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Q499T2

- GILT_RAT

UniProt

Q499T2 - GILT_RAT

Protein

Gamma-interferon-inducible lysosomal thiol reductase

Gene

Ifi30

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation By similarity.By similarity

    GO - Molecular functioni

    1. oxidoreductase activity, acting on a sulfur group of donors Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: UniProtKB
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
    3. negative regulation of fibroblast proliferation Source: Ensembl
    4. protein stabilization Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_198830. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-interferon-inducible lysosomal thiol reductase (EC:1.8.-.-)
    Alternative name(s):
    Interferon gamma inducible protein 30
    Gene namesi
    Name:Ifi30
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi1310758. Ifi30.

    Subcellular locationi

    Secreted By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. cell junction Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. lysosome Source: UniProtKB
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 5430Removed in mature formBy similarityPRO_0000406227Add
    BLAST
    Chaini55 – 230176Gamma-interferon-inducible lysosomal thiol reductasePRO_0000406228Add
    BLAST
    Propeptidei231 – 24818Removed in mature formBy similarityPRO_0000406229Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi69 ↔ 72Redox-activeBy similarity
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated. Sugar chains contain mannose-6-phosphate By similarity.By similarity
    Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ499T2.

    PTM databases

    PhosphoSiteiQ499T2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ499T2.

    Interactioni

    Subunit structurei

    Dimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026225.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GILT family.Curated

    Keywords - Domaini

    Redox-active center, Signal

    Phylogenomic databases

    eggNOGiNOG315223.
    GeneTreeiENSGT00390000010450.
    HOGENOMiHOG000238423.
    HOVERGENiHBG005837.
    InParanoidiQ5I0J7.
    KOiK08059.
    OMAiTELMHEN.
    OrthoDBiEOG71P2CG.
    PhylomeDBiQ499T2.
    TreeFamiTF315141.

    Family and domain databases

    InterProiIPR004911. Interferon-induced_GILT.
    [Graphical view]
    PANTHERiPTHR13234. PTHR13234. 1 hit.
    PfamiPF03227. GILT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q499T2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSCSPLVPFL SLLLLLFLPE VPRAATASLP QGSSEGAATC KAHDLCLFGP    50
    RRLLSAPPVN VSLYYESLCG ACRYFLVRNL FPTWLMVMEI MNITLVPYGN 100
    AQERNVSGTW EFTCQHGELE CKLNKVEACL LDKLEKEAAF LTIVCMEEME 150
    DMEKKLGPCL QLYVPEVSPE SIMECATGKR GTELMHENAQ LTDALQPPHE 200
    YVPWVLVNEK PLTDPSQLLS SVCELYQGTE KPDICSSMAD APREVCYK 248
    Length:248
    Mass (Da):27,644
    Last modified:September 13, 2005 - v1
    Checksum:i12A82B9AF6E2E3B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474031 Genomic DNA. Translation: EDL90735.1.
    BC099774 mRNA. Translation: AAH99774.1.
    BC088256 mRNA. Translation: AAH88256.1.
    RefSeqiNP_001025197.1. NM_001030026.1.
    UniGeneiRn.3370.

    Genome annotation databases

    EnsembliENSRNOT00000026225; ENSRNOP00000026225; ENSRNOG00000019387.
    GeneIDi290644.
    KEGGirno:290644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474031 Genomic DNA. Translation: EDL90735.1 .
    BC099774 mRNA. Translation: AAH99774.1 .
    BC088256 mRNA. Translation: AAH88256.1 .
    RefSeqi NP_001025197.1. NM_001030026.1.
    UniGenei Rn.3370.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026225.

    PTM databases

    PhosphoSitei Q499T2.

    Proteomic databases

    PaxDbi Q499T2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026225 ; ENSRNOP00000026225 ; ENSRNOG00000019387 .
    GeneIDi 290644.
    KEGGi rno:290644.

    Organism-specific databases

    CTDi 10437.
    RGDi 1310758. Ifi30.

    Phylogenomic databases

    eggNOGi NOG315223.
    GeneTreei ENSGT00390000010450.
    HOGENOMi HOG000238423.
    HOVERGENi HBG005837.
    InParanoidi Q5I0J7.
    KOi K08059.
    OMAi TELMHEN.
    OrthoDBi EOG71P2CG.
    PhylomeDBi Q499T2.
    TreeFami TF315141.

    Enzyme and pathway databases

    Reactomei REACT_198830. MHC class II antigen presentation.

    Miscellaneous databases

    NextBioi 631392.
    PROi Q499T2.

    Gene expression databases

    Genevestigatori Q499T2.

    Family and domain databases

    InterProi IPR004911. Interferon-induced_GILT.
    [Graphical view ]
    PANTHERi PTHR13234. PTHR13234. 1 hit.
    Pfami PF03227. GILT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiGILT_RAT
    AccessioniPrimary (citable) accession number: Q499T2
    Secondary accession number(s): Q5I0J7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Both precursor form and mature form have thiol reductase activity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3