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Protein

Lysine-specific demethylase 8

Gene

Kdm8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1) (By similarity).By similarity

Catalytic activityi

Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2.
Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi319Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi321Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi398Iron; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase 8 (EC:1.14.11.27)
Alternative name(s):
JmjC domain-containing protein 5
Jumonji domain-containing protein 5
Gene namesi
Name:Kdm8
Synonyms:Jmjd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304823. Kdm8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920121 – 414Lysine-specific demethylase 8Add BLAST414

Proteomic databases

PaxDbiQ497B8.
PRIDEiQ497B8.

PTM databases

PhosphoSitePlusiQ497B8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020388.

Structurei

3D structure databases

ProteinModelPortaliQ497B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 414JmjCPROSITE-ProRule annotationAdd BLAST146

Sequence similaritiesi

Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
HOVERGENiHBG105493.
InParanoidiQ497B8.
KOiK10277.
PhylomeDBiQ497B8.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q497B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDTTEPLV GPSTLWKDLR ALLPDTEEEL KLDLSEKVDR SMATLLRQAL
60 70 80 90 100
GLFYEGRWQK CLQASEAVLD YSWEKLNTGP WRDVDKEWRR VYSFGCLLKT
110 120 130 140 150
LCLCQAPQKA TAVAEALRVC DMGLLMGAAI LGDILLKVAT VLQTHLLPRK
160 170 180 190 200
QPACGPHQDQ PATKKAKHDA SSTPDVVLDR EVPRLRCPPL QHFKKHFLVP
210 220 230 240 250
GRPVILEGVA DHWPCMKKWS LQYIQEIAGC RTVPVEVGSR YTDEDWSQTL
260 270 280 290 300
MTVNEFIHKY ILSEAKDVGY LAQHQLFDQI PELKQDISIP DYCCLGNGEE
310 320 330 340 350
EEITINAWFG PQGTISPLHQ DPQQNFLVQV LGRKYIRLYS PQESEAVYPH
360 370 380 390 400
ETHILHNTSQ VDVENPDLEK FPKFTEAPFL SCILSPGDTL FIPAKYWHYV
410
RSLDLSFSVS FWWS
Length:414
Mass (Da):47,247
Last modified:September 13, 2005 - v1
Checksum:i7E5C0DC9BB0EBEB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100627 mRNA. Translation: AAI00628.1.
RefSeqiNP_001032273.1. NM_001037196.1.
UniGeneiRn.22093.

Genome annotation databases

GeneIDi308976.
KEGGirno:308976.
UCSCiRGD:1304823. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100627 mRNA. Translation: AAI00628.1.
RefSeqiNP_001032273.1. NM_001037196.1.
UniGeneiRn.22093.

3D structure databases

ProteinModelPortaliQ497B8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020388.

PTM databases

PhosphoSitePlusiQ497B8.

Proteomic databases

PaxDbiQ497B8.
PRIDEiQ497B8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi308976.
KEGGirno:308976.
UCSCiRGD:1304823. rat.

Organism-specific databases

CTDi79831.
RGDi1304823. Kdm8.

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
HOVERGENiHBG105493.
InParanoidiQ497B8.
KOiK10277.
PhylomeDBiQ497B8.

Miscellaneous databases

PROiQ497B8.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDM8_RAT
AccessioniPrimary (citable) accession number: Q497B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.