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Q499Z3 (SLNL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Schlafen-like protein 1
Gene names
Name:SLFNL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Schlafen family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q499Z3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q499Z3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     146-204: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q499Z3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     320-367: Missing.
Isoform 4 (identifier: Q499Z3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     146-260: EKEEEEEDSG...LNSEGGSLLV → VSGTFPKQAP...FLLGPTHLFN
     261-407: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Schlafen-like protein 1
PRO_0000282998

Regions

Nucleotide binding261 – 2688ATP Potential
Coiled coil366 – 39833 Potential

Natural variations

Alternative sequence146 – 260115EKEEE…GSLLV → VSGTFPKQAPKPHPKGEPLS GSGLQSGDGGVSLGKQGQIC KLGGCHSNDHGLRLVLPAFS GKNSLPQAQARRLCEERPRG DLLSLGPFTFQPLGLGDPRR HRGPDFLLGPTHLFN in isoform 4.
VSP_024275
Alternative sequence146 – 20459Missing in isoform 2.
VSP_024276
Alternative sequence261 – 407147Missing in isoform 4.
VSP_024277
Alternative sequence320 – 36748Missing in isoform 3.
VSP_024278
Natural variant301A → T. Ref.1
Corresponds to variant rs1138293 [ dbSNP | Ensembl ].
VAR_031459
Natural variant1281R → S. Ref.3
Corresponds to variant rs17851964 [ dbSNP | Ensembl ].
VAR_031460
Natural variant1441R → T.
Corresponds to variant rs3738368 [ dbSNP | Ensembl ].
VAR_031461

Experimental info

Sequence conflict1001V → I in AAH50353. Ref.3
Sequence conflict2801R → S in AAH37879. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 8000DDC8FE0C4D76

FASTA40745,603
        10         20         30         40         50         60 
MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY VGHLNPQFSV 

        70         80         90        100        110        120 
PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV HRDTLASLPW RLQTALEEHL 

       130        140        150        160        170        180 
ILKELAARGK DLLLSEAQGP FSHREEKEEE EEDSGLSPGP SPGSGVPLPT WPTHTLPDRP 

       190        200        210        220        230        240 
QAQQLQSCQG RPSGVCSDSA IVHQQIVGKD QLFQGAFLGS ETRNMEFKRG SGEYLSLAFK 

       250        260        270        280        290        300 
HHVRRYVCAF LNSEGGSLLV GVEDSGLVQG IRCSHRDEDR ARLLVDSILQ GFKPQIFPDA 

       310        320        330        340        350        360 
YTLTFIPVIS TSETSVPLKV IRLTVHTPKA QSQPQLYQTD QGEVFLRRDG SIQGPLSASA 

       370        380        390        400 
IQEWCRQRWL VELGKLEEKM KALMMEKEQL QQQLQQHGPV SCTCCVL 

« Hide

Isoform 2 [UniParc].

Checksum: 1C7E1EED7FA2FD14
Show »

FASTA34839,385
Isoform 3 [UniParc].

Checksum: EC270D4AB3F0904E
Show »

FASTA35940,183
Isoform 4 [UniParc].

Checksum: 2DAABAFAE548F4BD
Show »

FASTA26028,672

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), VARIANT THR-30.
Tissue: Lung and Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-128.
Tissue: Brain and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074458 mRNA. Translation: BAB85090.1.
AK097609 mRNA. No translation available.
AK292296 mRNA. Translation: BAF84985.1.
AL391730 Genomic DNA. Translation: CAH72798.1.
AL391730 Genomic DNA. Translation: CAH72799.1.
AL391730 Genomic DNA. Translation: CAH72800.1.
BC022037 mRNA. Translation: AAH22037.2.
BC037879 mRNA. Translation: AAH37879.1.
BC050353 mRNA. Translation: AAH50353.1.
CCDSCCDS460.1. [Q499Z3-1]
RefSeqNP_001161719.1. NM_001168247.1. [Q499Z3-1]
NP_659427.3. NM_144990.3. [Q499Z3-1]
XP_005270653.1. XM_005270596.1. [Q499Z3-1]
XP_005270654.1. XM_005270597.2. [Q499Z3-1]
XP_005270655.1. XM_005270598.2. [Q499Z3-1]
XP_005270656.1. XM_005270599.2. [Q499Z3-1]
XP_005270657.1. XM_005270600.2. [Q499Z3-3]
XP_005270658.1. XM_005270601.2. [Q499Z3-2]
XP_005270659.1. XM_005270602.2. [Q499Z3-2]
XP_006710495.1. XM_006710432.1. [Q499Z3-1]
UniGeneHs.194609.

3D structure databases

ProteinModelPortalQ499Z3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128306. 1 interaction.
STRING9606.ENSP00000304401.

PTM databases

PhosphoSiteQ499Z3.

Polymorphism databases

DMDM143585411.

Proteomic databases

PaxDbQ499Z3.
PRIDEQ499Z3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302946; ENSP00000304401; ENSG00000171790. [Q499Z3-1]
ENST00000359345; ENSP00000352299; ENSG00000171790. [Q499Z3-1]
ENST00000372611; ENSP00000361694; ENSG00000171790. [Q499Z3-2]
ENST00000372613; ENSP00000361696; ENSG00000171790. [Q499Z3-3]
ENST00000397197; ENSP00000380381; ENSG00000171790. [Q499Z3-3]
ENST00000439569; ENSP00000398938; ENSG00000171790. [Q499Z3-1]
GeneID200172.
KEGGhsa:200172.
UCSCuc001cgm.2. human. [Q499Z3-1]
uc001cgn.2. human. [Q499Z3-2]
uc009vwf.1. human. [Q499Z3-3]

Organism-specific databases

CTD200172.
GeneCardsGC01M041481.
HGNCHGNC:26313. SLFNL1.
HPAHPA029931.
neXtProtNX_Q499Z3.
PharmGKBPA144596362.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39769.
HOVERGENHBG096795.
InParanoidQ499Z3.
OMASCTCCVL.
OrthoDBEOG7QC7WK.
PhylomeDBQ499Z3.
TreeFamTF337569.

Gene expression databases

BgeeQ499Z3.
CleanExHS_SLFNL1.
GenevestigatorQ499Z3.

Family and domain databases

InterProIPR007421. ATPase_AAA-4.
[Graphical view]
PfamPF04326. AAA_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi200172.
NextBio89854.
PROQ499Z3.

Entry information

Entry nameSLNL1_HUMAN
AccessionPrimary (citable) accession number: Q499Z3
Secondary accession number(s): A8K8D1 expand/collapse secondary AC list , Q49AG8, Q5VW72, Q5VW74, Q8N7V7, Q8TCH6, Q8WVZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM