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Protein

Zinc finger BED domain-containing protein 5

Gene

ZBED5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri108 – 16457BED-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 5
Alternative name(s):
Transposon-derived Buster1 transposase-like protein
Gene namesi
Name:ZBED5
Synonyms:Buster1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30803. ZBED5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357120.

Polymorphism and mutation databases

BioMutaiZBED5.
DMDMi150416326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Zinc finger BED domain-containing protein 5PRO_0000291958Add
BLAST

Proteomic databases

EPDiQ49AG3.
MaxQBiQ49AG3.
PaxDbiQ49AG3.
PRIDEiQ49AG3.

PTM databases

iPTMnetiQ49AG3.
PhosphoSiteiQ49AG3.
SwissPalmiQ49AG3.

Expressioni

Gene expression databases

BgeeiQ49AG3.
CleanExiHS_ZBED5.
ExpressionAtlasiQ49AG3. baseline and differential.
GenevisibleiQ49AG3. HS.

Organism-specific databases

HPAiHPA048472.
HPA050994.

Interactioni

Protein-protein interaction databases

BioGridi121816. 1 interaction.
IntActiQ49AG3. 5 interactions.
MINTiMINT-1200303.
STRINGi9606.ENSP00000398106.

Structurei

3D structure databases

ProteinModelPortaliQ49AG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 BED-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri108 – 16457BED-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J4Q0. Eukaryota.
ENOG410ZSKF. LUCA.
GeneTreeiENSGT00760000119070.
HOGENOMiHOG000253000.
HOVERGENiHBG067573.
InParanoidiQ49AG3.
OMAiVSYHIAL.
OrthoDBiEOG75J0M6.
PhylomeDBiQ49AG3.
TreeFamiTF328297.

Family and domain databases

InterProiIPR012337. RNaseH-like_dom.
IPR003656. Znf_BED.
[Graphical view]
PfamiPF02892. zf-BED. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50808. ZF_BED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49AG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAPLLCILS YNFNTFAILN VYSKLTMFCT TNSLPMDLLL KQGSLKQEVE
60 70 80 90 100
SFCYQIVSES NDQKVGILQS EDKQLQPSVS KKSEGELSRV KFISNSNKIT
110 120 130 140 150
FSKKPKRRKY DESYLSFGFT YFGNRDAPHA QCVLCKKILS NSSLAPSKLR
160 170 180 190 200
RHLETKHAAY KDKDISFFKQ HLDSPENNKP PTPKIVNTDN ESATEASYNV
210 220 230 240 250
SYHIALSGEA HTIGELLIKP CAKDVVMRMF DEQYSKKIDA VQLSNSTVAR
260 270 280 290 300
RIKDLAADIE EELVCRLKIC DGFSLQLDES ADVSGLAVLL VFVRYRFNKS
310 320 330 340 350
IEEDLLLCES LQSNATGEEI FNCINSFMQK HEIEWEKCVD VCSDASRAVD
360 370 380 390 400
GKIAEAVTLI KYVAPESTSS HCLLYRHALA VKIMPTSLKN VLDQAVQIIN
410 420 430 440 450
YIKARPHQSR LLKILCEEMG AQHTALLLNT EVRWLSRGKV LVRLFELRRE
460 470 480 490 500
LLVFMDSAFR LSDCLTNSSW LLRLAYLADI FTKLNEVNLS MQGKNVTVFT
510 520 530 540 550
VFDKMSSLLR KLEFWASSVE EENFDCFPTL SDFLTEINST VDKDICSAIV
560 570 580 590 600
QHLRGLRATL LKYFPVTNDN NAWVRNPFTV TVKPASLVAR DYESLIDLTS
610 620 630 640 650
DSQVKQNFSE LSLNDFWSSL IQEYPSIARR AVRVLLPFAT MHLCETGFSY
660 670 680 690
YAATKTKYRK RLDAAPHMRI RLSNITPNIK RICDKKTQKH CSH
Length:693
Mass (Da):78,911
Last modified:June 26, 2007 - v2
Checksum:iEB69E97C9137FFB2
GO

