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Protein

Engulfment and cell motility protein 3

Gene

Elmo3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 3
Gene namesi
Name:Elmo3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1304734. Elmo3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Engulfment and cell motility protein 3PRO_0000375223Add
BLAST

Proteomic databases

PaxDbiQ499U2.
PRIDEiQ499U2.

Expressioni

Gene expression databases

GenevisibleiQ499U2. RN.

Interactioni

Subunit structurei

Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1 (By similarity). Interacts with ADGRB3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021362.

Structurei

3D structure databases

ProteinModelPortaliQ499U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini307 – 479173ELMOPROSITE-ProRule annotationAdd
BLAST
Domaini541 – 663123PHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi699 – 7068Poly-Pro

Sequence similaritiesi

Contains 1 ELMO domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2999. Eukaryota.
ENOG410XPKN. LUCA.
GeneTreeiENSGT00390000014155.
HOGENOMiHOG000230985.
InParanoidiQ499U2.
KOiK19241.
OMAiMGSEQTR.
OrthoDBiEOG7D85VW.
PhylomeDBiQ499U2.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR030719. ELMO3.
IPR006816. ELMO_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR12771:SF16. PTHR12771:SF16. 1 hit.
PfamiPF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
PF16457. PH_12. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPRNVVKI AVQMSDAIPQ LIQLDQAKPL ATVLKEVCDT WSLTHPEHYA
60 70 80 90 100
LQFADGHRKY ITENNRSEIK NGSILCLSTA PDLKAQQLLS RLQNASREGC
110 120 130 140 150
CEVLRNLVPL ASDMTFAQEV ISRDGLQKLS TIIENGDDLG EMLALGLRAF
160 170 180 190 200
LELMEHGVVS WETLSISFVR KVVSYVNMNL MDASVQPLAL RLLESVTLSS
210 220 230 240 250
PTLGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ GASPAERKDM
260 270 280 290 300
LDCLWKKNLR QFIYKNIIHS AAPMGDEMAH HLYVLQALTL GLLEPRMRTP
310 320 330 340 350
LDPYSQEQRE QLQALRQAAF EPDGESLGTG LSADRRRSLC VREFRKLGFS
360 370 380 390 400
NSSPAQDLER VPPGLLALDN MLYFSRHAPS AYSRFVLENS SREDKHECPF
410 420 430 440 450
ARSSIQLTVL LCELLHVGEP CSETAQDFSP MFFSQDHSFH ELFCVAIQLL
460 470 480 490 500
NKTWKEMRAT QEDFDKVMQV VREQLARTLA LKPTSLELFR TKVNALTYGE
510 520 530 540 550
VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL LRLCEGMLFR
560 570 580 590 600
KISSRRRQDK LWFCCLSPNH KVLQYGDVEE GANPPTLESL TEQLPVADIR
610 620 630 640 650
ALLMGKDCPH VREKGSGKQN KDLYELAFSI SYDHGEEEAY LNFIAPSKRD
660 670 680 690 700
FYLWTDGLSA LLGSTMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPEHPP
710 720
PVPPPPTNFN FCYDYSMTEP
Length:720
Mass (Da):81,659
Last modified:September 13, 2005 - v1
Checksum:i2F4230B0146340D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473972 Genomic DNA. Translation: EDL92366.1.
BC099761 mRNA. Translation: AAH99761.1.
RefSeqiNP_001025199.1. NM_001030028.1.
UniGeneiRn.151249.

Genome annotation databases

EnsembliENSRNOT00000021362; ENSRNOP00000021362; ENSRNOG00000015800.
GeneIDi291962.
KEGGirno:291962.
UCSCiRGD:1304734. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473972 Genomic DNA. Translation: EDL92366.1.
BC099761 mRNA. Translation: AAH99761.1.
RefSeqiNP_001025199.1. NM_001030028.1.
UniGeneiRn.151249.

3D structure databases

ProteinModelPortaliQ499U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021362.

Proteomic databases

PaxDbiQ499U2.
PRIDEiQ499U2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021362; ENSRNOP00000021362; ENSRNOG00000015800.
GeneIDi291962.
KEGGirno:291962.
UCSCiRGD:1304734. rat.

Organism-specific databases

CTDi79767.
RGDi1304734. Elmo3.

Phylogenomic databases

eggNOGiKOG2999. Eukaryota.
ENOG410XPKN. LUCA.
GeneTreeiENSGT00390000014155.
HOGENOMiHOG000230985.
InParanoidiQ499U2.
KOiK19241.
OMAiMGSEQTR.
OrthoDBiEOG7D85VW.
PhylomeDBiQ499U2.

Miscellaneous databases

NextBioi633495.
PROiQ499U2.

Gene expression databases

GenevisibleiQ499U2. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR030719. ELMO3.
IPR006816. ELMO_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR12771:SF16. PTHR12771:SF16. 1 hit.
PfamiPF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
PF16457. PH_12. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiELMO3_RAT
AccessioniPrimary (citable) accession number: Q499U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 13, 2005
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.