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Q499Z3

- SLNL1_HUMAN

UniProt

Q499Z3 - SLNL1_HUMAN

Protein

Schlafen-like protein 1

Gene

SLFNL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi261 – 2688ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Schlafen-like protein 1
    Gene namesi
    Name:SLFNL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26313. SLFNL1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Schlafen-like protein 1PRO_0000282998Add
    BLAST

    Proteomic databases

    PaxDbiQ499Z3.
    PRIDEiQ499Z3.

    PTM databases

    PhosphoSiteiQ499Z3.

    Expressioni

    Gene expression databases

    BgeeiQ499Z3.
    CleanExiHS_SLFNL1.
    GenevestigatoriQ499Z3.

    Organism-specific databases

    HPAiHPA029931.

    Interactioni

    Protein-protein interaction databases

    BioGridi128306. 1 interaction.
    STRINGi9606.ENSP00000304401.

    Structurei

    3D structure databases

    ProteinModelPortaliQ499Z3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili366 – 39833Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Schlafen family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39769.
    HOVERGENiHBG096795.
    InParanoidiQ499Z3.
    OMAiSCTCCVL.
    OrthoDBiEOG7QC7WK.
    PhylomeDBiQ499Z3.
    TreeFamiTF337569.

    Family and domain databases

    InterProiIPR007421. ATPase_AAA-4.
    [Graphical view]
    PfamiPF04326. AAA_4. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q499Z3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY    50
    VGHLNPQFSV PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV 100
    HRDTLASLPW RLQTALEEHL ILKELAARGK DLLLSEAQGP FSHREEKEEE 150
    EEDSGLSPGP SPGSGVPLPT WPTHTLPDRP QAQQLQSCQG RPSGVCSDSA 200
    IVHQQIVGKD QLFQGAFLGS ETRNMEFKRG SGEYLSLAFK HHVRRYVCAF 250
    LNSEGGSLLV GVEDSGLVQG IRCSHRDEDR ARLLVDSILQ GFKPQIFPDA 300
    YTLTFIPVIS TSETSVPLKV IRLTVHTPKA QSQPQLYQTD QGEVFLRRDG 350
    SIQGPLSASA IQEWCRQRWL VELGKLEEKM KALMMEKEQL QQQLQQHGPV 400
    SCTCCVL 407
    Length:407
    Mass (Da):45,603
    Last modified:April 3, 2007 - v2
    Checksum:i8000DDC8FE0C4D76
    GO
    Isoform 2 (identifier: Q499Z3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-204: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:348
    Mass (Da):39,385
    Checksum:i1C7E1EED7FA2FD14
    GO
    Isoform 3 (identifier: Q499Z3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         320-367: Missing.

    Show »
    Length:359
    Mass (Da):40,183
    Checksum:iEC270D4AB3F0904E
    GO
    Isoform 4 (identifier: Q499Z3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-260: EKEEEEEDSG...LNSEGGSLLV → VSGTFPKQAP...FLLGPTHLFN
         261-407: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:260
    Mass (Da):28,672
    Checksum:i2DAABAFAE548F4BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001V → I in AAH50353. (PubMed:15489334)Curated
    Sequence conflicti280 – 2801R → S in AAH37879. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301A → T.1 Publication
    Corresponds to variant rs1138293 [ dbSNP | Ensembl ].
    VAR_031459
    Natural varianti128 – 1281R → S.1 Publication
    Corresponds to variant rs17851964 [ dbSNP | Ensembl ].
    VAR_031460
    Natural varianti144 – 1441R → T.
    Corresponds to variant rs3738368 [ dbSNP | Ensembl ].
    VAR_031461

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei146 – 260115EKEEE…GSLLV → VSGTFPKQAPKPHPKGEPLS GSGLQSGDGGVSLGKQGQIC KLGGCHSNDHGLRLVLPAFS GKNSLPQAQARRLCEERPRG DLLSLGPFTFQPLGLGDPRR HRGPDFLLGPTHLFN in isoform 4. 1 PublicationVSP_024275Add
    BLAST
    Alternative sequencei146 – 20459Missing in isoform 2. 1 PublicationVSP_024276Add
    BLAST
    Alternative sequencei261 – 407147Missing in isoform 4. 1 PublicationVSP_024277Add
    BLAST
    Alternative sequencei320 – 36748Missing in isoform 3. 1 PublicationVSP_024278Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074458 mRNA. Translation: BAB85090.1.
    AK097609 mRNA. No translation available.
    AK292296 mRNA. Translation: BAF84985.1.
    AL391730 Genomic DNA. Translation: CAH72798.1.
    AL391730 Genomic DNA. Translation: CAH72799.1.
    AL391730 Genomic DNA. Translation: CAH72800.1.
    BC022037 mRNA. Translation: AAH22037.2.
    BC037879 mRNA. Translation: AAH37879.1.
    BC050353 mRNA. Translation: AAH50353.1.
    CCDSiCCDS460.1. [Q499Z3-1]
    RefSeqiNP_001161719.1. NM_001168247.1. [Q499Z3-1]
    NP_659427.3. NM_144990.3. [Q499Z3-1]
    XP_005270653.1. XM_005270596.1. [Q499Z3-1]
    XP_005270654.1. XM_005270597.2. [Q499Z3-1]
    XP_005270655.1. XM_005270598.2. [Q499Z3-1]
    XP_005270656.1. XM_005270599.2. [Q499Z3-1]
    XP_005270657.1. XM_005270600.2. [Q499Z3-3]
    XP_005270658.1. XM_005270601.2. [Q499Z3-2]
    XP_005270659.1. XM_005270602.2. [Q499Z3-2]
    XP_006710495.1. XM_006710432.1. [Q499Z3-1]
    UniGeneiHs.194609.

