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Protein

Putative C->U-editing enzyme APOBEC-4

Gene

Apobec4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Zinc; catalyticBy similarity
Active sitei94 – 941Proton donorBy similarity
Metal bindingi126 – 1261Zinc; catalyticBy similarity
Metal bindingi133 – 1331Zinc; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-)
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene namesi
Name:Apobec4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1918531. Apobec4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Putative C->U-editing enzyme APOBEC-4PRO_0000239357Add
BLAST

Proteomic databases

PRIDEiQ497M3.

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiQ497M3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069723.

Structurei

3D structure databases

ProteinModelPortaliQ497M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 176117CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG43268.
GeneTreeiENSGT00390000014243.
HOGENOMiHOG000033767.
HOVERGENiHBG080811.
InParanoidiQ497M3.
KOiK18773.
OMAiTIVKPYY.
OrthoDBiEOG7FV3QM.
PhylomeDBiQ497M3.
TreeFamiTF338173.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q497M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLYEEILT QGGTIVKPYY WLSLSLGCTN CPYHIRTGEE ARVPYTEFHQ
60 70 80 90 100
TFGFPWSTYP QTKHLTFYEL RSSSKNLIQK GLASNCTGSH NHPEAMLFEK
110 120 130 140 150
NGYLDAVIFH NSNIRHIILY SNNSPCNEAK HCCISKMYNF LMNYPEVTLS
160 170 180 190 200
VFFSQLYHTE KQFPTSAWNR KALQSLASLW PQVTLSPICG GLWHAILEKF
210 220 230 240 250
VSNISGSTVP QPFIAGRILA DRYNTYEINS IIAAKPYFTD GLLSRQKENQ
260 270 280 290 300
NREAWAAFEK HPLGSAAPAQ RQPTRGQDPR TPAVLMLVSN RDLPPIHVGS
310 320 330 340 350
TPQKPRTVVR HLNMLQLSSF KVKDVKKPPS GRPVEEVEVM KESARSQKAN
360 370
KKNRSQWKKQ TLVIKPRICR LLER
Length:374
Mass (Da):42,721
Last modified:June 13, 2006 - v2
Checksum:i43AC40F70049F9CD
GO

Sequence cautioni

The sequence AAI00466.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017014 mRNA. No translation available.
BC100465 mRNA. Translation: AAI00466.1. Sequence problems.
CCDSiCCDS35738.1.
UniGeneiMm.158650.

Genome annotation databases

EnsembliENSMUST00000068875; ENSMUSP00000069723; ENSMUSG00000055547.
KEGGimmu:71281.
UCSCiuc007czi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017014 mRNA. No translation available.
BC100465 mRNA. Translation: AAI00466.1. Sequence problems.
CCDSiCCDS35738.1.
UniGeneiMm.158650.

3D structure databases

ProteinModelPortaliQ497M3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069723.

Proteomic databases

PRIDEiQ497M3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068875; ENSMUSP00000069723; ENSMUSG00000055547.
KEGGimmu:71281.
UCSCiuc007czi.1. mouse.

Organism-specific databases

MGIiMGI:1918531. Apobec4.

Phylogenomic databases

eggNOGiNOG43268.
GeneTreeiENSGT00390000014243.
HOGENOMiHOG000033767.
HOVERGENiHBG080811.
InParanoidiQ497M3.
KOiK18773.
OMAiTIVKPYY.
OrthoDBiEOG7FV3QM.
PhylomeDBiQ497M3.
TreeFamiTF338173.

Miscellaneous databases

PROiQ497M3.
SOURCEiSearch...

Gene expression databases

BgeeiQ497M3.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-350.
    Tissue: Testis.
  3. "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis."
    Rogozin I.B., Basu M.K., Jordan I.K., Pavlov Y.I., Koonin E.V.
    Cell Cycle 4:1281-1285(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiABEC4_MOUSE
AccessioniPrimary (citable) accession number: Q497M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: July 22, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.