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Protein
Submitted name:

Mucolipin 2

Gene

Mcoln2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-RNO-3295583. TRP channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Mucolipin 2Imported
Submitted name:
Protein Mcoln2Imported
Gene namesi
Name:Mcoln2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308884. Mcoln2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei289 – 31628HelicalSequence analysisAdd
BLAST
Transmembranei346 – 36318HelicalSequence analysisAdd
BLAST
Transmembranei375 – 39723HelicalSequence analysisAdd
BLAST
Transmembranei417 – 43923HelicalSequence analysisAdd
BLAST
Transmembranei485 – 50622HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

PhosphoSiteiQ499S1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015089.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020452.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini378 – 513136PKD_channelInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3733. Eukaryota.
ENOG410Z1HH. LUCA.
GeneTreeiENSGT00390000017126.
HOGENOMiHOG000232158.
HOVERGENiHBG052430.
KOiK04993.
OMAiKFRARQQ.
OrthoDBiEOG091G026A.
TreeFamiTF317783.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEGEETLDL PAWNRAPDPA WGPQHRAAVA SLDSEVKEEC LREDLKFYFM
60 70 80 90 100
SPCEKYRARR QIPWKLALQI LKIVMVTTQL VRFGLGNQLV VAFKEDNTVA
110 120 130 140 150
FKHLFLKGFS GVDEDDYSCS IYTQEDAYES IFFAIKQYRH LKNISLATLG
160 170 180 190 200
YGKSEDNRTG LRFCKQHYKS GAMFSSNETL NIDSDIETDC THLDLQVLTK
210 220 230 240 250
DPEDWAQASF FRLDFHRLVQ VDISFALKGI DLQAVHSREV PDCYLFQNTI
260 270 280 290 300
TFDNTAHSGK IKIYFNSEAN IEECKHMNLS GSLQRSTRYV LVFDVFVIAI
310 320 330 340 350
CLASLILCTR SIVLALRLRK RFLNFFLEKY KQHVCDADRW EFINGWYVLV
360 370 380 390 400
TISDLMTIIG SILKMEIKAK NLTNYDLCSI LLGTSTLLVW VGVIRYLGYF
410 420 430 440 450
QTYNALILTM QASLPKVLRF SACAGLIYLG YTFCGWIVLG PYHEKFENLN
460 470 480 490 500
IVAECLFSLV NGDDMFATFA QIQQKSLLVW LFSRLYLYSF ISLFIYMVLS
510 520 530 540 550
LFIALITDSY HTIKKYQQNG FPETDLQKFL KESGSKEGYQ KEPSALLPCF
560
CCLRRRGSDD HLVLVD
Length:566
Mass (Da):65,160
Last modified:September 13, 2005 - v1
Checksum:iAD597A6E38958A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07013714 Genomic DNA. No translation available.
AABR07013715 Genomic DNA. No translation available.
BC099787 mRNA. Translation: AAH99787.1.
RefSeqiNP_001034094.1. NM_001039005.1.
UniGeneiRn.35113.

Genome annotation databases

EnsembliENSRNOT00000020452; ENSRNOP00000020452; ENSRNOG00000015089.
GeneIDi292168.
KEGGirno:292168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07013714 Genomic DNA. No translation available.
AABR07013715 Genomic DNA. No translation available.
BC099787 mRNA. Translation: AAH99787.1.
RefSeqiNP_001034094.1. NM_001039005.1.
UniGeneiRn.35113.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020452.

PTM databases

PhosphoSiteiQ499S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020452; ENSRNOP00000020452; ENSRNOG00000015089.
GeneIDi292168.
KEGGirno:292168.

Organism-specific databases

CTDi255231.
RGDi1308884. Mcoln2.

Phylogenomic databases

eggNOGiKOG3733. Eukaryota.
ENOG410Z1HH. LUCA.
GeneTreeiENSGT00390000017126.
HOGENOMiHOG000232158.
HOVERGENiHBG052430.
KOiK04993.
OMAiKFRARQQ.
OrthoDBiEOG091G026A.
TreeFamiTF317783.

Enzyme and pathway databases

ReactomeiR-RNO-3295583. TRP channels.

Gene expression databases

BgeeiENSRNOG00000015089.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ499S1_RAT
AccessioniPrimary (citable) accession number: Q499S1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.