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Protein

Keratin, type I cuticular Ha5

Gene

Krt35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei316StutterSequence analysis1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha5By similarity
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35By similarityImported
Short name:
K35
Gene namesi
Name:Krt35Imported
Synonyms:Krt1-24Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858899 Krt35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003610251 – 455Keratin, type I cuticular Ha5Add BLAST455

Proteomic databases

PaxDbiQ497I4
PeptideAtlasiQ497I4
PRIDEiQ497I4

PTM databases

iPTMnetiQ497I4
PhosphoSitePlusiQ497I4

Expressioni

Gene expression databases

BgeeiENSMUSG00000048013
GenevisibleiQ497I4 MM

Interactioni

Protein-protein interaction databases

BioGridi207334, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ497I4
SMRiQ497I4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 408IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97HeadSequence analysisAdd BLAST97
Regioni98 – 132Coil 1ASequence analysisAdd BLAST35
Regioni133 – 143Linker 1Sequence analysisAdd BLAST11
Regioni144 – 244Coil 1BSequence analysisAdd BLAST101
Regioni245 – 260Linker 12Sequence analysisAdd BLAST16
Regioni261 – 404Coil 2Sequence analysisAdd BLAST144
Regioni405 – 455TailSequence analysisAdd BLAST51

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHJD Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ497I4
KOiK07604
OMAiYRATSCL
OrthoDBiEOG091G087I
PhylomeDBiQ497I4
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q497I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCLKASF SSGSLKSPGK AGGGSTRVSN MYSSSSCKLP SPSRGARSFS
60 70 80 90 100
VCSAGLGRGN YRVSSCLPAL CLPTGGFATS YGTGGGWFGE GILTGNEKET
110 120 130 140 150
MQSLNDRLAS YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT
160 170 180 190 200
MEELQKKTLC SKAENARLVV QIDNAKLAAD DFRTKYETEV SLRQLVEADI
210 220 230 240 250
NGLRRILDDL TLCKADLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL
260 270 280 290 300
NVEVDAAPPV DLNRVLDEMR CQYETLVENN RRDAEDWYDT QTEELNQQVV
310 320 330 340 350
SSSEQLQSCQ SDIIELRRTV NSLEIELQAQ QSMRDALDST LAETEGRYSS
360 370 380 390 400
QLAQMQCMIG NVESQLGEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL
410 420 430 440 450
LESEDSKLPC NPCAPDYSSS KSCLPCLPAV SCSTGAARTT CSPRPVCVPC

PGGRF
Length:455
Mass (Da):50,530
Last modified:September 13, 2005 - v1
Checksum:i5C7AEC2D58472CD7
GO

Sequence cautioni

The sequence AAD01693 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI40966 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429A → V in AAD01693 (Ref. 1) Curated1
Sequence conflicti429A → V in AAI40966 (PubMed:15489334).Curated1
Sequence conflicti437A → R in AAD01693 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020790 mRNA Translation: AAD01693.1 Different initiation.
AL662808 Genomic DNA Translation: CAM15793.1
BC100542 mRNA Translation: AAI00543.1
BC140965 mRNA Translation: AAI40966.1 Different initiation.
CCDSiCCDS25407.2
RefSeqiNP_058576.2, NM_016880.2
UniGeneiMm.37952

Genome annotation databases

EnsembliENSMUST00000103127; ENSMUSP00000099416; ENSMUSG00000048013
GeneIDi53617
KEGGimmu:53617
UCSCiuc011yex.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKRT35_MOUSE
AccessioniPrimary (citable) accession number: Q497I4
Secondary accession number(s): B2RU48, Q9Z2T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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