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Q497M3 (ABEC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative C->U-editing enzyme APOBEC-4

EC=3.5.4.-
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene names
Name:Apobec4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative C to U editing enzyme whose physiological substrate is not yet known By similarity.

Cofactor

Zinc By similarity.

Tissue specificity

Predominantly expressed in testis. Ref.3

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Sequence caution

The sequence AAI00466.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Putative C->U-editing enzyme APOBEC-4
PRO_0000239357

Sites

Active site941Proton donor By similarity
Metal binding921Zinc; catalytic By similarity
Metal binding1261Zinc; catalytic By similarity
Metal binding1331Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q497M3 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 43AC40F70049F9CD

FASTA37442,721
        10         20         30         40         50         60 
MEPLYEEILT QGGTIVKPYY WLSLSLGCTN CPYHIRTGEE ARVPYTEFHQ TFGFPWSTYP 

        70         80         90        100        110        120 
QTKHLTFYEL RSSSKNLIQK GLASNCTGSH NHPEAMLFEK NGYLDAVIFH NSNIRHIILY 

       130        140        150        160        170        180 
SNNSPCNEAK HCCISKMYNF LMNYPEVTLS VFFSQLYHTE KQFPTSAWNR KALQSLASLW 

       190        200        210        220        230        240 
PQVTLSPICG GLWHAILEKF VSNISGSTVP QPFIAGRILA DRYNTYEINS IIAAKPYFTD 

       250        260        270        280        290        300 
GLLSRQKENQ NREAWAAFEK HPLGSAAPAQ RQPTRGQDPR TPAVLMLVSN RDLPPIHVGS 

       310        320        330        340        350        360 
TPQKPRTVVR HLNMLQLSSF KVKDVKKPPS GRPVEEVEVM KESARSQKAN KKNRSQWKKQ 

       370 
TLVIKPRICR LLER 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-350.
Tissue: Testis.
[3]"APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis."
Rogozin I.B., Basu M.K., Jordan I.K., Pavlov Y.I., Koonin E.V.
Cell Cycle 4:1281-1285(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK017014 mRNA. No translation available.
BC100465 mRNA. Translation: AAI00466.1. Sequence problems.
UniGeneMm.158650.

3D structure databases

ProteinModelPortalQ497M3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000069723.

Proteomic databases

PRIDEQ497M3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068875; ENSMUSP00000069723; ENSMUSG00000055547.
UCSCuc007czi.1. mouse.

Organism-specific databases

MGIMGI:1918531. Apobec4.

Phylogenomic databases

eggNOGNOG43268.
GeneTreeENSGT00390000014243.
HOGENOMHOG000033767.
HOVERGENHBG080811.
InParanoidQ497M3.
OMAFSQLYHT.
OrthoDBEOG7FV3QM.
PhylomeDBQ497M3.
TreeFamTF338173.

Gene expression databases

BgeeQ497M3.
GenevestigatorQ497M3.

Family and domain databases

InterProIPR013158. APOBEC_N.
[Graphical view]
PfamPF08210. APOBEC_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ497M3.
SOURCESearch...

Entry information

Entry nameABEC4_MOUSE
AccessionPrimary (citable) accession number: Q497M3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot