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Q49A17

- GLTL6_HUMAN

UniProt

Q49A17 - GLTL6_HUMAN

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Protein
Polypeptide N-acetylgalactosaminyltransferase-like 6
Gene
GALNTL6, GALNT17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor By similarity.

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

Cofactori

Manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei180 – 1801Substrate By similarity
Binding sitei209 – 2091Substrate By similarity
Metal bindingi232 – 2321Manganese By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi234 – 2341Manganese By similarity
Binding sitei337 – 3371Substrate By similarity
Metal bindingi365 – 3651Manganese By similarity
Binding sitei368 – 3681Substrate By similarity
Binding sitei373 – 3731Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Lectin, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

Names & Taxonomyi

Protein namesi
Recommended name:
Polypeptide N-acetylgalactosaminyltransferase-like 6 (EC:2.4.1.41)
Alternative name(s):
Polypeptide GalNAc transferase 17
Short name:
GalNAc-T17
Short name:
pp-GaNTase 17
Protein-UDP acetylgalactosaminyltransferase 17
Putative polypeptide N-acetylgalactosaminyltransferase 17
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17
Gene namesi
Name:GALNTL6
Synonyms:GALNT17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:33844. GALNTL6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini29 – 601573Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Polypeptide N-acetylgalactosaminyltransferase-like 6
PRO_0000325774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi130 ↔ 360 By similarity
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi351 ↔ 427 By similarity
Disulfide bondi466 ↔ 483 By similarity
Disulfide bondi518 ↔ 533 By similarity
Disulfide bondi558 ↔ 573 By similarity
Glycosylationi588 – 5881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ49A17.
PRIDEiQ49A17.

Expressioni

Gene expression databases

ArrayExpressiQ49A17.
BgeeiQ49A17.
CleanExiHS_GALNTL6.
GenevestigatoriQ49A17.

Organism-specific databases

HPAiHPA031019.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385382.

Structurei

3D structure databases

ProteinModelPortaliQ49A17.
SMRiQ49A17. Positions 63-598.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini453 – 585133Ricin B-type lectin
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 248110Catalytic subdomain A
Add
BLAST
Regioni306 – 36863Catalytic subdomain B
Add
BLAST

Domaini

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding By similarity.
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239675.
HOGENOMiHOG000038227.
HOVERGENiHBG051699.
InParanoidiQ49A17.
KOiK00710.
OMAiAVNRKWF.
OrthoDBiEOG7J9VP2.
PhylomeDBiQ49A17.
TreeFamiTF313267.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q49A17-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKRKQKRFLQ MTLLFTVALI FLPNVGLWSL YKDKHLVKSA EPGEQQTFPL    50
GLGDGQFYSW TDGLRRKDWH DYESIQKEAM RSGKGEHGKP YPLTEEDHDD 100
SAYRENGFNI FVSNNIALER SLPDIRHANC KHKMYLERLP NTSIIIPFHN 150
EGWTSLLRTI HSIINRTPGS LIAEIILVDD FSEREHLKDK LEEYMARFSK 200
VRIVRTKKRE GLIRTRLLGA SMARGEVLTF LDSHCEVNVN WLPPLLNQIA 250
LNHKTIVCPM IDVIDHNHFG YEAQAGDAMR GAFDWEMYYK RIPIPPELQR 300
ADPSDPFESP VMAGGLFAVD RKWFWELGGY DPGLEIWGGE QYEISFKVWM 350
CGGEMFDVPC SRVGHIYRKY VPYKVPSGTS LARNLKRVAE TWMDEFAEYI 400
YQRRPEYRHL STGDISAQKE LRKQLKCKDF KWFMAAVAWD VPKYYPPVEP 450
PPAAWGEIRN VAANLCVDSK HGATGTELRL DICVKDGSER TWSHEQLFTF 500
GWREDIRPGE PLHTRKFCFD AISHNSPVTL YDCHGMKGNQ LWGYRKDRTL 550
FHPVSNSCMD CNPAEKKIFM ARCDPLSETQ QWIFEHINMT VLEKFNHHAN 600
S 601
Length:601
Mass (Da):69,788
Last modified:May 18, 2010 - v2
Checksum:iDEFBE2E41DD2FC1D
GO
Isoform 2 (identifier: Q49A17-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MKRKQKRFLQMTLLFTVALIFLPNVGLWSLYKDKHLVKSAEPGEQ → MRAKFRAGAGHQRNPSISADHGVHELVY

