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Protein

Uncharacterized protein C8orf34

Gene

C8orf34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C8orf34
Alternative name(s):
Protein VEST-1
Gene namesi
Name:C8orf34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30905. C8orf34.

Pathology & Biotechi

Organism-specific databases

DisGeNETi116328.
OpenTargetsiENSG00000165084.
PharmGKBiPA142672353.

Polymorphism and mutation databases

BioMutaiC8orf34.
DMDMi187470865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300391 – 452Uncharacterized protein C8orf34Add BLAST452

Proteomic databases

PaxDbiQ49A92.
PRIDEiQ49A92.

PTM databases

iPTMnetiQ49A92.
PhosphoSitePlusiQ49A92.

Expressioni

Gene expression databases

BgeeiENSG00000165084.
CleanExiHS_C8orf34.
ExpressionAtlasiQ49A92. baseline and differential.
GenevisibleiQ49A92. HS.

Organism-specific databases

HPAiHPA044420.
HPA053065.

Interactioni

Protein-protein interaction databases

BioGridi125497. 6 interactors.
STRINGi9606.ENSP00000427820.

Structurei

3D structure databases

ProteinModelPortaliQ49A92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFD0. Eukaryota.
ENOG4111YR7. LUCA.
GeneTreeiENSGT00390000005870.
HOGENOMiHOG000060121.
HOVERGENiHBG107671.
InParanoidiQ49A92.
OMAiKFNQGRA.
OrthoDBiEOG091G15H5.
PhylomeDBiQ49A92.
TreeFamiTF332826.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q49A92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASHPQTRIQ AYLEKNKIGP LFEELMTKLI TETPDQPIPF LIDHLQSKQG
60 70 80 90 100
NRGQLQRTLS GSAALWAESE KSESKGTRRD FRSYDKPWQL NAKKPKKSKS
110 120 130 140 150
DLAVSNISPP SPDSKSLPRS VEHPKWNWRT KPQSRDFDEL NHILQESKKL
160 170 180 190 200
GKALENLSRS IAISDELDKE TVTFNSSLLR PRVIGEWIGR EENDADPLAA
210 220 230 240 250
EMLQPPIPRS KNDQWESEDS GSSPAGSLKM EPKNKGLKQQ QQQHKKLLAA
260 270 280 290 300
MLSQDSFESI HSPTPSVTEE DIDNEDDAME LLEDLNDLRM EGVTTLVPSG
310 320 330 340 350
SKFNQGRPTY PAEPQAKVTL NICSRCARLQ GDNLEERTEE SLPILHSPDE
360 370 380 390 400
KIPDSFDSLP GTEEALMEEG DEFEKASKLT GPGEASSGVG HSLKNYMEED
410 420 430 440 450
ESLKQLQVVH QPWILPSDTE SEGVEAEQEK RSADLLLCVP CSSCPTLVYS

GL
Note: No experimental confirmation available.
Length:452
Mass (Da):50,489
Last modified:April 29, 2008 - v2
Checksum:iF8406AA2DAA1FE8D
GO
Isoform 2 (identifier: Q49A92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Note: No experimental confirmation available.
Show »
Length:427
Mass (Da):47,593
Checksum:iA75B18021FA45BAB
GO
Isoform 3 (identifier: Q49A92-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-287: EDLND → GNFKD
     288-452: Missing.

Show »
Length:287
Mass (Da):32,461
Checksum:i49A18322096C958D
GO
Isoform 4 (identifier: Q49A92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-256: Missing.
     257-282: FESIHSPTPSVTEEDIDNEDDAMELL → MENGFTMCQTGRQHPVACGLHLSGGK
     431-452: RSADLLLCVPCSSCPTLVYSGL → HLLNQNLCGWDSEFCIFHTLASFLIYK

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,266
Checksum:iD5D282CF71B5F730
GO
Isoform 5 (identifier: Q49A92-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-129: LPRSVEHPKWNWR → CKEVSYSNAIQSM
     130-452: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,505
Checksum:i2E83D911DC7DAADA
GO
Isoform 6 (identifier: Q49A92-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSPLASELS...LSSRSHLFPM

Note: No experimental confirmation available.
Show »
Length:538
Mass (Da):59,434
Checksum:i813DC01121888F68
GO

