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Protein

Thioredoxin domain-containing protein 12

Gene

Txndc12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses significant protein thiol-disulfide oxidase activity.By similarity

Catalytic activityi

2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 12 (EC:1.8.4.2)
Gene namesi
Name:Txndc12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305960. Txndc12.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000023397525 – 170Thioredoxin domain-containing protein 12Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ498E0.
PRIDEiQ498E0.

PTM databases

iPTMnetiQ498E0.
PhosphoSitePlusiQ498E0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008090.
GenevisibleiQ498E0. RN.

Interactioni

Protein-protein interaction databases

IntActiQ498E0. 1 interactor.
MINTiMINT-4573819.
STRINGi10116.ENSRNOP00000010700.

Structurei

3D structure databases

ProteinModelPortaliQ498E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi167 – 170Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG410IWGE. Eukaryota.
ENOG4111X7E. LUCA.
GeneTreeiENSGT00530000063273.
HOVERGENiHBG107174.
InParanoidiQ498E0.
KOiK05360.
OMAiNIHWRTL.
OrthoDBiEOG091G0RHV.
TreeFamiTF321449.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q498E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA
60 70 80 90 100
SGLPLMVIIH KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD
110 120 130 140 150
EDFSPDGGYI PRILFLDPSG KVRPEIINES GNPSYKYFYV SAEQVVQGMK
160 170
EAQVRLTGDA FREKHFQDEL
Length:170
Mass (Da):19,019
Last modified:May 2, 2006 - v2
Checksum:i444B6C9BE12C5E44
GO

Sequence cautioni

The sequence AAI00256 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100255 mRNA. Translation: AAI00256.1. Different initiation.
RefSeqiNP_001094310.1. NM_001100840.1.
UniGeneiRn.5953.

Genome annotation databases

EnsembliENSRNOT00000010700; ENSRNOP00000010700; ENSRNOG00000008090.
GeneIDi298370.
KEGGirno:298370.
UCSCiRGD:1305960. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100255 mRNA. Translation: AAI00256.1. Different initiation.
RefSeqiNP_001094310.1. NM_001100840.1.
UniGeneiRn.5953.

3D structure databases

ProteinModelPortaliQ498E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ498E0. 1 interactor.
MINTiMINT-4573819.
STRINGi10116.ENSRNOP00000010700.

PTM databases

iPTMnetiQ498E0.
PhosphoSitePlusiQ498E0.

Proteomic databases

PaxDbiQ498E0.
PRIDEiQ498E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010700; ENSRNOP00000010700; ENSRNOG00000008090.
GeneIDi298370.
KEGGirno:298370.
UCSCiRGD:1305960. rat.

Organism-specific databases

CTDi51060.
RGDi1305960. Txndc12.

Phylogenomic databases

eggNOGiENOG410IWGE. Eukaryota.
ENOG4111X7E. LUCA.
GeneTreeiENSGT00530000063273.
HOVERGENiHBG107174.
InParanoidiQ498E0.
KOiK05360.
OMAiNIHWRTL.
OrthoDBiEOG091G0RHV.
TreeFamiTF321449.

Miscellaneous databases

PROiQ498E0.

Gene expression databases

BgeeiENSRNOG00000008090.
GenevisibleiQ498E0. RN.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXD12_RAT
AccessioniPrimary (citable) accession number: Q498E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.