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Protein

Zinc finger protein 672

Gene

ZNF672

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri42 – 64C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri70 – 92C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri99 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 672
Gene namesi
Name:ZNF672
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171161.12
HGNCiHGNC:26179 ZNF672
neXtProtiNX_Q499Z4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171161
PharmGKBiPA142670473

Polymorphism and mutation databases

BioMutaiZNF672
DMDMi116242864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339911 – 452Zinc finger protein 672Add BLAST452

Proteomic databases

EPDiQ499Z4
MaxQBiQ499Z4
PaxDbiQ499Z4
PeptideAtlasiQ499Z4
PRIDEiQ499Z4

PTM databases

iPTMnetiQ499Z4
PhosphoSitePlusiQ499Z4

Expressioni

Gene expression databases

BgeeiENSG00000171161
CleanExiHS_ZNF672
ExpressionAtlasiQ499Z4 baseline and differential
GenevisibleiQ499Z4 HS

Organism-specific databases

HPAiHPA055779
HPA062506

Interactioni

Protein-protein interaction databases

BioGridi122978, 2 interactors
IntActiQ499Z4, 3 interactors
STRINGi9606.ENSP00000421915

Structurei

3D structure databases

ProteinModelPortaliQ499Z4
SMRiQ499Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri42 – 64C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri70 – 92C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri99 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00730000111556
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ499Z4
OMAiCFSHSRS
OrthoDBiEOG091G02KC
PhylomeDBiQ499Z4
TreeFamiTF337999

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q499Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFATSGAVAA GKPYSCSECG KSFCYSSVLL RHERAHGGDG RFRCLECGER
60 70 80 90 100
CARAADLRAH RRTHAGQTLY ICSECGQSFR HSGRLDLHLG AHRQRCRTCP
110 120 130 140 150
CRTCGRRFPH LPALLLHRRR QHLPERPRRC PLCARTFRQS ALLFHQARAH
160 170 180 190 200
PLGTTSDPAA PPHRCAQCPR AFRSGAGLRS HARIHVSRSP TRPRVSDAHQ
210 220 230 240 250
CGVCGKCFGK SSTLTRHLQT HSGEKPFKCP ECGKGFLESA TLVRHQRTHT
260 270 280 290 300
GEKPYACGDC GRCFSESSTL LRHRRSHQGE RPHACATCGK GFGQRSDLVV
310 320 330 340 350
HQRIHTGEKP FACPECGRRF SDRSDLTKHR RTHTGEKPYR CELCGKRFTC
360 370 380 390 400
VSNLNVHRRN HAGHKPHKCP ECSKAFSVAS KLALHRKTHL GERPAECAEC
410 420 430 440 450
GKCFSHSRSL SQHQRAHTRA RTAAAVAIQS AVGTALVFEG PAEQEKPGFS

VS
Length:452
Mass (Da):50,224
Last modified:October 17, 2006 - v2
Checksum:i4D9D8B262748A39E
GO
Isoform 2 (identifier: Q499Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-223: RRCPLCARTF...LTRHLQTHSG → LLPCCPRITR...CRHVTSPVAS
     224-452: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):24,813
Checksum:i59CFD1EBDA0583AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182A → P in AAH50348 (PubMed:15489334).Curated1
Sequence conflicti182A → P in AAH35140 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018161128 – 223RRCPL…QTHSG → LLPCCPRITRILSSGVGAGS QGTLRLPCVQEPRCWCVPLM LLCSLVFLIFLPLFCLLLSY LIPAHIFSFPDYFCCPASSG NGHRFGCRHVTSPVAS in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_018162224 – 452Missing in isoform 2. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025954 mRNA Translation: BAB15294.1
AK027679 mRNA Translation: BAB55290.1
BC007385 mRNA Translation: AAH07385.2
BC008872 mRNA Translation: AAH08872.1
BC035140 mRNA Translation: AAH35140.1
BC050348 mRNA Translation: AAH50348.1
BC068506 mRNA Translation: AAH68506.1
CCDSiCCDS1638.1 [Q499Z4-1]
RefSeqiNP_079112.1, NM_024836.2 [Q499Z4-1]
XP_005270393.1, XM_005270336.1 [Q499Z4-1]
UniGeneiHs.521151

Genome annotation databases

EnsembliENST00000306562; ENSP00000421915; ENSG00000171161 [Q499Z4-1]
GeneIDi79894
KEGGihsa:79894
UCSCiuc001iex.4 human [Q499Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN672_HUMAN
AccessioniPrimary (citable) accession number: Q499Z4
Secondary accession number(s): Q96H65, Q96IM3, Q9H6G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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