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Protein

Cerebral dopamine neurotrophic factor

Gene

CDNF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).By similarity

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebral dopamine neurotrophic factor
Alternative name(s):
ARMET-like protein 1
Conserved dopamine neurotrophic factor
Gene namesi
Name:CDNF
Synonyms:ARMETL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24913. CDNF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165548325.

Polymorphism and mutation databases

BioMutaiCDNF.
DMDMi143955278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 187163Cerebral dopamine neurotrophic factorPRO_0000281137Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 1241 Publication
Disulfide bondi40 ↔ 1131 Publication
Disulfide bondi71 ↔ 821 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ49AH0.
PeptideAtlasiQ49AH0.
PRIDEiQ49AH0.

PTM databases

iPTMnetiQ49AH0.
PhosphoSiteiQ49AH0.

Expressioni

Tissue specificityi

Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.1 Publication

Inductioni

Not induced by endoplasmic reticulum stress.1 Publication

Gene expression databases

BgeeiQ49AH0.
CleanExiHS_ARMETL1.
GenevisibleiQ49AH0. HS.

Organism-specific databases

HPAiHPA044587.

Interactioni

Protein-protein interaction databases

BioGridi137570. 3 interactions.
STRINGi9606.ENSP00000419395.

Structurei

Secondary structure

1
187
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi38 – 5316Combined sources
Helixi60 – 7112Combined sources
Helixi76 – 849Combined sources
Helixi93 – 10311Combined sources
Turni104 – 1063Combined sources
Helixi109 – 1179Combined sources
Helixi121 – 1244Combined sources
Helixi133 – 1353Combined sources
Beta strandi139 – 1413Combined sources
Helixi144 – 15310Combined sources
Helixi164 – 17815Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LPNNMR-A27-131[»]
2W50X-ray1.60A/B32-133[»]
4BITNMR-A27-187[»]
ProteinModelPortaliQ49AH0.
SMRiQ49AH0. Positions 27-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ49AH0.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMET family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4154. Eukaryota.
ENOG4111QMZ. LUCA.
GeneTreeiENSGT00390000007160.
HOGENOMiHOG000264245.
InParanoidiQ49AH0.
OMAiCLDVKGK.
OrthoDBiEOG7PZS02.
PhylomeDBiQ49AH0.
TreeFamiTF314252.

Family and domain databases

InterProiIPR019345. Armet_prot.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49AH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWCASPVAVV AFCAGLLVSH PVLTQGQEAG GRPGADCEVC KEFLNRFYKS
60 70 80 90 100
LIDRGVNFSL DTIEKELISF CLDTKGKENR LCYYLGATKD AATKILSEVT
110 120 130 140 150
RPMSVHMPAM KICEKLKKLD SQICELKYEK TLDLASVDLR KMRVAELKQI
160 170 180
LHSWGEECRA CAEKTDYVNL IQELAPKYAA THPKTEL
Length:187
Mass (Da):20,964
Last modified:April 3, 2007 - v2
Checksum:i87460391592A10CA
GO
Isoform 2 (identifier: Q49AH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Note: No experimental confirmation available.
Show »
Length:85
Mass (Da):9,806
Checksum:i6DF6CCDF820C8838
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 2. 1 PublicationVSP_023986Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301259 mRNA. Translation: BAG62825.1.
CH471072 Genomic DNA. Translation: EAW86264.1.
BC037872 mRNA. Translation: AAH37872.1.
BC133042 mRNA. Translation: AAI33043.1.
BC133044 mRNA. Translation: AAI33045.1.
CCDSiCCDS31148.1. [Q49AH0-1]
RefSeqiNP_001025125.2. NM_001029954.2. [Q49AH0-1]
UniGeneiHs.559067.

Genome annotation databases

EnsembliENST00000378442; ENSP00000367703; ENSG00000185267. [Q49AH0-2]
ENST00000465530; ENSP00000419395; ENSG00000185267. [Q49AH0-1]
GeneIDi441549.
KEGGihsa:441549.
UCSCiuc001inb.2. human. [Q49AH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301259 mRNA. Translation: BAG62825.1.
CH471072 Genomic DNA. Translation: EAW86264.1.
BC037872 mRNA. Translation: AAH37872.1.
BC133042 mRNA. Translation: AAI33043.1.
BC133044 mRNA. Translation: AAI33045.1.
CCDSiCCDS31148.1. [Q49AH0-1]
RefSeqiNP_001025125.2. NM_001029954.2. [Q49AH0-1]
UniGeneiHs.559067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LPNNMR-A27-131[»]
2W50X-ray1.60A/B32-133[»]
4BITNMR-A27-187[»]
ProteinModelPortaliQ49AH0.
SMRiQ49AH0. Positions 27-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137570. 3 interactions.
STRINGi9606.ENSP00000419395.

PTM databases

iPTMnetiQ49AH0.
PhosphoSiteiQ49AH0.

Polymorphism and mutation databases

BioMutaiCDNF.
DMDMi143955278.

Proteomic databases

PaxDbiQ49AH0.
PeptideAtlasiQ49AH0.
PRIDEiQ49AH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378442; ENSP00000367703; ENSG00000185267. [Q49AH0-2]
ENST00000465530; ENSP00000419395; ENSG00000185267. [Q49AH0-1]
GeneIDi441549.
KEGGihsa:441549.
UCSCiuc001inb.2. human. [Q49AH0-1]

Organism-specific databases

CTDi441549.
GeneCardsiCDNF.
HGNCiHGNC:24913. CDNF.
HPAiHPA044587.
MIMi611233. gene.
neXtProtiNX_Q49AH0.
PharmGKBiPA165548325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4154. Eukaryota.
ENOG4111QMZ. LUCA.
GeneTreeiENSGT00390000007160.
HOGENOMiHOG000264245.
InParanoidiQ49AH0.
OMAiCLDVKGK.
OrthoDBiEOG7PZS02.
PhylomeDBiQ49AH0.
TreeFamiTF314252.

Miscellaneous databases

EvolutionaryTraceiQ49AH0.
GeneWikiiCerebral_dopamine_neurotrophic_factor.
GenomeRNAii441549.
PROiQ49AH0.
SOURCEiSearch...

Gene expression databases

BgeeiQ49AH0.
CleanExiHS_ARMETL1.
GenevisibleiQ49AH0. HS.

Family and domain databases

InterProiIPR019345. Armet_prot.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death."
    Apostolou A., Shen Y., Liang Y., Luo J., Fang S.
    Exp. Cell Res. 314:2454-2467(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.
  6. "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional."
    Parkash V., Lindholm P., Peranen J., Kalkkinen N., Oksanen E., Saarma M., Leppanen V.-M., Goldman A.
    Protein Eng. Des. Sel. 22:233-241(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 32-133, DISULFIDE BONDS.

Entry informationi

Entry nameiCDNF_HUMAN
AccessioniPrimary (citable) accession number: Q49AH0
Secondary accession number(s): A2RUU0, B4DVW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 6, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.