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Q498M4

- WDR5_RAT

UniProt

Q498M4 - WDR5_RAT

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Protein

WD repeat-containing protein 5

Gene

Wdr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei107 – 1071Important for interaction with histone H3By similarity
Sitei133 – 1331Important for interaction with histone H3By similarity
Sitei263 – 2631Important for interaction with histone H3By similarity
Sitei322 – 3221Important for interaction with histone H3By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity (H4-K16 specific) Source: Ensembl
  2. histone acetyltransferase activity (H4-K5 specific) Source: Ensembl
  3. histone acetyltransferase activity (H4-K8 specific) Source: Ensembl
  4. histone methyltransferase activity (H3-K4 specific) Source: Ensembl
  5. methylated histone binding Source: UniProtKB

GO - Biological processi

  1. histone H3 acetylation Source: Ensembl
  2. histone H3-K4 methylation Source: UniProtKB
  3. histone H4-K16 acetylation Source: UniProtKB
  4. histone H4-K5 acetylation Source: UniProtKB
  5. histone H4-K8 acetylation Source: UniProtKB
  6. histone lysine methylation Source: UniProtKB
  7. positive regulation of gluconeogenesis Source: Ensembl
  8. regulation of transcription, DNA-templated Source: UniProtKB-KW
  9. skeletal system development Source: Ensembl
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_198384. HATs acetylate histones.
REACT_254247. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 5
Gene namesi
Name:Wdr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1305159. Wdr5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: Ensembl
  2. histone acetyltransferase complex Source: UniProtKB
  3. histone methyltransferase complex Source: UniProtKB
  4. MLL1 complex Source: UniProtKB
  5. nucleus Source: UniProtKB
  6. Set1C/COMPASS complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 334333WD repeat-containing protein 5PRO_0000278192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei112 – 1121N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ498M4.
PRIDEiQ498M4.

Expressioni

Gene expression databases

GenevestigatoriQ498M4.

Interactioni

Subunit structurei

Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with histone H3. Interacts with SETD1A. Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with PER1.1 Publication

Protein-protein interaction databases

IntActiQ498M4. 1 interaction.
STRINGi10116.ENSRNOP00000011556.

Structurei

Secondary structure

1
334
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 416Combined sources
Beta strandi48 – 536Combined sources
Beta strandi57 – 648Combined sources
Beta strandi67 – 737Combined sources
Turni74 – 763Combined sources
Beta strandi79 – 846Combined sources
Beta strandi90 – 956Combined sources
Beta strandi99 – 1068Combined sources
Beta strandi111 – 1155Combined sources
Turni116 – 1183Combined sources
Beta strandi121 – 1255Combined sources
Beta strandi132 – 1376Combined sources
Beta strandi139 – 14810Combined sources
Beta strandi153 – 1575Combined sources
Turni158 – 1603Combined sources
Beta strandi163 – 1675Combined sources
Beta strandi174 – 1796Combined sources
Beta strandi183 – 1908Combined sources
Beta strandi195 – 1995Combined sources
Turni200 – 2023Combined sources
Beta strandi205 – 2095Combined sources
Beta strandi217 – 2226Combined sources
Beta strandi226 – 2338Combined sources
Turni234 – 2363Combined sources
Beta strandi237 – 2426Combined sources
Turni243 – 2464Combined sources
Beta strandi247 – 2526Combined sources
Beta strandi258 – 2603Combined sources
Beta strandi264 – 2674Combined sources
Beta strandi269 – 2713Combined sources
Beta strandi273 – 2764Combined sources
Beta strandi283 – 2875Combined sources
Turni288 – 2903Combined sources
Beta strandi293 – 2975Combined sources
Beta strandi304 – 3096Combined sources
Beta strandi311 – 32010Combined sources
Turni322 – 3243Combined sources
Beta strandi327 – 3315Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QQEX-ray1.80A24-334[»]
ProteinModelPortaliQ498M4.
SMRiQ498M4. Positions 31-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 8240WD 1Add
BLAST
Repeati85 – 12642WD 2Add
BLAST
Repeati128 – 16841WD 3Add
BLAST
Repeati169 – 20840WD 4Add
BLAST
Repeati212 – 25342WD 5Add
BLAST
Repeati256 – 29641WD 6Add
BLAST
Repeati299 – 33335WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000118869.
HOGENOMiHOG000091642.
HOVERGENiHBG055117.
InParanoidiQ498M4.
KOiK14963.
OMAiSVKPNYT.
OrthoDBiEOG7MH0ZD.
PhylomeDBiQ498M4.
TreeFamiTF314125.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q498M4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS
60 70 80 90 100
VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN
110 120 130 140 150
LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD
160 170 180 190 200
ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT
210 220 230 240 250
ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK
260 270 280 290 300
TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH
310 320 330
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC
Length:334
Mass (Da):36,588
Last modified:September 13, 2005 - v1
Checksum:i4BF30914A2250286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100156 mRNA. Translation: AAI00157.1.
RefSeqiNP_001034123.1. NM_001039034.1.
XP_006233893.1. XM_006233831.2.
UniGeneiRn.106818.

Genome annotation databases

EnsembliENSRNOT00000011556; ENSRNOP00000011556; ENSRNOG00000008212.
GeneIDi362093.
KEGGirno:362093.
UCSCiRGD:1305159. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100156 mRNA. Translation: AAI00157.1 .
RefSeqi NP_001034123.1. NM_001039034.1.
XP_006233893.1. XM_006233831.2.
UniGenei Rn.106818.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4QQE X-ray 1.80 A 24-334 [» ]
ProteinModelPortali Q498M4.
SMRi Q498M4. Positions 31-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q498M4. 1 interaction.
STRINGi 10116.ENSRNOP00000011556.

Chemistry

BindingDBi Q498M4.

Proteomic databases

PaxDbi Q498M4.
PRIDEi Q498M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011556 ; ENSRNOP00000011556 ; ENSRNOG00000008212 .
GeneIDi 362093.
KEGGi rno:362093.
UCSCi RGD:1305159. rat.

Organism-specific databases

CTDi 11091.
RGDi 1305159. Wdr5.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000118869.
HOGENOMi HOG000091642.
HOVERGENi HBG055117.
InParanoidi Q498M4.
KOi K14963.
OMAi SVKPNYT.
OrthoDBi EOG7MH0ZD.
PhylomeDBi Q498M4.
TreeFami TF314125.

Enzyme and pathway databases

Reactomei REACT_198384. HATs acetylate histones.
REACT_254247. RMTs methylate histone arginines.

Miscellaneous databases

NextBioi 678628.
PROi Q498M4.

Gene expression databases

Genevestigatori Q498M4.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator."
    Brown S.A., Ripperger J., Kadener S., Fleury-Olela F., Vilbois F., Rosbash M., Schibler U.
    Science 308:693-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PER1.

Entry informationi

Entry nameiWDR5_RAT
AccessioniPrimary (citable) accession number: Q498M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3