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Protein

Non-structural maintenance of chromosomes element 1 homolog

Gene

Nsmce1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 234NSE1-typeAdd BLAST47

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processDNA damage, DNA recombination, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-3108214. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural maintenance of chromosomes element 1 homolog (EC:6.3.2.-)
Short name:
Non-SMC element 1 homolog
Gene namesi
Name:Nsmce1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307760. Nsmce1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709471 – 266Non-structural maintenance of chromosomes element 1 homologAdd BLAST266

Proteomic databases

PaxDbiQ499U6.
PRIDEiQ499U6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015218.
ExpressionAtlasiQ499U6. baseline and differential.
GenevisibleiQ499U6. RN.

Interactioni

Subunit structurei

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Interacts with NSMCE3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051912.

Structurei

3D structure databases

ProteinModelPortaliQ499U6.
SMRiQ499U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 102Interaction with NSMCE3By similarityAdd BLAST102

Sequence similaritiesi

Belongs to the NSE1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 234NSE1-typeAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4718. Eukaryota.
ENOG4111RNS. LUCA.
GeneTreeiENSGT00390000009084.
HOGENOMiHOG000006778.
HOVERGENiHBG082058.
InParanoidiQ499U6.
PhylomeDBiQ499U6.
TreeFamiTF314721.

Family and domain databases

CDDicd16493. RING-CH-C4HC3_NSE1. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR011513. Nse1.
IPR002219. PE/DAG-bd.
IPR001841. Znf_RING.
IPR014857. Znf_RING-like.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR20973. PTHR20973. 1 hit.
PfamiView protein in Pfam
PF07574. SMC_Nse1. 1 hit.
PF08746. zf-RING-like. 1 hit.

Sequencei

Sequence statusi: Complete.

Q499U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGSTRRAGA MTDVHRRFLQ LLMTHGVLEE WEVRRLQNHC YKVHDRNATV
60 70 80 90 100
DKLEDFINNI NSVLESLYIE IKKGITEDDG RPIYALVNLA TTSVSKMATD
110 120 130 140 150
FAENELDLFR KALELIVDSE TGFASSTNIL NLVDQLKGKK MRKKEAEQVL
160 170 180 190 200
QKFVQSKWLI EKEGEFTLHG RAILEMEQFI RESYPDAVKM CNICHSLLIQ
210 220 230 240 250
GQSCETCGIR MHLPCVAKYF QSTAEPRCPH CNDYWPHDIP EVFDPEKERE
260
AGISKSSRKS LRTRQH
Length:266
Mass (Da):30,702
Last modified:January 9, 2007 - v2
Checksum:iAF60161836798E6E
GO

Sequence cautioni

The sequence AAH99757 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099757 mRNA. Translation: AAH99757.1. Different initiation.
RefSeqiNP_001034700.1. NM_001039611.1.
XP_006230353.1. XM_006230291.3.
XP_006230354.1. XM_006230292.3.
XP_006230355.1. XM_006230293.3.
UniGeneiRn.17063.

Genome annotation databases

EnsembliENSRNOT00000089464; ENSRNOP00000071768; ENSRNOG00000015218.
GeneIDi361645.
KEGGirno:361645.
UCSCiRGD:1307760. rat.

Similar proteinsi

Entry informationi

Entry nameiNSE1_RAT
AccessioniPrimary (citable) accession number: Q499U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families