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Protein

Forkhead box protein N3

Gene

Foxn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi114 – 21097Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N3
Alternative name(s):
Checkpoint suppressor 1
Gene namesi
Name:Foxn3
Synonyms:Ches1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1918625. Foxn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Forkhead box protein N3PRO_0000245102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ499D0.
PRIDEiQ499D0.

PTM databases

PhosphoSiteiQ499D0.

Expressioni

Gene expression databases

BgeeiQ499D0.
CleanExiMM_FOXN3.
ExpressionAtlasiQ499D0. baseline and differential.
GenevisibleiQ499D0. MM.

Interactioni

Subunit structurei

Interacts through its C-terminus with the C-terminus of SNW1/SKIP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036035.

Structurei

3D structure databases

ProteinModelPortaliQ499D0.
SMRiQ499D0. Positions 114-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi308 – 35851Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000095166.
HOVERGENiHBG051654.
InParanoidiQ499D0.
KOiK09407.
OMAiMRTESEQ.
OrthoDBiEOG75TMBM.
PhylomeDBiQ499D0.
TreeFamiTF105083.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q499D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVMPASKK AESSGISVSS GLSQRYRGSG FSKALQEDDD LDFPLPDIRL
60 70 80 90 100
EEGAMEDEEL TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH
110 120 130 140 150
SDMPYDARQN PNCKPPYSFS CLIFMAIEDS PTKRLPVKDI YNWILEHFPY
160 170 180 190 200
FANAPTGWKN SVRHNLSLNK CFKKVDKERS QSIGKGSLWC IDPEYRQNLI
210 220 230 240 250
QALKKTPYHP PPTPQAYQST SGPPIWPGST FFKRNGALLQ VSPGVIQNGA
260 270 280 290 300
RVLSRGLFPG VRPLPITPIG MTAAIRNSIT SCRMRTESEP PCGSPVVSGD
310 320 330 340 350
PKEDHNYSSA KSSTARSTSP TSDSISSSSS SADDHYEFAT KGSQEGSEGS
360 370 380 390 400
FQSHESHSEP EEEDRKPSPK EGKDALGDSG YASQHKKRQH FAKARKVPSD
410 420 430 440 450
TLPLKKRRTE KPPESDDEEM KEAAGSLLHL AGIRSCLNNI TNRTAKGQKE

QKETAKN
Length:457
Mass (Da):50,345
Last modified:September 13, 2005 - v1
Checksum:i52B473A3954C42B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099971 mRNA. Translation: AAH99971.1.
AK017346 mRNA. Translation: BAB30701.1.
AK077921 mRNA. Translation: BAC37064.1.
CCDSiCCDS26103.1.
RefSeqiNP_899009.2. NM_183186.2.
XP_006516302.1. XM_006516239.2.
XP_006516303.1. XM_006516240.2.
UniGeneiMm.341972.
Mm.448530.
Mm.489662.

Genome annotation databases

EnsembliENSMUST00000046859; ENSMUSP00000036035; ENSMUSG00000033713.
ENSMUST00000085108; ENSMUSP00000082189; ENSMUSG00000033713.
ENSMUST00000177451; ENSMUSP00000135082; ENSMUSG00000033713.
GeneIDi71375.
KEGGimmu:71375.
UCSCiuc007ors.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099971 mRNA. Translation: AAH99971.1.
AK017346 mRNA. Translation: BAB30701.1.
AK077921 mRNA. Translation: BAC37064.1.
CCDSiCCDS26103.1.
RefSeqiNP_899009.2. NM_183186.2.
XP_006516302.1. XM_006516239.2.
XP_006516303.1. XM_006516240.2.
UniGeneiMm.341972.
Mm.448530.
Mm.489662.

3D structure databases

ProteinModelPortaliQ499D0.
SMRiQ499D0. Positions 114-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036035.

PTM databases

PhosphoSiteiQ499D0.

Proteomic databases

MaxQBiQ499D0.
PRIDEiQ499D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046859; ENSMUSP00000036035; ENSMUSG00000033713.
ENSMUST00000085108; ENSMUSP00000082189; ENSMUSG00000033713.
ENSMUST00000177451; ENSMUSP00000135082; ENSMUSG00000033713.
GeneIDi71375.
KEGGimmu:71375.
UCSCiuc007ors.1. mouse.

Organism-specific databases

CTDi1112.
MGIiMGI:1918625. Foxn3.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000095166.
HOVERGENiHBG051654.
InParanoidiQ499D0.
KOiK09407.
OMAiMRTESEQ.
OrthoDBiEOG75TMBM.
PhylomeDBiQ499D0.
TreeFamiTF105083.

Miscellaneous databases

NextBioi333663.
PROiQ499D0.
SOURCEiSearch...

Gene expression databases

BgeeiQ499D0.
CleanExiMM_FOXN3.
ExpressionAtlasiQ499D0. baseline and differential.
GenevisibleiQ499D0. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129/Sv X 129SvCpImported.
    Tissue: Embryonic stem cellImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-457.
    Strain: C57BL/6JImported.
    Tissue: Embryonic testisImported and HeadImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFOXN3_MOUSE
AccessioniPrimary (citable) accession number: Q499D0
Secondary accession number(s): Q8C5N8, Q9CU83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: September 13, 2005
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.