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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:ML0579
ORF Names:B1496_F1_31
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2472476-phosphogluconolactonasePRO_0000090100Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0579.

Structurei

3D structure databases

ProteinModelPortaliQ49700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256283.
KOiK01057.
OMAiLFPGQTN.
OrthoDBiEOG63FW46.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASVEIFSD SKTMVGAAGK RLASTIQSAV AARERALIVL TGGSSGIGLL
60 70 80 90 100
RDLATRGQQI DWSRVHLFWG DERYVPKDDD ERNEKQARVA LLDHIDIPPS
110 120 130 140 150
QVHPMPAGDG EFGNDLEAAA LAYEQLLAAY AAPGYPTPNF DVHLMGMGPE
160 170 180 190 200
GHINSLFPNT VAVRETSRMV VGVRNSPKPP PERITLTLNA IQRSREVWLM
210 220 230 240
VSGTAKADAV AAAMGGAPSA SIPAAGAVGL ETTLWLLDEE AAAKIPG
Length:247
Mass (Da):26,161
Last modified:November 1, 1996 - v1
Checksum:i70FECAA8728FC34E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00013 Genomic DNA. Translation: AAA17114.1.
AL583919 Genomic DNA. Translation: CAC30087.1.
PIRiS72775.
RefSeqiNP_301491.1. NC_002677.1.
WP_010907815.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30087; CAC30087; CAC30087.
GeneIDi910133.
KEGGimle:ML0579.
PATRICi18052122. VBIMycLep78757_1008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00013 Genomic DNA. Translation: AAA17114.1.
AL583919 Genomic DNA. Translation: CAC30087.1.
PIRiS72775.
RefSeqiNP_301491.1. NC_002677.1.
WP_010907815.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ49700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30087; CAC30087; CAC30087.
GeneIDi910133.
KEGGimle:ML0579.
PATRICi18052122. VBIMycLep78757_1008.

Organism-specific databases

LepromaiML0579.

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256283.
KOiK01057.
OMAiLFPGQTN.
OrthoDBiEOG63FW46.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry namei6PGL_MYCLE
AccessioniPrimary (citable) accession number: Q49700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.