Reviewed, UniProtKB/Swiss-Prot Q49988 (PPGK_MYCLE)

Names and origin

Protein names

Recommended name:
    Polyphosphate glucokinase
    EC=2.7.1.63
Alternative name(s):
    Polyphosphate--glucose phosphotransferase

Gene names

Name:	ppgK
Ordered Locus Names:	ML1023
ORF Names:	u1764fg

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor.
Catalytic activity	(Phosphate)(n) + D-glucose = (phosphate)(n-1) + D-glucose 6-phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polyphosphate-glucose phosphotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Polyphosphate glucokinase		PRO_0000058535
Regions
	Nucleotide binding	83 – 88	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q49988-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 563A5C63CC9EF6EA	FASTA	324	34,102
	10 20 30 40 50 60 MIRLRSAAAR DRCQVLSLAY RITVAGRCQT VSPHHRQAKV SEQPSLAKEI AITSTDATAD 70 80 90 100 110 120 TPRTSPPSDT AGTTSRHRGF GIDIGGSSIK GGIVDLDIGQ LIGDRIKLLT PQPATPLAVA 130 140 150 160 170 180 KTIAEVVNAF GWTAPLGVTY PGVVTQGVVR TAANVDDSWI GTNARDIISA ELNSQEVTIL 190 200 210 220 230 240 NDADAAGLAE GRYGAGKNNS GLIVLLTFGT GIGSAVIHNG KLIPNTEFGH LEVDGKEAEQ 250 260 270 280 290 300 RAASSVKDKY KWSYRTWAKQ VTRVLVAIEN AMCPDLFIAG GGISRKADRW IPLLENRTPM 310 320 VAAALQNTAG IVGAAMASTA DVTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15181 Genomic DNA. Translation: AAA62940.1. AL583920 Genomic DNA. Translation: CAC31404.1.
PIR	A87037.
RefSeq	NP_301756.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	910085.
GenomeReviews	Gene locus ML1023 in contig AL450380_GR.
KEGG	mle:ML1023.
NMPDR	fig|272631.1.peg.628.
Organism-specific databases
Leproma	ML1023.
CMR	Search...
Phylogenomic databases
HOGENOM	Q49988.
OMA	Q49988. WEKWAKR.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1023-MON.
BRENDA	2.7.1.63. 808.
Family and domain databases
InterPro	IPR000600. ROK. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPGK_MYCLE

Accession

Primary (citable) accession number: Q49988

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)