Galactocerebrosidase precursor - Xenopus laevis (African clawed frog)

Contribute

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q498K0 (GALC_XENLA)

Last modified October 13, 2009. Version 17. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Galactocerebrosidase
      Short name=GALCERase
    EC=3.2.1.46
Alternative name(s):
    Galactosylceramidase

Gene names

Name:

galc

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	677 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride By similarity.
Catalytic activity	D-galactosyl-N-acylsphingosine + H₂O = D-galactose + N-acylsphingosine.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 59 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro galactosylceramide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro galactosylceramidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

33

Potential

Chain

644

Galactocerebrosidase

PRO_0000370715

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q498K0-1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 5ACED0C555AF7A04
Show »

677

75,061

        10         20         30         40         50         60 
MGTVPAGSRR APGCGEGMFI LCLALLLAPG APAQYSVDDF GGLGRMFDGI GAISGGGATS 

        70         80         90        100        110        120 
RLLVNYPEPQ RTEILDYLFK PNFGASLHIF KVEIGGDAQT TDGTEPSHMH YPDDQNYFRG 

       130        140        150        160        170        180 
YEWWLMKEAK KRNPAIKLIG LPWAFPGWIG YGKNWPYDFP DVTAYYVVSW IIGAKQYHNL 

       190        200        210        220        230        240 
DIDYIGIWNE RAYDIKYIKV LRHTLDRLGL TNVGIIAADG DWGIAHDVLI DPYLNEAVQV 

       250        260        270        280        290        300 
IGAHYPGTHA AQDAIQTGKT LWASEDYSTY NDEVGGGCWA RILNQNYVNG NMTSTISWNM 

       310        320        330        340        350        360 
VASYYEQLPF GLEGLMTAKE PWSGNYVVST PIWITAHTTQ FTQPGWYYLR TVGHLDKGGS 

       370        380        390        400        410        420 
YVALTDRLGN LTVIIETMSH NNSICIRPPL PEYNVSAQNA TFYLQGSFQN LQELQVWYSN 

       430        440        450        460        470        480 
LDINNTKPVT FKKLTPVKVQ NGSFTLQLGV NEVYTVTTLL TGQKGSFPDP PKSKPFPLKY 

       490        500        510        520        530        540 
KDDFSVRNPP FSEAPYFADQ SGVFEYFTNT SDPGDHVFTF RQVLTQRPIT WASDANQAIS 

       550        560        570        580        590        600 
VIGNYQWSNI TVTCDIYIET VETGGVFVAA RVDQGGSPTD RAKGIFFWVF ADGTYKVTGD 

       610        620        630        640        650        660 
LIGEIVLCKG LAGVRARSWH TLTLHVDGTN ASGLLNGSPL WKEVVTGGPL HGWAAIGTSS 

       670 
FEFTQFDNFM IEAKDPE

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Kidney.

Cross-references

Sequence databases
	BC081270 mRNA. Translation: AAH81270.1. BC100187 mRNA. Translation: AAI00188.1. Different initiation.
UniGene	Xl.5500
3D structure databases
ModBase	Search...
Organism-specific databases
Xenbase	XB-FEAT-1000106. galc.
Phylogenomic databases
HOVERGEN	Q498K0.
Family and domain databases
InterPro	IPR001286. Glyco_hydro_59. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PANTHER	PTHR15172. Glyco_hydro_59. 1 hit.
Pfam	PF02057. Glyco_hydro_59. 1 hit. [Graphical view]
PRINTS	PR00850. GLHYDRLASE59.
ProtoNet	Search...

Entry information

Entry name

GALC_XENLA

Accession

Primary (citable) accession number: Q498K0
Secondary accession number(s): Q66IP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 5, 2009
Last modified:	October 13, 2009
This is version 17 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents