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Protein

L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

Gene

mshC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.By similarity

Catalytic activityi

1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP = 1-O-(2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + AMP + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44ZincBy similarity1
Binding sitei59Cysteinyl adenylateBy similarity1
Binding sitei227Cysteinyl adenylateBy similarity1
Metal bindingi231ZincBy similarity1
Metal bindingi256ZincBy similarity1
Binding sitei283Cysteinyl adenylate; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (EC:6.3.1.13)
Short name:
L-Cys:GlcN-Ins ligase
Alternative name(s):
Mycothiol ligase
Short name:
MSH ligase
Gene namesi
Name:mshC
Synonyms:cysS2
Ordered Locus Names:ML1302
ORF Names:B2126_C2_193
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001594381 – 412L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligaseAdd BLAST412

Proteomic databases

PRIDEiQ49784

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272631.ML1302

Structurei

3D structure databases

ProteinModelPortaliQ49784
SMRiQ49784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 47Cysteinyl adenylate bindingBy similarity4
Regioni82 – 84Cysteinyl adenylate bindingBy similarity3
Regioni249 – 251Cysteinyl adenylate bindingBy similarity3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 56"HIGH" regionAdd BLAST11
Motifi187 – 192"ERGGDP" region6
Motifi289 – 293"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0215 LUCA
HOGENOMiHOG000245251
OrthoDBiPOG091H004K

Family and domain databases

CDDicd00672 CysRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_01697 MshC, 1 hit
InterProiView protein in InterPro
IPR024909 Cys-tRNA/MSH_ligase
IPR017812 Mycothiol_ligase_MshC
IPR014729 Rossmann-like_a/b/a_fold
IPR032678 tRNA-synt_1_cat_dom
PANTHERiPTHR10890 PTHR10890, 1 hit
PTHR10890:SF13 PTHR10890:SF13, 1 hit
PfamiView protein in Pfam
PF01406 tRNA-synt_1e, 1 hit
PRINTSiPR00983 TRNASYNTHCYS
TIGRFAMsiTIGR03447 mycothiol_MshC, 1 hit

Sequencei

Sequence statusi: Complete.

Q49784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFRTGSGVA GRGPELRLYD TSDRQVRPVS AAVAPTCKAT MYVCGITPYD
60 70 80 90 100
ATHLGHAATY LAFDLIHRLW LDLGHEVHYV QNVTDVDDPL FERADRNGVD
110 120 130 140 150
WRDLAEREVA LFRDDMASLR ILPPHDYVAA TETIVEIVEL VDKMLVSGAA
160 170 180 190 200
YVIDDEYPDI YFRADATLQF GYESGYDRDT MLRLYEQSGG DPRRPGKNGE
210 220 230 240 250
LDALLWRAAR PGEPSWSSPF GPGRPGWHVE CAAIALSRIG IGLDIQGGGS
260 270 280 290 300
DLIFPHHEFT AAHAECVRGE RRFARHYVHA GMIGWDEHKM SKSRGNLVLV
310 320 330 340 350
STLRAQGAPP SAIRLGLLAG HYRADRFWSS QLLDDAIARL HRWRTAASMP
360 370 380 390 400
AGPDVADVIA RVRGYLADDL DTPKAIAALD GWVTDALEYG GHDAAAPKLL
410
ATAIDALLGV DL
Length:412
Mass (Da):45,293
Last modified:April 27, 2001 - v3
Checksum:i48165EF99409A25B
GO

Sequence cautioni

The sequence AAA17194 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAC31683 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00017 Genomic DNA Translation: AAA17194.1 Frameshift.
AL583921 Genomic DNA Translation: CAC31683.1 Different initiation.
PIRiH87071
RefSeqiWP_010908257.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31683; CAC31683; CAC31683

Entry informationi

Entry nameiMSHC_MYCLE
AccessioniPrimary (citable) accession number: Q49784
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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