Q499Z3 (SLNL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Schlafen-like protein 1

Gene names

Name:

SLFNL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Schlafen family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q499Z3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q499Z3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     146-204: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q499Z3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     320-367: Missing.

Isoform 4 (identifier: Q499Z3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     146-260: EKEEEEEDSG...LNSEGGSLLV → VSGTFPKQAP...FLLGPTHLFN
     261-407: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Schlafen-like protein 1		PRO_0000282998
Regions
	Nucleotide binding	261 – 268	8	ATP Potential
	Coiled coil	366 – 398	33	Potential
Natural variations
	Alternative sequence	146 – 260	115	EKEEE…GSLLV → VSGTFPKQAPKPHPKGEPLS GSGLQSGDGGVSLGKQGQIC KLGGCHSNDHGLRLVLPAFS GKNSLPQAQARRLCEERPRG DLLSLGPFTFQPLGLGDPRR HRGPDFLLGPTHLFN in isoform 4.		VSP_024275
	Alternative sequence	146 – 204	59	Missing in isoform 2.		VSP_024276
	Alternative sequence	261 – 407	147	Missing in isoform 4.		VSP_024277
	Alternative sequence	320 – 367	48	Missing in isoform 3.		VSP_024278
	Natural variant	30	1	A → T. Ref.1 Corresponds to variant rs1138293 [ dbSNP | Ensembl ].		VAR_031459
	Natural variant	128	1	R → S. Ref.3 Corresponds to variant rs17851964 [ dbSNP | Ensembl ].		VAR_031460
	Natural variant	144	1	R → T. Corresponds to variant rs3738368 [ dbSNP | Ensembl ].		VAR_031461
Experimental info
	Sequence conflict	100	1	V → I in AAH50353. Ref.3
	Sequence conflict	280	1	R → S in AAH37879. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 8000DDC8FE0C4D76	FASTA	407	45,603
	10 20 30 40 50 60 MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY VGHLNPQFSV 70 80 90 100 110 120 PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV HRDTLASLPW RLQTALEEHL 130 140 150 160 170 180 ILKELAARGK DLLLSEAQGP FSHREEKEEE EEDSGLSPGP SPGSGVPLPT WPTHTLPDRP 190 200 210 220 230 240 QAQQLQSCQG RPSGVCSDSA IVHQQIVGKD QLFQGAFLGS ETRNMEFKRG SGEYLSLAFK 250 260 270 280 290 300 HHVRRYVCAF LNSEGGSLLV GVEDSGLVQG IRCSHRDEDR ARLLVDSILQ GFKPQIFPDA 310 320 330 340 350 360 YTLTFIPVIS TSETSVPLKV IRLTVHTPKA QSQPQLYQTD QGEVFLRRDG SIQGPLSASA 370 380 390 400 IQEWCRQRWL VELGKLEEKM KALMMEKEQL QQQLQQHGPV SCTCCVL
	Isoform 2 [UniParc]. Checksum: 1C7E1EED7FA2FD14	FASTA	348	39,385
	10 20 30 40 50 60 MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY VGHLNPQFSV 70 80 90 100 110 120 PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV HRDTLASLPW RLQTALEEHL 130 140 150 160 170 180 ILKELAARGK DLLLSEAQGP FSHREQIVGK DQLFQGAFLG SETRNMEFKR GSGEYLSLAF 190 200 210 220 230 240 KHHVRRYVCA FLNSEGGSLL VGVEDSGLVQ GIRCSHRDED RARLLVDSIL QGFKPQIFPD 250 260 270 280 290 300 AYTLTFIPVI STSETSVPLK VIRLTVHTPK AQSQPQLYQT DQGEVFLRRD GSIQGPLSAS 310 320 330 340 AIQEWCRQRW LVELGKLEEK MKALMMEKEQ LQQQLQQHGP VSCTCCVL
	Isoform 3 [UniParc]. Checksum: EC270D4AB3F0904E	FASTA	359	40,183
	10 20 30 40 50 60 MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY VGHLNPQFSV 70 80 90 100 110 120 PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV HRDTLASLPW RLQTALEEHL 130 140 150 160 170 180 ILKELAARGK DLLLSEAQGP FSHREEKEEE EEDSGLSPGP SPGSGVPLPT WPTHTLPDRP 190 200 210 220 230 240 QAQQLQSCQG RPSGVCSDSA IVHQQIVGKD QLFQGAFLGS ETRNMEFKRG SGEYLSLAFK 250 260 270 280 290 300 HHVRRYVCAF LNSEGGSLLV GVEDSGLVQG IRCSHRDEDR ARLLVDSILQ GFKPQIFPDA 310 320 330 340 350 YTLTFIPVIS TSETSVPLKR WLVELGKLEE KMKALMMEKE QLQQQLQQHG PVSCTCCVL
	Isoform 4 [UniParc]. Checksum: 2DAABAFAE548F4BD	FASTA	260	28,672
	10 20 30 40 50 60 MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY VGHLNPQFSV 70 80 90 100 110 120 PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV HRDTLASLPW RLQTALEEHL 130 140 150 160 170 180 ILKELAARGK DLLLSEAQGP FSHREVSGTF PKQAPKPHPK GEPLSGSGLQ SGDGGVSLGK 190 200 210 220 230 240 QGQICKLGGC HSNDHGLRLV LPAFSGKNSL PQAQARRLCE ERPRGDLLSL GPFTFQPLGL 250 260 GDPRRHRGPD FLLGPTHLFN

