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Protein

Engulfment and cell motility protein 3

Gene

Elmo3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 3
Gene namesi
Name:Elmo3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1304734 Elmo3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003752231 – 720Engulfment and cell motility protein 3Add BLAST720

Proteomic databases

PaxDbiQ499U2
PRIDEiQ499U2

Expressioni

Gene expression databases

BgeeiENSRNOG00000015800
GenevisibleiQ499U2 RN

Interactioni

Subunit structurei

Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1 (By similarity). Interacts with ADGRB3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021362

Structurei

3D structure databases

ProteinModelPortaliQ499U2
SMRiQ499U2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 479ELMOPROSITE-ProRule annotationAdd BLAST173
Domaini541 – 663PHAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi699 – 706Poly-Pro8

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2999 Eukaryota
ENOG410XPKN LUCA
GeneTreeiENSGT00390000014155
HOGENOMiHOG000230985
InParanoidiQ499U2
KOiK19241
OMAiMGSEQTR
OrthoDBiEOG091G03JJ
PhylomeDBiQ499U2

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR024574 DUF3361
IPR030719 ELMO3
IPR006816 ELMO_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12771:SF16 PTHR12771:SF16, 1 hit
PfamiView protein in Pfam
PF11841 DUF3361, 1 hit
PF04727 ELMO_CED12, 1 hit
PF16457 PH_12, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit

Sequencei

Sequence statusi: Complete.

Q499U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPRNVVKI AVQMSDAIPQ LIQLDQAKPL ATVLKEVCDT WSLTHPEHYA
60 70 80 90 100
LQFADGHRKY ITENNRSEIK NGSILCLSTA PDLKAQQLLS RLQNASREGC
110 120 130 140 150
CEVLRNLVPL ASDMTFAQEV ISRDGLQKLS TIIENGDDLG EMLALGLRAF
160 170 180 190 200
LELMEHGVVS WETLSISFVR KVVSYVNMNL MDASVQPLAL RLLESVTLSS
210 220 230 240 250
PTLGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ GASPAERKDM
260 270 280 290 300
LDCLWKKNLR QFIYKNIIHS AAPMGDEMAH HLYVLQALTL GLLEPRMRTP
310 320 330 340 350
LDPYSQEQRE QLQALRQAAF EPDGESLGTG LSADRRRSLC VREFRKLGFS
360 370 380 390 400
NSSPAQDLER VPPGLLALDN MLYFSRHAPS AYSRFVLENS SREDKHECPF
410 420 430 440 450
ARSSIQLTVL LCELLHVGEP CSETAQDFSP MFFSQDHSFH ELFCVAIQLL
460 470 480 490 500
NKTWKEMRAT QEDFDKVMQV VREQLARTLA LKPTSLELFR TKVNALTYGE
510 520 530 540 550
VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL LRLCEGMLFR
560 570 580 590 600
KISSRRRQDK LWFCCLSPNH KVLQYGDVEE GANPPTLESL TEQLPVADIR
610 620 630 640 650
ALLMGKDCPH VREKGSGKQN KDLYELAFSI SYDHGEEEAY LNFIAPSKRD
660 670 680 690 700
FYLWTDGLSA LLGSTMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPEHPP
710 720
PVPPPPTNFN FCYDYSMTEP
Length:720
Mass (Da):81,659
Last modified:September 13, 2005 - v1
Checksum:i2F4230B0146340D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473972 Genomic DNA Translation: EDL92366.1
BC099761 mRNA Translation: AAH99761.1
RefSeqiNP_001025199.1, NM_001030028.1
UniGeneiRn.151249

Genome annotation databases

EnsembliENSRNOT00000021362; ENSRNOP00000021362; ENSRNOG00000015800
GeneIDi291962
KEGGirno:291962
UCSCiRGD:1304734 rat

Similar proteinsi

Entry informationi

Entry nameiELMO3_RAT
AccessioniPrimary (citable) accession number: Q499U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health