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Protein

DNA replication complex GINS protein SLD5

Gene

Gins4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. SLD5 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein SLD5
Alternative name(s):
GINS complex subunit 4
Cleaved into the following chain:
Gene namesi
Name:Gins4
Synonyms:Sld5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307397. Gins4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223DNA replication complex GINS protein SLD5PRO_0000327622Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 223222DNA replication complex GINS protein SLD5, N-terminally processedPRO_0000421796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processedBy similarity
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei16 – 161PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ499W2.
PRIDEiQ499W2.

PTM databases

iPTMnetiQ499W2.
PhosphoSiteiQ499W2.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024301.

Structurei

3D structure databases

ProteinModelPortaliQ499W2.
SMRiQ499W2. Positions 21-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 22358Important for GINS complex assemblyBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the GINS4/SLD5 family.Curated

Phylogenomic databases

eggNOGiKOG3176. Eukaryota.
COG5086. LUCA.
HOGENOMiHOG000215319.
HOVERGENiHBG059490.
InParanoidiQ499W2.
KOiK10735.
PhylomeDBiQ499W2.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR008591. GINS_Sld5.
IPR031633. SLD5_C.
[Graphical view]
PANTHERiPTHR21206. PTHR21206. 1 hit.
PfamiPF05916. Sld5. 1 hit.
PF16922. SLD5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF007764. Sld5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q499W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVQDLHGQ DSDEGSEEVV LTPAELIERL EQAWMNEKFA PELLESKSEI
60 70 80 90 100
VECVMEQLEH MEENLRRAKK GDLKVSIHRM EMERIRYVLS SYLRCRLMKI
110 120 130 140 150
EKFFPHILEK EKTRPAGEPS SLSPEEFVFA KEYMDHTETH FKNVALKHMP
160 170 180 190 200
PNLQKVDLMR AVPKPDLDSY VFLRVKERQE NILVEPEADE QRDYVIDLEE
210 220
GSQHLIRYKT IAPLVASGAV QLI
Length:223
Mass (Da):26,062
Last modified:September 13, 2005 - v1
Checksum:iAB1AD1042978AC5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099741 mRNA. Translation: AAH99741.1.
RefSeqiNP_001025198.1. NM_001030027.1.
UniGeneiRn.103411.

Genome annotation databases

GeneIDi290842.
KEGGirno:290842.
UCSCiRGD:1307397. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099741 mRNA. Translation: AAH99741.1.
RefSeqiNP_001025198.1. NM_001030027.1.
UniGeneiRn.103411.

3D structure databases

ProteinModelPortaliQ499W2.
SMRiQ499W2. Positions 21-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024301.

PTM databases

iPTMnetiQ499W2.
PhosphoSiteiQ499W2.

Proteomic databases

PaxDbiQ499W2.
PRIDEiQ499W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi290842.
KEGGirno:290842.
UCSCiRGD:1307397. rat.

Organism-specific databases

CTDi84296.
RGDi1307397. Gins4.

Phylogenomic databases

eggNOGiKOG3176. Eukaryota.
COG5086. LUCA.
HOGENOMiHOG000215319.
HOVERGENiHBG059490.
InParanoidiQ499W2.
KOiK10735.
PhylomeDBiQ499W2.

Miscellaneous databases

PROiQ499W2.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR008591. GINS_Sld5.
IPR031633. SLD5_C.
[Graphical view]
PANTHERiPTHR21206. PTHR21206. 1 hit.
PfamiPF05916. Sld5. 1 hit.
PF16922. SLD5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF007764. Sld5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSLD5_RAT
AccessioniPrimary (citable) accession number: Q499W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 13, 2005
Last modified: July 6, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.