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Protein

Zinc finger protein 518A

Gene

Znf518a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1444 – 146623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 518A
Gene namesi
Name:Znf518a
Synonyms:Zfp518, Zfp518a, Znf518
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305314. Zfp518a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14781478Zinc finger protein 518APRO_0000349266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki358 – 358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki707 – 707Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki987 – 987Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1441 – 1441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ499R0.
PRIDEiQ499R0.

PTM databases

iPTMnetiQ499R0.
PhosphoSiteiQ499R0.

Expressioni

Gene expression databases

GenevisibleiQ499R0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051600.

Structurei

3D structure databases

ProteinModelPortaliQ499R0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1444 – 146623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155775.
HOVERGENiHBG098619.
InParanoidiQ499R0.
OMAiVDGKQHI.
OrthoDBiEOG7FJGZX.
PhylomeDBiQ499R0.
TreeFamiTF332842.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR027760. ZNF518A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF198. PTHR10032:SF198. 3 hits.
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFEQTQLFC DEKQTILKKI DTRNEIPDTI KSIPIPKISE AGFHYEPKNV
60 70 80 90 100
NICLPKINIP NEILMKHEVE KYRKLFQSKP QTARKSVSVR TVSCAKGCAQ
110 120 130 140 150
RCESERAEDE AGKMCAKILN FTCSKCQDRT QYSPNDLQKH FEMWHHGELP
160 170 180 190 200
SFPCEMCSFS ASDFQIFKQH RKTHRNTFVK CDICNSERSY TLLDLTKHFT
210 220 230 240 250
SKHCVNGNFQ CEECRFFTQD VGTFVQHIHR HKEVHYKCGK CHHLCFTKGE
260 270 280 290 300
LQKHLRVHSG TLPFTCHYCS YGAIHKDQLV RHVITLHKEH LYAKEKLERD
310 320 330 340 350
QYDKRVAKTT TGLKLILKRY KIGPTKTFWK RKTIASGNDE SIGKNAQAFN
360 370 380 390 400
IVSKTQTKSE DQSQEQLNEE KGGRQHCEDG DKPIESGSEK ATVLSTGQCN
410 420 430 440 450
KADEGASAPS SVLSAVQGPT VLLVRNNKIT IPANYSAKFM GFKMVDGRQH
460 470 480 490 500
IVIKLLPANK QILPSPALQP NTEKESTANL PPQAMDNTGF ATGLTAMNDT
510 520 530 540 550
DFVKAAPLSC SSPELPRKVI SEKETAFISE KNNMLQMVDD SKSVTSLPTP
560 570 580 590 600
SESVTSVRLT TKVEARDNVD LWENPSTQSH PDLIGTSINS PDKVNLTIRP
610 620 630 640 650
NAYSCGDMHN YCINYVNSEL PAESSNCFEF SNQGSLPFHN YSKVNNKRRR
660 670 680 690 700
FSRGAVCENL QRESSNKTVT QQSTSDSDTT SPLRKESSNS DSLLASISPL
710 720 730 740 750
SGTLKIKTEI EEPCDLEETQ NFNEQSLFTN ENQNLLNMTE EPKWDDIPCA
760 770 780 790 800
GSPMMPRITS VFSLQSEQAS EFLPPEVNQL LQDTLKPRSD IKEDSNNIPS
810 820 830 840 850
KNLPLDCDQT LKKSKEEVIK SSKDFQMQDI ISVPSASVGV NVPANDLNLK
860 870 880 890 900
CNGQEKQALS VLQDVRDPGV TTKIPSIITL LKTQSDAIIT QQLVKDKLRT
910 920 930 940 950
TTQHSGPVYV QNPLLTSEQK NPVFVQTPKG FIIPLHVANK PGLHVFSGRP
960 970 980 990 1000
VPLVNTQSVP AALLVNKKPG VVLTVNNGKP EGVPTVKTEN VHSYGTVTKE
1010 1020 1030 1040 1050
PCRTPFLKAE HNRYCLTPGL CSSIGSCVNM KTCSENTLPL KGSYIIKTSV
1060 1070 1080 1090 1100
SSSVKAVPFA NVLPEQQGPN VNVLDAVKQQ NESLPKASLY TLMPDGKQAV
1110 1120 1130 1140 1150
FFKCMMPNNT KLLKPRLVQN STYQRIQPKR PAGAPQKILL KIFNPVLSMS
1160 1170 1180 1190 1200
AVNNLSVGNS ASSFQKEIVP SKPTVHGEQK VPQSSRDALP VSVQDLMPAN
1210 1220 1230 1240 1250
EAVLSSTAAC PGSSEEPVHI SERSETRVSR SKANCTIERN FNKRKTCKNK
1260 1270 1280 1290 1300
FAKIKTRISQ DSETAFVSRN RSCKRKYIDN YQEPPRKKSA THRKCKERAN
1310 1320 1330 1340 1350
AEDVQETFGF SRPRLPKDSG RTLRLFPFNS EQLVKCPRRN QPVVVLNHPD
1360 1370 1380 1390 1400
ADAPEVERVM KTITKFNGRV LKVSLSKATI NALLKPVSIT SETTYSDFSK
1410 1420 1430 1440 1450
RHKMLKPVNS VKERFVLKLT LKKTSKNNYQ IVKTTSEDVL KSKFNCWFCG
1460 1470
RVFDNQDVWA GHGQRHLVEA TKDWNMLE
Length:1,478
Mass (Da):165,539
Last modified:September 13, 2005 - v1
Checksum:i7D5A04C646980C6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099801 mRNA. Translation: AAH99801.1.
RefSeqiNP_001025209.1. NM_001030038.1.
XP_006231459.1. XM_006231397.2.
XP_006231460.1. XM_006231398.2.
XP_008758662.1. XM_008760440.1.
UniGeneiRn.107229.

Genome annotation databases

EnsembliENSRNOT00000054717; ENSRNOP00000051600; ENSRNOG00000036592.
GeneIDi309478.
KEGGirno:309478.
UCSCiRGD:1305314. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099801 mRNA. Translation: AAH99801.1.
RefSeqiNP_001025209.1. NM_001030038.1.
XP_006231459.1. XM_006231397.2.
XP_006231460.1. XM_006231398.2.
XP_008758662.1. XM_008760440.1.
UniGeneiRn.107229.

3D structure databases

ProteinModelPortaliQ499R0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051600.

PTM databases

iPTMnetiQ499R0.
PhosphoSiteiQ499R0.

Proteomic databases

PaxDbiQ499R0.
PRIDEiQ499R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054717; ENSRNOP00000051600; ENSRNOG00000036592.
GeneIDi309478.
KEGGirno:309478.
UCSCiRGD:1305314. rat.

Organism-specific databases

CTDi72672.
RGDi1305314. Zfp518a.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155775.
HOVERGENiHBG098619.
InParanoidiQ499R0.
OMAiVDGKQHI.
OrthoDBiEOG7FJGZX.
PhylomeDBiQ499R0.
TreeFamiTF332842.

Miscellaneous databases

NextBioi660870.
PROiQ499R0.

Gene expression databases

GenevisibleiQ499R0. RN.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR027760. ZNF518A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF198. PTHR10032:SF198. 3 hits.
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiZ518A_RAT
AccessioniPrimary (citable) accession number: Q499R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 13, 2005
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.