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Q498E0

- TXD12_RAT

UniProt

Q498E0 - TXD12_RAT

Protein

Thioredoxin domain-containing protein 12

Gene

Txndc12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    Possesses significant protein thiol-disulfide oxidase activity.By similarity

    Catalytic activityi

    2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

    GO - Molecular functioni

    1. protein-disulfide reductase (glutathione) activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin domain-containing protein 12 (EC:1.8.4.2)
    Gene namesi
    Name:Txndc12
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1305960. Txndc12.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 170146Thioredoxin domain-containing protein 12PRO_0000233975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ498E0.
    PRIDEiQ498E0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ498E0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ498E0. 1 interaction.
    MINTiMINT-4573819.

    Structurei

    3D structure databases

    ProteinModelPortaliQ498E0.
    SMRiQ498E0. Positions 28-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi167 – 1704Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Signal

    Phylogenomic databases

    eggNOGiNOG77442.
    GeneTreeiENSGT00530000063273.
    HOVERGENiHBG107174.
    InParanoidiQ498E0.
    KOiK05360.
    OMAiSYKYFYT.
    OrthoDBiEOG7DNNX2.
    TreeFamiTF321449.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q498E0-1 [UniParc]FASTAAdd to Basket

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    MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA    50
    SGLPLMVIIH KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD 100
    EDFSPDGGYI PRILFLDPSG KVRPEIINES GNPSYKYFYV SAEQVVQGMK 150
    EAQVRLTGDA FREKHFQDEL 170
    Length:170
    Mass (Da):19,019
    Last modified:May 2, 2006 - v2
    Checksum:i444B6C9BE12C5E44
    GO

    Sequence cautioni

    The sequence AAI00256.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100255 mRNA. Translation: AAI00256.1. Different initiation.
    RefSeqiNP_001094310.1. NM_001100840.1.
    UniGeneiRn.5953.

    Genome annotation databases

    EnsembliENSRNOT00000010700; ENSRNOP00000010700; ENSRNOG00000008090.
    GeneIDi298370.
    KEGGirno:298370.
    UCSCiRGD:1305960. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100255 mRNA. Translation: AAI00256.1 . Different initiation.
    RefSeqi NP_001094310.1. NM_001100840.1.
    UniGenei Rn.5953.

    3D structure databases

    ProteinModelPortali Q498E0.
    SMRi Q498E0. Positions 28-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q498E0. 1 interaction.
    MINTi MINT-4573819.

    Proteomic databases

    PaxDbi Q498E0.
    PRIDEi Q498E0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010700 ; ENSRNOP00000010700 ; ENSRNOG00000008090 .
    GeneIDi 298370.
    KEGGi rno:298370.
    UCSCi RGD:1305960. rat.

    Organism-specific databases

    CTDi 51060.
    RGDi 1305960. Txndc12.

    Phylogenomic databases

    eggNOGi NOG77442.
    GeneTreei ENSGT00530000063273.
    HOVERGENi HBG107174.
    InParanoidi Q498E0.
    KOi K05360.
    OMAi SYKYFYT.
    OrthoDBi EOG7DNNX2.
    TreeFami TF321449.

    Miscellaneous databases

    NextBioi 643554.
    PROi Q498E0.

    Gene expression databases

    Genevestigatori Q498E0.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTXD12_RAT
    AccessioniPrimary (citable) accession number: Q498E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3