Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytidylate kinase

Gene

cmk

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:cmkUniRule annotation
Ordered Locus Names:ML1371
ORF Names:MLCB1351.02c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1371.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Cytidylate kinasePRO_0000131938Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1371.

Structurei

3D structure databases

ProteinModelPortaliQ49885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
HOGENOMiHOG000242850.
KOiK00945.
OMAiVRARRRY.
OrthoDBiPOG091H00RB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIVVAIDG PAGTGKSSVS RGLARELGAR YLDTGAMYRM MTLAVLRAGI
60 70 80 90 100
DPADAAAIGE SVWKVQMLSD HDRYFLGGED VSSEIRTEEV TQAVSAVSAI
110 120 130 140 150
PAVRVRLVDL QRQMAEGRGS VVVEGRDIGT VVLPDAPVKI FLTASPETRA
160 170 180 190 200
RRRNDQNVAS GSADDYDRVL AEVRRRDHLD STRAVSPLYV AQDAMIVDTS
210 220
KMAEAEVIAH LMDLVKQRSG AVW
Length:223
Mass (Da):24,110
Last modified:November 1, 1996 - v1
Checksum:i6CBDB9EEEAF62016
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00021 Genomic DNA. Translation: AAA50919.1.
Z95117 Genomic DNA. Translation: CAB08279.1.
AL583921 Genomic DNA. Translation: CAC31752.1.
PIRiS72954.
RefSeqiNP_301979.1. NC_002677.1.
WP_010908300.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31752; CAC31752; CAC31752.
GeneIDi910501.
KEGGimle:ML1371.
PATRICi18055188. VBIMycLep78757_2528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00021 Genomic DNA. Translation: AAA50919.1.
Z95117 Genomic DNA. Translation: CAB08279.1.
AL583921 Genomic DNA. Translation: CAC31752.1.
PIRiS72954.
RefSeqiNP_301979.1. NC_002677.1.
WP_010908300.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ49885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31752; CAC31752; CAC31752.
GeneIDi910501.
KEGGimle:ML1371.
PATRICi18055188. VBIMycLep78757_2528.

Organism-specific databases

LepromaiML1371.

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
HOGENOMiHOG000242850.
KOiK00945.
OMAiVRARRRY.
OrthoDBiPOG091H00RB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCY_MYCLE
AccessioniPrimary (citable) accession number: Q49885
Secondary accession number(s): O05667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.