNC	HGNC:24913. ARMETL1.
MIM	611233. gene.
PharmGKB	PA134870440.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q49AH0.
Gene expression databases
ArrayExpress	Q49AH0.
CleanEx	HS_ARMETL1.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	110303.
SOURCE	Search...

Entry information

Entry name

ARMEL_HUMAN

Accession

Primary (citable) accession number: Q49AH0
Secondary accession number(s): A2RUU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	November 4, 2008
This is version 17 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)