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Protein

Uncharacterized protein C8orf34

Gene

C8orf34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-87 is the initiator methionine.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C8orf34
Alternative name(s):
Protein VEST-1
Gene namesi
Name:C8orf34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000165084.15
HGNCiHGNC:30905 C8orf34
neXtProtiNX_Q49A92

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165084
PharmGKBiPA142672353

Polymorphism and mutation databases

BioMutaiC8orf34
DMDMi187470865

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300391 – 538Uncharacterized protein C8orf34Add BLAST538

Proteomic databases

PaxDbiQ49A92
PeptideAtlasiQ49A92
PRIDEiQ49A92

PTM databases

iPTMnetiQ49A92
PhosphoSitePlusiQ49A92

Expressioni

Gene expression databases

BgeeiENSG00000165084
CleanExiHS_C8orf34
ExpressionAtlasiQ49A92 baseline and differential
GenevisibleiQ49A92 HS

Organism-specific databases

HPAiHPA044420
HPA053065

Interactioni

Protein-protein interaction databases

BioGridi125497, 6 interactors
STRINGi9606.ENSP00000427820

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFD0 Eukaryota
ENOG4111YR7 LUCA
GeneTreeiENSGT00390000005870
HOGENOMiHOG000060121
HOVERGENiHBG107671
InParanoidiQ49A92
OMAiEHKGTRR
OrthoDBiEOG091G15H5
PhylomeDBiQ49A92
TreeFamiTF332826

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49A92-6) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPLASELS ELAALRPGFR LSAPHARVAP RAATHARGRG RASHAGQPRL
60 70 80 90 100
RSSCPGPSPG KRRVVPSGGA QPRVLPALSS RSHLFPMASH PQTRIQAYLE
110 120 130 140 150
KNKIGPLFEE LMTKLITETP DQPIPFLIDH LQSKQGNRGQ LQRTLSGSAA
160 170 180 190 200
LWAESEKSES KGTRRDFRSY DKPWQLNAKK PKKSKSDLAV SNISPPSPDS
210 220 230 240 250
KSLPRSVEHP KWNWRTKPQS RDFDELNHIL QESKKLGKAL ENLSRSIAIS
260 270 280 290 300
DELDKETVTF NSSLLRPRVI GEWIGREEND ADPLAAEMLQ PPIPRSKNDQ
310 320 330 340 350
WESEDSGSSP AGSLKMEPKN KGLKQQQQQH KKLLAAMLSQ DSFESIHSPT
360 370 380 390 400
PSVTEEDIDN EDDAMELLED LNDLRMEGVT TLVPSGSKFN QGRPTYPAEP
410 420 430 440 450
QAKVTLNICS RCARLQGDNL EERTEESLPI LHSPDEKIPD SFDSLPGTEE
460 470 480 490 500
ALMEEGDEFE KASKLTGPGE ASSGVGHSLK NYMEEDESLK QLQVVHQPWI
510 520 530
LPSDTESEGV EAEQEKRSAD LLLCVPCSSC PTLVYSGL
Note: No experimental confirmation available.Curated
Length:538
Mass (Da):59,434
Last modified:March 28, 2018 - v3
Checksum:i813DC01121888F68
GO
Isoform 2 (identifier: Q49A92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:427
Mass (Da):47,593
Checksum:iA75B18021FA45BAB
GO
Isoform 3 (identifier: Q49A92-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     369-373: EDLND → GNFKN
     374-538: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:287
Mass (Da):32,460
Checksum:i47418322096C958D
GO
Isoform 4 (identifier: Q49A92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-368: MSSPLASELS...DNEDDAMELL → MENGFTMCQTGRQHPVACGLHLSGGK
     517-538: RSADLLLCVPCSSCPTLVYSGL → HLLNQNLCGWDSEFCIFHTLASFLIYK

Note: No experimental confirmation available.Curated
Show »
Length:201
Mass (Da):22,266
Checksum:iD5D282CF71B5F730
GO

Sequence cautioni

The sequence AAH41961 differs from that shown. Reason: Frameshift at position 515.Curated
The sequence AAH41961 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042690161K → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042691512A → T1 PublicationCorresponds to variant dbSNP:rs16935065Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0594731 – 368MSSPL…AMELL → MENGFTMCQTGRQHPVACGL HLSGGK in isoform 4. Add BLAST368
Alternative sequenceiVSP_0594741 – 111Missing in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0594751 – 86Missing in isoform 3. Add BLAST86
Alternative sequenceiVSP_059476369 – 373EDLND → GNFKN in isoform 3. 2 Publications5
Alternative sequenceiVSP_059477374 – 538Missing in isoform 3. Add BLAST165
Alternative sequenceiVSP_059478517 – 538RSADL…VYSGL → HLLNQNLCGWDSEFCIFHTL ASFLIYK in isoform 4. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056652 mRNA Translation: BAB64433.1
AK094191 mRNA Translation: BAC04304.1
AK094650 mRNA Translation: BAC04395.1
AK291436 mRNA Translation: BAF84125.1
AL834454 mRNA Translation: CAD39114.2
AC011884 Genomic DNA No translation available.
AC067871 Genomic DNA No translation available.
AC083967 Genomic DNA No translation available.
AC090096 Genomic DNA No translation available.
KF458778 Genomic DNA No translation available.
KF458774 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86947.1
CH471068 Genomic DNA Translation: EAW86949.1
BC041961 mRNA Translation: AAH41961.1 Sequence problems.
CCDSiCCDS6203.2 [Q49A92-6]
RefSeqiNP_443190.2, NM_052958.2 [Q49A92-6]
UniGeneiHs.491941
Hs.656087

Genome annotation databases

EnsembliENST00000325233; ENSP00000319532; ENSG00000165084 [Q49A92-4]
ENST00000337103; ENSP00000337174; ENSG00000165084 [Q49A92-2]
ENST00000348340; ENSP00000345255; ENSG00000165084 [Q49A92-3]
ENST00000518698; ENSP00000427820; ENSG00000165084 [Q49A92-6]
GeneIDi116328
KEGGihsa:116328
UCSCiuc003xyb.4 human [Q49A92-6]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCH034_HUMAN
AccessioniPrimary (citable) accession number: Q49A92
Secondary accession number(s): A0A0C4DFS7
, A8K5X1, G3XAM6, Q8N1X0, Q8N9M7, Q8ND19, Q96Q28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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