Mitogen-activated protein kinase 1 - Homo sapiens (Human)

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Unreviewed, UniProtKB/TrEMBL Q499G7 (Q499G7_HUMAN)

Last modified January 19, 2010. Version 46. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
Mitogen-activated protein kinase 1 EMBL AAH99905.1

Gene names

Name:

MAPK1 EMBL AAH99905.1

Organism

Homo sapiens (Human) EMBL AAH99905.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Spearmint SPM003527

Sequence similarities

Belongs to the protein kinase superfamily.

Contains 1 protein kinase domain.

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Ontologies

Keywords
Ligand	ATP-binding Spearmint SPM003527 RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Spearmint SPM003527 Transferase
Gene Ontology (GO)
Biological process	B cell receptor signaling pathway Inferred from electronic annotation. Source: Compara T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara cytosine metabolic process Inferred from electronic annotation. Source: Compara lipopolysaccharide-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cell differentiation Inferred from electronic annotation. Source: Compara nuclear translocation of MAPK Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of transcription Inferred from electronic annotation. Source: Compara positive regulation of translation Inferred from electronic annotation. Source: Compara protein amino acid phosphorylation Inferred from electronic annotation. Source: Compara response to DNA damage stimulus Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to exogenous dsRNA Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from electronic annotation. Source: Compara
Cellular component	axon part Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara dendrite cytoplasm Inferred from electronic annotation. Source: Compara insoluble fraction Inferred from electronic annotation. Source: Compara nucleoplasm Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara soluble fraction Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase 2 activity Inferred from electronic annotation. Source: Compara mitogen-activated protein kinase kinase kinase binding Inferred from electronic annotation. Source: Compara phosphotyrosine binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q499G7-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: D4271876ABA25E32
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FASTA

360

41,331

        10         20         30         40         50         60 
MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 

        70         80         90        100        110        120 
HQTYCQRTLR EIKILLRSRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 

       130        140        150        160        170        180 
LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLEICDFGL ARVADPDHDH 

       190        200        210        220        230        240 
TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 

       250        260        270        280        290        300 
LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 

       310        320        330        340        350        360 
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS

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References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH99905.1.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	BC099905 mRNA. Translation: AAH99905.1.
IPI	IPI00003479.
RefSeq	NP_002736.3.
UniGene	Hs.431850
3D structure databases
SMR	Q499G7. Positions 8-357.
ModBase	Search...
Protein-protein interaction databases
STRING	Q499G7.
Genome annotation databases
Ensembl	ENST00000215832; ENSP00000215832; ENSG00000100030; Homo sapiens. [Genome view] ENST00000398822; ENSP00000381803; ENSG00000100030; Homo sapiens. [Genome view]
GeneID	5594.
KEGG	hsa:5594.
Organism-specific databases
CTD	5594.
HGNC	HGNC:6871. MAPK1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q499G7.
Family and domain databases
InterPro	IPR008349. Erk_1_2_MAPK. IPR011009. Kinase-like_dom. IPR003527. MAP_kinase_CS. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01770. ERK1ERK2MAPK.
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS01351. MAPK. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

Q499G7_HUMAN

Accession

Primary (citable) accession number: Q499G7

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	January 19, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information