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Q49897

- NADK_MYCLE

UniProt

Q49897 - NADK_MYCLE

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Protein

NAD kinase

Gene

nadK

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Binding sitei94 – 941NADUniRule annotation
Binding sitei193 – 1931NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902NADUniRule annotation
Nucleotide bindingi163 – 1642NADUniRule annotation
Nucleotide bindingi204 – 2096NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:ML1359
ORF Names:MLC1351.13c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1359.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311NAD kinasePRO_0000120634Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1359.

Structurei

3D structure databases

ProteinModelPortaliQ49897.
SMRiQ49897. Positions 7-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49897-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPRKAAQRT VLLVVHTGRD EATETARRVK KIVGDNGIAL RVLSAEAVDR
60 70 80 90 100
GSLHLALDNM RAMGVDIEVV DADPHVAQGC ELVLVLGGDG TFLRAAELAR
110 120 130 140 150
TARIPVLGVN LGRIGFLAEA EAEAIDVVLE HVIARSYRVE ERLTLDIVVR
160 170 180 190 200
QGGNIIDQGW ALNEASLEKG PRLGVLGVVV EIEGRPVSTF GCDGVLVSTP
210 220 230 240 250
TGSTAYAFSA GGPVLWPDLE AILVVPNNAH ALFGRPMVTS PDATVAIELE
260 270 280 290 300
ANGNDALVFC DGRREMIIPA GGRLEVTRCA TPVKWARLDS APFTDRLVSK
310
FRLPVTGWRG K
Length:311
Mass (Da):33,218
Last modified:November 1, 1996 - v1
Checksum:i0AD22150CC82D33B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00021 Genomic DNA. Translation: AAA50923.1.
Z95117 Genomic DNA. Translation: CAB08286.1.
AL583921 Genomic DNA. Translation: CAC31740.1.
PIRiS72967.
RefSeqiNP_301969.1. NC_002677.1.
WP_010908290.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31740; CAC31740; CAC31740.
GeneIDi910485.
KEGGimle:ML1359.
PATRICi18055164. VBIMycLep78757_2516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00021 Genomic DNA. Translation: AAA50923.1 .
Z95117 Genomic DNA. Translation: CAB08286.1 .
AL583921 Genomic DNA. Translation: CAC31740.1 .
PIRi S72967.
RefSeqi NP_301969.1. NC_002677.1.
WP_010908290.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q49897.
SMRi Q49897. Positions 7-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31740 ; CAC31740 ; CAC31740 .
GeneIDi 910485.
KEGGi mle:ML1359.
PATRICi 18055164. VBIMycLep78757_2516.

Organism-specific databases

Lepromai ML1359.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227223.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiNADK_MYCLE
AccessioniPrimary (citable) accession number: Q49897
Secondary accession number(s): O05675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3