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Q499U1 (S2538_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 25 member 38
Gene names
Name:Slc25a38
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane By similarity. HAMAP-Rule MF_03064

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_03064.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Solute carrier family 25 member 38 HAMAP-Rule MF_03064
PRO_0000291804

Regions

Transmembrane51 – 7626Helical; Name=1; Potential
Transmembrane109 – 13527Helical; Name=2; Potential
Transmembrane147 – 17226Helical; Name=3; Potential
Transmembrane200 – 22324Helical; Name=4; Potential
Transmembrane241 – 26727Helical; Name=5; Potential
Transmembrane296 – 31419Helical; Name=6; Potential
Repeat45 – 13490Solcar 1 HAMAP-Rule MF_03064
Repeat141 – 22585Solcar 2 HAMAP-Rule MF_03064
Repeat237 – 32185Solcar 3 HAMAP-Rule MF_03064

Experimental info

Sequence conflict1021S → T in AAH99762. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q499U1 [UniParc].

Last modified February 19, 2014. Version 2.
Checksum: D86497EAF92FFECD

FASTA32635,230
        10         20         30         40         50         60 
MGVSAEPRSL SVARAGLASP VIEKARSALL PSQDVEDTVE TLMLHPVIKA FLCGSISGTC 

        70         80         90        100        110        120 
STLLFQPLDL LKTRLQTLQP SDVGPRRVGM LSVFLKVVRT ESLLGLWKGM SPSIVRCVPG 

       130        140        150        160        170        180 
VGIYFGTLYS SKQYFLRGHP PTALESVILG MGSRSVAGVC MSPITVVKTR YESGAYSYES 

       190        200        210        220        230        240 
VYAALRSIYC SEGSRGLFRG LTATLLRDAP FSGLYLMFYS QTRATVLHGA DELDAALMPL 

       250        260        270        280        290        300 
VNFSCGVFAG ILASLVTQPA DVIKTHMQLS TVKCQCIGQV ATLILKTHGL RGFFHGSVPR 

       310        320 
ALRRTLMAAM AWTVYEEMMA KMGLKS 

« Hide

References

[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06057577 Genomic DNA. No translation available.
AABR06057578 Genomic DNA. No translation available.
CH473954 Genomic DNA. Translation: EDL76885.1.
BC099762 mRNA. Translation: AAH99762.1.
RefSeqNP_001025203.1. NM_001030032.1.
UniGeneRn.21048.

3D structure databases

ProteinModelPortalQ499U1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000025142.

Proteomic databases

PaxDbQ499U1.
PRIDEQ499U1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025142; ENSRNOP00000025142; ENSRNOG00000018552.
GeneID301067.
KEGGrno:301067.
UCSCRGD:1311914. rat.

Organism-specific databases

CTD54977.
RGD1311914. Slc25a38.

Phylogenomic databases

eggNOGNOG268441.
GeneTreeENSGT00550000075117.
HOGENOMHOG000006978.
HOVERGENHBG054682.
InParanoidQ499U1.
KOK15118.
OrthoDBEOG7BGHMD.
PhylomeDBQ499U1.

Gene expression databases

GenevestigatorQ499U1.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
HAMAPMF_03064. SLC25A38.
InterProIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio35584141.

Entry information

Entry nameS2538_RAT
AccessionPrimary (citable) accession number: Q499U1
Secondary accession number(s): G3V8E7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 19, 2014
Last modified: April 16, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families