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Q499U1

- S2538_RAT

UniProt

Q499U1 - S2538_RAT

Protein

Solute carrier family 25 member 38

Gene

Slc25a38

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (19 Feb 2014)
      Previous versions | rss
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    Functioni

    Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

    GO - Biological processi

    1. erythrocyte differentiation Source: UniProtKB
    2. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 25 member 38UniRule annotation
    Gene namesi
    Name:Slc25a38
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8, UP000002494: Unplaced

    Organism-specific databases

    RGDi1311914. Slc25a38.

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Solute carrier family 25 member 38PRO_0000291804Add
    BLAST

    Proteomic databases

    PaxDbiQ499U1.
    PRIDEiQ499U1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ499U1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025142.

    Structurei

    3D structure databases

    ProteinModelPortaliQ499U1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7626Helical; Name=1UniRule annotationAdd
    BLAST
    Transmembranei109 – 13527Helical; Name=2UniRule annotationAdd
    BLAST
    Transmembranei147 – 17226Helical; Name=3UniRule annotationAdd
    BLAST
    Transmembranei200 – 22324Helical; Name=4UniRule annotationAdd
    BLAST
    Transmembranei241 – 26727Helical; Name=5UniRule annotationAdd
    BLAST
    Transmembranei296 – 31419Helical; Name=6UniRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati45 – 13490Solcar 1Add
    BLAST
    Repeati141 – 22585Solcar 2Add
    BLAST
    Repeati237 – 32185Solcar 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
    Contains 3 Solcar repeats.UniRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268441.
    GeneTreeiENSGT00550000075117.
    HOGENOMiHOG000006978.
    HOVERGENiHBG054682.
    InParanoidiQ499U1.
    KOiK15118.
    OMAiRWIGQAV.
    OrthoDBiEOG7BGHMD.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    HAMAPiMF_03064. SLC25A38.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q499U1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVSAEPRSL SVARAGLASP VIEKARSALL PSQDVEDTVE TLMLHPVIKA    50
    FLCGSISGTC STLLFQPLDL LKTRLQTLQP SDVGPRRVGM LSVFLKVVRT 100
    ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS SKQYFLRGHP PTALESVILG 150
    MGSRSVAGVC MSPITVVKTR YESGAYSYES VYAALRSIYC SEGSRGLFRG 200
    LTATLLRDAP FSGLYLMFYS QTRATVLHGA DELDAALMPL VNFSCGVFAG 250
    ILASLVTQPA DVIKTHMQLS TVKCQCIGQV ATLILKTHGL RGFFHGSVPR 300
    ALRRTLMAAM AWTVYEEMMA KMGLKS 326
    Length:326
    Mass (Da):35,230
    Last modified:February 19, 2014 - v2
    Checksum:iD86497EAF92FFECD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021S → T in AAH99762. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06057577 Genomic DNA. No translation available.
    AABR06057578 Genomic DNA. No translation available.
    CH473954 Genomic DNA. Translation: EDL76885.1.
    BC099762 mRNA. Translation: AAH99762.1.
    RefSeqiNP_001025203.1. NM_001030032.1.
    UniGeneiRn.21048.

    Genome annotation databases

    EnsembliENSRNOT00000025142; ENSRNOP00000025142; ENSRNOG00000018552.
    GeneIDi301067.
    KEGGirno:301067.
    UCSCiRGD:1311914. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06057577 Genomic DNA. No translation available.
    AABR06057578 Genomic DNA. No translation available.
    CH473954 Genomic DNA. Translation: EDL76885.1 .
    BC099762 mRNA. Translation: AAH99762.1 .
    RefSeqi NP_001025203.1. NM_001030032.1.
    UniGenei Rn.21048.

    3D structure databases

    ProteinModelPortali Q499U1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025142.

    Proteomic databases

    PaxDbi Q499U1.
    PRIDEi Q499U1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025142 ; ENSRNOP00000025142 ; ENSRNOG00000018552 .
    GeneIDi 301067.
    KEGGi rno:301067.
    UCSCi RGD:1311914. rat.

    Organism-specific databases

    CTDi 54977.
    RGDi 1311914. Slc25a38.

    Phylogenomic databases

    eggNOGi NOG268441.
    GeneTreei ENSGT00550000075117.
    HOGENOMi HOG000006978.
    HOVERGENi HBG054682.
    InParanoidi Q499U1.
    KOi K15118.
    OMAi RWIGQAV.
    OrthoDBi EOG7BGHMD.

    Miscellaneous databases

    NextBioi 35584141.

    Gene expression databases

    Genevestigatori Q499U1.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    HAMAPi MF_03064. SLC25A38.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiS2538_RAT
    AccessioniPrimary (citable) accession number: Q499U1
    Secondary accession number(s): G3V8E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: February 19, 2014
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3