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Q49901

- SYW_MYCLE

UniProt

Q49901 - SYW_MYCLE

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:ML0686
ORF Names:L308_C1_147
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0686.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Tryptophan--tRNA ligasePRO_0000136650Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0686.

Structurei

3D structure databases

ProteinModelPortaliQ49901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi16 – 2510"HIGH" region
Motifi205 – 2095"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49901-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTATGFSRI FSGVQPTSDS LHLGNALGAI TQWVALQYDH PDEYEAFFCV
60 70 80 90 100
VDLHAITIAQ DPETLWRRTL VTAAQYLALG IDPGRAVVFV QSHVPAHTQL
110 120 130 140 150
AWVLGCFTGF GQASRMTQFK DKALRQGADS TTVGLFTYPV LQAADVLAYD
160 170 180 190 200
TDLVPVGEDQ RQHLELARDL AQRFNSRFPD TFVVPDMFIP KMAAKIYDLA
210 220 230 240 250
DPTSKMSKSA SSDAGLINLL DDPALSVKKI RAAVTDSERE IRYDPEVKPG
260 270 280 290 300
VSNLLNIQSA VTGVDVDTLV QRYVGHGYGD LKKDTAEAVV EFVSPIKDRV
310 320 330 340
DELMADLTEL EVVLAVGAQR AQDVAGKTMQ RVYDRLGFLP QRG
Length:343
Mass (Da):37,608
Last modified:November 1, 1996 - v1
Checksum:iC0CD552AA6B02D88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00022 Genomic DNA. Translation: AAA17323.1.
AL583919 Genomic DNA. Translation: CAC30195.1.
PIRiS73024.
RefSeqiNP_301552.1. NC_002677.1.
WP_010907876.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30195; CAC30195; CAC30195.
GeneIDi909578.
KEGGimle:ML0686.
PATRICi18052560. VBIMycLep78757_1226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00022 Genomic DNA. Translation: AAA17323.1 .
AL583919 Genomic DNA. Translation: CAC30195.1 .
PIRi S73024.
RefSeqi NP_301552.1. NC_002677.1.
WP_010907876.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q49901.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0686.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30195 ; CAC30195 ; CAC30195 .
GeneIDi 909578.
KEGGi mle:ML0686.
PATRICi 18052560. VBIMycLep78757_1226.

Organism-specific databases

Lepromai ML0686.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG686NJQ.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiSYW_MYCLE
AccessioniPrimary (citable) accession number: Q49901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3