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Protein

Dynein regulatory complex subunit 4

Gene

Gas8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5635838 Activation of SMO

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex subunit 4By similarity
Alternative name(s):
Growth arrest-specific protein 11
Short name:
GAS-11
Growth arrest-specific protein 8
Short name:
GAS-8
Gene namesi
Name:Gas8
Synonyms:Drc4By similarity, Gas11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1307817 Gas8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003063321 – 478Dynein regulatory complex subunit 4Add BLAST478

Proteomic databases

PaxDbiQ499U4
PRIDEiQ499U4

Expressioni

Gene expression databases

BgeeiENSRNOG00000026964
GenevisibleiQ499U4 RN

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC). Interacts with microtubules. Interacts with SMO. Interacts (via coiled-coil domains) with RAB3B (in GTP-bound form).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031180

Structurei

3D structure databases

ProteinModelPortaliQ499U4
SMRiQ499U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 114Regulates microtubule-bindingBy similarityAdd BLAST114
Regioni115 – 258Microtubule-bindingBy similarityAdd BLAST144
Regioni357 – 478Interaction with SMOBy similarityAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili24 – 201Sequence analysisAdd BLAST178
Coiled coili243 – 427Sequence analysisAdd BLAST185

Sequence similaritiesi

Belongs to the DRC4 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE2T Eukaryota
ENOG410XPBD LUCA
GeneTreeiENSGT00390000009477
HOGENOMiHOG000038763
HOVERGENiHBG039458
InParanoidiQ499U4
KOiK19942
OMAiAREEMSE
OrthoDBiEOG091G0851
PhylomeDBiQ499U4

Family and domain databases

InterProiView protein in InterPro
IPR025593 GAS8
PfamiView protein in Pfam
PF13851 GAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q499U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKRRGKKG KAKGNAVVDG VAPEDMSKEQ VEEHVARIRE ELDREREERN
60 70 80 90 100
YFQLERDKIH TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ
110 120 130 140 150
KVKHLLYEHQ NNLAEVKTEG TVVMKLAQKE HRAQEGALRK DMRVLKVELK
160 170 180 190 200
EQELANEVVI KNLRLKQAEE ITKMRNDFER QVREIEAKYD KKMKMLRDEL
210 220 230 240 250
DLRRKTEIHE VEERKNGQIS TLMQRHEEAF TDIKNYYNDI TLNNLALINS
260 270 280 290 300
LKEQMEDMRK KEEYLEREMA EVSLQNKRLA EPLQRAKEEM SEMQKRLGNH
310 320 330 340 350
ERDKQILACT KARLKVTEKE LKDLKWEHEI LEQRFIKVQQ EREELYRKFT
360 370 380 390 400
AAIQEVQQKT GFKNLVLERK LQALNAAVEK REVQFNEVLA ASNLDPTALT
410 420 430 440 450
LVSRKLEDVL ESKNTTIKDL QYELARVCKA HNDLLRTYEA KLLAFGIPLD
460 470
NVGFKPLETA VIGQTLGQGP AGLVGAPT
Length:478
Mass (Da):56,313
Last modified:September 13, 2005 - v1
Checksum:iDD3282C9AA68E929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099759 mRNA Translation: AAH99759.1
RefSeqiNP_001034119.1, NM_001039030.1
UniGeneiRn.209051

Genome annotation databases

EnsembliENSRNOT00000029999; ENSRNOP00000031180; ENSRNOG00000026964
GeneIDi361438
KEGGirno:361438
UCSCiRGD:1307817 rat

Similar proteinsi

Entry informationi

Entry nameiDRC4_RAT
AccessioniPrimary (citable) accession number: Q499U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health