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Protein

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene

Coq2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.UniRule annotation

Catalytic activityi

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

BRENDAi2.5.1.39. 5301.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotation (EC:2.5.1.39UniRule annotation)
Short name:
4-HB polyprenyltransferaseUniRule annotation
Alternative name(s):
Para-hydroxybenzoate--polyprenyltransferaseUniRule annotation
Short name:
PHB:PPTUniRule annotation
Short name:
PHB:polyprenyltransferaseUniRule annotation
Gene namesi
Name:Coq2UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306722. Coq2.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Matrix side UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei154 – 17421HelicalUniRule annotationAdd
BLAST
Transmembranei177 – 19721HelicalUniRule annotationAdd
BLAST
Transmembranei201 – 22121HelicalUniRule annotationAdd
BLAST
Transmembranei231 – 25121HelicalUniRule annotationAdd
BLAST
Transmembranei278 – 29821HelicalUniRule annotationAdd
BLAST
Transmembranei301 – 32121HelicalUniRule annotationAdd
BLAST
Transmembranei333 – 35321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6363MitochondrionUniRule annotationAdd
BLAST
Chaini64 – 3743114-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotationPRO_0000228625Add
BLAST

Proteomic databases

PaxDbiQ499N4.
PRIDEiQ499N4.

PTM databases

PhosphoSiteiQ499N4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002987.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 14423Allylic polyprenyl diphosphate-binding siteUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.UniRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1381. Eukaryota.
COG0382. LUCA.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ499N4.
KOiK06125.
PhylomeDBiQ499N4.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q499N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLGGAGLV RGLRVVSPAW LRGPGGLPLA LARTTGTSGA RDRRAPASGT
60 70 80 90 100
QRGRALSLSA AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA
110 120 130 140 150
ADPGCFPDWY MLSLFGTGAI LMRGAGCTIN DMWDRDFDKK VERTANRPIA
160 170 180 190 200
AGDISAFQSF VFLGAQLTLA LGVLLHLNYY SIAMGAASLL LVVTYPLMKR
210 220 230 240 250
VTFWPQLALG LTFNWGALLG WSAVKGSCDP AVCLPLYFSG VMWTLIYDTI
260 270 280 290 300
YAHQDKKDDA LIGLKSTALL FRENTKQWLS GFGVAMVGAL SLVGASSGQT
310 320 330 340 350
LPYYAAVAAV GAHLAHQIYT VDIHRAEDCW EKFTSNRTVG LLLFLGIVLG
360 370
NLYKDKPDET KGVDAVGEES ERTS
Length:374
Mass (Da):40,406
Last modified:September 13, 2005 - v1
Checksum:iE464573BC4989C14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099827 mRNA. Translation: AAH99827.1.
RefSeqiNP_001037720.1. NM_001044255.1.
UniGeneiRn.7463.

Genome annotation databases

GeneIDi498332.
KEGGirno:498332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099827 mRNA. Translation: AAH99827.1.
RefSeqiNP_001037720.1. NM_001044255.1.
UniGeneiRn.7463.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002987.

PTM databases

PhosphoSiteiQ499N4.

Proteomic databases

PaxDbiQ499N4.
PRIDEiQ499N4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi498332.
KEGGirno:498332.

Organism-specific databases

CTDi27235.
RGDi1306722. Coq2.

Phylogenomic databases

eggNOGiKOG1381. Eukaryota.
COG0382. LUCA.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ499N4.
KOiK06125.
PhylomeDBiQ499N4.

Enzyme and pathway databases

UniPathwayiUPA00232.
BRENDAi2.5.1.39. 5301.

Miscellaneous databases

PROiQ499N4.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiCOQ2_RAT
AccessioniPrimary (citable) accession number: Q499N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2005
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.