Q49988 (PPGK_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polyphosphate glucokinase
EC=2.7.1.63

Alternative name(s):
Polyphosphate--glucose phosphotransferase

Gene names

Name:	ppgK
Ordered Locus Names:	ML1023
ORF Names:	u1764fg

Organism

Mycobacterium leprae (strain TN) [Complete proteome] [HAMAP]

Taxonomic identifier

272631 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium leprae

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor.
Catalytic activity	(Phosphate)(n) + D-glucose = (phosphate)(n-1) + D-glucose 6-phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polyphosphate-glucose phosphotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Polyphosphate glucokinase		PRO_0000058535
Regions
	Nucleotide binding	83 – 88	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49988 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 563A5C63CC9EF6EA	FASTA	324	34,102
	10 20 30 40 50 60 MIRLRSAAAR DRCQVLSLAY RITVAGRCQT VSPHHRQAKV SEQPSLAKEI AITSTDATAD 70 80 90 100 110 120 TPRTSPPSDT AGTTSRHRGF GIDIGGSSIK GGIVDLDIGQ LIGDRIKLLT PQPATPLAVA 130 140 150 160 170 180 KTIAEVVNAF GWTAPLGVTY PGVVTQGVVR TAANVDDSWI GTNARDIISA ELNSQEVTIL 190 200 210 220 230 240 NDADAAGLAE GRYGAGKNNS GLIVLLTFGT GIGSAVIHNG KLIPNTEFGH LEVDGKEAEQ 250 260 270 280 290 300 RAASSVKDKY KWSYRTWAKQ VTRVLVAIEN AMCPDLFIAG GGISRKADRW IPLLENRTPM 310 320 VAAALQNTAG IVGAAMASTA DVTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15181 Genomic DNA. Translation: AAA62940.1. AL583920 Genomic DNA. Translation: CAC31404.1.
PIR	A87037.
RefSeq	NP_301756.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q49988.
ModBase	Search...
Protein-protein interaction databases
STRING	272631.ML1023.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC31404; CAC31404; CAC31404.
GeneID	910085.
KEGG	mle:ML1023.
PATRIC	18053814. VBIMycLep78757_1852.
Organism-specific databases
Leproma	ML1023.
CMR	Search...
Phylogenomic databases
eggNOG	COG1940.
HOGENOM	HOG000150086.
KO	K00886.
OMA	AANVDKG.
ProtClustDB	CLSK2460514.
Family and domain databases
InterPro	IPR000600. ROK. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPGK_MYCLE

Accession

Primary (citable) accession number: Q49988

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program