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Reviewed, UniProtKB/Swiss-Prot Q49A17 (GLTL6_HUMAN)

Last modified October 13, 2009. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Polypeptide N-acetylgalactosaminyltransferase-like 6
    EC=2.4.1.41
Alternative name(s):
    Putative polypeptide N-acetylgalactosaminyltransferase 17
    Polypeptide GalNAc transferase 17
      Short name=pp-GaNTase 17
      Short name=GalNAc-T17
    Protein-UDP acetylgalactosaminyltransferase 17
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17
Gene names
Name: GALNTL6
Synonyms: GALNT17
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor By similarity.

Catalytic activity

UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.

Cofactor

Manganese By similarity.

Calcium By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein By similarity.

Domain

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding By similarity.

The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity By similarity.

Sequence similarities

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

Contains 1 ricin B-type lectin domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q49A17-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q49A17-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MKRKQKRFLQMTLLFTVALIFLPNVGLWSLYKDKHLVKSAEPGEQ → MRAKFRAGAGHQRNPSISADHGVHELVY

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 601601Polypeptide N-acetylgalactosaminyltransferase-like 6
PRO_0000325774

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Signal-anchor for type II membrane protein Potential
Topological domain29 – 601573Lumenal Potential
Domain453 – 585133Ricin B-type lectin
Region139 – 248110Catalytic subdomain A
Region306 – 36863Catalytic subdomain B

Sites

Metal binding2321Manganese By similarity
Metal binding2341Manganese By similarity
Metal binding3651Manganese By similarity

Amino acid modifications

Glycosylation1411N-linked (GlcNAc...) Potential
Glycosylation5881N-linked (GlcNAc...) Potential
Disulfide bond130 ↔ 360 By similarity
Disulfide bond351 ↔ 427 By similarity
Disulfide bond466 ↔ 483 By similarity
Disulfide bond518 ↔ 533 By similarity
Disulfide bond558 ↔ 573 By similarity

Natural variations

Alternative sequence1 – 4545MKRKQ…EPGEQ → MRAKFRAGAGHQRNPSISAD HGVHELVY in isoform 2.
VSP_032402

Experimental info

Sequence conflict831R → G in CAF25036. Ref.1
Sequence conflict2501P → A in CAF25036. Ref.1
Sequence conflict5631H → P in CAF25036. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: BC98BD4750EFDAB3

FASTA60169,953
        10         20         30         40         50         60 
MKRKQKRFLQ MTLLFTVALI FLPNVGLWSL YKDKHLVKSA EPGEQQTFPL GLGDGQFYSW 

        70         80         90        100        110        120 
TDGLRRKDWH DYESIQKEAM RSRKGEHGKP YPLTEEDHDD SAYRENGFNI FVSNNIALER 

       130        140        150        160        170        180 
SLPDIRHANC KHKMYLERLP NTSIIIPFHN EGWTSLLRTI HSIINRTPGS LIAEIILVDD 

       190        200        210        220        230        240 
FSEREHLKDK LEEYMARFSK VRIVRTKKRE GLIRTRLLGA SMARGEVLTF LDSHCEVNVN 

       250        260        270        280        290        300 
WLPPLLNQIP LNHKTIVCPM IDVIDHNHFG YEAQAGDAMR GAFDWEMYYK RIPIPPELQR 

       310        320        330        340        350        360 
ADPSDPFESP VMAGGLFAVD RKWFWELGGY DPGLEIWGGE QYEISFKVWM CGGEMFDVPC 

       370        380        390        400        410        420 
SRVGHIYRKY VPYKVPSGTS LARNLKRVAE TWMDEFAEYI YQRRPEYRHL STGDISAQKE 

       430        440        450        460        470        480 
LRKQLKCKDF KWFMAAVAWD VPKYYPPVEP PPAAWGEIRN VAANLCVDSK HGATGTELRL 

       490        500        510        520        530        540 
DICVKDGSER TWSHEQLFTF GWREDIRPGE PLHTRKFCFD AISHNSPVTL YDCHGMKGNQ 

       550        560        570        580        590        600 
LWGYRKDRTL FHPVSNSCMD CNHAEKKIFM ARCDPLSETQ QWIFEHINMT VLEKFNHHAN 


S 

« Hide

Isoform 2.

Checksum: 38F4B2E394963821
Show »

FASTA58467,754

References

« Hide 'large scale' references
[1]"The GalNAc-transferase gene family."
Bennett E.P.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

AJ626725 mRNA. Translation: CAF25036.1.
BC047551 mRNA. Translation: AAH47551.1.
IPIIPI00454894.
IPI00888755.
RefSeqNP_001030017.2.
UniGeneHs.386236

3D structure databases

SMRQ49A17. Positions 63-598.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ49A17.

Protein family/group databases

CAZyCBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

Proteomic databases

PRIDEQ49A17.

Genome annotation databases

EnsemblENST00000308120; ENSP00000308828; ENSG00000174473; Homo sapiens. [Genome view]
ENST00000404275; ENSP00000385382; ENSG00000174473; Homo sapiens. [Genome view]
ENST00000457021; ENSP00000392006; ENSG00000174473; Homo sapiens. [Genome view]
GeneID442117.
KEGGhsa:442117.
UCSCuc003isv.1. human.

Organism-specific databases

CTD442117.
GeneCardsGC04P172972.
HGNCHGNC:33844. GALNTL6.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ49A17.
HOVERGENQ49A17.

Enzyme and pathway databases

BRENDA2.4.1.41. 247.

Gene expression databases

ArrayExpressQ49A17.
BgeeQ49A17.
CleanExHS_GALNTL6.
GenevestigatorQ49A17.

Family and domain databases

InterProIPR001173. Glyco_trans_2.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamPF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTSM00458. RICIN. 1 hit.
[Graphical view]
PROSITEPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio110727.

Entry information

Entry nameGLTL6_HUMAN
AccessionPrimary (citable) accession number: Q49A17
Secondary accession number(s): Q2L4S6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 13, 2005
Last modified: October 13, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents