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Protein

Zinc finger protein ZFP69

Gene

ZFP69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFP69
Alternative name(s):
Zinc finger protein 642
Gene namesi
Name:ZFP69
Synonyms:ZNF642
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24708. ZFP69.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917508.

Polymorphism and mutation databases

BioMutaiZFP69.
DMDMi115502934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Zinc finger protein ZFP69PRO_0000252161Add
BLAST

Proteomic databases

PaxDbiQ49AA0.
PeptideAtlasiQ49AA0.
PRIDEiQ49AA0.

PTM databases

iPTMnetiQ49AA0.
PhosphoSiteiQ49AA0.

Expressioni

Gene expression databases

BgeeiENSG00000187815.
CleanExiHS_ZNF642.
GenevisibleiQ49AA0. HS.

Organism-specific databases

HPAiHPA027808.
HPA054942.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361790.

Structurei

3D structure databases

ProteinModelPortaliQ49AA0.
SMRiQ49AA0. Positions 76-117, 228-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 3939SCAN boxAdd
BLAST
Domaini76 – 14772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ49AA0.
KOiK09228.
OMAiSEHIRIH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ49AA0.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49AA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQQLLITLP TEASTWVKLQ HPKKAVEGAP LWEDVTKMFE GEALLSQDAE
60 70 80 90 100
DVKTQRESLE DEVTPGLPTA ESQELLTFKD ISIDFTQEEW GQLAPAHQNL
110 120 130 140 150
YREVMLENYS NLVSVGYQLS KPSVISQLEK GEEPWMAEKE GPGDPSSDLK
160 170 180 190 200
SKIETIESTA KSTISQERLY HGIMMESFMR DDIIYSTLRK VSTYDDVLER
210 220 230 240 250
HQETCMRDVR QAILTHKKRV QETNKFGENI IVHSNVIIEQ RHHKYDTPTK
260 270 280 290 300
RNTYKLDLIN HPTSYIRTKT YECNICEKIF KQPIHLTEHM RIHTGEKPFR
310 320 330 340 350
CKECGRAFSQ SASLSTHQRI HTGEKPFECE ECGKAFRHRS SLNQHHRTHT
360 370 380 390 400
GEKPYVCDKC QKAFSQNISL VQHLRTHSGE KPFTCNECGK TFRQIRHLSE
410 420 430 440 450
HIRIHTGEKP YACTACCKTF SHRAYLTHHQ RIHTGERPYK CKECGKAFRQ
460 470 480 490 500
RIHLSNHKTV HTGVKAYECN RCGKAYRHDS SFKKHQRHHT GEKPYECNEC
510 520
GKAFSYNSSL SRHHEIHRRN AFRNKV
Length:526
Mass (Da):61,181
Last modified:October 3, 2006 - v2
Checksum:iF0B624CF36BF4F36
GO

Sequence cautioni

The sequence BAC85492 differs from that shown. Reason: Erroneous termination at position 506. Translated as Tyr.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591T → A in AAH41873 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131V → L.
Corresponds to variant rs34752670 [ dbSNP | Ensembl ].
VAR_033583

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122618 mRNA. Translation: BAC85492.1. Sequence problems.
AL603839 Genomic DNA. Translation: CAI16297.1.
BC041873 mRNA. Translation: AAH41873.1.
CCDSiCCDS30686.1.
RefSeqiNP_001307107.1. NM_001320178.1.
NP_001307108.1. NM_001320179.1.
NP_940896.2. NM_198494.2.
XP_006710669.1. XM_006710606.3.
UniGeneiHs.434385.

Genome annotation databases

EnsembliENST00000372705; ENSP00000361790; ENSG00000187815.
ENST00000372706; ENSP00000361791; ENSG00000187815.
GeneIDi339559.
KEGGihsa:339559.
UCSCiuc001cfo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122618 mRNA. Translation: BAC85492.1. Sequence problems.
AL603839 Genomic DNA. Translation: CAI16297.1.
BC041873 mRNA. Translation: AAH41873.1.
CCDSiCCDS30686.1.
RefSeqiNP_001307107.1. NM_001320178.1.
NP_001307108.1. NM_001320179.1.
NP_940896.2. NM_198494.2.
XP_006710669.1. XM_006710606.3.
UniGeneiHs.434385.

3D structure databases

ProteinModelPortaliQ49AA0.
SMRiQ49AA0. Positions 76-117, 228-519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361790.

PTM databases

iPTMnetiQ49AA0.
PhosphoSiteiQ49AA0.

Polymorphism and mutation databases

BioMutaiZFP69.
DMDMi115502934.

Proteomic databases

PaxDbiQ49AA0.
PeptideAtlasiQ49AA0.
PRIDEiQ49AA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372705; ENSP00000361790; ENSG00000187815.
ENST00000372706; ENSP00000361791; ENSG00000187815.
GeneIDi339559.
KEGGihsa:339559.
UCSCiuc001cfo.4. human.

Organism-specific databases

CTDi339559.
GeneCardsiZFP69.
HGNCiHGNC:24708. ZFP69.
HPAiHPA027808.
HPA054942.
neXtProtiNX_Q49AA0.
PharmGKBiPA134917508.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ49AA0.
KOiK09228.
OMAiSEHIRIH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ49AA0.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii339559.
PROiQ49AA0.

Gene expression databases

BgeeiENSG00000187815.
CleanExiHS_ZNF642.
GenevisibleiQ49AA0. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFP69_HUMAN
AccessioniPrimary (citable) accession number: Q49AA0
Secondary accession number(s): Q5SWM5, Q6ZWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.