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Protein

SAP domain-containing ribonucleoprotein

Gene

Sarnp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transcription, Transcription regulation, Translation regulation, Transport

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SAP domain-containing ribonucleoprotein
Alternative name(s):
Nuclear protein Hcc-1
Gene namesi
Name:Sarnp
Synonyms:Hcc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305692. Sarnp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 210209SAP domain-containing ribonucleoproteinPRO_0000083918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei10 – 101N6-acetyllysineBy similarity
Modified residuei142 – 1421N6-acetyllysineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ498U4.
PRIDEiQ498U4.

PTM databases

iPTMnetiQ498U4.

Expressioni

Gene expression databases

GenevisibleiQ498U4. RN.

Interactioni

Subunit structurei

Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009155.

Structurei

3D structure databases

ProteinModelPortaliQ498U4.
SMRiQ498U4. Positions 6-47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4235SAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4259. Eukaryota.
ENOG4111IA4. LUCA.
GeneTreeiENSGT00390000002944.
HOGENOMiHOG000013054.
InParanoidiQ498U4.
KOiK18732.
OMAiKPMVNMD.
OrthoDBiEOG7J9VRJ.
PhylomeDBiQ498U4.
TreeFamiTF319843.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q498U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATETVELHK LKLAELKQEC LARGLETKGI KQDLINRLQA YLEEHAEEEA
60 70 80 90 100
NEEDVLGDET EEEEPKPIEL PVKEEEPPEK VVDMASEKKV VKITSGIPQT
110 120 130 140 150
ERMQKRAERF NVPVSLESKK AARAARFGIS SVPTKGLSSD TKPMVNLDKL
160 170 180 190 200
KERAQRFGLN VSSISRKSED DEKLKKRKER FGIVTSSAGT GTTEDTEAKK
210
RKRAERFGIA
Length:210
Mass (Da):23,605
Last modified:January 23, 2007 - v3
Checksum:i9FAE0C30E62C0751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100070 mRNA. Translation: AAI00071.1.
RefSeqiNP_001028242.1. NM_001033070.1.
UniGeneiRn.1506.

Genome annotation databases

EnsembliENSRNOT00000009155; ENSRNOP00000009155; ENSRNOG00000030520.
GeneIDi362819.
KEGGirno:362819.
UCSCiRGD:1305692. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100070 mRNA. Translation: AAI00071.1.
RefSeqiNP_001028242.1. NM_001033070.1.
UniGeneiRn.1506.

3D structure databases

ProteinModelPortaliQ498U4.
SMRiQ498U4. Positions 6-47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009155.

PTM databases

iPTMnetiQ498U4.

Proteomic databases

PaxDbiQ498U4.
PRIDEiQ498U4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009155; ENSRNOP00000009155; ENSRNOG00000030520.
GeneIDi362819.
KEGGirno:362819.
UCSCiRGD:1305692. rat.

Organism-specific databases

CTDi84324.
RGDi1305692. Sarnp.

Phylogenomic databases

eggNOGiKOG4259. Eukaryota.
ENOG4111IA4. LUCA.
GeneTreeiENSGT00390000002944.
HOGENOMiHOG000013054.
InParanoidiQ498U4.
KOiK18732.
OMAiKPMVNMD.
OrthoDBiEOG7J9VRJ.
PhylomeDBiQ498U4.
TreeFamiTF319843.

Miscellaneous databases

NextBioi681377.
PROiQ498U4.

Gene expression databases

GenevisibleiQ498U4. RN.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR003034. SAP_dom.
[Graphical view]
PfamiPF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
PROSITEiPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 93-102; 110-119; 127-149 AND 157-166, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  3. Lubec G., Chen W.-Q.
    Submitted (FEB-2007) to UniProtKB
    Cited for: ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSARNP_RAT
AccessioniPrimary (citable) accession number: Q498U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.