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), VARIANT THR-30. Tissue: Lung and Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-128. Tissue: Brain and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK074458 mRNA. Translation: BAB85090.1. AK097609 mRNA. No translation available. AK292296 mRNA. Translation: BAF84985.1. AL391730 Genomic DNA. Translation: CAH72798.1. AL391730 Genomic DNA. Translation: CAH72799.1. AL391730 Genomic DNA. Translation: CAH72800.1. BC022037 mRNA. Translation: AAH22037.2. BC037879 mRNA. Translation: AAH37879.1. BC050353 mRNA. Translation: AAH50353.1.
IPI	IPI00383042. IPI00419184. IPI00477792. IPI00844016.
RefSeq	NP_001161719.1. NM_001168247.1. NP_659427.3. NM_144990.3.
UniGene	Hs.194609.
3D structure databases
ProteinModelPortal	Q499Z3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000304401.
PTM databases
PhosphoSite	Q499Z3.
Polymorphism databases
DMDM	143585411.
Proteomic databases
PaxDb	Q499Z3.
PRIDE	Q499Z3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302946; ENSP00000304401; ENSG00000171790. ENST00000359345; ENSP00000352299; ENSG00000171790. ENST00000372611; ENSP00000361694; ENSG00000171790. ENST00000372613; ENSP00000361696; ENSG00000171790. ENST00000397197; ENSP00000380381; ENSG00000171790. ENST00000439569; ENSP00000398938; ENSG00000171790.
GeneID	200172.
KEGG	hsa:200172.
UCSC	uc001cgm.2. human. uc001cgn.2. human. uc009vwf.1. human.
Organism-specific databases
CTD	200172.
GeneCards	GC01M041481.
HGNC	HGNC:26313. SLFNL1.
HPA	HPA029931.
neXtProt	NX_Q499Z3.
PharmGKB	PA144596362.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39769.
HOVERGEN	HBG096795.
InParanoid	Q499Z3.
OMA	CAFLNSE.
OrthoDB	EOG4F1X3M.
PhylomeDB	Q499Z3.
Gene expression databases
Bgee	Q499Z3.
CleanEx	HS_SLFNL1.
Genevestigator	Q499Z3.
Family and domain databases
InterPro	IPR007421. ATPase_AAA-4. [Graphical view]
Pfam	PF04326. AAA_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	200172.
NextBio	89854.

Entry information

Entry name

SLNL1_HUMAN

Accession

Primary (citable) accession number: Q499Z3
Secondary accession number(s): A8K8D1 , Q49AG8, Q5VW72, Q5VW74, Q8N7V7, Q8TCH6, Q8WVZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.