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Protein

Schlafen-like protein 1

Gene

SLFNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi261 – 2688ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen-like protein 1
Gene namesi
Name:SLFNL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26313. SLFNL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Schlafen-like protein 1PRO_0000282998Add
BLAST

Proteomic databases

PaxDbiQ499Z3.
PRIDEiQ499Z3.

PTM databases

PhosphoSiteiQ499Z3.

Expressioni

Gene expression databases

BgeeiQ499Z3.
CleanExiHS_SLFNL1.
GenevestigatoriQ499Z3.

Interactioni

Protein-protein interaction databases

BioGridi128306. 1 interaction.
STRINGi9606.ENSP00000304401.

Structurei

3D structure databases

ProteinModelPortaliQ499Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili366 – 39833Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the Schlafen family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39769.
GeneTreeiENSGT00390000003858.
HOVERGENiHBG096795.
InParanoidiQ499Z3.
OMAiSLAFKHH.
OrthoDBiEOG7QC7WK.
PhylomeDBiQ499Z3.
TreeFamiTF337569.

Family and domain databases

InterProiIPR007421. ATPase_AAA-4.
IPR029684. Schlafen.
IPR029667. SLFNL1.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PTHR12155:SF19. PTHR12155:SF19. 1 hit.
PfamiPF04326. AAA_4. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q499Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY
60 70 80 90 100
VGHLNPQFSV PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV
110 120 130 140 150
HRDTLASLPW RLQTALEEHL ILKELAARGK DLLLSEAQGP FSHREEKEEE
160 170 180 190 200
EEDSGLSPGP SPGSGVPLPT WPTHTLPDRP QAQQLQSCQG RPSGVCSDSA
210 220 230 240 250
IVHQQIVGKD QLFQGAFLGS ETRNMEFKRG SGEYLSLAFK HHVRRYVCAF
260 270 280 290 300
LNSEGGSLLV GVEDSGLVQG IRCSHRDEDR ARLLVDSILQ GFKPQIFPDA
310 320 330 340 350
YTLTFIPVIS TSETSVPLKV IRLTVHTPKA QSQPQLYQTD QGEVFLRRDG
360 370 380 390 400
SIQGPLSASA IQEWCRQRWL VELGKLEEKM KALMMEKEQL QQQLQQHGPV

SCTCCVL
Length:407
Mass (Da):45,603
Last modified:April 3, 2007 - v2
Checksum:i8000DDC8FE0C4D76
GO
Isoform 2 (identifier: Q499Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-204: Missing.

Note: No experimental confirmation available.

Show »
Length:348
Mass (Da):39,385
Checksum:i1C7E1EED7FA2FD14
GO
Isoform 3 (identifier: Q499Z3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-367: Missing.

Show »
Length:359
Mass (Da):40,183
Checksum:iEC270D4AB3F0904E
GO
Isoform 4 (identifier: Q499Z3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-260: EKEEEEEDSG...LNSEGGSLLV → VSGTFPKQAP...FLLGPTHLFN
     261-407: Missing.

Note: No experimental confirmation available.

Show »
Length:260
Mass (Da):28,672
Checksum:i2DAABAFAE548F4BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001V → I in AAH50353 (PubMed:15489334).Curated
Sequence conflicti280 – 2801R → S in AAH37879 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301A → T.1 Publication
Corresponds to variant rs1138293 [ dbSNP | Ensembl ].
VAR_031459
Natural varianti128 – 1281R → S.1 Publication
Corresponds to variant rs17851964 [ dbSNP | Ensembl ].
VAR_031460
Natural varianti144 – 1441R → T.
Corresponds to variant rs3738368 [ dbSNP | Ensembl ].
VAR_031461

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei146 – 260115EKEEE…GSLLV → VSGTFPKQAPKPHPKGEPLS GSGLQSGDGGVSLGKQGQIC KLGGCHSNDHGLRLVLPAFS GKNSLPQAQARRLCEERPRG DLLSLGPFTFQPLGLGDPRR HRGPDFLLGPTHLFN in isoform 4. 1 PublicationVSP_024275Add
BLAST
Alternative sequencei146 – 20459Missing in isoform 2. 1 PublicationVSP_024276Add
BLAST
Alternative sequencei261 – 407147Missing in isoform 4. 1 PublicationVSP_024277Add
BLAST
Alternative sequencei320 – 36748Missing in isoform 3. 1 PublicationVSP_024278Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074458 mRNA. Translation: BAB85090.1.
AK097609 mRNA. No translation available.
AK292296 mRNA. Translation: BAF84985.1.
AL391730 Genomic DNA. Translation: CAH72798.1.
AL391730 Genomic DNA. Translation: CAH72799.1.
AL391730 Genomic DNA. Translation: CAH72800.1.
BC022037 mRNA. Translation: AAH22037.2.
BC037879 mRNA. Translation: AAH37879.1.
BC050353 mRNA. Translation: AAH50353.1.
CCDSiCCDS460.1. [Q499Z3-1]
CCDS72766.1. [Q499Z3-2]
RefSeqiNP_001161719.1. NM_001168247.2. [Q499Z3-1]
NP_001287788.1. NM_001300859.1. [Q499Z3-2]
NP_659427.3. NM_144990.3. [Q499Z3-1]
XP_005270653.1. XM_005270596.1. [Q499Z3-1]
XP_005270654.1. XM_005270597.2. [Q499Z3-1]
XP_005270655.1. XM_005270598.2. [Q499Z3-1]
XP_005270656.1. XM_005270599.2. [Q499Z3-1]
XP_005270657.1. XM_005270600.2. [Q499Z3-3]
XP_005270658.1. XM_005270601.2. [Q499Z3-2]
XP_006710495.1. XM_006710432.1. [Q499Z3-1]
UniGeneiHs.194609.

