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Q498M4

- WDR5_RAT

UniProt

Q498M4 - WDR5_RAT

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Protein
WD repeat-containing protein 5
Gene
Wdr5
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei107 – 1071Important for interaction with histone H3 By similarity
Sitei133 – 1331Important for interaction with histone H3 By similarity
Sitei263 – 2631Important for interaction with histone H3 By similarity
Sitei322 – 3221Important for interaction with histone H3 By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity (H4-K16 specific) Source: Ensembl
  2. histone acetyltransferase activity (H4-K5 specific) Source: Ensembl
  3. histone acetyltransferase activity (H4-K8 specific) Source: Ensembl
  4. histone methyltransferase activity (H3-K4 specific) Source: Ensembl
  5. methylated histone binding Source: UniProtKB
  6. protein binding Source: UniProtKB

GO - Biological processi

  1. histone H3 acetylation Source: Ensembl
  2. histone H3-K4 methylation Source: UniProtKB
  3. histone H4-K16 acetylation Source: UniProtKB
  4. histone H4-K5 acetylation Source: UniProtKB
  5. histone H4-K8 acetylation Source: UniProtKB
  6. histone lysine methylation Source: UniProtKB
  7. regulation of transcription, DNA-templated Source: UniProtKB-KW
  8. skeletal system development Source: Ensembl
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_198384. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 5
Gene namesi
Name:Wdr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1305159. Wdr5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: Ensembl
  2. MLL1 complex Source: UniProtKB
  3. Set1C/COMPASS complex Source: UniProtKB
  4. histone acetyltransferase complex Source: UniProtKB
  5. histone methyltransferase complex Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 334333WD repeat-containing protein 5
PRO_0000278192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei112 – 1121N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ498M4.
PRIDEiQ498M4.

Expressioni

Gene expression databases

GenevestigatoriQ498M4.

Interactioni

Subunit structurei

Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with histone H3. Interacts with SETD1A. Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with PER1.1 Publication

Protein-protein interaction databases

IntActiQ498M4. 1 interaction.
STRINGi10116.ENSRNOP00000011556.

Structurei

3D structure databases

ProteinModelPortaliQ498M4.
SMRiQ498M4. Positions 31-334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 8240WD 1
Add
BLAST
Repeati85 – 12642WD 2
Add
BLAST
Repeati128 – 16841WD 3
Add
BLAST
Repeati169 – 20840WD 4
Add
BLAST
Repeati212 – 25342WD 5
Add
BLAST
Repeati256 – 29641WD 6
Add
BLAST
Repeati299 – 33335WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00740000115166.
HOGENOMiHOG000091642.
HOVERGENiHBG055117.
InParanoidiQ498M4.
KOiK14963.
OMAiSVKPNYT.
OrthoDBiEOG7MH0ZD.
PhylomeDBiQ498M4.
TreeFamiTF314125.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q498M4-1 [UniParc]FASTAAdd to Basket

« Hide

MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS    50
VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN 100
LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD 150
ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT 200
ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK 250
TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH 300
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC 334
Length:334
Mass (Da):36,588
Last modified:September 13, 2005 - v1
Checksum:i4BF30914A2250286
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC100156 mRNA. Translation: AAI00157.1.
RefSeqiNP_001034123.1. NM_001039034.1.
XP_006233893.1. XM_006233831.1.
UniGeneiRn.106818.

Genome annotation databases

EnsembliENSRNOT00000011556; ENSRNOP00000011556; ENSRNOG00000008212.
GeneIDi362093.
KEGGirno:362093.
UCSCiRGD:1305159. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC100156 mRNA. Translation: AAI00157.1 .
RefSeqi NP_001034123.1. NM_001039034.1.
XP_006233893.1. XM_006233831.1.
UniGenei Rn.106818.

3D structure databases

ProteinModelPortali Q498M4.
SMRi Q498M4. Positions 31-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q498M4. 1 interaction.
STRINGi 10116.ENSRNOP00000011556.

Chemistry

BindingDBi Q498M4.

Proteomic databases

PaxDbi Q498M4.
PRIDEi Q498M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011556 ; ENSRNOP00000011556 ; ENSRNOG00000008212 .
GeneIDi 362093.
KEGGi rno:362093.
UCSCi RGD:1305159. rat.

Organism-specific databases

CTDi 11091.
RGDi 1305159. Wdr5.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00740000115166.
HOGENOMi HOG000091642.
HOVERGENi HBG055117.
InParanoidi Q498M4.
KOi K14963.
OMAi SVKPNYT.
OrthoDBi EOG7MH0ZD.
PhylomeDBi Q498M4.
TreeFami TF314125.

Enzyme and pathway databases

Reactomei REACT_198384. HATs acetylate histones.

Miscellaneous databases

NextBioi 678628.
PROi Q498M4.

Gene expression databases

Genevestigatori Q498M4.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator."
    Brown S.A., Ripperger J., Kadener S., Fleury-Olela F., Vilbois F., Rosbash M., Schibler U.
    Science 308:693-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PER1.

Entry informationi

Entry nameiWDR5_RAT
AccessioniPrimary (citable) accession number: Q498M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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