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Q49700

- 6PGL_MYCLE

UniProt

Q49700 - 6PGL_MYCLE

Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    Name:pgl
    Synonyms:devB
    Ordered Locus Names:ML0579
    ORF Names:B1496_F1_31
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0579.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2472476-phosphogluconolactonasePRO_0000090100Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0579.

    Structurei

    3D structure databases

    ProteinModelPortaliQ49700.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0363.
    HOGENOMiHOG000256283.
    KOiK01057.
    OMAiGVKWDKW.
    OrthoDBiEOG63FW46.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q49700-1 [UniParc]FASTAAdd to Basket

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    MSASVEIFSD SKTMVGAAGK RLASTIQSAV AARERALIVL TGGSSGIGLL    50
    RDLATRGQQI DWSRVHLFWG DERYVPKDDD ERNEKQARVA LLDHIDIPPS 100
    QVHPMPAGDG EFGNDLEAAA LAYEQLLAAY AAPGYPTPNF DVHLMGMGPE 150
    GHINSLFPNT VAVRETSRMV VGVRNSPKPP PERITLTLNA IQRSREVWLM 200
    VSGTAKADAV AAAMGGAPSA SIPAAGAVGL ETTLWLLDEE AAAKIPG 247
    Length:247
    Mass (Da):26,161
    Last modified:November 1, 1996 - v1
    Checksum:i70FECAA8728FC34E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00013 Genomic DNA. Translation: AAA17114.1.
    AL583919 Genomic DNA. Translation: CAC30087.1.
    PIRiS72775.
    RefSeqiNP_301491.1. NC_002677.1.
    WP_010907815.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30087; CAC30087; CAC30087.
    GeneIDi910133.
    KEGGimle:ML0579.
    PATRICi18052122. VBIMycLep78757_1008.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00013 Genomic DNA. Translation: AAA17114.1 .
    AL583919 Genomic DNA. Translation: CAC30087.1 .
    PIRi S72775.
    RefSeqi NP_301491.1. NC_002677.1.
    WP_010907815.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q49700.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30087 ; CAC30087 ; CAC30087 .
    GeneIDi 910133.
    KEGGi mle:ML0579.
    PATRICi 18052122. VBIMycLep78757_1008.

    Organism-specific databases

    Lepromai ML0579.

    Phylogenomic databases

    eggNOGi COG0363.
    HOGENOMi HOG000256283.
    KOi K01057.
    OMAi GVKWDKW.
    OrthoDBi EOG63FW46.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry namei6PGL_MYCLE
    AccessioniPrimary (citable) accession number: Q49700
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3