Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial glycine transporter

Gene

Slc25a38

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38UniRule annotation
Gene namesi
Name:Slc25a38UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1311914 Slc25a38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 76Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei109 – 135Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei147 – 172Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei200 – 223Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei241 – 267Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei296 – 314Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918041 – 326Mitochondrial glycine transporterAdd BLAST326

Proteomic databases

PaxDbiQ499U1
PRIDEiQ499U1

Expressioni

Gene expression databases

BgeeiENSRNOG00000018552
ExpressionAtlasiQ499U1 baseline and differential
GenevisibleiQ499U1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025142

Structurei

3D structure databases

ProteinModelPortaliQ499U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 134Solcar 1UniRule annotationAdd BLAST90
Repeati141 – 225Solcar 2UniRule annotationAdd BLAST85
Repeati237 – 321Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
GeneTreeiENSGT00550000075117
HOGENOMiHOG000006978
HOVERGENiHBG054682
InParanoidiQ499U1
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG091G0IR1

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q499U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVSAEPRSL SVARAGLASP VIEKARSALL PSQDVEDTVE TLMLHPVIKA
60 70 80 90 100
FLCGSISGTC STLLFQPLDL LKTRLQTLQP SDVGPRRVGM LSVFLKVVRT
110 120 130 140 150
ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS SKQYFLRGHP PTALESVILG
160 170 180 190 200
MGSRSVAGVC MSPITVVKTR YESGAYSYES VYAALRSIYC SEGSRGLFRG
210 220 230 240 250
LTATLLRDAP FSGLYLMFYS QTRATVLHGA DELDAALMPL VNFSCGVFAG
260 270 280 290 300
ILASLVTQPA DVIKTHMQLS TVKCQCIGQV ATLILKTHGL RGFFHGSVPR
310 320
ALRRTLMAAM AWTVYEEMMA KMGLKS
Length:326
Mass (Da):35,230
Last modified:February 19, 2014 - v2
Checksum:iD86497EAF92FFECD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102S → T in AAH99762 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06057577 Genomic DNA No translation available.
AABR06057578 Genomic DNA No translation available.
CH473954 Genomic DNA Translation: EDL76885.1
BC099762 mRNA Translation: AAH99762.1
RefSeqiNP_001025203.1, NM_001030032.1
UniGeneiRn.21048

Genome annotation databases

EnsembliENSRNOT00000025142; ENSRNOP00000025142; ENSRNOG00000018552
GeneIDi301067
KEGGirno:301067
UCSCiRGD:1311914 rat

Similar proteinsi

Entry informationi

Entry nameiS2538_RAT
AccessioniPrimary (citable) accession number: Q499U1
Secondary accession number(s): G3V8E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 19, 2014
Last modified: April 25, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health