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Q499S5

- MMP11_RAT

UniProt

Q499S5 - MMP11_RAT

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Protein

Stromelysin-3

Gene
Mmp11
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play an important role in the progression of epithelial malignancies By similarity.

Cofactori

Binds 1 calcium ion per subunit.
Binds 2 zinc ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Zinc 2; in inhibited form By similarity
Metal bindingi168 – 1681Zinc 1 By similarity
Metal bindingi170 – 1701Zinc 1 By similarity
Metal bindingi175 – 1751Calcium By similarity
Metal bindingi176 – 1761Calcium; via carbonyl oxygen By similarity
Metal bindingi178 – 1781Calcium; via carbonyl oxygen By similarity
Metal bindingi180 – 1801Calcium; via carbonyl oxygen By similarity
Metal bindingi183 – 1831Zinc 1 By similarity
Metal bindingi196 – 1961Zinc 1 By similarity
Metal bindingi218 – 2181Zinc 2; catalytic By similarity
Active sitei219 – 2191 By similarity
Metal bindingi222 – 2221Zinc 2; catalytic By similarity
Metal bindingi228 – 2281Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. basement membrane organization Source: Ensembl
  2. collagen catabolic process Source: UniProtKB-KW
  3. collagen fibril organization Source: Ensembl
  4. multicellular organismal development Source: InterPro
  5. negative regulation of fat cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198590. Activation of Matrix Metalloproteinases.
REACT_199177. Collagen degradation.

Protein family/group databases

MEROPSiM10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Stromelysin-3 (EC:3.4.24.-)
Short name:
SL-3
Short name:
ST3
Alternative name(s):
Matrix metalloproteinase-11
Short name:
MMP-11
Gene namesi
Name:Mmp11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi3099. Mmp11.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed predictionAdd
BLAST
Propeptidei36 – 10166Activation peptide By similarityPRO_0000042649Add
BLAST
Chaini102 – 491390Stromelysin-3PRO_0000042650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi297 ↔ 483 By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ499S5.
PRIDEiQ499S5.

PTM databases

PhosphoSiteiQ499S5.

Expressioni

Tissue specificityi

Highly expressed in ovary and uterus.1 Publication

Inductioni

In skin fibroblasts of superficial dermis upon skin lesion with highest level between days 5-10.1 Publication

Gene expression databases

GenevestigatoriQ499S5.

Interactioni

Protein-protein interaction databases

BioGridi247514. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ499S5.
SMRiQ499S5. Positions 102-264.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati298 – 34245Hemopexin 1Add
BLAST
Repeati343 – 38543Hemopexin 2Add
BLAST
Repeati387 – 43549Hemopexin 3Add
BLAST
Repeati436 – 48348Hemopexin 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi82 – 898Cysteine switch By similarity

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG236137.
GeneTreeiENSGT00750000117332.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
InParanoidiQ499S5.
KOiK07993.
OMAiVDTNEIA.
OrthoDBiEOG7XPZ57.
PhylomeDBiQ499S5.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR028705. Stromelysin-3.
[Graphical view]
PANTHERiPTHR10201:SF20. PTHR10201:SF20. 1 hit.
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q499S5-1 [UniParc]FASTAAdd to Basket

« Hide

MARAACLLRA ISRALLLPLP LLLLLLLLLP PQLMARARPP ENHRHRPVKR    50
VPQLLPAALP NSLPSVPASH WVPGPASSSR PLRCGVPDPP DVLNARNRQK 100
RFVLSGGRWE KTDLTYRILR FPWQLVREQV RQTVAEALRV WSEVTPLTFT 150
EVHEGRADIM IDFTRYWHGD NLPFDGPGGI LAHAFFPKTH REGDVHFDYD 200
ETWTIGDKGT DLLQVAAHEF GHVLGLQHTT AAKALMSPFY TFRYPLSLSP 250
DDRRGIQHLY GRPQLTPTSP TPTLSSQAGT DTNEIALQEP EVPPEVCETS 300
FDAVSTIRGE LFFFKAGFVW RLRSGQLQPG YPALASRHWQ GLPSPVDAAF 350
EDAQGQIWFF QGAQYWVYDG EKPVLGPAPL SKLGLQGSPV HAALVWGPEK 400
NKIYFFRGGD YWRFHPRTQR VDNPVPRRTT DWRGVPSEID AAFQDAEGYA 450
YFLRGHLYWK FDPVKVKVLE SFPRPIGPDF FDCAEPANTF R 491
Length:491
Mass (Da):55,511
Last modified:September 13, 2005 - v1
Checksum:iB0C5B191A623FD41
GO

Sequence cautioni

The sequence AAC53061.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH99781.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46034 mRNA. Translation: AAC53061.1. Different initiation.
BC099781 mRNA. Translation: AAH99781.2. Different initiation.
RefSeqiNP_037112.2. NM_012980.2.
UniGeneiRn.11123.

Genome annotation databases

EnsembliENSRNOT00000031400; ENSRNOP00000035334; ENSRNOG00000028344.
GeneIDi25481.
KEGGirno:25481.
UCSCiRGD:3099. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46034 mRNA. Translation: AAC53061.1 . Different initiation.
BC099781 mRNA. Translation: AAH99781.2 . Different initiation.
RefSeqi NP_037112.2. NM_012980.2.
UniGenei Rn.11123.

3D structure databases

ProteinModelPortali Q499S5.
SMRi Q499S5. Positions 102-264.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247514. 2 interactions.

Protein family/group databases

MEROPSi M10.007.

PTM databases

PhosphoSitei Q499S5.

Proteomic databases

PaxDbi Q499S5.
PRIDEi Q499S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000031400 ; ENSRNOP00000035334 ; ENSRNOG00000028344 .
GeneIDi 25481.
KEGGi rno:25481.
UCSCi RGD:3099. rat.

Organism-specific databases

CTDi 4320.
RGDi 3099. Mmp11.

Phylogenomic databases

eggNOGi NOG236137.
GeneTreei ENSGT00750000117332.
HOGENOMi HOG000217927.
HOVERGENi HBG052484.
InParanoidi Q499S5.
KOi K07993.
OMAi VDTNEIA.
OrthoDBi EOG7XPZ57.
PhylomeDBi Q499S5.

Enzyme and pathway databases

Reactomei REACT_198590. Activation of Matrix Metalloproteinases.
REACT_199177. Collagen degradation.

Miscellaneous databases

NextBioi 606819.
PROi Q499S5.

Gene expression databases

Genevestigatori Q499S5.

Family and domain databases

Gene3Di 2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR028705. Stromelysin-3.
[Graphical view ]
PANTHERi PTHR10201:SF20. PTHR10201:SF20. 1 hit.
Pfami PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF50923. SSF50923. 1 hit.
PROSITEi PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues."
    Okada A., Saez S., Misumi Y., Basset P.
    Gene 185:187-193(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, PROTEOLYTIC PROCESSING.
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiMMP11_RAT
AccessioniPrimary (citable) accession number: Q499S5
Secondary accession number(s): P97568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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