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Q49901 (SYW_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:ML0686
ORF Names:L308_C1_147
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140_B

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Tryptophan--tRNA ligase HAMAP-Rule MF_00140_B
PRO_0000136650

Regions

Motif16 – 2510"HIGH" region HAMAP-Rule MF_00140_B
Motif205 – 2095"KMSKS" region HAMAP-Rule MF_00140_B

Sites

Binding site2081ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q49901 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C0CD552AA6B02D88

FASTA34337,608
        10         20         30         40         50         60 
MSTATGFSRI FSGVQPTSDS LHLGNALGAI TQWVALQYDH PDEYEAFFCV VDLHAITIAQ 

        70         80         90        100        110        120 
DPETLWRRTL VTAAQYLALG IDPGRAVVFV QSHVPAHTQL AWVLGCFTGF GQASRMTQFK 

       130        140        150        160        170        180 
DKALRQGADS TTVGLFTYPV LQAADVLAYD TDLVPVGEDQ RQHLELARDL AQRFNSRFPD 

       190        200        210        220        230        240 
TFVVPDMFIP KMAAKIYDLA DPTSKMSKSA SSDAGLINLL DDPALSVKKI RAAVTDSERE 

       250        260        270        280        290        300 
IRYDPEVKPG VSNLLNIQSA VTGVDVDTLV QRYVGHGYGD LKKDTAEAVV EFVSPIKDRV 

       310        320        330        340 
DELMADLTEL EVVLAVGAQR AQDVAGKTMQ RVYDRLGFLP QRG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00022 Genomic DNA. Translation: AAA17323.1.
AL583919 Genomic DNA. Translation: CAC30195.1.
PIRS73024.
RefSeqNP_301552.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ49901.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0686.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30195; CAC30195; CAC30195.
GeneID909578.
KEGGmle:ML0686.
PATRIC18052560. VBIMycLep78757_1226.

Organism-specific databases

LepromaML0686.
CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAGWGQFKP.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_MYCLE
AccessionPrimary (citable) accession number: Q49901
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries