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Q499U1

- S2538_RAT

UniProt

Q499U1 - S2538_RAT

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Protein

Solute carrier family 25 member 38

Gene

Slc25a38

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Biological processi

  1. erythrocyte differentiation Source: UniProtKB
  2. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38UniRule annotation
Gene namesi
Name:Slc25a38
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8, UP000002494: Unplaced

Organism-specific databases

RGDi1311914. Slc25a38.

Subcellular locationi

Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Solute carrier family 25 member 38PRO_0000291804Add
BLAST

Proteomic databases

PaxDbiQ499U1.
PRIDEiQ499U1.

Expressioni

Gene expression databases

GenevestigatoriQ499U1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025142.

Structurei

3D structure databases

ProteinModelPortaliQ499U1.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7626Helical; Name=1UniRule annotationAdd
BLAST
Transmembranei109 – 13527Helical; Name=2UniRule annotationAdd
BLAST
Transmembranei147 – 17226Helical; Name=3UniRule annotationAdd
BLAST
Transmembranei200 – 22324Helical; Name=4UniRule annotationAdd
BLAST
Transmembranei241 – 26727Helical; Name=5UniRule annotationAdd
BLAST
Transmembranei296 – 31419Helical; Name=6UniRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 13490Solcar 1Add
BLAST
Repeati141 – 22585Solcar 2Add
BLAST
Repeati237 – 32185Solcar 3Add
BLAST

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
Contains 3 Solcar repeats.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268441.
GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
HOVERGENiHBG054682.
InParanoidiQ499U1.
KOiK15118.
OMAiRWIGQAV.
OrthoDBiEOG7BGHMD.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499U1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVSAEPRSL SVARAGLASP VIEKARSALL PSQDVEDTVE TLMLHPVIKA
60 70 80 90 100
FLCGSISGTC STLLFQPLDL LKTRLQTLQP SDVGPRRVGM LSVFLKVVRT
110 120 130 140 150
ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS SKQYFLRGHP PTALESVILG
160 170 180 190 200
MGSRSVAGVC MSPITVVKTR YESGAYSYES VYAALRSIYC SEGSRGLFRG
210 220 230 240 250
LTATLLRDAP FSGLYLMFYS QTRATVLHGA DELDAALMPL VNFSCGVFAG
260 270 280 290 300
ILASLVTQPA DVIKTHMQLS TVKCQCIGQV ATLILKTHGL RGFFHGSVPR
310 320
ALRRTLMAAM AWTVYEEMMA KMGLKS
Length:326
Mass (Da):35,230
Last modified:February 19, 2014 - v2
Checksum:iD86497EAF92FFECD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021S → T in AAH99762. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06057577 Genomic DNA. No translation available.
AABR06057578 Genomic DNA. No translation available.
CH473954 Genomic DNA. Translation: EDL76885.1.
BC099762 mRNA. Translation: AAH99762.1.
RefSeqiNP_001025203.1. NM_001030032.1.
UniGeneiRn.21048.

Genome annotation databases

EnsembliENSRNOT00000025142; ENSRNOP00000025142; ENSRNOG00000018552.
GeneIDi301067.
KEGGirno:301067.
UCSCiRGD:1311914. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06057577 Genomic DNA. No translation available.
AABR06057578 Genomic DNA. No translation available.
CH473954 Genomic DNA. Translation: EDL76885.1 .
BC099762 mRNA. Translation: AAH99762.1 .
RefSeqi NP_001025203.1. NM_001030032.1.
UniGenei Rn.21048.

3D structure databases

ProteinModelPortali Q499U1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025142.

Proteomic databases

PaxDbi Q499U1.
PRIDEi Q499U1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025142 ; ENSRNOP00000025142 ; ENSRNOG00000018552 .
GeneIDi 301067.
KEGGi rno:301067.
UCSCi RGD:1311914. rat.

Organism-specific databases

CTDi 54977.
RGDi 1311914. Slc25a38.

Phylogenomic databases

eggNOGi NOG268441.
GeneTreei ENSGT00550000075117.
HOGENOMi HOG000006978.
HOVERGENi HBG054682.
InParanoidi Q499U1.
KOi K15118.
OMAi RWIGQAV.
OrthoDBi EOG7BGHMD.

Miscellaneous databases

NextBioi 35584141.

Gene expression databases

Genevestigatori Q499U1.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
HAMAPi MF_03064. SLC25A38.
InterProi IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiS2538_RAT
AccessioniPrimary (citable) accession number: Q499U1
Secondary accession number(s): G3V8E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 19, 2014
Last modified: October 29, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3