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Q49700 (6PGL_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31
Gene names
Name:pgl
Synonyms:devB
Ordered Locus Names:ML0579
ORF Names:B1496_F1_31
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activity

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.

Sequence similarities

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpentose-phosphate shunt

Inferred from electronic annotation. Source: InterPro

   Molecular function6-phosphogluconolactonase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2472476-phosphogluconolactonase
PRO_0000090100

Sequences

Sequence LengthMass (Da)Tools
Q49700 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 70FECAA8728FC34E

FASTA24726,161
        10         20         30         40         50         60 
MSASVEIFSD SKTMVGAAGK RLASTIQSAV AARERALIVL TGGSSGIGLL RDLATRGQQI 

        70         80         90        100        110        120 
DWSRVHLFWG DERYVPKDDD ERNEKQARVA LLDHIDIPPS QVHPMPAGDG EFGNDLEAAA 

       130        140        150        160        170        180 
LAYEQLLAAY AAPGYPTPNF DVHLMGMGPE GHINSLFPNT VAVRETSRMV VGVRNSPKPP 

       190        200        210        220        230        240 
PERITLTLNA IQRSREVWLM VSGTAKADAV AAAMGGAPSA SIPAAGAVGL ETTLWLLDEE 


AAAKIPG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00013 Genomic DNA. Translation: AAA17114.1.
AL583919 Genomic DNA. Translation: CAC30087.1.
PIRS72775.
RefSeqNP_301491.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ49700.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000027976; EBMYCP00000027582; EBMYCG00000027971.
GeneID910133.
GenomeReviewsGene locus ML0579 in contig AL450380_GR.
KEGGmle:ML0579.
NMPDRfig|272631.1.peg.363.
PATRIC18052122. VBIMycLep78757_1008.

Organism-specific databases

LepromaML0579.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017647.
HOGENOMHBG725991.
OMAPDTHVAS.
ProtClustDBCLSK791167.

Enzyme and pathway databases

BioCycMLEP272631:ML0579-MONOMER.

Family and domain databases

InterProIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
KOK01057.
PfamPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsTIGR01198. Pgl. 1 hit.
ProtoNetSearch...

Entry information

Entry name6PGL_MYCLE
AccessionPrimary (citable) accession number: Q49700
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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