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Protein

Inhibitor of growth protein 3

Gene

Ing3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei365Histone H3K4me3By similarity1
Metal bindingi366Zinc 1By similarity1
Metal bindingi368Zinc 1By similarity1
Binding sitei376Histone H3K4me3By similarity1
Metal bindingi379Zinc 2By similarity1
Binding sitei380Histone H3K4me3By similarity1
Metal bindingi384Zinc 2By similarity1
Binding sitei388Histone H3K4me3By similarity1
Metal bindingi390Zinc 1; via pros nitrogenBy similarity1
Metal bindingi393Zinc 1By similarity1
Metal bindingi406Zinc 2By similarity1
Metal bindingi409Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri363 – 412PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processGrowth regulation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 3
Gene namesi
Name:Ing3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1310556. Ing3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003546921 – 421Inhibitor of growth protein 3Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei181N6-acetyllysineBy similarity1
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei264N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ498T3.

PTM databases

iPTMnetiQ498T3.
PhosphoSitePlusiQ498T3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005496.
GenevisibleiQ498T3. RN.

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2 (By similarity). Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007476.

Structurei

3D structure databases

ProteinModelPortaliQ498T3.
SMRiQ498T3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi313 – 324Poly-SerAdd BLAST12

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.By similarity

Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri363 – 412PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1973. Eukaryota.
COG5034. LUCA.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239725.
HOVERGENiHBG006607.
InParanoidiQ498T3.
KOiK11319.
OMAiPDWTYDP.
OrthoDBiEOG091G0J8Y.
PhylomeDBiQ498T3.
TreeFamiTF106497.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR028651. ING_fam.
IPR024610. ING_N_histone_binding.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR10333. PTHR10333. 1 hit.
PfamiView protein in Pfam
PF12998. ING. 1 hit.
SMARTiView protein in SMART
SM01408. ING. 1 hit.
SM00249. PHD. 1 hit.
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q498T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA
60 70 80 90 100
KKNKPEWREE QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE
110 120 130 140 150
LAKFKMELEA DNAGITEILE RRSLELDAPS QPVNNHHAHS HTPVEKRKYN
160 170 180 190 200
PTSHHTATDH IPEKKFKSEA LLSTLTSDAS KENTLGCRNN NSTASCNNAY
210 220 230 240 250
NVNSSQPLAS YNIGSLSSGA GAGAITMAAA QAVQATAQMK EGRRTSSLKA
260 270 280 290 300
SYEAFKNNDF QLGKEFSMPR ETAGYSSSSA LMTTLTQNAS SSAADSRSGR
310 320 330 340 350
KSKNNTKSSS QQSSSSSSSS SSSSLSLCSS SSTVVQEVSQ QTTVVPESDS
360 370 380 390 400
NSQVDWTYDP NEPRYCICNQ VSYGEMVGCD NQDCPIEWFH YGCVGLTEAP
410 420
KGKWFCPQCT AAMKRRGSRH K
Length:421
Mass (Da):46,925
Last modified:September 13, 2005 - v1
Checksum:i9002A15417B0CF3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473959 Genomic DNA. Translation: EDM15142.1.
BC100082 mRNA. Translation: AAI00083.1.
RefSeqiNP_001029279.1. NM_001034107.1.
UniGeneiRn.52988.

Genome annotation databases

EnsembliENSRNOT00000007476; ENSRNOP00000007476; ENSRNOG00000005496.
GeneIDi312154.
KEGGirno:312154.
UCSCiRGD:1310556. rat.

Similar proteinsi

Entry informationi

Entry nameiING3_RAT
AccessioniPrimary (citable) accession number: Q498T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 13, 2005
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families