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Protein

C1GALT1-specific chaperone 1

Gene

C1galt1c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-RNO-913709 O-linked glycosylation of mucins

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
C1GALT1-specific chaperone 1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1311230 C1galt1c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini27 – 316LumenalSequence analysisAdd BLAST290

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850761 – 316C1GALT1-specific chaperone 1Add BLAST316

Proteomic databases

PaxDbiQ499P3
PRIDEiQ499P3

Expressioni

Gene expression databases

BgeeiENSRNOG00000002536
GenevisibleiQ499P3 RN

Interactioni

Subunit structurei

Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003449

Structurei

3D structure databases

ProteinModelPortaliQ499P3
SMRiQ499P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246 Eukaryota
ENOG410YRJG LUCA
GeneTreeiENSGT00530000063264
HOGENOMiHOG000013033
HOVERGENiHBG059493
InParanoidiQ499P3
KOiK09653
OMAiCLKYTGV
OrthoDBiEOG091G0F36
PhylomeDBiQ499P3
TreeFamiTF317293

Family and domain databases

InterProiView protein in InterPro
IPR026731 C1GALT1C1
PANTHERiPTHR23033:SF2 PTHR23033:SF2, 1 hit

Sequencei

Sequence statusi: Complete.

Q499P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSESSSFLK GVMLGSIFCA LITMLGHIRI GNRMHHHEHH HLQAPNKDDI
60 70 80 90 100
LKISETERME LSKSFQVYCI VLVKPKDVSL WAAVKETWTK HCDKAEFFSS
110 120 130 140 150
ENVKVFESIN MDTNDMWLMM RKAYKYAYDK YKDQYNWFFL ARPTTFAVIE
160 170 180 190 200
NLKYFLLRKD PSQPFYLGHT VKSGDLEYVS VDGGIVLSIE SMKRLNGLLS
210 220 230 240 250
VPEKCPEQGG MIWKISEDKQ LAVCLKYAGV FAENAEDADG KDVFNTKSVG
260 270 280 290 300
LFIKEAMTNQ PNQVVEGCCS DMAVTFNGLT PNQMHVMMYG VYRLRAFGHV
310
FNDALVFLPP NGSEND
Length:316
Mass (Da):36,035
Last modified:September 13, 2005 - v1
Checksum:i50CB306A457C1035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099818 mRNA Translation: AAH99818.1
RefSeqiNP_001025204.1, NM_001030033.1
XP_006257549.1, XM_006257487.1
UniGeneiRn.110010

Genome annotation databases

EnsembliENSRNOT00000003449; ENSRNOP00000003449; ENSRNOG00000002536
GeneIDi302499
KEGGirno:302499
UCSCiRGD:1311230 rat

Similar proteinsi

Entry informationi

Entry nameiC1GLC_RAT
AccessioniPrimary (citable) accession number: Q499P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health