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Protein

Inactive rhomboid protein 1

Gene

Rhbdf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive rhomboid protein 1
Short name:
iRhom1
Alternative name(s):
Rhomboid family member 1
Gene namesi
Name:Rhbdf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305075 Rhbdf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 412CytoplasmicSequence analysisAdd BLAST412
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 656LumenalSequence analysisAdd BLAST223
Transmembranei657 – 677HelicalSequence analysisAdd BLAST21
Topological domaini678 – 692CytoplasmicSequence analysisAdd BLAST15
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 715LumenalSequence analysis2
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Topological domaini737 – 747CytoplasmicSequence analysisAdd BLAST11
Transmembranei748 – 768HelicalSequence analysisAdd BLAST21
Topological domaini769 – 773LumenalSequence analysis5
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Topological domaini795 – 804CytoplasmicSequence analysis10
Transmembranei805 – 825HelicalSequence analysisAdd BLAST21
Topological domaini826 – 856LumenalSequence analysisAdd BLAST31

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003401101 – 856Inactive rhomboid protein 1Add BLAST856

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei180PhosphothreonineBy similarity1
Modified residuei183PhosphothreonineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ499S9
PRIDEiQ499S9

PTM databases

iPTMnetiQ499S9
PhosphoSitePlusiQ499S9

Expressioni

Gene expression databases

BgeeiENSRNOG00000020594
GenevisibleiQ499S9 RN

Interactioni

Subunit structurei

Homodimer, or homooligomer. Interacts with TGFA and HBEGF. Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027965

Structurei

3D structure databases

ProteinModelPortaliQ499S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2290 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000012532
HOGENOMiHOG000154118
HOVERGENiHBG059673
InParanoidiQ499S9
OMAiHMDCAIT
OrthoDBiEOG091G021G
PhylomeDBiQ499S9
TreeFamiTF312988

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR022241 Rhomboid_SP
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PF12595 Rhomboid_SP, 1 hit

Sequencei

Sequence statusi: Complete.

Q499S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEARRDSTS SLQRKKPPWL KLDIPAVVPP AAEEPSFLQP LRRQAFLRSV
60 70 80 90 100
SMPAETARVP SPHHEPRRLA LQRQTSITQT IRRGTADWFG VSKDSDSTQK
110 120 130 140 150
WQRKSIRHCS QRYGKLKPQV IRELDLPSQD NVSLTSTETP PPLYVGPCQL
160 170 180 190 200
GMQKIIDPLA RGRAFRMADD TADGLSAPHT PVTPGAASLC SFSSSRSGFN
210 220 230 240 250
RLPRRRKRES VAKMSFRAAA ALVKGRSIRD GTLRRGQRRS FTPASFLEED
260 270 280 290 300
MVDFPDELDT SFFAREGVLH EELSTYPDEV FESPSEAALK DWEKAPDQAD
310 320 330 340 350
LTGGALDRSE LERSHLMLPL ERGWRKQKEG GTLAPQPKVR LRQEVVSAAG
360 370 380 390 400
PRRGQRIAVP VRKLFAREKR PYGLGMVGRL TNRTYRKRID SYVKRQIEDM
410 420 430 440 450
DDHRPFFTYW LTFVHSLVTI LAVCIYGIAP VGFSQHETVD SVLRKRGVYE
460 470 480 490 500
NVKYVQQENF WIGPSSEALI HLGAKFSPCM RQDPQVHNFI LAAREREKHS
510 520 530 540 550
ACCVRNDRSG CVQTSKEECS STLAVWVKWP VHPSAPDLAG NKRQFGSVCH
560 570 580 590 600
QDPRVCDEPS SEDPHEWPED ITKWPICTKN SAGNHTNHPH MDCVITGRPC
610 620 630 640 650
CIGTKGRCEI TSREYCDFMK GYFHEEATLC SQVHCMDDVC GLLPFLNPEV
660 670 680 690 700
PDQFYRLWLS LFLHAGILHC LVSVCFQMTV LRDLEKLAGW HRIAIIYLLS
710 720 730 740 750
GVTGNLASAI FLPYRAEVGP AGSQFGILAC LFVELFQSWQ ILARPWRAFF
760 770 780 790 800
KLLAVVLFLF AFGLLPWIDN FAHISGFVSG LFLSFAFLPY ISFGKFDLYR
810 820 830 840 850
KRCQIIIFQA VFLGLLAGLV VLFYFYPVRC EWCEFLTCIP FTDKFCEKYE

LDAQLH
Length:856
Mass (Da):97,262
Last modified:September 13, 2005 - v1
Checksum:iB62626B0AD0B131B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099777 mRNA Translation: AAH99777.1
RefSeqiNP_001025205.1, NM_001030034.1
XP_008765802.1, XM_008767580.1
XP_017452723.1, XM_017597234.1
XP_017452724.1, XM_017597235.1
UniGeneiRn.6381

Genome annotation databases

EnsembliENSRNOT00000027965; ENSRNOP00000027965; ENSRNOG00000020594
GeneIDi303008
KEGGirno:303008
UCSCiRGD:1305075 rat

Similar proteinsi

Entry informationi

Entry nameiRHDF1_RAT
AccessioniPrimary (citable) accession number: Q499S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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