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Q498M4 (WDR5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 5
Gene names
Name:Wdr5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation By similarity.

Subunit structure

Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with histone H3. Interacts with SETD1A. Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with PER1. Ref.2

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the WD repeat WDR5/wds family.

Contains 7 WD repeats.

Ontologies

Keywords
   Biological processBiological rhythms
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
WD repeat
   Molecular functionChromatin regulator
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistone H3 acetylation

Inferred from electronic annotation. Source: Ensembl

histone H3-K4 methylation

Inferred from sequence or structural similarity. Source: UniProtKB

histone H4-K16 acetylation

Inferred from sequence or structural similarity. Source: UniProtKB

histone H4-K5 acetylation

Inferred from sequence or structural similarity. Source: UniProtKB

histone H4-K8 acetylation

Inferred from sequence or structural similarity. Source: UniProtKB

histone lysine methylation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

skeletal system development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentAda2/Gcn5/Ada3 transcription activator complex

Inferred from electronic annotation. Source: Ensembl

MLL1 complex

Inferred from sequence or structural similarity. Source: UniProtKB

Set1C/COMPASS complex

Inferred from sequence or structural similarity. Source: UniProtKB

histone acetyltransferase complex

Inferred from sequence or structural similarity. Source: UniProtKB

histone methyltransferase complex

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionhistone acetyltransferase activity (H4-K16 specific)

Inferred from electronic annotation. Source: Ensembl

histone acetyltransferase activity (H4-K5 specific)

Inferred from electronic annotation. Source: Ensembl

histone acetyltransferase activity (H4-K8 specific)

Inferred from electronic annotation. Source: Ensembl

histone methyltransferase activity (H3-K4 specific)

Inferred from electronic annotation. Source: Ensembl

methylated histone binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 334333WD repeat-containing protein 5
PRO_0000278192

Regions

Repeat43 – 8240WD 1
Repeat85 – 12642WD 2
Repeat128 – 16841WD 3
Repeat169 – 20840WD 4
Repeat212 – 25342WD 5
Repeat256 – 29641WD 6
Repeat299 – 33335WD 7

Sites

Site1071Important for interaction with histone H3 By similarity
Site1331Important for interaction with histone H3 By similarity
Site2631Important for interaction with histone H3 By similarity
Site3221Important for interaction with histone H3 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1121N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q498M4 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 4BF30914A2250286

FASTA33436,588
        10         20         30         40         50         60 
MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 

        70         80         90        100        110        120 
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 

       130        140        150        160        170        180 
CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN 

       190        200        210        220        230        240 
RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL 

       250        260        270        280        290        300 
WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH 

       310        320        330 
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]"PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator."
Brown S.A., Ripperger J., Kadener S., Fleury-Olela F., Vilbois F., Rosbash M., Schibler U.
Science 308:693-696(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PER1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC100156 mRNA. Translation: AAI00157.1.
RefSeqNP_001034123.1. NM_001039034.1.
XP_006233893.1. XM_006233831.1.
UniGeneRn.106818.

3D structure databases

ProteinModelPortalQ498M4.
SMRQ498M4. Positions 31-334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ498M4. 1 interaction.
STRING10116.ENSRNOP00000011556.

Chemistry

BindingDBQ498M4.

Proteomic databases

PaxDbQ498M4.
PRIDEQ498M4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011556; ENSRNOP00000011556; ENSRNOG00000008212.
GeneID362093.
KEGGrno:362093.
UCSCRGD:1305159. rat.

Organism-specific databases

CTD11091.
RGD1305159. Wdr5.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00740000115166.
HOGENOMHOG000091642.
HOVERGENHBG055117.
InParanoidQ498M4.
KOK14963.
OMASVKPNYT.
OrthoDBEOG7MH0ZD.
PhylomeDBQ498M4.
TreeFamTF314125.

Gene expression databases

GenevestigatorQ498M4.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio678628.
PROQ498M4.

Entry information

Entry nameWDR5_RAT
AccessionPrimary (citable) accession number: Q498M4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families