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Protein

Solute carrier family 25 member 38

Gene

Slc25a38

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38UniRule annotation
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1311914. Slc25a38.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 76Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei109 – 135Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei147 – 172Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei200 – 223Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei241 – 267Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei296 – 314Helical; Name=6UniRule annotationAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918041 – 326Solute carrier family 25 member 38Add BLAST326

Proteomic databases

PaxDbiQ499U1.
PRIDEiQ499U1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018552.
ExpressionAtlasiQ499U1. baseline and differential.
GenevisibleiQ499U1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025142.

Structurei

3D structure databases

ProteinModelPortaliQ499U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 134Solcar 1Add BLAST90
Repeati141 – 225Solcar 2Add BLAST85
Repeati237 – 321Solcar 3Add BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
Contains 3 Solcar repeats.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
HOVERGENiHBG054682.
InParanoidiQ499U1.
KOiK15118.
OMAiRWIGQAV.
OrthoDBiEOG091G0IR1.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVSAEPRSL SVARAGLASP VIEKARSALL PSQDVEDTVE TLMLHPVIKA
60 70 80 90 100
FLCGSISGTC STLLFQPLDL LKTRLQTLQP SDVGPRRVGM LSVFLKVVRT
110 120 130 140 150
ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS SKQYFLRGHP PTALESVILG
160 170 180 190 200
MGSRSVAGVC MSPITVVKTR YESGAYSYES VYAALRSIYC SEGSRGLFRG
210 220 230 240 250
LTATLLRDAP FSGLYLMFYS QTRATVLHGA DELDAALMPL VNFSCGVFAG
260 270 280 290 300
ILASLVTQPA DVIKTHMQLS TVKCQCIGQV ATLILKTHGL RGFFHGSVPR
310 320
ALRRTLMAAM AWTVYEEMMA KMGLKS
Length:326
Mass (Da):35,230
Last modified:February 19, 2014 - v2
Checksum:iD86497EAF92FFECD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102S → T in AAH99762 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06057577 Genomic DNA. No translation available.
AABR06057578 Genomic DNA. No translation available.
CH473954 Genomic DNA. Translation: EDL76885.1.
BC099762 mRNA. Translation: AAH99762.1.
RefSeqiNP_001025203.1. NM_001030032.1.
UniGeneiRn.21048.

Genome annotation databases

EnsembliENSRNOT00000025142; ENSRNOP00000025142; ENSRNOG00000018552.
GeneIDi301067.
KEGGirno:301067.
UCSCiRGD:1311914. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06057577 Genomic DNA. No translation available.
AABR06057578 Genomic DNA. No translation available.
CH473954 Genomic DNA. Translation: EDL76885.1.
BC099762 mRNA. Translation: AAH99762.1.
RefSeqiNP_001025203.1. NM_001030032.1.
UniGeneiRn.21048.

3D structure databases

ProteinModelPortaliQ499U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025142.

Proteomic databases

PaxDbiQ499U1.
PRIDEiQ499U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025142; ENSRNOP00000025142; ENSRNOG00000018552.
GeneIDi301067.
KEGGirno:301067.
UCSCiRGD:1311914. rat.

Organism-specific databases

CTDi54977.
RGDi1311914. Slc25a38.

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
HOVERGENiHBG054682.
InParanoidiQ499U1.
KOiK15118.
OMAiRWIGQAV.
OrthoDBiEOG091G0IR1.

Miscellaneous databases

PROiQ499U1.

Gene expression databases

BgeeiENSRNOG00000018552.
ExpressionAtlasiQ499U1. baseline and differential.
GenevisibleiQ499U1. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2538_RAT
AccessioniPrimary (citable) accession number: Q499U1
Secondary accession number(s): G3V8E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 19, 2014
Last modified: November 30, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.