Q49700 (6PGL_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB
Ordered Locus Names:	ML0579
ORF Names:	B1496_F1_31

Organism

Mycobacterium leprae (strain TN) [Complete proteome] [HAMAP]

Taxonomic identifier

272631 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium leprae

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	6-phosphogluconolactonase		PRO_0000090100

Sequences

	Sequence		Length	Mass (Da)
	Q49700 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 70FECAA8728FC34E	FASTA	247	26,161
	10 20 30 40 50 60 MSASVEIFSD SKTMVGAAGK RLASTIQSAV AARERALIVL TGGSSGIGLL RDLATRGQQI 70 80 90 100 110 120 DWSRVHLFWG DERYVPKDDD ERNEKQARVA LLDHIDIPPS QVHPMPAGDG EFGNDLEAAA 130 140 150 160 170 180 LAYEQLLAAY AAPGYPTPNF DVHLMGMGPE GHINSLFPNT VAVRETSRMV VGVRNSPKPP 190 200 210 220 230 240 PERITLTLNA IQRSREVWLM VSGTAKADAV AAAMGGAPSA SIPAAGAVGL ETTLWLLDEE AAAKIPG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00013 Genomic DNA. Translation: AAA17114.1. AL583919 Genomic DNA. Translation: CAC30087.1.
PIR	S72775.
RefSeq	NP_301491.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q49700.
ModBase	Search...
Protein-protein interaction databases
STRING	272631.ML0579.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC30087; CAC30087; CAC30087.
GeneID	910133.
KEGG	mle:ML0579.
PATRIC	18052122. VBIMycLep78757_1008.
Organism-specific databases
Leproma	ML0579.
CMR	Search...
Phylogenomic databases
eggNOG	COG0363.
HOGENOM	HOG000256283.
KO	K01057.
OMA	GPDTHVA.
ProtClustDB	CLSK791167.
Enzyme and pathway databases
UniPathway	UPA00115; UER00409.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_MYCLE

Accession

Primary (citable) accession number: Q49700

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program