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Protein

Growth arrest-specific protein 8

Gene

Gas8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 8
Short name:
GAS-8
Alternative name(s):
Growth arrest-specific protein 11
Short name:
GAS-11
Gene namesi
Name:Gas8
Synonyms:Gas11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1307817. Gas8.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity
  • Cell projectionciliumflagellum By similarity
  • Cytoplasmcytoskeletoncilium axoneme By similarity
  • Cytoplasmcytoskeletoncilium basal body By similarity
  • Golgi apparatus By similarity

  • Note: Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Growth arrest-specific protein 8PRO_0000306332Add
BLAST

Proteomic databases

PaxDbiQ499U4.
PRIDEiQ499U4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000026964.
GenevisibleiQ499U4. RN.

Interactioni

Subunit structurei

Interacts with microtubules.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031180.

Structurei

3D structure databases

ProteinModelPortaliQ499U4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 114114Regulates microtubule-bindingBy similarityAdd
BLAST
Regioni115 – 258144Microtubule-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili24 – 201178Sequence analysisAdd
BLAST
Coiled coili243 – 427185Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GAS8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE2T. Eukaryota.
ENOG410XPBD. LUCA.
GeneTreeiENSGT00390000009477.
HOGENOMiHOG000038763.
HOVERGENiHBG039458.
InParanoidiQ499U4.
KOiK19942.
OMAiEHRTQEG.
OrthoDBiEOG091G0851.
PhylomeDBiQ499U4.

Family and domain databases

InterProiIPR025593. GAS8.
[Graphical view]
PfamiPF13851. GAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKRRGKKG KAKGNAVVDG VAPEDMSKEQ VEEHVARIRE ELDREREERN
60 70 80 90 100
YFQLERDKIH TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ
110 120 130 140 150
KVKHLLYEHQ NNLAEVKTEG TVVMKLAQKE HRAQEGALRK DMRVLKVELK
160 170 180 190 200
EQELANEVVI KNLRLKQAEE ITKMRNDFER QVREIEAKYD KKMKMLRDEL
210 220 230 240 250
DLRRKTEIHE VEERKNGQIS TLMQRHEEAF TDIKNYYNDI TLNNLALINS
260 270 280 290 300
LKEQMEDMRK KEEYLEREMA EVSLQNKRLA EPLQRAKEEM SEMQKRLGNH
310 320 330 340 350
ERDKQILACT KARLKVTEKE LKDLKWEHEI LEQRFIKVQQ EREELYRKFT
360 370 380 390 400
AAIQEVQQKT GFKNLVLERK LQALNAAVEK REVQFNEVLA ASNLDPTALT
410 420 430 440 450
LVSRKLEDVL ESKNTTIKDL QYELARVCKA HNDLLRTYEA KLLAFGIPLD
460 470
NVGFKPLETA VIGQTLGQGP AGLVGAPT
Length:478
Mass (Da):56,313
Last modified:September 13, 2005 - v1
Checksum:iDD3282C9AA68E929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099759 mRNA. Translation: AAH99759.1.
RefSeqiNP_001034119.1. NM_001039030.1.
UniGeneiRn.209051.

Genome annotation databases

EnsembliENSRNOT00000029999; ENSRNOP00000031180; ENSRNOG00000026964.
GeneIDi361438.
KEGGirno:361438.
UCSCiRGD:1307817. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099759 mRNA. Translation: AAH99759.1.
RefSeqiNP_001034119.1. NM_001039030.1.
UniGeneiRn.209051.

3D structure databases

ProteinModelPortaliQ499U4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031180.

Proteomic databases

PaxDbiQ499U4.
PRIDEiQ499U4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029999; ENSRNOP00000031180; ENSRNOG00000026964.
GeneIDi361438.
KEGGirno:361438.
UCSCiRGD:1307817. rat.

Organism-specific databases

CTDi2622.
RGDi1307817. Gas8.

Phylogenomic databases

eggNOGiENOG410IE2T. Eukaryota.
ENOG410XPBD. LUCA.
GeneTreeiENSGT00390000009477.
HOGENOMiHOG000038763.
HOVERGENiHBG039458.
InParanoidiQ499U4.
KOiK19942.
OMAiEHRTQEG.
OrthoDBiEOG091G0851.
PhylomeDBiQ499U4.

Miscellaneous databases

PROiQ499U4.

Gene expression databases

BgeeiENSRNOG00000026964.
GenevisibleiQ499U4. RN.

Family and domain databases

InterProiIPR025593. GAS8.
[Graphical view]
PfamiPF13851. GAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS8_RAT
AccessioniPrimary (citable) accession number: Q499U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.