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Protein

Stromelysin-3

Gene

Mmp11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the progression of epithelial malignancies.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Ca2+Note: Binds 1 Ca2+ ion per subunit.
  • Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Zinc 2; in inhibited formBy similarity1
Metal bindingi168Zinc 1By similarity1
Metal bindingi170Zinc 1By similarity1
Metal bindingi175CalciumBy similarity1
Metal bindingi176Calcium; via carbonyl oxygenBy similarity1
Metal bindingi178Calcium; via carbonyl oxygenBy similarity1
Metal bindingi180Calcium; via carbonyl oxygenBy similarity1
Metal bindingi183Zinc 1By similarity1
Metal bindingi196Zinc 1By similarity1
Metal bindingi218Zinc 2; catalyticBy similarity1
Active sitei219PROSITE-ProRule annotation1
Metal bindingi222Zinc 2; catalyticBy similarity1
Metal bindingi228Zinc 2; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCollagen degradation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1474228 Degradation of the extracellular matrix
R-RNO-1592389 Activation of Matrix Metalloproteinases

Protein family/group databases

MEROPSiM10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Stromelysin-3 (EC:3.4.24.-)
Short name:
SL-3
Short name:
ST3
Alternative name(s):
Matrix metalloproteinase-11
Short name:
MMP-11
Gene namesi
Name:Mmp11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3099 Mmp11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
PropeptideiPRO_000004264936 – 101Activation peptideBy similarityAdd BLAST66
ChainiPRO_0000042650102 – 491Stromelysin-3Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi297 ↔ 483By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ499S5
PRIDEiQ499S5

PTM databases

PhosphoSitePlusiQ499S5

Expressioni

Tissue specificityi

Highly expressed in ovary and uterus.1 Publication

Inductioni

In skin fibroblasts of superficial dermis upon skin lesion with highest level between days 5-10.1 Publication

Gene expression databases

BgeeiENSRNOG00000028344
GenevisibleiQ499S5 RN

Interactioni

Protein-protein interaction databases

BioGridi247514, 2 interactors
STRINGi10116.ENSRNOP00000035334

Structurei

3D structure databases

ProteinModelPortaliQ499S5
SMRiQ499S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati298 – 342Hemopexin 1Add BLAST45
Repeati343 – 385Hemopexin 2Add BLAST43
Repeati387 – 435Hemopexin 3Add BLAST49
Repeati436 – 483Hemopexin 4Add BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi82 – 89Cysteine switchBy similarity8

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217927
HOVERGENiHBG052484
InParanoidiQ499S5
KOiK07993
OMAiHIWFFQG
OrthoDBiEOG091G03DP
PhylomeDBiQ499S5

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR006026 Peptidase_Metallo
IPR028705 Stromelysin-3
PANTHERiPTHR10201:SF20 PTHR10201:SF20, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q499S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAACLLRA ISRALLLPLP LLLLLLLLLP PQLMARARPP ENHRHRPVKR
60 70 80 90 100
VPQLLPAALP NSLPSVPASH WVPGPASSSR PLRCGVPDPP DVLNARNRQK
110 120 130 140 150
RFVLSGGRWE KTDLTYRILR FPWQLVREQV RQTVAEALRV WSEVTPLTFT
160 170 180 190 200
EVHEGRADIM IDFTRYWHGD NLPFDGPGGI LAHAFFPKTH REGDVHFDYD
210 220 230 240 250
ETWTIGDKGT DLLQVAAHEF GHVLGLQHTT AAKALMSPFY TFRYPLSLSP
260 270 280 290 300
DDRRGIQHLY GRPQLTPTSP TPTLSSQAGT DTNEIALQEP EVPPEVCETS
310 320 330 340 350
FDAVSTIRGE LFFFKAGFVW RLRSGQLQPG YPALASRHWQ GLPSPVDAAF
360 370 380 390 400
EDAQGQIWFF QGAQYWVYDG EKPVLGPAPL SKLGLQGSPV HAALVWGPEK
410 420 430 440 450
NKIYFFRGGD YWRFHPRTQR VDNPVPRRTT DWRGVPSEID AAFQDAEGYA
460 470 480 490
YFLRGHLYWK FDPVKVKVLE SFPRPIGPDF FDCAEPANTF R
Length:491
Mass (Da):55,511
Last modified:September 13, 2005 - v1
Checksum:iB0C5B191A623FD41
GO

Sequence cautioni

The sequence AAC53061 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH99781 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46034 mRNA Translation: AAC53061.1 Different initiation.
BC099781 mRNA Translation: AAH99781.2 Different initiation.
RefSeqiNP_037112.2, NM_012980.2
XP_008772050.1, XM_008773828.2
UniGeneiRn.11123

Genome annotation databases

EnsembliENSRNOT00000031400; ENSRNOP00000035334; ENSRNOG00000028344
ENSRNOT00000087725; ENSRNOP00000074176; ENSRNOG00000054959
GeneIDi103694874
25481
KEGGirno:103694874
rno:25481
UCSCiRGD:3099 rat

Similar proteinsi

Entry informationi

Entry nameiMMP11_RAT
AccessioniPrimary (citable) accession number: Q499S5
Secondary accession number(s): P97568
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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