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Q498M4

- WDR5_RAT

UniProt

Q498M4 - WDR5_RAT

Protein

WD repeat-containing protein 5

Gene

Wdr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei107 – 1071Important for interaction with histone H3By similarity
    Sitei133 – 1331Important for interaction with histone H3By similarity
    Sitei263 – 2631Important for interaction with histone H3By similarity
    Sitei322 – 3221Important for interaction with histone H3By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity (H4-K16 specific) Source: Ensembl
    2. histone acetyltransferase activity (H4-K5 specific) Source: Ensembl
    3. histone acetyltransferase activity (H4-K8 specific) Source: Ensembl
    4. histone methyltransferase activity (H3-K4 specific) Source: Ensembl
    5. methylated histone binding Source: UniProtKB
    6. protein binding Source: UniProtKB

    GO - Biological processi

    1. histone H3 acetylation Source: Ensembl
    2. histone H3-K4 methylation Source: UniProtKB
    3. histone H4-K16 acetylation Source: UniProtKB
    4. histone H4-K5 acetylation Source: UniProtKB
    5. histone H4-K8 acetylation Source: UniProtKB
    6. histone lysine methylation Source: UniProtKB
    7. regulation of transcription, DNA-templated Source: UniProtKB-KW
    8. rhythmic process Source: UniProtKB-KW
    9. skeletal system development Source: Ensembl
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_198384. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 5
    Gene namesi
    Name:Wdr5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1305159. Wdr5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: Ensembl
    2. histone acetyltransferase complex Source: UniProtKB
    3. histone methyltransferase complex Source: UniProtKB
    4. MLL1 complex Source: UniProtKB
    5. nucleus Source: UniProtKB
    6. Set1C/COMPASS complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 334333WD repeat-containing protein 5PRO_0000278192Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei112 – 1121N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ498M4.
    PRIDEiQ498M4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ498M4.

    Interactioni

    Subunit structurei

    Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with histone H3. Interacts with SETD1A. Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with PER1.1 Publication

    Protein-protein interaction databases

    IntActiQ498M4. 1 interaction.
    STRINGi10116.ENSRNOP00000011556.

    Structurei

    3D structure databases

    ProteinModelPortaliQ498M4.
    SMRiQ498M4. Positions 31-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 8240WD 1Add
    BLAST
    Repeati85 – 12642WD 2Add
    BLAST
    Repeati128 – 16841WD 3Add
    BLAST
    Repeati169 – 20840WD 4Add
    BLAST
    Repeati212 – 25342WD 5Add
    BLAST
    Repeati256 – 29641WD 6Add
    BLAST
    Repeati299 – 33335WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat WDR5/wds family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00740000115166.
    HOGENOMiHOG000091642.
    HOVERGENiHBG055117.
    InParanoidiQ498M4.
    KOiK14963.
    OMAiSVKPNYT.
    OrthoDBiEOG7MH0ZD.
    PhylomeDBiQ498M4.
    TreeFamiTF314125.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 4 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q498M4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS    50
    VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN 100
    LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD 150
    ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT 200
    ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK 250
    TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH 300
    TDVVISTACH PTENIIASAA LENDKTIKLW KSDC 334
    Length:334
    Mass (Da):36,588
    Last modified:September 13, 2005 - v1
    Checksum:i4BF30914A2250286
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100156 mRNA. Translation: AAI00157.1.
    RefSeqiNP_001034123.1. NM_001039034.1.
    XP_006233893.1. XM_006233831.1.
    UniGeneiRn.106818.

    Genome annotation databases

    EnsembliENSRNOT00000011556; ENSRNOP00000011556; ENSRNOG00000008212.
    GeneIDi362093.
    KEGGirno:362093.
    UCSCiRGD:1305159. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100156 mRNA. Translation: AAI00157.1 .
    RefSeqi NP_001034123.1. NM_001039034.1.
    XP_006233893.1. XM_006233831.1.
    UniGenei Rn.106818.

    3D structure databases

    ProteinModelPortali Q498M4.
    SMRi Q498M4. Positions 31-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q498M4. 1 interaction.
    STRINGi 10116.ENSRNOP00000011556.

    Chemistry

    BindingDBi Q498M4.

    Proteomic databases

    PaxDbi Q498M4.
    PRIDEi Q498M4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011556 ; ENSRNOP00000011556 ; ENSRNOG00000008212 .
    GeneIDi 362093.
    KEGGi rno:362093.
    UCSCi RGD:1305159. rat.

    Organism-specific databases

    CTDi 11091.
    RGDi 1305159. Wdr5.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00740000115166.
    HOGENOMi HOG000091642.
    HOVERGENi HBG055117.
    InParanoidi Q498M4.
    KOi K14963.
    OMAi SVKPNYT.
    OrthoDBi EOG7MH0ZD.
    PhylomeDBi Q498M4.
    TreeFami TF314125.

    Enzyme and pathway databases

    Reactomei REACT_198384. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 678628.
    PROi Q498M4.

    Gene expression databases

    Genevestigatori Q498M4.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 4 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. "PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator."
      Brown S.A., Ripperger J., Kadener S., Fleury-Olela F., Vilbois F., Rosbash M., Schibler U.
      Science 308:693-696(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PER1.

    Entry informationi

    Entry nameiWDR5_RAT
    AccessioniPrimary (citable) accession number: Q498M4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3