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Q498E0

- TXD12_RAT

UniProt

Q498E0 - TXD12_RAT

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Protein

Thioredoxin domain-containing protein 12

Gene

Txndc12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Possesses significant protein thiol-disulfide oxidase activity.By similarity

Catalytic activityi

2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

GO - Molecular functioni

  1. protein-disulfide reductase (glutathione) activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 12 (EC:1.8.4.2)
Gene namesi
Name:Txndc12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi1305960. Txndc12.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 170146Thioredoxin domain-containing protein 12PRO_0000233975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ498E0.
PRIDEiQ498E0.

Expressioni

Gene expression databases

ExpressionAtlasiQ498E0. baseline.
GenevestigatoriQ498E0.

Interactioni

Protein-protein interaction databases

IntActiQ498E0. 1 interaction.
MINTiMINT-4573819.

Structurei

3D structure databases

ProteinModelPortaliQ498E0.
SMRiQ498E0. Positions 28-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi167 – 1704Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiNOG77442.
GeneTreeiENSGT00530000063273.
HOVERGENiHBG107174.
InParanoidiQ498E0.
KOiK05360.
OMAiSYKYFYT.
OrthoDBiEOG7DNNX2.
TreeFamiTF321449.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q498E0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA
60 70 80 90 100
SGLPLMVIIH KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD
110 120 130 140 150
EDFSPDGGYI PRILFLDPSG KVRPEIINES GNPSYKYFYV SAEQVVQGMK
160 170
EAQVRLTGDA FREKHFQDEL
Length:170
Mass (Da):19,019
Last modified:May 2, 2006 - v2
Checksum:i444B6C9BE12C5E44
GO

Sequence cautioni

The sequence AAI00256.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC100255 mRNA. Translation: AAI00256.1. Different initiation.
RefSeqiNP_001094310.1. NM_001100840.1.
UniGeneiRn.5953.

Genome annotation databases

EnsembliENSRNOT00000010700; ENSRNOP00000010700; ENSRNOG00000008090.
GeneIDi298370.
KEGGirno:298370.
UCSCiRGD:1305960. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC100255 mRNA. Translation: AAI00256.1 . Different initiation.
RefSeqi NP_001094310.1. NM_001100840.1.
UniGenei Rn.5953.

3D structure databases

ProteinModelPortali Q498E0.
SMRi Q498E0. Positions 28-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q498E0. 1 interaction.
MINTi MINT-4573819.

Proteomic databases

PaxDbi Q498E0.
PRIDEi Q498E0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010700 ; ENSRNOP00000010700 ; ENSRNOG00000008090 .
GeneIDi 298370.
KEGGi rno:298370.
UCSCi RGD:1305960. rat.

Organism-specific databases

CTDi 51060.
RGDi 1305960. Txndc12.

Phylogenomic databases

eggNOGi NOG77442.
GeneTreei ENSGT00530000063273.
HOVERGENi HBG107174.
InParanoidi Q498E0.
KOi K05360.
OMAi SYKYFYT.
OrthoDBi EOG7DNNX2.
TreeFami TF321449.

Miscellaneous databases

NextBioi 643554.
PROi Q498E0.

Gene expression databases

ExpressionAtlasi Q498E0. baseline.
Genevestigatori Q498E0.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTXD12_RAT
AccessioniPrimary (citable) accession number: Q498E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3