Reviewed, UniProtKB/Swiss-Prot Q498E0 (TXD12_RAT)

Names and origin

Protein names

Recommended name:
    Thioredoxin domain-containing protein 12
    EC=1.8.4.2

Gene names

Name:

Txndc12

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Possesses significant protein thiol-disulfide oxidase activity By similarity.
Catalytic activity	2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.
Subcellular location	Endoplasmic reticulum lumenBy similarity.
Sequence similarities	Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Redox-active center Signal
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: InterPro endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein-disulfide reductase (glutathione) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	By similarity
	Chain	25 – 170	146	Thioredoxin domain-containing protein 12		PRO_0000233975
Regions
	Motif	167 – 170	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	128	1	N-linked (GlcNAc...) Potential
	Disulfide bond	64 ↔ 67		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q498E0-1 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 444B6C9BE12C5E44	FASTA	170	19,019
	10 20 30 40 50 60 MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA SGLPLMVIIH 70 80 90 100 110 120 KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD EDFSPDGGYI PRILFLDPSG 130 140 150 160 170 KVRPEIINES GNPSYKYFYV SAEQVVQGMK EAQVRLTGDA FREKHFQDEL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC100255 mRNA. Translation: AAI00256.1. Different initiation.
RefSeq	NP_001094310.1.
UniGene	Rn.5953
3D structure databases
SMR	Q498E0. Positions 28-161.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000008090. Rattus norvegicus. [Contig view]
GeneID	298370.
NMPDR	fig|10116.3.peg.23626.
Organism-specific databases
RGD	1305960. Txndc12.
Phylogenomic databases
HOVERGEN	Q498E0.
Gene expression databases
ArrayExpress	Q498E0.
GermOnline	ENSRNOG00000008090. Rattus norvegicus.
Family and domain databases
InterPro	IPR000886. ER_targeting_sequence. IPR006662. Thioredoxin-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TXD12_RAT

Accession

Primary (citable) accession number: Q498E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	December 16, 2008
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)