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Protein

Inactive rhomboid protein 1

Gene

Rhbdf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive rhomboid protein 1
Short name:
iRhom1
Alternative name(s):
Rhomboid family member 1
Gene namesi
Name:Rhbdf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305075. Rhbdf1.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Predominantly localized in the endoplasmic reticulum membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 412412CytoplasmicSequence analysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence analysisAdd
BLAST
Topological domaini434 – 656223LumenalSequence analysisAdd
BLAST
Transmembranei657 – 67721HelicalSequence analysisAdd
BLAST
Topological domaini678 – 69215CytoplasmicSequence analysisAdd
BLAST
Transmembranei693 – 71321HelicalSequence analysisAdd
BLAST
Topological domaini714 – 7152LumenalSequence analysis
Transmembranei716 – 73621HelicalSequence analysisAdd
BLAST
Topological domaini737 – 74711CytoplasmicSequence analysisAdd
BLAST
Transmembranei748 – 76821HelicalSequence analysisAdd
BLAST
Topological domaini769 – 7735LumenalSequence analysis
Transmembranei774 – 79421HelicalSequence analysisAdd
BLAST
Topological domaini795 – 80410CytoplasmicSequence analysis
Transmembranei805 – 82521HelicalSequence analysisAdd
BLAST
Topological domaini826 – 85631LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Inactive rhomboid protein 1PRO_0000340110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761PhosphoserineBy similarity
Modified residuei176 – 1761PhosphoserineBy similarity
Modified residuei180 – 1801PhosphothreonineBy similarity
Modified residuei183 – 1831PhosphothreonineBy similarity
Modified residuei391 – 3911PhosphoserineBy similarity
Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ499S9.

PTM databases

iPTMnetiQ499S9.
PhosphoSiteiQ499S9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020594.
GenevisibleiQ499S9. RN.

Interactioni

Subunit structurei

Homodimer, or homooligomer. Interacts with TGFA and HBEGF. Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027965.

Structurei

3D structure databases

ProteinModelPortaliQ499S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2290. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000012532.
HOGENOMiHOG000154118.
HOVERGENiHBG059673.
InParanoidiQ499S9.
OMAiHMDCAIT.
OrthoDBiEOG091G021G.
PhylomeDBiQ499S9.
TreeFamiTF312988.

Family and domain databases

Gene3Di1.20.1540.10. 2 hits.
InterProiIPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view]
PfamiPF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEARRDSTS SLQRKKPPWL KLDIPAVVPP AAEEPSFLQP LRRQAFLRSV
60 70 80 90 100
SMPAETARVP SPHHEPRRLA LQRQTSITQT IRRGTADWFG VSKDSDSTQK
110 120 130 140 150
WQRKSIRHCS QRYGKLKPQV IRELDLPSQD NVSLTSTETP PPLYVGPCQL
160 170 180 190 200
GMQKIIDPLA RGRAFRMADD TADGLSAPHT PVTPGAASLC SFSSSRSGFN
210 220 230 240 250
RLPRRRKRES VAKMSFRAAA ALVKGRSIRD GTLRRGQRRS FTPASFLEED
260 270 280 290 300
MVDFPDELDT SFFAREGVLH EELSTYPDEV FESPSEAALK DWEKAPDQAD
310 320 330 340 350
LTGGALDRSE LERSHLMLPL ERGWRKQKEG GTLAPQPKVR LRQEVVSAAG
360 370 380 390 400
PRRGQRIAVP VRKLFAREKR PYGLGMVGRL TNRTYRKRID SYVKRQIEDM
410 420 430 440 450
DDHRPFFTYW LTFVHSLVTI LAVCIYGIAP VGFSQHETVD SVLRKRGVYE
460 470 480 490 500
NVKYVQQENF WIGPSSEALI HLGAKFSPCM RQDPQVHNFI LAAREREKHS
510 520 530 540 550
ACCVRNDRSG CVQTSKEECS STLAVWVKWP VHPSAPDLAG NKRQFGSVCH
560 570 580 590 600
QDPRVCDEPS SEDPHEWPED ITKWPICTKN SAGNHTNHPH MDCVITGRPC
610 620 630 640 650
CIGTKGRCEI TSREYCDFMK GYFHEEATLC SQVHCMDDVC GLLPFLNPEV
660 670 680 690 700
PDQFYRLWLS LFLHAGILHC LVSVCFQMTV LRDLEKLAGW HRIAIIYLLS
710 720 730 740 750
GVTGNLASAI FLPYRAEVGP AGSQFGILAC LFVELFQSWQ ILARPWRAFF
760 770 780 790 800
KLLAVVLFLF AFGLLPWIDN FAHISGFVSG LFLSFAFLPY ISFGKFDLYR
810 820 830 840 850
KRCQIIIFQA VFLGLLAGLV VLFYFYPVRC EWCEFLTCIP FTDKFCEKYE

LDAQLH
Length:856
Mass (Da):97,262
Last modified:September 13, 2005 - v1
Checksum:iB62626B0AD0B131B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099777 mRNA. Translation: AAH99777.1.
RefSeqiNP_001025205.1. NM_001030034.1.
XP_006246039.1. XM_006245977.2.
XP_008765800.1. XM_008767578.1.
XP_008765801.1. XM_008767579.1.
XP_008765802.1. XM_008767580.1.
UniGeneiRn.6381.

Genome annotation databases

EnsembliENSRNOT00000027965; ENSRNOP00000027965; ENSRNOG00000020594.
GeneIDi303008.
KEGGirno:303008.
UCSCiRGD:1305075. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099777 mRNA. Translation: AAH99777.1.
RefSeqiNP_001025205.1. NM_001030034.1.
XP_006246039.1. XM_006245977.2.
XP_008765800.1. XM_008767578.1.
XP_008765801.1. XM_008767579.1.
XP_008765802.1. XM_008767580.1.
UniGeneiRn.6381.

3D structure databases

ProteinModelPortaliQ499S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027965.

PTM databases

iPTMnetiQ499S9.
PhosphoSiteiQ499S9.

Proteomic databases

PaxDbiQ499S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027965; ENSRNOP00000027965; ENSRNOG00000020594.
GeneIDi303008.
KEGGirno:303008.
UCSCiRGD:1305075. rat.

Organism-specific databases

CTDi64285.
RGDi1305075. Rhbdf1.

Phylogenomic databases

eggNOGiKOG2290. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000012532.
HOGENOMiHOG000154118.
HOVERGENiHBG059673.
InParanoidiQ499S9.
OMAiHMDCAIT.
OrthoDBiEOG091G021G.
PhylomeDBiQ499S9.
TreeFamiTF312988.

Miscellaneous databases

PROiQ499S9.

Gene expression databases

BgeeiENSRNOG00000020594.
GenevisibleiQ499S9. RN.

Family and domain databases

Gene3Di1.20.1540.10. 2 hits.
InterProiIPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view]
PfamiPF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHDF1_RAT
AccessioniPrimary (citable) accession number: Q499S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.