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Protein

Non-structural maintenance of chromosomes element 1 homolog

Gene

Nsmce1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 23447NSE1-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-3108214. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural maintenance of chromosomes element 1 homolog (EC:6.3.2.-)
Short name:
Non-SMC element 1 homolog
Gene namesi
Name:Nsmce1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307760. Nsmce1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Non-structural maintenance of chromosomes element 1 homologPRO_0000270947Add
BLAST

Proteomic databases

PaxDbiQ499U6.

Expressioni

Gene expression databases

ExpressionAtlasiQ499U6. baseline and differential.
GenevisibleiQ499U6. RN.

Interactioni

Subunit structurei

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051912.

Structurei

3D structure databases

ProteinModelPortaliQ499U6.
SMRiQ499U6. Positions 181-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 102102Interaction with NSMCE3By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the NSE1 family.Curated
Contains 1 NSE1-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 23447NSE1-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4718. Eukaryota.
ENOG4111RNS. LUCA.
GeneTreeiENSGT00390000009084.
HOGENOMiHOG000006778.
HOVERGENiHBG082058.
InParanoidiQ499U6.
OrthoDBiEOG7WDN3G.
PhylomeDBiQ499U6.
TreeFamiTF314721.

Family and domain databases

InterProiIPR011513. Nse1.
IPR002219. PE/DAG-bd.
IPR001841. Znf_RING.
IPR014857. Znf_RING-like.
[Graphical view]
PANTHERiPTHR20973:SF0. PTHR20973:SF0. 1 hit.
PfamiPF07574. SMC_Nse1. 1 hit.
PF08746. zf-RING-like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGSTRRAGA MTDVHRRFLQ LLMTHGVLEE WEVRRLQNHC YKVHDRNATV
60 70 80 90 100
DKLEDFINNI NSVLESLYIE IKKGITEDDG RPIYALVNLA TTSVSKMATD
110 120 130 140 150
FAENELDLFR KALELIVDSE TGFASSTNIL NLVDQLKGKK MRKKEAEQVL
160 170 180 190 200
QKFVQSKWLI EKEGEFTLHG RAILEMEQFI RESYPDAVKM CNICHSLLIQ
210 220 230 240 250
GQSCETCGIR MHLPCVAKYF QSTAEPRCPH CNDYWPHDIP EVFDPEKERE
260
AGISKSSRKS LRTRQH
Length:266
Mass (Da):30,702
Last modified:January 9, 2007 - v2
Checksum:iAF60161836798E6E
GO

Sequence cautioni

The sequence AAH99757.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099757 mRNA. Translation: AAH99757.1. Different initiation.
RefSeqiNP_001034700.1. NM_001039611.1.
XP_006230353.1. XM_006230291.2.
XP_006230354.1. XM_006230292.2.
XP_006230355.1. XM_006230293.2.
UniGeneiRn.17063.

Genome annotation databases

EnsembliENSRNOT00000089464; ENSRNOP00000071768; ENSRNOG00000015218.
GeneIDi361645.
KEGGirno:361645.
UCSCiRGD:1307760. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099757 mRNA. Translation: AAH99757.1. Different initiation.
RefSeqiNP_001034700.1. NM_001039611.1.
XP_006230353.1. XM_006230291.2.
XP_006230354.1. XM_006230292.2.
XP_006230355.1. XM_006230293.2.
UniGeneiRn.17063.

3D structure databases

ProteinModelPortaliQ499U6.
SMRiQ499U6. Positions 181-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051912.

Proteomic databases

PaxDbiQ499U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089464; ENSRNOP00000071768; ENSRNOG00000015218.
GeneIDi361645.
KEGGirno:361645.
UCSCiRGD:1307760. rat.

Organism-specific databases

CTDi197370.
RGDi1307760. Nsmce1.

Phylogenomic databases

eggNOGiKOG4718. Eukaryota.
ENOG4111RNS. LUCA.
GeneTreeiENSGT00390000009084.
HOGENOMiHOG000006778.
HOVERGENiHBG082058.
InParanoidiQ499U6.
OrthoDBiEOG7WDN3G.
PhylomeDBiQ499U6.
TreeFamiTF314721.

Enzyme and pathway databases

ReactomeiR-RNO-3108214. SUMOylation of DNA damage response and repair proteins.

Miscellaneous databases

NextBioi677069.
PROiQ499U6.

Gene expression databases

ExpressionAtlasiQ499U6. baseline and differential.
GenevisibleiQ499U6. RN.

Family and domain databases

InterProiIPR011513. Nse1.
IPR002219. PE/DAG-bd.
IPR001841. Znf_RING.
IPR014857. Znf_RING-like.
[Graphical view]
PANTHERiPTHR20973:SF0. PTHR20973:SF0. 1 hit.
PfamiPF07574. SMC_Nse1. 1 hit.
PF08746. zf-RING-like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiNSE1_RAT
AccessioniPrimary (citable) accession number: Q499U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.