Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q498E0 (TXD12_RAT)

Last modified December 16, 2008. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Thioredoxin domain-containing protein 12
    EC=1.8.4.2
Gene names
Name: Txndc12
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Possesses significant protein thiol-disulfide oxidase activity By similarity.

Catalytic activity

2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

Subcellular location

Endoplasmic reticulum lumenBy similarity.

Sequence similarities

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 170146Thioredoxin domain-containing protein 12
PRO_0000233975

Regions

Motif167 – 1704Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1281N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 67Redox-active Potential

Sequences

Sequence LengthMass (Da)Tools
Q498E0-1 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: 444B6C9BE12C5E44

FASTA17019,019
        10         20         30         40         50         60 
MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA SGLPLMVIIH 

        70         80         90        100        110        120 
KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD EDFSPDGGYI PRILFLDPSG 

       130        140        150        160        170 
KVRPEIINES GNPSYKYFYV SAEQVVQGMK EAQVRLTGDA FREKHFQDEL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

BC100255 mRNA. Translation: AAI00256.1. Different initiation.
RefSeqNP_001094310.1.
UniGeneRn.5953

3D structure databases

SMRQ498E0. Positions 28-161.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000008090. Rattus norvegicus. [Contig view]
GeneID298370.
NMPDRfig|10116.3.peg.23626.

Organism-specific databases

RGD1305960. Txndc12.

Phylogenomic databases

HOVERGENQ498E0.

Gene expression databases

ArrayExpressQ498E0.
GermOnlineENSRNOG00000008090. Rattus norvegicus.

Family and domain databases

InterProIPR000886. ER_targeting_sequence.
IPR006662. Thioredoxin-like.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTXD12_RAT
AccessionPrimary (citable) accession number: Q498E0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: December 16, 2008
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents