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Protein

Transcriptional repressor NrdR

Gene

nrdR

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 3432UniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor NrdRUniRule annotation
Gene namesi
Name:nrdRUniRule annotation
Ordered Locus Names:ML1005
ORF Names:B2235_C2_209, u2235a
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Transcriptional repressor NrdRPRO_0000182319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1005.

Structurei

3D structure databases

ProteinModelPortaliQ49844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 13691ATP-coneUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NrdR family.UniRule annotation
Contains 1 ATP-cone domain.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 3432UniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1327. LUCA.
HOGENOMiHOG000097653.
KOiK07738.
OMAiRFTTYET.
OrthoDBiEOG6XM7J6.

Family and domain databases

HAMAPiMF_00440. NrdR.
InterProiIPR005144. ATP-cone_dom.
IPR003796. RNR_NrdR-like.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00244. TIGR00244. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q49844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCPFCRHSD SRVIDSRETD EGQAIRRRRS CPECGRRFTT VETAVVAVVK
60 70 80 90 100
RSGVTEPFSR GKVIRGVRRA CQGRQVDDDA LNLLAQQVED TVRAAGLPEV
110 120 130 140 150
PSHEVGLAIL GPLRELDEVA YLRFASVYRS FSSADDFERE IEALRAHRRV

STSR
Length:154
Mass (Da):17,326
Last modified:November 1, 1996 - v1
Checksum:iD0F5A5237F8C7923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00019 Genomic DNA. Translation: AAA17275.1.
AL583920 Genomic DNA. Translation: CAC31386.1.
PIRiS72939.
RefSeqiNP_301744.1. NC_002677.1.
WP_010908068.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31386; CAC31386; CAC31386.
GeneIDi910064.
KEGGimle:ML1005.
PATRICi18053760. VBIMycLep78757_1825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00019 Genomic DNA. Translation: AAA17275.1.
AL583920 Genomic DNA. Translation: CAC31386.1.
PIRiS72939.
RefSeqiNP_301744.1. NC_002677.1.
WP_010908068.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ49844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31386; CAC31386; CAC31386.
GeneIDi910064.
KEGGimle:ML1005.
PATRICi18053760. VBIMycLep78757_1825.

Organism-specific databases

LepromaiML1005.

Phylogenomic databases

eggNOGiCOG1327. LUCA.
HOGENOMiHOG000097653.
KOiK07738.
OMAiRFTTYET.
OrthoDBiEOG6XM7J6.

Family and domain databases

HAMAPiMF_00440. NrdR.
InterProiIPR005144. ATP-cone_dom.
IPR003796. RNR_NrdR-like.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00244. TIGR00244. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiNRDR_MYCLE
AccessioniPrimary (citable) accession number: Q49844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.