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Protein

Tigger transposable element derived 5

Gene

Tigd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi84 – 10421H-T-H motifBy similarityAdd
BLAST
DNA bindingi155 – 18834H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element derived 5
Gene namesi
Name:Tigd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145902. Tigd5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Tigger transposable element derived 5PRO_0000416768Add
BLAST

Proteomic databases

PRIDEiQ499M4.

Expressioni

Gene expression databases

GenevisibleiQ499M4. MM.

Structurei

3D structure databases

ProteinModelPortaliQ499M4.
SMRiQ499M4. Positions 51-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 10852HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini122 – 19574HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini240 – 365126DDEAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 5452Pro-richAdd
BLAST
Compositional biasi572 – 5765Poly-Glu

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119149.
HOVERGENiHBG069618.
InParanoidiQ499M4.
OMAiWLENQDP.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q499M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYPASPPAGP ALHPVPHRAR LPQPRCLAEP PRSPAPGPGS TARPPPPPAP
60 70 80 90 100
GPRPRVAVKM TFRKAYSIKD KLQAIERVKG GERQASVCRD FGVPGGTLRG
110 120 130 140 150
WLKDEPKLRW FLDQLGGEVG TQRKKMRLAN EEEIDRAVYS WFLTLRQHGV
160 170 180 190 200
PLSGPVIQAQ AEAFARQIYG PECTFKASHG WFWRWQKRHG ISSQRIYGEA
210 220 230 240 250
ESPVAGPAPV KEEPAQSPGA VLVPDGAPAT LPHSEGGYGD EQIYNANVTG
260 270 280 290 300
LYWRLLPEQA STPGTGDSKE PGGCSRRWRS DRVTVLLAAN LTGSHKLKPL
310 320 330 340 350
VIGQLPDPPS LRHHNQDKFP ASYRYSPDAW LSRPLLRGWF FEEFVPGVKR
360 370 380 390 400
YLRRSCLQQK AVLLVAHPPC PSWATSMPPL EESEETPRQC QPELLGSPEE
410 420 430 440 450
LQTPDGAVRV LFLSKGTSRA HIPAPLEHGV VAAFKHLYKR ELLRLAVSCA
460 470 480 490 500
SGSPLDFMRS FVLKDMLYLA GLSWDLVQAG SIERCWLLGL RAAFEPGQQP
510 520 530 540 550
AHQVEETAEH SRVLSDLTHL AALAYKRLAP EEVAQWLHLD DDGGLPEGCR
560 570 580 590 600
EEVAPAAPPS PASLPSSIGA GEEEEEATEQ GGVLVPTAGE AVWGLETALR
610 620 630 640
WLESQDPREV GPLRLVQLRS LITMARRLGG IGPSAVTSDD GV
Length:642
Mass (Da):70,249
Last modified:September 13, 2005 - v1
Checksum:i5281A7CF947FDEDE
GO
Isoform 2 (identifier: Q499M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-642: SRAHIPAPLE...PSAVTSDDGV → VGARRGGSLQ...LLAAGSASSL

Show »
Length:486
Mass (Da):53,166
Checksum:iB9CB638DD6603486
GO

Sequence cautioni

The sequence BAC29359.1 differs from that shown. Reason: Frameshift at position 610. Curated
The sequence BAC39713.1 differs from that shown. Reason: Frameshift at position 228. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441Missing in BAC29359 (PubMed:16141072).Curated
Sequence conflicti436 – 4361H → R in BAC29359 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei418 – 642225SRAHI…SDDGV → VGARRGGSLQAFVQTRAPAA CCVLCQWLPSGLHEKLRSQG HAVPGWPLLGLGPGRQHRAL LAAGSASSL in isoform 2. 1 PublicationVSP_042797Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051177 mRNA. Translation: BAC34547.1.
AK086663 mRNA. Translation: BAC39713.1. Frameshift.
AK036241 mRNA. Translation: BAC29359.1. Frameshift.
BC099838 mRNA. Translation: AAH99838.1.
BC138289 mRNA. Translation: AAI38290.1.
CCDSiCCDS79379.1. [Q499M4-1]
RefSeqiNP_848761.2. NM_178646.4. [Q499M4-1]
UniGeneiMm.275583.

Genome annotation databases

EnsembliENSMUST00000192937; ENSMUSP00000141473; ENSMUSG00000103906. [Q499M4-1]
GeneIDi105734.
KEGGimmu:105734.
UCSCiuc007whp.1. mouse. [Q499M4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051177 mRNA. Translation: BAC34547.1.
AK086663 mRNA. Translation: BAC39713.1. Frameshift.
AK036241 mRNA. Translation: BAC29359.1. Frameshift.
BC099838 mRNA. Translation: AAH99838.1.
BC138289 mRNA. Translation: AAI38290.1.
CCDSiCCDS79379.1. [Q499M4-1]
RefSeqiNP_848761.2. NM_178646.4. [Q499M4-1]
UniGeneiMm.275583.

3D structure databases

ProteinModelPortaliQ499M4.
SMRiQ499M4. Positions 51-188.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ499M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192937; ENSMUSP00000141473; ENSMUSG00000103906. [Q499M4-1]
GeneIDi105734.
KEGGimmu:105734.
UCSCiuc007whp.1. mouse. [Q499M4-1]

Organism-specific databases

CTDi84948.
MGIiMGI:2145902. Tigd5.

Phylogenomic databases

GeneTreeiENSGT00760000119149.
HOVERGENiHBG069618.
InParanoidiQ499M4.
OMAiWLENQDP.

Miscellaneous databases

NextBioi357856.
PROiQ499M4.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ499M4. MM.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head and Spinal ganglion.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiTIGD5_MOUSE
AccessioniPrimary (citable) accession number: Q499M4
Secondary accession number(s): Q8BQA1, Q8C381, Q8CBD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: September 13, 2005
Last modified: March 16, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.