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Q49897

- NADK_MYCLE

UniProt

Q49897 - NADK_MYCLE

Protein

NAD kinase

Gene

nadK

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorUniRule annotation
    Binding sitei94 – 941NADUniRule annotation
    Binding sitei193 – 1931NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 902NADUniRule annotation
    Nucleotide bindingi163 – 1642NADUniRule annotation
    Nucleotide bindingi204 – 2096NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:ML1359
    ORF Names:MLC1351.13c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1359.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311NAD kinasePRO_0000120634Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML1359.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49897.
    SMRiQ49897. Positions 7-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227223.
    KOiK00858.
    OMAiGVLWCDG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49897-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPRKAAQRT VLLVVHTGRD EATETARRVK KIVGDNGIAL RVLSAEAVDR    50
    GSLHLALDNM RAMGVDIEVV DADPHVAQGC ELVLVLGGDG TFLRAAELAR 100
    TARIPVLGVN LGRIGFLAEA EAEAIDVVLE HVIARSYRVE ERLTLDIVVR 150
    QGGNIIDQGW ALNEASLEKG PRLGVLGVVV EIEGRPVSTF GCDGVLVSTP 200
    TGSTAYAFSA GGPVLWPDLE AILVVPNNAH ALFGRPMVTS PDATVAIELE 250
    ANGNDALVFC DGRREMIIPA GGRLEVTRCA TPVKWARLDS APFTDRLVSK 300
    FRLPVTGWRG K 311
    Length:311
    Mass (Da):33,218
    Last modified:November 1, 1996 - v1
    Checksum:i0AD22150CC82D33B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00021 Genomic DNA. Translation: AAA50923.1.
    Z95117 Genomic DNA. Translation: CAB08286.1.
    AL583921 Genomic DNA. Translation: CAC31740.1.
    PIRiS72967.
    RefSeqiNP_301969.1. NC_002677.1.
    WP_010908290.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31740; CAC31740; CAC31740.
    GeneIDi910485.
    KEGGimle:ML1359.
    PATRICi18055164. VBIMycLep78757_2516.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00021 Genomic DNA. Translation: AAA50923.1 .
    Z95117 Genomic DNA. Translation: CAB08286.1 .
    AL583921 Genomic DNA. Translation: CAC31740.1 .
    PIRi S72967.
    RefSeqi NP_301969.1. NC_002677.1.
    WP_010908290.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q49897.
    SMRi Q49897. Positions 7-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31740 ; CAC31740 ; CAC31740 .
    GeneIDi 910485.
    KEGGi mle:ML1359.
    PATRICi 18055164. VBIMycLep78757_2516.

    Organism-specific databases

    Lepromai ML1359.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227223.
    KOi K00858.
    OMAi GVLWCDG.
    OrthoDBi EOG6PZXDR.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiNADK_MYCLE
    AccessioniPrimary (citable) accession number: Q49897
    Secondary accession number(s): O05675
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3