Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cuticular Ha5

Gene

Krt35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei316StutterSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha5By similarity
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35By similarityImported
Short name:
K35
Gene namesi
Name:Krt35Imported
Synonyms:Krt1-24Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858899. Krt35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003610251 – 455Keratin, type I cuticular Ha5Add BLAST455

Proteomic databases

PaxDbiQ497I4.
PeptideAtlasiQ497I4.
PRIDEiQ497I4.

PTM databases

PhosphoSitePlusiQ497I4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048013.
GenevisibleiQ497I4. MM.

Interactioni

Protein-protein interaction databases

BioGridi207334. 1 interactor.
STRINGi10090.ENSMUSP00000099416.

Structurei

3D structure databases

ProteinModelPortaliQ497I4.
SMRiQ497I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97HeadSequence analysisAdd BLAST97
Regioni98 – 404RodSequence analysisAdd BLAST307
Regioni98 – 132Coil 1ASequence analysisAdd BLAST35
Regioni133 – 143Linker 1Sequence analysisAdd BLAST11
Regioni144 – 244Coil 1BSequence analysisAdd BLAST101
Regioni245 – 260Linker 12Sequence analysisAdd BLAST16
Regioni261 – 404Coil 2Sequence analysisAdd BLAST144
Regioni405 – 455TailSequence analysisAdd BLAST51

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHJD. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ497I4.
KOiK07604.
OMAiYRATSCL.
OrthoDBiEOG091G087I.
PhylomeDBiQ497I4.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q497I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCLKASF SSGSLKSPGK AGGGSTRVSN MYSSSSCKLP SPSRGARSFS
60 70 80 90 100
VCSAGLGRGN YRVSSCLPAL CLPTGGFATS YGTGGGWFGE GILTGNEKET
110 120 130 140 150
MQSLNDRLAS YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT
160 170 180 190 200
MEELQKKTLC SKAENARLVV QIDNAKLAAD DFRTKYETEV SLRQLVEADI
210 220 230 240 250
NGLRRILDDL TLCKADLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL
260 270 280 290 300
NVEVDAAPPV DLNRVLDEMR CQYETLVENN RRDAEDWYDT QTEELNQQVV
310 320 330 340 350
SSSEQLQSCQ SDIIELRRTV NSLEIELQAQ QSMRDALDST LAETEGRYSS
360 370 380 390 400
QLAQMQCMIG NVESQLGEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL
410 420 430 440 450
LESEDSKLPC NPCAPDYSSS KSCLPCLPAV SCSTGAARTT CSPRPVCVPC

PGGRF
Length:455
Mass (Da):50,530
Last modified:September 13, 2005 - v1
Checksum:i5C7AEC2D58472CD7
GO

Sequence cautioni

The sequence AAD01693 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI40966 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429A → V in AAD01693 (Ref. 1) Curated1
Sequence conflicti429A → V in AAI40966 (PubMed:15489334).Curated1
Sequence conflicti437A → R in AAD01693 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020790 mRNA. Translation: AAD01693.1. Different initiation.
AL662808 Genomic DNA. Translation: CAM15793.1.
BC100542 mRNA. Translation: AAI00543.1.
BC140965 mRNA. Translation: AAI40966.1. Different initiation.
CCDSiCCDS25407.2.
RefSeqiNP_058576.2. NM_016880.2.
UniGeneiMm.37952.

Genome annotation databases

EnsembliENSMUST00000103127; ENSMUSP00000099416; ENSMUSG00000048013.
GeneIDi53617.
KEGGimmu:53617.
UCSCiuc011yex.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020790 mRNA. Translation: AAD01693.1. Different initiation.
AL662808 Genomic DNA. Translation: CAM15793.1.
BC100542 mRNA. Translation: AAI00543.1.
BC140965 mRNA. Translation: AAI40966.1. Different initiation.
CCDSiCCDS25407.2.
RefSeqiNP_058576.2. NM_016880.2.
UniGeneiMm.37952.

3D structure databases

ProteinModelPortaliQ497I4.
SMRiQ497I4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207334. 1 interactor.
STRINGi10090.ENSMUSP00000099416.

PTM databases

PhosphoSitePlusiQ497I4.

Proteomic databases

PaxDbiQ497I4.
PeptideAtlasiQ497I4.
PRIDEiQ497I4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103127; ENSMUSP00000099416; ENSMUSG00000048013.
GeneIDi53617.
KEGGimmu:53617.
UCSCiuc011yex.1. mouse.

Organism-specific databases

CTDi3886.
MGIiMGI:1858899. Krt35.

Phylogenomic databases

eggNOGiENOG410IHJD. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ497I4.
KOiK07604.
OMAiYRATSCL.
OrthoDBiEOG091G087I.
PhylomeDBiQ497I4.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ497I4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048013.
GenevisibleiQ497I4. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT35_MOUSE
AccessioniPrimary (citable) accession number: Q497I4
Secondary accession number(s): B2RU48, Q9Z2T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 13, 2005
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.