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Protein
Submitted name:

Retinoic acid receptor, alpha

Gene

Rara

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi82 – 157Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

  • drug binding Source: RGD
  • mRNA 5'-UTR binding Source: RGD
  • phosphatidylinositol 3-kinase regulator activity Source: UniProtKB
  • retinoic acid receptor activity Source: RGD
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • translation repressor activity, mRNA regulatory element binding Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • female pregnancy Source: RGD
  • hippocampus development Source: RGD
  • liver development Source: RGD
  • male gonad development Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of translation Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • prostate gland development Source: RGD
  • regulation of apoptotic process Source: RGD
  • regulation of myelination Source: RGD
  • regulation of synaptic plasticity Source: RGD
  • response to cytokine Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to vitamin A Source: RGD
  • retinoic acid receptor signaling pathway Source: RGD
  • transcription, DNA-templated Source: UniProtKB-UniRule

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-5362517 Signaling by Retinoic Acid

Names & Taxonomyi

Protein namesi
Submitted name:
Retinoic acid receptor, alphaImported
Submitted name:
Retinoic acid receptor, alpha, isoform CRA_bImported
Gene namesi
Name:RaraImported
ORF Names:rCG_33521Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3534 Rara

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2269

Expressioni

Gene expression databases

BgeeiENSRNOG00000009972
ExpressionAtlasiQ499N1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008659

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 157Nuclear receptorInterPro annotationAdd BLAST76
Domaini180 – 414NR LBDInterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000010312
HOVERGENiHBG005606
KOiK08527

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q499N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYESVEVGGL APAPNPFLVV DFYNQNRACL LQEKGLPAPG PYSTPLRTPL
60 70 80 90 100
WNGSNHSIET QSSSSEEIVP SPPSPPPLPR IYKPCFVCQD KSSGYHYGVS
110 120 130 140 150
ACEGCKGFFR RSIQKNMVYT CHRDKNCIIN KVTRNRCQYC RLQKCFEVGM
160 170 180 190 200
SKESVRNDRN KKKKETPKPE CSESYTLTPE VGELIEKVRK AHQETFPALC
210 220 230 240 250
QLGKYTTNNS SEQRVSLDID LWDKFSELST KCIIKTVEFA KQLPGFTTLT
260 270 280 290 300
IADQITLLKA ACLDILILRI CTRYTPEQDT MTFSDGLTLN RTQMHNAGFG
310 320 330 340 350
PLTDLVFAFA NQLLPLEMDD AETGLLSAIC LICGDRQDLE QPDKVDMLQE
360 370 380 390 400
PLLEALKVYV RKRRPSRPHM FPKMLMKITD LRSISAKGAE RVITLKMEIP
410 420 430 440 450
GSMPPLIQEM LENSEGLDTL SGQSGGGTRD GGGLAPPPGS CSPSLSPSSH

RSSPATQSP
Length:459
Mass (Da):50,949
Last modified:September 13, 2005 - v1
Checksum:i066A556C10E57D78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC141969 Genomic DNA No translation available.
BC099830 mRNA Translation: AAH99830.1
CH473948 Genomic DNA Translation: EDM05964.1
RefSeqiNP_113716.2, NM_031528.2
UniGeneiRn.226723
Rn.91057

Genome annotation databases

EnsembliENSRNOT00000008659; ENSRNOP00000008659; ENSRNOG00000009972
GeneIDi24705
KEGGirno:24705

Similar proteinsi

Entry informationi

Entry nameiQ499N1_RAT
AccessioniPrimary (citable) accession number: Q499N1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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