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Protein

DNA replication complex GINS protein SLD5

Gene

Gins4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. SLD5 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein SLD5
Alternative name(s):
GINS complex subunit 4
Cleaved into the following chain:
Gene namesi
Name:Gins4
Synonyms:Sld5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307397. Gins4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217961 – 223DNA replication complex GINS protein SLD5Add BLAST223
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00003276222 – 223DNA replication complex GINS protein SLD5, N-terminally processedAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processedBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ499W2.
PRIDEiQ499W2.

PTM databases

iPTMnetiQ499W2.
PhosphoSitePlusiQ499W2.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024301.

Structurei

3D structure databases

ProteinModelPortaliQ499W2.
SMRiQ499W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 223Important for GINS complex assemblyBy similarityAdd BLAST58

Sequence similaritiesi

Belongs to the GINS4/SLD5 family.Curated

Phylogenomic databases

eggNOGiKOG3176. Eukaryota.
COG5086. LUCA.
HOGENOMiHOG000215319.
HOVERGENiHBG059490.
InParanoidiQ499W2.
KOiK10735.
PhylomeDBiQ499W2.

Family and domain databases

InterProiView protein in InterPro
IPR021151. GINS_A.
IPR036224. GINS_bundle-like_dom_sf.
IPR008591. GINS_Sld5.
IPR031633. SLD5_C.
PANTHERiPTHR21206. PTHR21206. 1 hit.
PfamiView protein in Pfam
PF05916. Sld5. 1 hit.
PF16922. SLD5_C. 1 hit.
PIRSFiPIRSF007764. Sld5. 1 hit.
SUPFAMiSSF158573. SSF158573. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q499W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVQDLHGQ DSDEGSEEVV LTPAELIERL EQAWMNEKFA PELLESKSEI
60 70 80 90 100
VECVMEQLEH MEENLRRAKK GDLKVSIHRM EMERIRYVLS SYLRCRLMKI
110 120 130 140 150
EKFFPHILEK EKTRPAGEPS SLSPEEFVFA KEYMDHTETH FKNVALKHMP
160 170 180 190 200
PNLQKVDLMR AVPKPDLDSY VFLRVKERQE NILVEPEADE QRDYVIDLEE
210 220
GSQHLIRYKT IAPLVASGAV QLI
Length:223
Mass (Da):26,062
Last modified:September 13, 2005 - v1
Checksum:iAB1AD1042978AC5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099741 mRNA. Translation: AAH99741.1.
RefSeqiNP_001025198.1. NM_001030027.1.
UniGeneiRn.103411.

Genome annotation databases

GeneIDi290842.
KEGGirno:290842.
UCSCiRGD:1307397. rat.

Similar proteinsi

Entry informationi

Entry nameiSLD5_RAT
AccessioniPrimary (citable) accession number: Q499W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 13, 2005
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families