    Genome annotation databases

    EnsembliENST00000302946; ENSP00000304401; ENSG00000171790. [Q499Z3-1]
    ENST00000359345; ENSP00000352299; ENSG00000171790. [Q499Z3-1]
    ENST00000372611; ENSP00000361694; ENSG00000171790. [Q499Z3-2]
    ENST00000372613; ENSP00000361696; ENSG00000171790. [Q499Z3-3]
    ENST00000439569; ENSP00000398938; ENSG00000171790. [Q499Z3-1]
    GeneIDi200172.
    KEGGihsa:200172.
    UCSCiuc001cgm.2. human. [Q499Z3-1]
    uc001cgn.2. human. [Q499Z3-2]
    uc009vwf.1. human. [Q499Z3-3]

    Polymorphism databases

    DMDMi143585411.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074458 mRNA. Translation: BAB85090.1 .
    AK097609 mRNA. No translation available.
    AK292296 mRNA. Translation: BAF84985.1 .
    AL391730 Genomic DNA. Translation: CAH72798.1 .
    AL391730 Genomic DNA. Translation: CAH72799.1 .
    AL391730 Genomic DNA. Translation: CAH72800.1 .
    BC022037 mRNA. Translation: AAH22037.2 .
    BC037879 mRNA. Translation: AAH37879.1 .
    BC050353 mRNA. Translation: AAH50353.1 .
    CCDSi CCDS460.1. [Q499Z3-1 ]
    RefSeqi NP_001161719.1. NM_001168247.1. [Q499Z3-1 ]
    NP_659427.3. NM_144990.3. [Q499Z3-1 ]
    XP_005270653.1. XM_005270596.1. [Q499Z3-1 ]
    XP_005270654.1. XM_005270597.2. [Q499Z3-1 ]
    XP_005270655.1. XM_005270598.2. [Q499Z3-1 ]
    XP_005270656.1. XM_005270599.2. [Q499Z3-1 ]
    XP_005270657.1. XM_005270600.2. [Q499Z3-3 ]
    XP_005270658.1. XM_005270601.2. [Q499Z3-2 ]
    XP_005270659.1. XM_005270602.2. [Q499Z3-2 ]
    XP_006710495.1. XM_006710432.1. [Q499Z3-1 ]
    UniGenei Hs.194609.

    3D structure databases

    ProteinModelPortali Q499Z3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128306. 1 interaction.
    STRINGi 9606.ENSP00000304401.

    PTM databases

    PhosphoSitei Q499Z3.

    Polymorphism databases

    DMDMi 143585411.

    Proteomic databases

    PaxDbi Q499Z3.
    PRIDEi Q499Z3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302946 ; ENSP00000304401 ; ENSG00000171790 . [Q499Z3-1 ]
    ENST00000359345 ; ENSP00000352299 ; ENSG00000171790 . [Q499Z3-1 ]
    ENST00000372611 ; ENSP00000361694 ; ENSG00000171790 . [Q499Z3-2 ]
    ENST00000372613 ; ENSP00000361696 ; ENSG00000171790 . [Q499Z3-3 ]
    ENST00000439569 ; ENSP00000398938 ; ENSG00000171790 . [Q499Z3-1 ]
    GeneIDi 200172.
    KEGGi hsa:200172.
    UCSCi uc001cgm.2. human. [Q499Z3-1 ]
    uc001cgn.2. human. [Q499Z3-2 ]
    uc009vwf.1. human. [Q499Z3-3 ]

    Organism-specific databases

    CTDi 200172.
    GeneCardsi GC01M041481.
    HGNCi HGNC:26313. SLFNL1.
    HPAi HPA029931.
    neXtProti NX_Q499Z3.
    PharmGKBi PA144596362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39769.
    HOVERGENi HBG096795.
    InParanoidi Q499Z3.
    OMAi SCTCCVL.
    OrthoDBi EOG7QC7WK.
    PhylomeDBi Q499Z3.
    TreeFami TF337569.

    Miscellaneous databases

    GenomeRNAii 200172.
    NextBioi 89854.
    PROi Q499Z3.

    Gene expression databases

    Bgeei Q499Z3.
    CleanExi HS_SLFNL1.
    Genevestigatori Q499Z3.

    Family and domain databases

    InterProi IPR007421. ATPase_AAA-4.
    [Graphical view ]
    Pfami PF04326. AAA_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), VARIANT THR-30.
      Tissue: Lung and Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-128.
      Tissue: Brain and Testis.

    Entry informationi

    Entry nameiSLNL1_HUMAN
    AccessioniPrimary (citable) accession number: Q499Z3
    Secondary accession number(s): A8K8D1
    , Q49AG8, Q5VW72, Q5VW74, Q8N7V7, Q8TCH6, Q8WVZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3