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Protein

C1GALT1-specific chaperone 1

Gene

C1galt1c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-RNO-913709. O-linked glycosylation of mucins.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
C1GALT1-specific chaperone 1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1311230. C1galt1c1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini27 – 316LumenalSequence analysisAdd BLAST290

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850761 – 316C1GALT1-specific chaperone 1Add BLAST316

Proteomic databases

PaxDbiQ499P3.
PRIDEiQ499P3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002536.
GenevisibleiQ499P3. RN.

Interactioni

Subunit structurei

Associates with core 1 beta-3-galactosyltransferase (C1GALT1), probably not with the soluble active form.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003449.

Structurei

3D structure databases

ProteinModelPortaliQ499P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000013033.
HOVERGENiHBG059493.
InParanoidiQ499P3.
KOiK09653.
OMAiCLKYTGV.
OrthoDBiEOG091G0F36.
PhylomeDBiQ499P3.
TreeFamiTF317293.

Family and domain databases

InterProiIPR026731. C1GALT1C1.
[Graphical view]
PANTHERiPTHR23033:SF2. PTHR23033:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q499P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSESSSFLK GVMLGSIFCA LITMLGHIRI GNRMHHHEHH HLQAPNKDDI
60 70 80 90 100
LKISETERME LSKSFQVYCI VLVKPKDVSL WAAVKETWTK HCDKAEFFSS
110 120 130 140 150
ENVKVFESIN MDTNDMWLMM RKAYKYAYDK YKDQYNWFFL ARPTTFAVIE
160 170 180 190 200
NLKYFLLRKD PSQPFYLGHT VKSGDLEYVS VDGGIVLSIE SMKRLNGLLS
210 220 230 240 250
VPEKCPEQGG MIWKISEDKQ LAVCLKYAGV FAENAEDADG KDVFNTKSVG
260 270 280 290 300
LFIKEAMTNQ PNQVVEGCCS DMAVTFNGLT PNQMHVMMYG VYRLRAFGHV
310
FNDALVFLPP NGSEND
Length:316
Mass (Da):36,035
Last modified:September 13, 2005 - v1
Checksum:i50CB306A457C1035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099818 mRNA. Translation: AAH99818.1.
RefSeqiNP_001025204.1. NM_001030033.1.
XP_006257549.1. XM_006257487.1.
UniGeneiRn.110010.

Genome annotation databases

EnsembliENSRNOT00000003449; ENSRNOP00000003449; ENSRNOG00000002536.
GeneIDi302499.
KEGGirno:302499.
UCSCiRGD:1311230. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099818 mRNA. Translation: AAH99818.1.
RefSeqiNP_001025204.1. NM_001030033.1.
XP_006257549.1. XM_006257487.1.
UniGeneiRn.110010.

3D structure databases

ProteinModelPortaliQ499P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003449.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

PaxDbiQ499P3.
PRIDEiQ499P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003449; ENSRNOP00000003449; ENSRNOG00000002536.
GeneIDi302499.
KEGGirno:302499.
UCSCiRGD:1311230. rat.

Organism-specific databases

CTDi29071.
RGDi1311230. C1galt1c1.

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000013033.
HOVERGENiHBG059493.
InParanoidiQ499P3.
KOiK09653.
OMAiCLKYTGV.
OrthoDBiEOG091G0F36.
PhylomeDBiQ499P3.
TreeFamiTF317293.

Enzyme and pathway databases

ReactomeiR-RNO-913709. O-linked glycosylation of mucins.

Miscellaneous databases

PROiQ499P3.

Gene expression databases

BgeeiENSRNOG00000002536.
GenevisibleiQ499P3. RN.

Family and domain databases

InterProiIPR026731. C1GALT1C1.
[Graphical view]
PANTHERiPTHR23033:SF2. PTHR23033:SF2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC1GLC_RAT
AccessioniPrimary (citable) accession number: Q499P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.