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Protein

Zinc finger protein 672

Gene

ZNF672

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri42 – 64C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri70 – 92C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri99 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 672
Gene namesi
Name:ZNF672
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26179. ZNF672.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171161.
PharmGKBiPA142670473.

Polymorphism and mutation databases

BioMutaiZNF672.
DMDMi116242864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339911 – 452Zinc finger protein 672Add BLAST452

Proteomic databases

EPDiQ499Z4.
MaxQBiQ499Z4.
PaxDbiQ499Z4.
PeptideAtlasiQ499Z4.
PRIDEiQ499Z4.

PTM databases

iPTMnetiQ499Z4.
PhosphoSitePlusiQ499Z4.

Expressioni

Gene expression databases

BgeeiENSG00000171161.
CleanExiHS_ZNF672.
ExpressionAtlasiQ499Z4. baseline and differential.
GenevisibleiQ499Z4. HS.

Organism-specific databases

HPAiHPA055779.
HPA062506.

Interactioni

Protein-protein interaction databases

BioGridi122978. 2 interactors.
IntActiQ499Z4. 3 interactors.
STRINGi9606.ENSP00000421915.

Structurei

3D structure databases

ProteinModelPortaliQ499Z4.
SMRiQ499Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri42 – 64C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri70 – 92C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri99 – 122C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111556.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ499Z4.
OMAiHQGERPH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ499Z4.
TreeFamiTF337999.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q499Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFATSGAVAA GKPYSCSECG KSFCYSSVLL RHERAHGGDG RFRCLECGER
60 70 80 90 100
CARAADLRAH RRTHAGQTLY ICSECGQSFR HSGRLDLHLG AHRQRCRTCP
110 120 130 140 150
CRTCGRRFPH LPALLLHRRR QHLPERPRRC PLCARTFRQS ALLFHQARAH
160 170 180 190 200
PLGTTSDPAA PPHRCAQCPR AFRSGAGLRS HARIHVSRSP TRPRVSDAHQ
210 220 230 240 250
CGVCGKCFGK SSTLTRHLQT HSGEKPFKCP ECGKGFLESA TLVRHQRTHT
260 270 280 290 300
GEKPYACGDC GRCFSESSTL LRHRRSHQGE RPHACATCGK GFGQRSDLVV
310 320 330 340 350
HQRIHTGEKP FACPECGRRF SDRSDLTKHR RTHTGEKPYR CELCGKRFTC
360 370 380 390 400
VSNLNVHRRN HAGHKPHKCP ECSKAFSVAS KLALHRKTHL GERPAECAEC
410 420 430 440 450
GKCFSHSRSL SQHQRAHTRA RTAAAVAIQS AVGTALVFEG PAEQEKPGFS

VS
Length:452
Mass (Da):50,224
Last modified:October 17, 2006 - v2
Checksum:i4D9D8B262748A39E
GO
Isoform 2 (identifier: Q499Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-223: RRCPLCARTF...LTRHLQTHSG → LLPCCPRITR...CRHVTSPVAS
     224-452: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):24,813
Checksum:i59CFD1EBDA0583AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182A → P in AAH50348 (PubMed:15489334).Curated1
Sequence conflicti182A → P in AAH35140 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018161128 – 223RRCPL…QTHSG → LLPCCPRITRILSSGVGAGS QGTLRLPCVQEPRCWCVPLM LLCSLVFLIFLPLFCLLLSY LIPAHIFSFPDYFCCPASSG NGHRFGCRHVTSPVAS in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_018162224 – 452Missing in isoform 2. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025954 mRNA. Translation: BAB15294.1.
AK027679 mRNA. Translation: BAB55290.1.
BC007385 mRNA. Translation: AAH07385.2.
BC008872 mRNA. Translation: AAH08872.1.
BC035140 mRNA. Translation: AAH35140.1.
BC050348 mRNA. Translation: AAH50348.1.
BC068506 mRNA. Translation: AAH68506.1.
CCDSiCCDS1638.1. [Q499Z4-1]
RefSeqiNP_079112.1. NM_024836.2. [Q499Z4-1]
XP_005270393.1. XM_005270336.1. [Q499Z4-1]
UniGeneiHs.521151.

Genome annotation databases

EnsembliENST00000306562; ENSP00000421915; ENSG00000171161. [Q499Z4-1]
GeneIDi79894.
KEGGihsa:79894.
UCSCiuc001iex.4. human. [Q499Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025954 mRNA. Translation: BAB15294.1.
AK027679 mRNA. Translation: BAB55290.1.
BC007385 mRNA. Translation: AAH07385.2.
BC008872 mRNA. Translation: AAH08872.1.
BC035140 mRNA. Translation: AAH35140.1.
BC050348 mRNA. Translation: AAH50348.1.
BC068506 mRNA. Translation: AAH68506.1.
CCDSiCCDS1638.1. [Q499Z4-1]
RefSeqiNP_079112.1. NM_024836.2. [Q499Z4-1]
XP_005270393.1. XM_005270336.1. [Q499Z4-1]
UniGeneiHs.521151.

3D structure databases

ProteinModelPortaliQ499Z4.
SMRiQ499Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122978. 2 interactors.
IntActiQ499Z4. 3 interactors.
STRINGi9606.ENSP00000421915.

PTM databases

iPTMnetiQ499Z4.
PhosphoSitePlusiQ499Z4.

Polymorphism and mutation databases

BioMutaiZNF672.
DMDMi116242864.

Proteomic databases

EPDiQ499Z4.
MaxQBiQ499Z4.
PaxDbiQ499Z4.
PeptideAtlasiQ499Z4.
PRIDEiQ499Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306562; ENSP00000421915; ENSG00000171161. [Q499Z4-1]
GeneIDi79894.
KEGGihsa:79894.
UCSCiuc001iex.4. human. [Q499Z4-1]

Organism-specific databases

CTDi79894.
GeneCardsiZNF672.
HGNCiHGNC:26179. ZNF672.
HPAiHPA055779.
HPA062506.
neXtProtiNX_Q499Z4.
OpenTargetsiENSG00000171161.
PharmGKBiPA142670473.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111556.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ499Z4.
OMAiHQGERPH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ499Z4.
TreeFamiTF337999.

Miscellaneous databases

ChiTaRSiZNF672. human.
GenomeRNAii79894.
PROiQ499Z4.

Gene expression databases

BgeeiENSG00000171161.
CleanExiHS_ZNF672.
ExpressionAtlasiQ499Z4. baseline and differential.
GenevisibleiQ499Z4. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN672_HUMAN
AccessioniPrimary (citable) accession number: Q499Z4
Secondary accession number(s): Q96H65, Q96IM3, Q9H6G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.