Show »
Length:584
Mass (Da):67,589
Checksum:i5A97ED40D9AB1E8F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545MKRKQ…EPGEQ → MRAKFRAGAGHQRNPSISAD HGVHELVY in isoform 2.
VSP_032402Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831G → R in AAH47551. 1 Publication
Sequence conflicti250 – 2501A → P in AAH47551. 1 Publication
Sequence conflicti563 – 5631P → H in AAH47551. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ626725 mRNA. Translation: CAF25036.1.
AC024706 Genomic DNA. No translation available.
AC025561 Genomic DNA. No translation available.
AC025821 Genomic DNA. No translation available.
AC093803 Genomic DNA. No translation available.
AC095045 Genomic DNA. No translation available.
AC095063 Genomic DNA. No translation available.
AC097496 Genomic DNA. No translation available.
AC105285 Genomic DNA. No translation available.
AC108064 Genomic DNA. No translation available.
AC109520 Genomic DNA. No translation available.
AC110776 Genomic DNA. No translation available.
AC131952 Genomic DNA. No translation available.
BC047551 mRNA. Translation: AAH47551.1.
CCDSiCCDS34104.1. [Q49A17-1]
RefSeqiNP_001030017.2. NM_001034845.2. [Q49A17-1]
UniGeneiHs.386236.

Genome annotation databases

EnsembliENST00000506823; ENSP00000423313; ENSG00000174473. [Q49A17-1]
ENST00000508122; ENSP00000423827; ENSG00000174473. [Q49A17-2]
GeneIDi442117.
KEGGihsa:442117.
UCSCiuc003isv.3. human. [Q49A17-1]

Polymorphism databases

DMDMi296434516.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ626725 mRNA. Translation: CAF25036.1 .
AC024706 Genomic DNA. No translation available.
AC025561 Genomic DNA. No translation available.
AC025821 Genomic DNA. No translation available.
AC093803 Genomic DNA. No translation available.
AC095045 Genomic DNA. No translation available.
AC095063 Genomic DNA. No translation available.
AC097496 Genomic DNA. No translation available.
AC105285 Genomic DNA. No translation available.
AC108064 Genomic DNA. No translation available.
AC109520 Genomic DNA. No translation available.
AC110776 Genomic DNA. No translation available.
AC131952 Genomic DNA. No translation available.
BC047551 mRNA. Translation: AAH47551.1 .
CCDSi CCDS34104.1. [Q49A17-1 ]
RefSeqi NP_001030017.2. NM_001034845.2. [Q49A17-1 ]
UniGenei Hs.386236.

3D structure databases

ProteinModelPortali Q49A17.
SMRi Q49A17. Positions 63-598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000385382.

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

Polymorphism databases

DMDMi 296434516.

Proteomic databases

PaxDbi Q49A17.
PRIDEi Q49A17.

Protocols and materials databases

DNASUi 442117.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000506823 ; ENSP00000423313 ; ENSG00000174473 . [Q49A17-1 ]
ENST00000508122 ; ENSP00000423827 ; ENSG00000174473 . [Q49A17-2 ]
GeneIDi 442117.
KEGGi hsa:442117.
UCSCi uc003isv.3. human. [Q49A17-1 ]

Organism-specific databases

CTDi 442117.
GeneCardsi GC04P172735.
HGNCi HGNC:33844. GALNTL6.
HPAi HPA031019.
neXtProti NX_Q49A17.
PharmGKBi PA164720162.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239675.
HOGENOMi HOG000038227.
HOVERGENi HBG051699.
InParanoidi Q49A17.
KOi K00710.
OMAi AVNRKWF.
OrthoDBi EOG7J9VP2.
PhylomeDBi Q49A17.
TreeFami TF313267.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_115606. O-linked glycosylation of mucins.

Miscellaneous databases

GenomeRNAii 442117.
NextBioi 110727.
PROi Q49A17.

Gene expression databases

ArrayExpressi Q49A17.
Bgeei Q49A17.
CleanExi HS_GALNTL6.
Genevestigatori Q49A17.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The GalNAc-transferase gene family."
    Bennett E.P.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiGLTL6_HUMAN
AccessioniPrimary (citable) accession number: Q49A17
Secondary accession number(s): Q2L4S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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