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Protein

Forkhead box protein P1

Gene

Foxp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri340 – 36526C2H2-typeAdd
BLAST
DNA bindingi499 – 58991Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P1
Gene namesi
Name:Foxp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1308669. Foxp1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Not found in the nucleolus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Forkhead box protein P1PRO_0000294519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei687 – 6871PhosphothreonineBy similarity
Modified residuei692 – 6921PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ498D1.

PTM databases

iPTMnetiQ498D1.
PhosphoSiteiQ498D1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009184.
GenevisibleiQ498D1. RN.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Self-associates. Interacts with CTBP1. Interacts with NCOR2 and AR. Interacts with FOXP2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013271.

Structurei

3D structure databases

ProteinModelPortaliQ498D1.
SMRiQ498D1. Positions 498-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni382 – 40322Leucine-zipperAdd
BLAST
Regioni416 – 4205CTBP1-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 264210Gln-richAdd
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri340 – 36526C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ498D1.
KOiK09409.
OMAiNNIPLYT.
OrthoDBiEOG091G08HY.
PhylomeDBiQ498D1.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q498D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQESGSEAK SNGSTIQNGS SGGNHLLECG TLRDTRSNGE APAVDLGAAD
60 70 80 90 100
LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
110 120 130 140 150
QQQQQQQQQV SGLKSPKRND KQPALQVPVS VAMMTPQVIT PQQMQQILQQ
160 170 180 190 200
QVLSPQQLQV LLQQQQALML QQQQLQEFYK KQQEQLQLQL LQQQHAGKQP
210 220 230 240 250
KEQQQQQVAT QQLAFQQQLL QMQQLQQQHL LSLQRQGLLT IQPGQPALPL
260 270 280 290 300
QPLAQGMIPT ELQQLWKEVT SAHTAEETTG SNHSSLDLTS TCVSSSAPSK
310 320 330 340 350
TSLIMNPHAS TNGQLSVHTP KRESLSHEEH PHSHPLYGHG VCKWPGCEAV
360 370 380 390 400
CDDFPAFLKH LNSEHALDDR STAQCRVQMQ VVQQLELQLA KDKERLQAMM
410 420 430 440 450
THLHVKSTEP KAAPQPLNLV SSVTLSKSAS EASPQSLPHT PTTPTAPLTP
460 470 480 490 500
VTQGPSVITT TSMHTVGPIR RRYSDKYNVP ISSADIAQNQ EFYKNAEVRP
510 520 530 540 550
PFTYASLIRQ AILESPEKQL TLNEIYNWFT RMFAYFRRNA ATWKNAVRHN
560 570 580 590 600
LSLHKCFVRV ENVKGAVWTV DEVEFQKRRP QKISGNPSLI KNMQSGHAYC
610 620 630 640 650
TPLNAALQAS MAENSIPLYT TASMGNPTLG SLASAIREEL NGAMEHTNSN
660 670 680 690 700
ESDSSPGRSP MQAVHPIHVK EEPLDPEEAE GPLSLVTTAN HSPDFDHDRD
710
YEDEPVNEDM E
Length:711
Mass (Da):79,586
Last modified:September 13, 2005 - v1
Checksum:i9DE9B570A79CAFB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100267 mRNA. Translation: AAI00268.1.
RefSeqiNP_001029303.1. NM_001034131.1.
XP_008761370.1. XM_008763148.1.
XP_008761371.1. XM_008763149.1.
XP_008761372.1. XM_008763150.1.
XP_008761373.1. XM_008763151.1.
XP_008761374.1. XM_008763152.1.
XP_008761375.1. XM_008763153.1.
UniGeneiRn.33321.
Rn.35036.

Genome annotation databases

EnsembliENSRNOT00000013271; ENSRNOP00000013271; ENSRNOG00000009184.
GeneIDi297480.
KEGGirno:297480.
UCSCiRGD:1308669. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100267 mRNA. Translation: AAI00268.1.
RefSeqiNP_001029303.1. NM_001034131.1.
XP_008761370.1. XM_008763148.1.
XP_008761371.1. XM_008763149.1.
XP_008761372.1. XM_008763150.1.
XP_008761373.1. XM_008763151.1.
XP_008761374.1. XM_008763152.1.
XP_008761375.1. XM_008763153.1.
UniGeneiRn.33321.
Rn.35036.

3D structure databases

ProteinModelPortaliQ498D1.
SMRiQ498D1. Positions 498-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013271.

PTM databases

iPTMnetiQ498D1.
PhosphoSiteiQ498D1.

Proteomic databases

PaxDbiQ498D1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013271; ENSRNOP00000013271; ENSRNOG00000009184.
GeneIDi297480.
KEGGirno:297480.
UCSCiRGD:1308669. rat.

Organism-specific databases

CTDi27086.
RGDi1308669. Foxp1.

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ498D1.
KOiK09409.
OMAiNNIPLYT.
OrthoDBiEOG091G08HY.
PhylomeDBiQ498D1.
TreeFamiTF326978.

Miscellaneous databases

PROiQ498D1.

Gene expression databases

BgeeiENSRNOG00000009184.
GenevisibleiQ498D1. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXP1_RAT
AccessioniPrimary (citable) accession number: Q498D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.