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Protein
Submitted name:

Protein Rara

Gene

Rara

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi82 – 157Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

  • drug binding Source: RGD
  • histone deacetylase binding Source: RGD
  • mRNA 5'-UTR binding Source: RGD
  • phosphatidylinositol 3-kinase regulator activity Source: UniProtKB
  • retinoic acid receptor activity Source: RGD
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • transcription factor binding Source: RGD
  • translation repressor activity, nucleic acid binding Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • female pregnancy Source: RGD
  • hippocampus development Source: RGD
  • liver development Source: RGD
  • male gonad development Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of translation Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • prostate gland development Source: RGD
  • regulation of apoptotic process Source: RGD
  • regulation of myelination Source: RGD
  • regulation of synaptic plasticity Source: RGD
  • response to cytokine Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to vitamin A Source: RGD
  • retinoic acid receptor signaling pathway Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.
R-RNO-5362517. Signaling by Retinoic Acid.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein RaraImported
Submitted name:
Retinoic acid receptor, alphaImported
Submitted name:
Retinoic acid receptor, alpha, isoform CRA_bImported
Gene namesi
Name:RaraImported
ORF Names:rCG_33521Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3534. Rara.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
  • perinuclear region of cytoplasm Source: RGD

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2269.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009972.
ExpressionAtlasiQ499N1. baseline and differential.

Interactioni

GO - Molecular functioni

  • histone deacetylase binding Source: RGD
  • transcription factor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008659.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 157Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00870000136372.
HOGENOMiHOG000010312.
HOVERGENiHBG005606.
KOiK08527.
PhylomeDBiQ499N1.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q499N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYESVEVGGL APAPNPFLVV DFYNQNRACL LQEKGLPAPG PYSTPLRTPL
60 70 80 90 100
WNGSNHSIET QSSSSEEIVP SPPSPPPLPR IYKPCFVCQD KSSGYHYGVS
110 120 130 140 150
ACEGCKGFFR RSIQKNMVYT CHRDKNCIIN KVTRNRCQYC RLQKCFEVGM
160 170 180 190 200
SKESVRNDRN KKKKETPKPE CSESYTLTPE VGELIEKVRK AHQETFPALC
210 220 230 240 250
QLGKYTTNNS SEQRVSLDID LWDKFSELST KCIIKTVEFA KQLPGFTTLT
260 270 280 290 300
IADQITLLKA ACLDILILRI CTRYTPEQDT MTFSDGLTLN RTQMHNAGFG
310 320 330 340 350
PLTDLVFAFA NQLLPLEMDD AETGLLSAIC LICGDRQDLE QPDKVDMLQE
360 370 380 390 400
PLLEALKVYV RKRRPSRPHM FPKMLMKITD LRSISAKGAE RVITLKMEIP
410 420 430 440 450
GSMPPLIQEM LENSEGLDTL SGQSGGGTRD GGGLAPPPGS CSPSLSPSSH

RSSPATQSP
Length:459
Mass (Da):50,949
Last modified:September 13, 2005 - v1
Checksum:i066A556C10E57D78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC141969 Genomic DNA. No translation available.
BC099830 mRNA. Translation: AAH99830.1.
CH473948 Genomic DNA. Translation: EDM05964.1.
RefSeqiNP_113716.2. NM_031528.2.
UniGeneiRn.226723.
Rn.91057.

Genome annotation databases

EnsembliENSRNOT00000008659; ENSRNOP00000008659; ENSRNOG00000009972.
GeneIDi24705.
KEGGirno:24705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC141969 Genomic DNA. No translation available.
BC099830 mRNA. Translation: AAH99830.1.
CH473948 Genomic DNA. Translation: EDM05964.1.
RefSeqiNP_113716.2. NM_031528.2.
UniGeneiRn.226723.
Rn.91057.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008659.

Chemistry databases

ChEMBLiCHEMBL2269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008659; ENSRNOP00000008659; ENSRNOG00000009972.
GeneIDi24705.
KEGGirno:24705.

Organism-specific databases

CTDi5914.
RGDi3534. Rara.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00870000136372.
HOGENOMiHOG000010312.
HOVERGENiHBG005606.
KOiK08527.
PhylomeDBiQ499N1.

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.
R-RNO-5362517. Signaling by Retinoic Acid.

Gene expression databases

BgeeiENSRNOG00000009972.
ExpressionAtlasiQ499N1. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ499N1_RAT
AccessioniPrimary (citable) accession number: Q499N1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 15, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.