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Q49897 (PPNK_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inorganic polyphosphate/ATP-NAD kinase

Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23
Gene names
Name:ppnK
Ordered Locus Names:ML1359
ORF Names:MLC1351.13c
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Inorganic polyphosphate/ATP-NAD kinase HAMAP-Rule MF_00361
PRO_0000120634

Sequences

Sequence LengthMass (Da)Tools
Q49897 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0AD22150CC82D33B

FASTA31133,218
        10         20         30         40         50         60 
MTPRKAAQRT VLLVVHTGRD EATETARRVK KIVGDNGIAL RVLSAEAVDR GSLHLALDNM 

        70         80         90        100        110        120 
RAMGVDIEVV DADPHVAQGC ELVLVLGGDG TFLRAAELAR TARIPVLGVN LGRIGFLAEA 

       130        140        150        160        170        180 
EAEAIDVVLE HVIARSYRVE ERLTLDIVVR QGGNIIDQGW ALNEASLEKG PRLGVLGVVV 

       190        200        210        220        230        240 
EIEGRPVSTF GCDGVLVSTP TGSTAYAFSA GGPVLWPDLE AILVVPNNAH ALFGRPMVTS 

       250        260        270        280        290        300 
PDATVAIELE ANGNDALVFC DGRREMIIPA GGRLEVTRCA TPVKWARLDS APFTDRLVSK 

       310 
FRLPVTGWRG K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00021 Genomic DNA. Translation: AAA50923.1.
Z95117 Genomic DNA. Translation: CAB08286.1.
AL583921 Genomic DNA. Translation: CAC31740.1.
PIRS72967.
RefSeqNP_301969.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ49897.
SMRQ49897. Positions 7-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31740; CAC31740; CAC31740.
GeneID910485.
KEGGmle:ML1359.
PATRIC18055164. VBIMycLep78757_2516.

Organism-specific databases

LepromaML1359.
CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227223.
KOK00858.
OMAGVLWCDG.
OrthoDBEOG6PZXDR.
ProtClustDBPRK03372.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK_prd.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPNK_MYCLE
AccessionPrimary (citable) accession number: Q49897
Secondary accession number(s): O05675
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families