Genome annotation databases

EnsembliENST00000302946; ENSP00000304401; ENSG00000171790. [Q499Z3-1]
ENST00000359345; ENSP00000352299; ENSG00000171790. [Q499Z3-1]
ENST00000372611; ENSP00000361694; ENSG00000171790. [Q499Z3-2]
ENST00000372613; ENSP00000361696; ENSG00000171790. [Q499Z3-3]
ENST00000439569; ENSP00000398938; ENSG00000171790. [Q499Z3-1]
GeneIDi200172.
KEGGihsa:200172.
UCSCiuc001cgm.2. human. [Q499Z3-1]
uc001cgn.2. human. [Q499Z3-2]
uc009vwf.1. human. [Q499Z3-3]

Polymorphism databases

DMDMi143585411.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074458 mRNA. Translation: BAB85090.1.
AK097609 mRNA. No translation available.
AK292296 mRNA. Translation: BAF84985.1.
AL391730 Genomic DNA. Translation: CAH72798.1.
AL391730 Genomic DNA. Translation: CAH72799.1.
AL391730 Genomic DNA. Translation: CAH72800.1.
BC022037 mRNA. Translation: AAH22037.2.
BC037879 mRNA. Translation: AAH37879.1.
BC050353 mRNA. Translation: AAH50353.1.
CCDSiCCDS460.1. [Q499Z3-1]
CCDS72766.1. [Q499Z3-2]
RefSeqiNP_001161719.1. NM_001168247.2. [Q499Z3-1]
NP_001287788.1. NM_001300859.1. [Q499Z3-2]
NP_659427.3. NM_144990.3. [Q499Z3-1]
XP_005270653.1. XM_005270596.1. [Q499Z3-1]
XP_005270654.1. XM_005270597.2. [Q499Z3-1]
XP_005270655.1. XM_005270598.2. [Q499Z3-1]
XP_005270656.1. XM_005270599.2. [Q499Z3-1]
XP_005270657.1. XM_005270600.2. [Q499Z3-3]
XP_005270658.1. XM_005270601.2. [Q499Z3-2]
XP_006710495.1. XM_006710432.1. [Q499Z3-1]
UniGeneiHs.194609.

3D structure databases

ProteinModelPortaliQ499Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128306. 1 interaction.
STRINGi9606.ENSP00000304401.

PTM databases

PhosphoSiteiQ499Z3.

Polymorphism databases

DMDMi143585411.

Proteomic databases

PaxDbiQ499Z3.
PRIDEiQ499Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302946; ENSP00000304401; ENSG00000171790. [Q499Z3-1]
ENST00000359345; ENSP00000352299; ENSG00000171790. [Q499Z3-1]
ENST00000372611; ENSP00000361694; ENSG00000171790. [Q499Z3-2]
ENST00000372613; ENSP00000361696; ENSG00000171790. [Q499Z3-3]
ENST00000439569; ENSP00000398938; ENSG00000171790. [Q499Z3-1]
GeneIDi200172.
KEGGihsa:200172.
UCSCiuc001cgm.2. human. [Q499Z3-1]
uc001cgn.2. human. [Q499Z3-2]
uc009vwf.1. human. [Q499Z3-3]

Organism-specific databases

CTDi200172.
GeneCardsiGC01M041481.
HGNCiHGNC:26313. SLFNL1.
neXtProtiNX_Q499Z3.
PharmGKBiPA144596362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39769.
GeneTreeiENSGT00390000003858.
HOVERGENiHBG096795.
InParanoidiQ499Z3.
OMAiSLAFKHH.
OrthoDBiEOG7QC7WK.
PhylomeDBiQ499Z3.
TreeFamiTF337569.

Miscellaneous databases

GenomeRNAii200172.
NextBioi89854.
PROiQ499Z3.

Gene expression databases

BgeeiQ499Z3.
CleanExiHS_SLFNL1.
GenevestigatoriQ499Z3.

Family and domain databases

InterProiIPR007421. ATPase_AAA-4.
IPR029684. Schlafen.
IPR029667. SLFNL1.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PTHR12155:SF19. PTHR12155:SF19. 1 hit.
PfamiPF04326. AAA_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), VARIANT THR-30.
    Tissue: Lung and Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-128.
    Tissue: Brain and Testis.

Entry informationi

Entry nameiSLNL1_HUMAN
AccessioniPrimary (citable) accession number: Q499Z3
Secondary accession number(s): A8K8D1
, Q49AG8, Q5VW72, Q5VW74, Q8N7V7, Q8TCH6, Q8WVZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 4, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.