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Protein

Keratin, type I cuticular Ha5

Gene

Krt35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei316 – 3161StutterSequence analysis

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha5By similarity
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35By similarityImported
Short name:
K35
Gene namesi
Name:Krt35Imported
Synonyms:Krt1-24Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858899. Krt35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Keratin, type I cuticular Ha5PRO_0000361025Add
BLAST

Proteomic databases

MaxQBiQ497I4.
PaxDbiQ497I4.
PeptideAtlasiQ497I4.
PRIDEiQ497I4.

PTM databases

PhosphoSiteiQ497I4.

Expressioni

Gene expression databases

BgeeiQ497I4.
GenevisibleiQ497I4. MM.

Interactioni

Protein-protein interaction databases

BioGridi207334. 1 interaction.
STRINGi10090.ENSMUSP00000099416.

Structurei

3D structure databases

ProteinModelPortaliQ497I4.
SMRiQ497I4. Positions 147-245, 315-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9797HeadSequence analysisAdd
BLAST
Regioni98 – 404307RodSequence analysisAdd
BLAST
Regioni98 – 13235Coil 1ASequence analysisAdd
BLAST
Regioni133 – 14311Linker 1Sequence analysisAdd
BLAST
Regioni144 – 244101Coil 1BSequence analysisAdd
BLAST
Regioni245 – 26016Linker 12Sequence analysisAdd
BLAST
Regioni261 – 404144Coil 2Sequence analysisAdd
BLAST
Regioni405 – 45551TailSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHJD. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ497I4.
KOiK07604.
OMAiYRATSCL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ497I4.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q497I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCLKASF SSGSLKSPGK AGGGSTRVSN MYSSSSCKLP SPSRGARSFS
60 70 80 90 100
VCSAGLGRGN YRVSSCLPAL CLPTGGFATS YGTGGGWFGE GILTGNEKET
110 120 130 140 150
MQSLNDRLAS YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT
160 170 180 190 200
MEELQKKTLC SKAENARLVV QIDNAKLAAD DFRTKYETEV SLRQLVEADI
210 220 230 240 250
NGLRRILDDL TLCKADLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL
260 270 280 290 300
NVEVDAAPPV DLNRVLDEMR CQYETLVENN RRDAEDWYDT QTEELNQQVV
310 320 330 340 350
SSSEQLQSCQ SDIIELRRTV NSLEIELQAQ QSMRDALDST LAETEGRYSS
360 370 380 390 400
QLAQMQCMIG NVESQLGEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL
410 420 430 440 450
LESEDSKLPC NPCAPDYSSS KSCLPCLPAV SCSTGAARTT CSPRPVCVPC

PGGRF
Length:455
Mass (Da):50,530
Last modified:September 13, 2005 - v1
Checksum:i5C7AEC2D58472CD7
GO

Sequence cautioni

The sequence AAD01693.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI40966.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291A → V in AAD01693 (Ref. 1) Curated
Sequence conflicti429 – 4291A → V in AAI40966 (PubMed:15489334).Curated
Sequence conflicti437 – 4371A → R in AAD01693 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020790 mRNA. Translation: AAD01693.1. Different initiation.
AL662808 Genomic DNA. Translation: CAM15793.1.
BC100542 mRNA. Translation: AAI00543.1.
BC140965 mRNA. Translation: AAI40966.1. Different initiation.
CCDSiCCDS25407.2.
RefSeqiNP_058576.2. NM_016880.2.
UniGeneiMm.37952.

Genome annotation databases

EnsembliENSMUST00000103127; ENSMUSP00000099416; ENSMUSG00000048013.
GeneIDi53617.
KEGGimmu:53617.
UCSCiuc011yex.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020790 mRNA. Translation: AAD01693.1. Different initiation.
AL662808 Genomic DNA. Translation: CAM15793.1.
BC100542 mRNA. Translation: AAI00543.1.
BC140965 mRNA. Translation: AAI40966.1. Different initiation.
CCDSiCCDS25407.2.
RefSeqiNP_058576.2. NM_016880.2.
UniGeneiMm.37952.

3D structure databases

ProteinModelPortaliQ497I4.
SMRiQ497I4. Positions 147-245, 315-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207334. 1 interaction.
STRINGi10090.ENSMUSP00000099416.

PTM databases

PhosphoSiteiQ497I4.

Proteomic databases

MaxQBiQ497I4.
PaxDbiQ497I4.
PeptideAtlasiQ497I4.
PRIDEiQ497I4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103127; ENSMUSP00000099416; ENSMUSG00000048013.
GeneIDi53617.
KEGGimmu:53617.
UCSCiuc011yex.1. mouse.

Organism-specific databases

CTDi3886.
MGIiMGI:1858899. Krt35.

Phylogenomic databases

eggNOGiENOG410IHJD. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ497I4.
KOiK07604.
OMAiYRATSCL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ497I4.
TreeFamiTF332742.

Miscellaneous databases

PROiQ497I4.
SOURCEiSearch...

Gene expression databases

BgeeiQ497I4.
GenevisibleiQ497I4. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Inoue T., Kizawa K.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICRImported.
    Tissue: SkinImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart and Liver.

Entry informationi

Entry nameiKRT35_MOUSE
AccessioniPrimary (citable) accession number: Q497I4
Secondary accession number(s): B2RU48, Q9Z2T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 13, 2005
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.