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Q49807

- CMAS2_MYCLE

UniProt

Q49807 - CMAS2_MYCLE

Protein

Cyclopropane mycolic acid synthase 2

Gene

cmaA2

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei290 – 2901By similarity

    GO - Molecular functioni

    1. cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00915.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclopropane mycolic acid synthase 2 (EC:2.1.1.79)
    Short name:
    CMAS
    Alternative name(s):
    Cyclopropane-fatty-acyl-phospholipid synthase
    Short name:
    CFA synthase
    Short name:
    Cyclopropane fatty acid synthase
    Mycolic acid methyltransferase
    Short name:
    MA-MT
    S-adenosylmethionine-dependent methyltransferase
    Short name:
    AdoMet-MT
    Short name:
    SAM-MT
    Gene namesi
    Name:cmaA2
    Ordered Locus Names:ML2426
    ORF Names:B2168_F3_130
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML2426.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Cyclopropane mycolic acid synthase 2PRO_0000089568Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML2426.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49807.
    SMRiQ49807. Positions 15-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni44 – 452S-adenosyl-L-methionine bindingBy similarity
    Regioni79 – 879S-adenosyl-L-methionine bindingBy similarity
    Regioni105 – 1106S-adenosyl-L-methionine bindingBy similarity
    Regioni137 – 1382S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the CFA/CMAS family.Curated

    Phylogenomic databases

    eggNOGiCOG2230.
    HOGENOMiHOG000245191.
    KOiK00574.
    OMAiDASWERY.
    OrthoDBiEOG6BGNZP.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02353. CMAS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003085. CMAS. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49807-1 [UniParc]FASTAAdd to Basket

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    MVPSQSHPAK TPRKQLKPPI EAVQSHYDRS NEFFKLWLDP SMTYSCAYFE    50
    RPDLTLEEAQ RAKRDLALSK LGLEPGMTLL DIGCGWGSTM LHAIEKYDVN 100
    VIGLTLSANQ LAHNKLKFAE IDHTRTDRTK DVRLQGWEQF DEPVDRIISL 150
    GAFEHFADGA GDAGFERYDS FFKMCYDVLP DDGRMLLHTI IVPDAKETKE 200
    LGLTTPMSLL RFIKFILTEI FPGGRLPKIS QVDHYSSNAG FTVERYHRIG 250
    SHYVPTLNAW AAALEAHKDE AIALQGRQIY DTYMHYLTGC SDLFRDRYTD 300
    VCQFTLVK 308
    Length:308
    Mass (Da):35,132
    Last modified:November 1, 1996 - v1
    Checksum:i9068380ED6D324AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00018 Genomic DNA. Translation: AAA17222.1.
    AL583925 Genomic DNA. Translation: CAC31942.1.
    PIRiS72886.
    RefSeqiNP_302570.1. NC_002677.1.
    WP_010908890.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31942; CAC31942; CAC31942.
    GeneIDi908573.
    KEGGimle:ML2426.
    PATRICi18059499. VBIMycLep78757_4664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00018 Genomic DNA. Translation: AAA17222.1 .
    AL583925 Genomic DNA. Translation: CAC31942.1 .
    PIRi S72886.
    RefSeqi NP_302570.1. NC_002677.1.
    WP_010908890.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q49807.
    SMRi Q49807. Positions 15-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML2426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31942 ; CAC31942 ; CAC31942 .
    GeneIDi 908573.
    KEGGi mle:ML2426.
    PATRICi 18059499. VBIMycLep78757_4664.

    Organism-specific databases

    Lepromai ML2426.

    Phylogenomic databases

    eggNOGi COG2230.
    HOGENOMi HOG000245191.
    KOi K00574.
    OMAi DASWERY.
    OrthoDBi EOG6BGNZP.

    Enzyme and pathway databases

    UniPathwayi UPA00915 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02353. CMAS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003085. CMAS. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiCMAS2_MYCLE
    AccessioniPrimary (citable) accession number: Q49807
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3