Sequence cautioni

The sequence AAH41961 differs from that shown. Reason: Frameshift at position 429.Curated
The sequence AAH41961 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q49A92-3)
Sequence conflicti287D → N in CAD39114 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04269075K → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042691426A → T.1 PublicationCorresponds to variant rs16935065dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0330081 – 256Missing in isoform 4. 1 PublicationAdd BLAST256
Alternative sequenceiVSP_0330091 – 25Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0472421M → MSSPLASELSELAALRPGFR LSAPHARVAPRAATHARGRG RASHAGQPRLRSSCPGPSPG KRRVVPSGGAQPRVLPALSS RSHLFPM in isoform 6. 1 Publication1
Alternative sequenceiVSP_033010117 – 129LPRSV…KWNWR → CKEVSYSNAIQSM in isoform 5. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_033011130 – 452Missing in isoform 5. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_033012257 – 282FESIH…AMELL → MENGFTMCQTGRQHPVACGL HLSGGK in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_033013283 – 287EDLND → GNFKD in isoform 3. 2 Publications5
Alternative sequenceiVSP_033014288 – 452Missing in isoform 3. 2 PublicationsAdd BLAST165
Alternative sequenceiVSP_033015431 – 452RSADL…VYSGL → HLLNQNLCGWDSEFCIFHTL ASFLIYK in isoform 4. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056652 mRNA. Translation: BAB64433.1.
AK094191 mRNA. Translation: BAC04304.1.
AK094650 mRNA. Translation: BAC04395.1.
AK291436 mRNA. Translation: BAF84125.1.
AL834454 mRNA. Translation: CAD39114.2.
AC011884 Genomic DNA. No translation available.
AC067871 Genomic DNA. No translation available.
AC083967 Genomic DNA. No translation available.
AC090096 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86947.1.
CH471068 Genomic DNA. Translation: EAW86949.1.
BC041961 mRNA. Translation: AAH41961.1. Sequence problems.
CCDSiCCDS6203.2. [Q49A92-6]
RefSeqiNP_001182568.1. NM_001195639.1.
NP_443190.2. NM_052958.2. [Q49A92-6]
UniGeneiHs.491941.

Genome annotation databases

EnsembliENST00000325233; ENSP00000319532; ENSG00000165084. [Q49A92-4]
ENST00000337103; ENSP00000337174; ENSG00000165084. [Q49A92-2]
ENST00000518698; ENSP00000427820; ENSG00000165084. [Q49A92-6]
ENST00000523686; ENSP00000429102; ENSG00000165084. [Q49A92-5]
GeneIDi116328.
KEGGihsa:116328.
UCSCiuc003xyb.4. human. [Q49A92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056652 mRNA. Translation: BAB64433.1.
AK094191 mRNA. Translation: BAC04304.1.
AK094650 mRNA. Translation: BAC04395.1.
AK291436 mRNA. Translation: BAF84125.1.
AL834454 mRNA. Translation: CAD39114.2.
AC011884 Genomic DNA. No translation available.
AC067871 Genomic DNA. No translation available.
AC083967 Genomic DNA. No translation available.
AC090096 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86947.1.
CH471068 Genomic DNA. Translation: EAW86949.1.
BC041961 mRNA. Translation: AAH41961.1. Sequence problems.
CCDSiCCDS6203.2. [Q49A92-6]
RefSeqiNP_001182568.1. NM_001195639.1.
NP_443190.2. NM_052958.2. [Q49A92-6]
UniGeneiHs.491941.

3D structure databases

ProteinModelPortaliQ49A92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125497. 6 interactors.
STRINGi9606.ENSP00000427820.

PTM databases

iPTMnetiQ49A92.
PhosphoSitePlusiQ49A92.

Polymorphism and mutation databases

BioMutaiC8orf34.
DMDMi187470865.

Proteomic databases

PaxDbiQ49A92.
PRIDEiQ49A92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325233; ENSP00000319532; ENSG00000165084. [Q49A92-4]
ENST00000337103; ENSP00000337174; ENSG00000165084. [Q49A92-2]
ENST00000518698; ENSP00000427820; ENSG00000165084. [Q49A92-6]
ENST00000523686; ENSP00000429102; ENSG00000165084. [Q49A92-5]
GeneIDi116328.
KEGGihsa:116328.
UCSCiuc003xyb.4. human. [Q49A92-1]

Organism-specific databases

CTDi116328.
DisGeNETi116328.
GeneCardsiC8orf34.
H-InvDBHIX0007569.
HGNCiHGNC:30905. C8orf34.
HPAiHPA044420.
HPA053065.
neXtProtiNX_Q49A92.
OpenTargetsiENSG00000165084.
PharmGKBiPA142672353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFD0. Eukaryota.
ENOG4111YR7. LUCA.
GeneTreeiENSGT00390000005870.
HOGENOMiHOG000060121.
HOVERGENiHBG107671.
InParanoidiQ49A92.
OMAiKFNQGRA.
OrthoDBiEOG091G15H5.
PhylomeDBiQ49A92.
TreeFamiTF332826.

Miscellaneous databases

ChiTaRSiC8orf34. human.
GenomeRNAii116328.
PROiQ49A92.

Gene expression databases

BgeeiENSG00000165084.
CleanExiHS_C8orf34.
ExpressionAtlasiQ49A92. baseline and differential.
GenevisibleiQ49A92. HS.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCH034_HUMAN
AccessioniPrimary (citable) accession number: Q49A92
Secondary accession number(s): A8K5X1
, G3XAM6, Q8N1X0, Q8N9M7, Q8ND19, Q96Q28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.