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Protein

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene

Coq2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.UniRule annotation

Catalytic activityi

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

BRENDAi2.5.1.39 5301
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotation (EC:2.5.1.39UniRule annotation)
Short name:
4-HB polyprenyltransferaseUniRule annotation
Alternative name(s):
Para-hydroxybenzoate--polyprenyltransferaseUniRule annotation
Short name:
PHB:PPTUniRule annotation
Short name:
PHB:polyprenyltransferaseUniRule annotation
Gene namesi
Name:Coq2UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306722 Coq2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini64 – 83Mitochondrial matrixBy similarityAdd BLAST20
Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Topological domaini105 – 108Mitochondrial intermembraneBy similarity4
Transmembranei109 – 129HelicalUniRule annotationAdd BLAST21
Topological domaini130 – 153Mitochondrial matrixBy similarityAdd BLAST24
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Topological domaini175 – 176Mitochondrial intermembraneBy similarity2
Transmembranei177 – 197HelicalUniRule annotationAdd BLAST21
Topological domaini198 – 200Mitochondrial matrixBy similarity3
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Topological domaini222 – 230Mitochondrial intermembraneBy similarity9
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Topological domaini252 – 277Mitochondrial matrixBy similarityAdd BLAST26
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Topological domaini299 – 300Mitochondrial intermembraneBy similarity2
Transmembranei301 – 321HelicalUniRule annotationAdd BLAST21
Topological domaini322 – 332Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei333 – 353HelicalUniRule annotationAdd BLAST21
Topological domaini354 – 374Mitochondrial intermembraneBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 63MitochondrionUniRule annotationAdd BLAST63
ChainiPRO_000022862564 – 3744-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotationAdd BLAST311

Proteomic databases

PaxDbiQ499N4
PRIDEiQ499N4

PTM databases

PhosphoSitePlusiQ499N4

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002987

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 144Allylic polyprenyl diphosphate-binding siteUniRule annotationAdd BLAST23

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.UniRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1381 Eukaryota
COG0382 LUCA
HOGENOMiHOG000003697
HOVERGENiHBG081302
InParanoidiQ499N4
KOiK06125
PhylomeDBiQ499N4

Family and domain databases

HAMAPiMF_01635 UbiA, 1 hit
InterProiView protein in InterPro
IPR031103 HB_octoprenylTrfase
IPR006370 HB_polyprenyltransferase
IPR000537 UbiA_prenyltransferase
IPR030470 UbiA_prenylTrfase_CS
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
TIGRFAMsiTIGR01474 ubiA_proteo, 1 hit
PROSITEiView protein in PROSITE
PS00943 UBIA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q499N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLGGAGLV RGLRVVSPAW LRGPGGLPLA LARTTGTSGA RDRRAPASGT
60 70 80 90 100
QRGRALSLSA AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA
110 120 130 140 150
ADPGCFPDWY MLSLFGTGAI LMRGAGCTIN DMWDRDFDKK VERTANRPIA
160 170 180 190 200
AGDISAFQSF VFLGAQLTLA LGVLLHLNYY SIAMGAASLL LVVTYPLMKR
210 220 230 240 250
VTFWPQLALG LTFNWGALLG WSAVKGSCDP AVCLPLYFSG VMWTLIYDTI
260 270 280 290 300
YAHQDKKDDA LIGLKSTALL FRENTKQWLS GFGVAMVGAL SLVGASSGQT
310 320 330 340 350
LPYYAAVAAV GAHLAHQIYT VDIHRAEDCW EKFTSNRTVG LLLFLGIVLG
360 370
NLYKDKPDET KGVDAVGEES ERTS
Length:374
Mass (Da):40,406
Last modified:September 13, 2005 - v1
Checksum:iE464573BC4989C14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099827 mRNA Translation: AAH99827.1
RefSeqiNP_001037720.1, NM_001044255.1
UniGeneiRn.7463

Genome annotation databases

GeneIDi498332
KEGGirno:498332

Similar proteinsi

Entry informationi

Entry nameiCOQ2_RAT
AccessioniPrimary (citable) accession number: Q499N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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