Q498E0 (TXD12_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin domain-containing protein 12
EC=1.8.4.2

Gene names

Name:

Txndc12

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possesses significant protein thiol-disulfide oxidase activity By similarity.
Catalytic activity	2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Contains 1 thioredoxin domain.
Sequence caution	The sequence AAI00256.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Redox-active center Signal
Molecular function	Oxidoreductase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein-disulfide reductase (glutathione) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	By similarity
	Chain	25 – 170	146	Thioredoxin domain-containing protein 12		PRO_0000233975
Regions
	Motif	167 – 170	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	128	1	N-linked (GlcNAc...) Potential
	Disulfide bond	64 ↔ 67		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q498E0 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 444B6C9BE12C5E44	FASTA	170	19,019
	10 20 30 40 50 60 MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA SGLPLMVIIH 70 80 90 100 110 120 KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD EDFSPDGGYI PRILFLDPSG 130 140 150 160 170 KVRPEIINES GNPSYKYFYV SAEQVVQGMK EAQVRLTGDA FREKHFQDEL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC100255 mRNA. Translation: AAI00256.1. Different initiation.
IPI	IPI00914741.
RefSeq	NP_001094310.1. NM_001100840.1.
UniGene	Rn.5953.
3D structure databases
ProteinModelPortal	Q498E0.
SMR	Q498E0. Positions 28-161.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q498E0. 1 interaction.
MINT	MINT-4573819.
Proteomic databases
PaxDb	Q498E0.
PRIDE	Q498E0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000010700; ENSRNOP00000010700; ENSRNOG00000008090.
GeneID	298370.
KEGG	rno:298370.
UCSC	RGD:1305960. rat.
Organism-specific databases
CTD	51060.
RGD	1305960. Txndc12.
Phylogenomic databases
eggNOG	NOG77442.
GeneTree	ENSGT00530000063273.
HOVERGEN	HBG107174.
InParanoid	Q498E0.
KO	K05360.
OrthoDB	EOG4W3SP9.
Gene expression databases
ArrayExpress	Q498E0.
Genevestigator	Q498E0.
GermOnline	ENSRNOG00000008090. Rattus norvegicus.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	643554.

Entry information

Entry name

TXD12_RAT

Accession

Primary (citable) accession number: Q498E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	May 29, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program