Reviewed,
UniProtKB/Swiss-Prot Q49AH0 (CDNF_HUMAN)
Last modified
January 19, 2010.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cerebral dopamine neurotrophic factor Alternative name(s): Conserved dopamine neurotrophic factor ARMET-like protein 1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 187 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra By similarity. |
| Subcellular location | |
| Tissue specificity | Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. Ref.4 |
| Induction | Not induced by endoplasmic reticulum (ER) stress. Ref.5 |
| Sequence similarities | Belongs to the ARMET family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Alternative splicing |
| Domain | Signal |
| Molecular function | Growth factor |
| PTM | Disulfide bond |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q49AH0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q49AH0-2) The sequence of this isoform differs from the canonical sequence as follows: 1-102: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||
Molecule processing | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | |||||||||||||||||||
| Chain | 25 – 187 | 163 | Cerebral dopamine neurotrophic factor | PRO_0000281137 | ||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||
| Disulfide bond | 37 ↔ 124 | Ref.6 | ||||||||||||||||||||
| Disulfide bond | 40 ↔ 113 | Ref.6 | ||||||||||||||||||||
| Disulfide bond | 71 ↔ 82 | Ref.6 | ||||||||||||||||||||
Natural variations | ||||||||||||||||||||||
| Alternative sequence | 1 – 102 | 102 | Missing in isoform 2. | VSP_023986 | ||||||||||||||||||
Secondary structure | ||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||
| Helix | 38 – 53 | 16 | ||||||||||||||||||||
| Helix | 60 – 71 | 12 | ||||||||||||||||||||
| Helix | 78 – 84 | 7 | ||||||||||||||||||||
| Helix | 93 – 103 | 11 | ||||||||||||||||||||
| Turn | 104 – 106 | 3 | ||||||||||||||||||||
| Helix | 109 – 117 | 9 | ||||||||||||||||||||
| Helix | 121 – 124 | 4 | ||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Spleen. |
| [2] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis. |
| [4] | "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo." Lindholm P., Voutilainen M.H., Lauren J., Peraenen J., Leppaenen V.-M., Andressoo J.-O., Lindahl M., Janhunen S., Kalkkinen N., Timmusk T., Tuominen R.K., Saarma M. Nature 448:73-77(2007) [PubMed: 17611540] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| [5] | "Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death." Apostolou A., Shen Y., Liang Y., Luo J., Fang S. Exp. Cell Res. 314:2454-2467(2008) [PubMed: 18561914] [Abstract] Cited for: SUBCELLULAR LOCATION, INDUCTION. |
| [6] | "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional." Parkash V., Lindholm P., Peranen J., Kalkkinen N., Oksanen E., Saarma M., Leppanen V.-M., Goldman A. Protein Eng. Des. Sel. 22:233-241(2009) [PubMed: 19258449] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 32-133, DISULFIDE BONDS. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AK301259 mRNA. Translation: BAG62825.1. CH471072 Genomic DNA. Translation: EAW86264.1. BC037872 mRNA. Translation: AAH37872.1. BC133042 mRNA. Translation: AAI33043.1. BC133044 mRNA. Translation: AAI33045.1. | ||||||||||||
| IPI | IPI00646351. IPI00647956. | ||||||||||||
| RefSeq | NP_001025125.2. | ||||||||||||
| UniGene | Hs.559067 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | Q49AH0. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q49AH0. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q49AH0. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000465530; ENSP00000419395; ENSG00000185267; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 441549. | ||||||||||||
| KEGG | hsa:441549. | ||||||||||||
| UCSC | uc001inb.1. human. uc001inc.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 441549. | ||||||||||||
| GeneCards | GC10M014866. | ||||||||||||
| HGNC | HGNC:24913. CDNF. | ||||||||||||
| MIM | 611233. gene. | ||||||||||||
| PharmGKB | PA134870440. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG08973. | ||||||||||||
| InParanoid | Q49AH0. | ||||||||||||
| OMA | GADCEVC. | ||||||||||||
| OrthoDB | EOG9CZF3T. | ||||||||||||
| PhylomeDB | Q49AH0. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q49AH0. | ||||||||||||
| Bgee | Q49AH0. | ||||||||||||
| CleanEx | HS_ARMETL1. | ||||||||||||
| Genevestigator | Q49AH0. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR019345. Armet_prot. [Graphical view] | ||||||||||||
| Pfam | PF10208. Armet. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 110303. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CDNF_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q49AH0 Secondary accession number(s): A2RUU0, B4DVW3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


