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Q499D0

- FOXN3_MOUSE

UniProt

Q499D0 - FOXN3_MOUSE

Protein

Forkhead box protein N3

Gene

Foxn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi114 – 21097Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. negative regulation of transcription, DNA-templated Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein N3
    Alternative name(s):
    Checkpoint suppressor 1
    Gene namesi
    Name:Foxn3
    Synonyms:Ches1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1918625. Foxn3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Forkhead box protein N3PRO_0000245102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei85 – 851PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ499D0.

    PTM databases

    PhosphoSiteiQ499D0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ499D0.
    BgeeiQ499D0.
    CleanExiMM_FOXN3.
    GenevestigatoriQ499D0.

    Interactioni

    Subunit structurei

    Interacts through its C-terminus with the C-terminus of SNW1/SKIP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ499D0.
    SMRiQ499D0. Positions 114-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi308 – 35851Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117509.
    HOGENOMiHOG000095166.
    HOVERGENiHBG051654.
    InParanoidiQ499D0.
    KOiK09407.
    OMAiMRTESEQ.
    OrthoDBiEOG75TMBM.
    PhylomeDBiQ499D0.
    TreeFamiTF105083.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q499D0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPVMPASKK AESSGISVSS GLSQRYRGSG FSKALQEDDD LDFPLPDIRL    50
    EEGAMEDEEL TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH 100
    SDMPYDARQN PNCKPPYSFS CLIFMAIEDS PTKRLPVKDI YNWILEHFPY 150
    FANAPTGWKN SVRHNLSLNK CFKKVDKERS QSIGKGSLWC IDPEYRQNLI 200
    QALKKTPYHP PPTPQAYQST SGPPIWPGST FFKRNGALLQ VSPGVIQNGA 250
    RVLSRGLFPG VRPLPITPIG MTAAIRNSIT SCRMRTESEP PCGSPVVSGD 300
    PKEDHNYSSA KSSTARSTSP TSDSISSSSS SADDHYEFAT KGSQEGSEGS 350
    FQSHESHSEP EEEDRKPSPK EGKDALGDSG YASQHKKRQH FAKARKVPSD 400
    TLPLKKRRTE KPPESDDEEM KEAAGSLLHL AGIRSCLNNI TNRTAKGQKE 450
    QKETAKN 457
    Length:457
    Mass (Da):50,345
    Last modified:September 13, 2005 - v1
    Checksum:i52B473A3954C42B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099971 mRNA. Translation: AAH99971.1.
    AK017346 mRNA. Translation: BAB30701.1.
    AK077921 mRNA. Translation: BAC37064.1.
    CCDSiCCDS26103.1.
    RefSeqiNP_899009.2. NM_183186.2.
    XP_006516302.1. XM_006516239.1.
    XP_006516303.1. XM_006516240.1.
    UniGeneiMm.341972.
    Mm.448530.
    Mm.489662.

    Genome annotation databases

    EnsembliENSMUST00000046859; ENSMUSP00000036035; ENSMUSG00000033713.
    ENSMUST00000085108; ENSMUSP00000082189; ENSMUSG00000033713.
    ENSMUST00000177451; ENSMUSP00000135082; ENSMUSG00000033713.
    GeneIDi71375.
    KEGGimmu:71375.
    UCSCiuc007ors.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099971 mRNA. Translation: AAH99971.1 .
    AK017346 mRNA. Translation: BAB30701.1 .
    AK077921 mRNA. Translation: BAC37064.1 .
    CCDSi CCDS26103.1.
    RefSeqi NP_899009.2. NM_183186.2.
    XP_006516302.1. XM_006516239.1.
    XP_006516303.1. XM_006516240.1.
    UniGenei Mm.341972.
    Mm.448530.
    Mm.489662.

    3D structure databases

    ProteinModelPortali Q499D0.
    SMRi Q499D0. Positions 114-194.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q499D0.

    Proteomic databases

    PRIDEi Q499D0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046859 ; ENSMUSP00000036035 ; ENSMUSG00000033713 .
    ENSMUST00000085108 ; ENSMUSP00000082189 ; ENSMUSG00000033713 .
    ENSMUST00000177451 ; ENSMUSP00000135082 ; ENSMUSG00000033713 .
    GeneIDi 71375.
    KEGGi mmu:71375.
    UCSCi uc007ors.1. mouse.

    Organism-specific databases

    CTDi 1112.
    MGIi MGI:1918625. Foxn3.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117509.
    HOGENOMi HOG000095166.
    HOVERGENi HBG051654.
    InParanoidi Q499D0.
    KOi K09407.
    OMAi MRTESEQ.
    OrthoDBi EOG75TMBM.
    PhylomeDBi Q499D0.
    TreeFami TF105083.

    Miscellaneous databases

    NextBioi 333663.
    PROi Q499D0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q499D0.
    Bgeei Q499D0.
    CleanExi MM_FOXN3.
    Genevestigatori Q499D0.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129/Sv X 129SvCpImported.
      Tissue: Embryonic stem cellImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-457.
      Strain: C57BL/6JImported.
      Tissue: Embryonic testisImported and HeadImported.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiFOXN3_MOUSE
    AccessioniPrimary (citable) accession number: Q499D0
    Secondary accession number(s): Q8C5N8, Q9CU83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3