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Q498E0 (TXD12_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin domain-containing protein 12

EC=1.8.4.2
Gene names
Name:Txndc12
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possesses significant protein thiol-disulfide oxidase activity By similarity.

Catalytic activity

2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Contains 1 thioredoxin domain.

Sequence caution

The sequence AAI00256.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRedox-active center
Signal
   Molecular functionOxidoreductase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein-disulfide reductase (glutathione) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 170146Thioredoxin domain-containing protein 12
PRO_0000233975

Regions

Motif167 – 1704Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1281N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 67Redox-active Potential

Sequences

Sequence LengthMass (Da)Tools
Q498E0 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: 444B6C9BE12C5E44

FASTA17019,019
        10         20         30         40         50         60 
MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA SGLPLMVIIH 

        70         80         90        100        110        120 
KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD EDFSPDGGYI PRILFLDPSG 

       130        140        150        160        170 
KVRPEIINES GNPSYKYFYV SAEQVVQGMK EAQVRLTGDA FREKHFQDEL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC100255 mRNA. Translation: AAI00256.1. Different initiation.
RefSeqNP_001094310.1. NM_001100840.1.
UniGeneRn.5953.

3D structure databases

ProteinModelPortalQ498E0.
SMRQ498E0. Positions 28-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ498E0. 1 interaction.
MINTMINT-4573819.

Proteomic databases

PaxDbQ498E0.
PRIDEQ498E0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010700; ENSRNOP00000010700; ENSRNOG00000008090.
GeneID298370.
KEGGrno:298370.
UCSCRGD:1305960. rat.

Organism-specific databases

CTD51060.
RGD1305960. Txndc12.

Phylogenomic databases

eggNOGNOG77442.
GeneTreeENSGT00530000063273.
HOVERGENHBG107174.
InParanoidQ498E0.
KOK05360.
OMASYKYFYT.
OrthoDBEOG7DNNX2.
TreeFamTF321449.

Gene expression databases

GenevestigatorQ498E0.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio643554.
PROQ498E0.

Entry information

Entry nameTXD12_RAT
AccessionPrimary (citable) accession number: Q498E0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families