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Reviewed, UniProtKB/Swiss-Prot Q49807 (CFA2_MYCLE)

Last modified June 16, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesRecommended name:
    Cyclopropane-fatty-acyl-phospholipid synthase
      Short name=Cyclopropane fatty acid synthase
      Short name=CFA synthase
    EC=2.1.1.79
Alternative name(s):
    Cyclopropane mycolic acid synthase
Gene names
Name: cmaA2
Ordered Locus Names: ML2426
ORF Names: B2168_F3_130
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. Mycolic acids, which represent the major constituent of mycobacterial cell wall complex, act as substrates By similarity.

Catalytic activity

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

Subcellular location

Cytoplasm By similarity.

Ontologies

Keywords
   Biological processLipid synthesis
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncyclopropane-fatty-acyl-phospholipid synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Cyclopropane-fatty-acyl-phospholipid synthase
PRO_0000089568

Regions

Region44 – 452S-adenosyl-L-methionine binding By similarity
Region79 – 879S-adenosyl-L-methionine binding By similarity
Region105 – 1106S-adenosyl-L-methionine binding By similarity

Sites

Site2901Essential for catalysis Probable

Sequences

Sequence LengthMass (Da)Tools
Q49807-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9068380ED6D324AA

FASTA30835,132
        10         20         30         40         50         60 
MVPSQSHPAK TPRKQLKPPI EAVQSHYDRS NEFFKLWLDP SMTYSCAYFE RPDLTLEEAQ 

        70         80         90        100        110        120 
RAKRDLALSK LGLEPGMTLL DIGCGWGSTM LHAIEKYDVN VIGLTLSANQ LAHNKLKFAE 

       130        140        150        160        170        180 
IDHTRTDRTK DVRLQGWEQF DEPVDRIISL GAFEHFADGA GDAGFERYDS FFKMCYDVLP 

       190        200        210        220        230        240 
DDGRMLLHTI IVPDAKETKE LGLTTPMSLL RFIKFILTEI FPGGRLPKIS QVDHYSSNAG 

       250        260        270        280        290        300 
FTVERYHRIG SHYVPTLNAW AAALEAHKDE AIALQGRQIY DTYMHYLTGC SDLFRDRYTD 


VCQFTLVK 

« Hide

Cross-references

Sequence databases

U00018 Genomic DNA. Translation: AAA17222.1.
AL583925 Genomic DNA. Translation: CAC31942.1.
PIRS72886.
RefSeqNP_302570.1.

3D structure databases

HSSPHSSP built from PDB template 1KPI based on UniProtKB Q11196.
SMRQ49807. Positions 15-308.
ModBaseSearch...

Genome annotation databases

GeneID908573.
GenomeReviewsGene locus ML2426 in contig AL450380_GR.
KEGGmle:ML2426.
NMPDRfig|272631.1.peg.1442.

Organism-specific databases

LepromaML2426.
CMRSearch...

Phylogenomic databases

HOGENOMQ49807.
OMAQ49807. RYHRIGS.

Enzyme and pathway databases

BioCycMLEP272631:ML2426-MON.
BRENDA2.1.1.79. 808.

Family and domain databases

InterProIPR003333. CMAS.
[Graphical view]
PfamPF02353. CMAS. 1 hit.
[Graphical view]
PIRSFPIRSF003085. CMAS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCFA2_MYCLE
AccessionPrimary (citable) accession number: Q49807
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information