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Protein

Thioredoxin domain-containing protein 12

Gene

Txndc12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possesses significant protein thiol-disulfide oxidase activity.By similarity

Catalytic activityi

2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 12 (EC:1.8.4.2)
Gene namesi
Name:Txndc12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305960 Txndc12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000023397525 – 170Thioredoxin domain-containing protein 12Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ498E0
PRIDEiQ498E0

PTM databases

iPTMnetiQ498E0
PhosphoSitePlusiQ498E0

Expressioni

Gene expression databases

BgeeiENSRNOG00000008090
GenevisibleiQ498E0 RN

Interactioni

Protein-protein interaction databases

IntActiQ498E0, 1 interactor
STRINGi10116.ENSRNOP00000010700

Structurei

3D structure databases

ProteinModelPortaliQ498E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi167 – 170Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG410IWGE Eukaryota
ENOG4111X7E LUCA
GeneTreeiENSGT00530000063273
HOVERGENiHBG107174
InParanoidiQ498E0
KOiK05360
OMAiGNPNYKY
OrthoDBiEOG091G0RHV
TreeFamiTF321449

Family and domain databases

CDDicd02959 ERp19, 1 hit
InterProiView protein in InterPro
IPR037462 ERp19
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q498E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA
60 70 80 90 100
SGLPLMVIIH KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD
110 120 130 140 150
EDFSPDGGYI PRILFLDPSG KVRPEIINES GNPSYKYFYV SAEQVVQGMK
160 170
EAQVRLTGDA FREKHFQDEL
Length:170
Mass (Da):19,019
Last modified:May 2, 2006 - v2
Checksum:i444B6C9BE12C5E44
GO

Sequence cautioni

The sequence AAI00256 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100255 mRNA Translation: AAI00256.1 Different initiation.
RefSeqiNP_001094310.1, NM_001100840.1
UniGeneiRn.5953

Genome annotation databases

EnsembliENSRNOT00000010700; ENSRNOP00000010700; ENSRNOG00000008090
GeneIDi298370
KEGGirno:298370
UCSCiRGD:1305960 rat

Similar proteinsi

Entry informationi

Entry nameiTXD12_RAT
AccessioniPrimary (citable) accession number: Q498E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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