Sequence cautioni

The sequence AAH17803.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH47754.1 differs from that shown. Reason: Frameshift at position 495. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171A → V.
Corresponds to variant rs2232918 [ dbSNP | Ensembl ].
VAR_032895
Natural varianti47 – 471Q → R.
Corresponds to variant rs2232919 [ dbSNP | Ensembl ].
VAR_032896
Natural varianti77 – 771P → S.
Corresponds to variant rs2232920 [ dbSNP | Ensembl ].
VAR_032897
Natural varianti480 – 4801I → V.1 Publication
Corresponds to variant rs1046297 [ dbSNP | Ensembl ].
VAR_059741

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205600 mRNA. Translation: AAF18454.1.
AF205601 Genomic DNA. Translation: AAF18455.1.
AK315033 mRNA. Translation: BAG37518.1.
AC069360 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68550.1.
BC017803 mRNA. Translation: AAH17803.1. Sequence problems.
BC047754 mRNA. Translation: AAH47754.1. Frameshift.
AL137577 mRNA. Translation: CAB70820.2.
PIRiT46273.
RefSeqiNP_001137139.1. NM_001143667.1.
NP_067034.2. NM_021211.3.
UniGeneiHs.655066.
Hs.728118.

Genome annotation databases

EnsembliENST00000413761; ENSP00000415939; ENSG00000236287.
ENST00000432999; ENSP00000398106; ENSG00000236287.
GeneIDi58486.
KEGGihsa:58486.
UCSCiuc001mji.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205600 mRNA. Translation: AAF18454.1.
AF205601 Genomic DNA. Translation: AAF18455.1.
AK315033 mRNA. Translation: BAG37518.1.
AC069360 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68550.1.
BC017803 mRNA. Translation: AAH17803.1. Sequence problems.
BC047754 mRNA. Translation: AAH47754.1. Frameshift.
AL137577 mRNA. Translation: CAB70820.2.
PIRiT46273.
RefSeqiNP_001137139.1. NM_001143667.1.
NP_067034.2. NM_021211.3.
UniGeneiHs.655066.
Hs.728118.

3D structure databases

ProteinModelPortaliQ49AG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121816. 1 interaction.
IntActiQ49AG3. 5 interactions.
MINTiMINT-1200303.
STRINGi9606.ENSP00000398106.

PTM databases

iPTMnetiQ49AG3.
PhosphoSiteiQ49AG3.
SwissPalmiQ49AG3.

Polymorphism and mutation databases

BioMutaiZBED5.
DMDMi150416326.

Proteomic databases

EPDiQ49AG3.
MaxQBiQ49AG3.
PaxDbiQ49AG3.
PRIDEiQ49AG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000413761; ENSP00000415939; ENSG00000236287.
ENST00000432999; ENSP00000398106; ENSG00000236287.
GeneIDi58486.
KEGGihsa:58486.
UCSCiuc001mji.4. human.

Organism-specific databases

CTDi58486.
GeneCardsiZBED5.
H-InvDBHIX0009447.
HGNCiHGNC:30803. ZBED5.
HPAiHPA048472.
HPA050994.
MIMi615251. gene.
neXtProtiNX_Q49AG3.
PharmGKBiPA147357120.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4Q0. Eukaryota.
ENOG410ZSKF. LUCA.
GeneTreeiENSGT00760000119070.
HOGENOMiHOG000253000.
HOVERGENiHBG067573.
InParanoidiQ49AG3.
OMAiVSYHIAL.
OrthoDBiEOG75J0M6.
PhylomeDBiQ49AG3.
TreeFamiTF328297.

Miscellaneous databases

ChiTaRSiZBED5. human.
GenomeRNAii58486.
NextBioi64942.
PROiQ49AG3.
SOURCEiSearch...

Gene expression databases

BgeeiQ49AG3.
CleanExiHS_ZBED5.
ExpressionAtlasiQ49AG3. baseline and differential.
GenevisibleiQ49AG3. HS.

Family and domain databases

InterProiIPR012337. RNaseH-like_dom.
IPR003656. Znf_BED.
[Graphical view]
PfamiPF02892. zf-BED. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50808. ZF_BED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interspersed repeats and other mementos of transposable elements in mammalian genomes."
    Smit A.F.A.
    Curr. Opin. Genet. Dev. 9:657-663(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT VAL-480.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-104.
    Tissue: Brain.

Entry informationi

Entry nameiZBED5_HUMAN
AccessioniPrimary (citable) accession number: Q49AG3
Secondary accession number(s): B2RCC1
, Q05D82, Q86WW3, Q9NT24, Q9UBJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: March 16, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May be derived from an ancient transposon that has lost its ability to translocate.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.