ID   TXD12_RAT               Reviewed;         170 AA.
AC   Q498E0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Thioredoxin domain-containing protein 12;
DE            EC=1.8.4.2;
DE   Flags: Precursor;
GN   Name=Txndc12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Possesses significant protein thiol-disulfide oxidase
CC       activity (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + protein-disulfide =
CC       glutathione disulfide + protein-dithiol.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).
CC   -!- SIMILARITY: Contains 1 thioredoxin domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BC100255; AAI00256.1; ALT_INIT; mRNA.
DR   IPI; IPI00914741; -.
DR   RefSeq; NP_001094310.1; -.
DR   UniGene; Rn.5953; -.
DR   SMR; Q498E0; 28-161.
DR   Ensembl; ENSRNOG00000008090; Rattus norvegicus.
DR   GeneID; 298370; -.
DR   KEGG; rno:298370; -.
DR   NMPDR; fig|10116.3.peg.23626; -.
DR   RGD; 1305960; Txndc12.
DR   HOVERGEN; Q498E0; -.
DR   BRENDA; 1.8.4.2; 248.
DR   ArrayExpress; Q498E0; -.
DR   GermOnline; ENSRNOG00000008090; Rattus norvegicus.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0019153; F:protein-disulfide reductase (glutathione) a...; IEA:EC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000886; ER_targeting_sequence.
DR   InterPro; IPR017936; Thioredoxin-like.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Glycoprotein; Oxidoreductase;
KW   Redox-active center; Signal.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    170       Thioredoxin domain-containing protein 12.
FT                                /FTId=PRO_0000233975.
FT   MOTIF       167    170       Prevents secretion from ER (Potential).
FT   CARBOHYD    128    128       N-linked (GlcNAc...) (Potential).
FT   DISULFID     64     67       Redox-active (Potential).
SQ   SEQUENCE   170 AA;  19019 MW;  444B6C9BE12C5E44 CRC64;
     MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA SGLPLMVIIH
     KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD EDFSPDGGYI PRILFLDPSG
     KVRPEIINES GNPSYKYFYV SAEQVVQGMK EAQVRLTGDA FREKHFQDEL
//