Q497I4 (KRT35_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cuticular Ha5

Alternative name(s):
Hair keratin, type I Ha5
Keratin-35
Short name=K35

Gene names

Name:	Krt35
Synonyms:	Krt1-24

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.
Sequence caution	The sequence AAD01693.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI40966.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Keratin, type I cuticular Ha5		PRO_0000361025
Regions
	Region	1 – 97	97	Head
	Region	98 – 404	307	Rod
	Region	98 – 132	35	Coil 1A
	Region	133 – 143	11	Linker 1
	Region	144 – 244	101	Coil 1B
	Region	245 – 260	16	Linker 12
	Region	261 – 404	144	Coil 2
	Region	405 – 455	51	Tail
Sites
	Site	316	1	Stutter
Experimental info
	Sequence conflict	429	1	A → V in AAD01693. Ref.1
	Sequence conflict	429	1	A → V in AAI40966. Ref.3
	Sequence conflict	437	1	A → R in AAD01693. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q497I4 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5C7AEC2D58472CD7	FASTA	455	50,530
	10 20 30 40 50 60 MASKCLKASF SSGSLKSPGK AGGGSTRVSN MYSSSSCKLP SPSRGARSFS VCSAGLGRGN 70 80 90 100 110 120 YRVSSCLPAL CLPTGGFATS YGTGGGWFGE GILTGNEKET MQSLNDRLAS YLEKVRQLEQ 130 140 150 160 170 180 ENASLESRIR EWCEQQVPYM CPDYQSYFRT MEELQKKTLC SKAENARLVV QIDNAKLAAD 190 200 210 220 230 240 DFRTKYETEV SLRQLVEADI NGLRRILDDL TLCKADLEAQ VESLKEELLC LKKNHEEEVN 250 260 270 280 290 300 SLRCQLGDRL NVEVDAAPPV DLNRVLDEMR CQYETLVENN RRDAEDWYDT QTEELNQQVV 310 320 330 340 350 360 SSSEQLQSCQ SDIIELRRTV NSLEIELQAQ QSMRDALDST LAETEGRYSS QLAQMQCMIG 370 380 390 400 410 420 NVESQLGEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSSS 430 440 450 KSCLPCLPAV SCSTGAARTT CSPRPVCVPC PGGRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Inoue T., Kizawa K. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Skin.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF020790 mRNA. Translation: AAD01693.1. Different initiation. AL662808 Genomic DNA. Translation: CAM15793.1. BC100542 mRNA. Translation: AAI00543.1. BC140965 mRNA. Translation: AAI40966.1. Different initiation.
IPI	IPI00131382.
RefSeq	NP_058576.2. NM_016880.2.
UniGene	Mm.37952.
3D structure databases
ProteinModelPortal	Q497I4.
SMR	Q497I4. Positions 147-245, 315-402.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000099416.
PTM databases
PhosphoSite	Q497I4.
Proteomic databases
PaxDb	Q497I4.
PRIDE	Q497I4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000103127; ENSMUSP00000099416; ENSMUSG00000048013.
GeneID	53617.
KEGG	mmu:53617.
UCSC	uc011yex.1. mouse.
Organism-specific databases
CTD	3886.
MGI	MGI:1858899. Krt35.
Phylogenomic databases
eggNOG	NOG145287.
GeneTree	ENSGT00560000076638.
HOGENOM	HOG000230975.
HOVERGEN	HBG013015.
InParanoid	Q497I4.
KO	K07604.
OMA	ARSFSAC.
OrthoDB	EOG4GF3F6.
Gene expression databases
ArrayExpress	Q497I4.
Bgee	Q497I4.
Genevestigator	Q497I4.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	310335.
SOURCE	Search...

Entry information

Entry name

KRT35_MOUSE

Accession

Primary (citable) accession number: Q497I4
Secondary accession number(s): B2RU48, Q9Z2T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program