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Protein

AP-5 complex subunit mu-1

Gene

Ap5m1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-5 complex subunit mu-1
Alternative name(s):
Adaptor-related protein complex 5 subunit mu-1
Short name:
Mu5
Mu-2-related death-inducing proteinBy similarity
Short name:
MuDBy similarity
Gene namesi
Name:Ap5m1
Synonyms:Mudeng
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1308087. Ap5m1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490AP-5 complex subunit mu-1PRO_0000374055Add
BLAST

Proteomic databases

PaxDbiQ499N2.
PRIDEiQ499N2.

PTM databases

iPTMnetiQ499N2.
PhosphoSiteiQ499N2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014148.
GenevisibleiQ499N2. RN.

Interactioni

Subunit structurei

Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018972.

Structurei

3D structure databases

ProteinModelPortaliQ499N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 476271MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.Sequence analysis
Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00390000006191.
HOGENOMiHOG000113695.
InParanoidiQ499N2.
KOiK19023.
OMAiEFCEAHI.
OrthoDBiEOG091G0M9Y.
PhylomeDBiQ499N2.
TreeFamiTF331963.

Family and domain databases

InterProiIPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 1 hit.
PROSITEiPS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRAVWLIR HEPGTPLGGT VKFSRRYPTV EKRAKVFNGM NYVPVPEDGP
60 70 80 90 100
FLKALLFQLR LLDDDKDFVE SRDSCSNINK TSIYGLSVGG EDLWPVIAFL
110 120 130 140 150
RNDMIYASVP LVEQALSPRP PLISISGVSQ GLELLLGVHD FLYSSQKNDT
160 170 180 190 200
DLHSRLSQLP DLLLQACPLG TLLDANLQNS LNSLNFVSVT QPQKQPAWKV
210 220 230 240 250
GTYKGKAQIS ISITENVKSM QYGKQDIADT WQVVGTVACK CDLEGVMPNV
260 270 280 290 300
TISLNLPTNG SPLQDIIVHP CVTSLDSAIL TSSSIDTVDD SAFSGPYKFP
310 320 330 340 350
FTPPLESFNL CHYTSQVPVP PILGSYHMKE DGAQLKITVN LKLHESVRNN
360 370 380 390 400
FEICEAHIPF YNRGPITHLE YKVSFGQLEV FREKSLLVWI IGQKFPKSME
410 420 430 440 450
ISLSGTLTFR VQGHNRQPFD HICIGSTAYV KLNFRIADYT LTGCYADQHS
460 470 480 490
VQVFASGKPK ISAYRKLISS DYYIWNSKAS APVTYASLLP
Length:490
Mass (Da):54,439
Last modified:September 13, 2005 - v1
Checksum:iA91466D47291E3FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099829 mRNA. Translation: AAH99829.1.
RefSeqiNP_001025207.1. NM_001030036.1.
UniGeneiRn.162064.

Genome annotation databases

EnsembliENSRNOT00000018972; ENSRNOP00000018972; ENSRNOG00000014148.
GeneIDi305861.
KEGGirno:305861.
UCSCiRGD:1308087. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099829 mRNA. Translation: AAH99829.1.
RefSeqiNP_001025207.1. NM_001030036.1.
UniGeneiRn.162064.

3D structure databases

ProteinModelPortaliQ499N2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018972.

PTM databases

iPTMnetiQ499N2.
PhosphoSiteiQ499N2.

Proteomic databases

PaxDbiQ499N2.
PRIDEiQ499N2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018972; ENSRNOP00000018972; ENSRNOG00000014148.
GeneIDi305861.
KEGGirno:305861.
UCSCiRGD:1308087. rat.

Organism-specific databases

CTDi55745.
RGDi1308087. Ap5m1.

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00390000006191.
HOGENOMiHOG000113695.
InParanoidiQ499N2.
KOiK19023.
OMAiEFCEAHI.
OrthoDBiEOG091G0M9Y.
PhylomeDBiQ499N2.
TreeFamiTF331963.

Miscellaneous databases

PROiQ499N2.

Gene expression databases

BgeeiENSRNOG00000014148.
GenevisibleiQ499N2. RN.

Family and domain databases

InterProiIPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 1 hit.
PROSITEiPS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP5M1_RAT
AccessioniPrimary (citable) accession number: Q499N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.