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Q49700

- 6PGL_MYCLE

UniProt

Q49700 - 6PGL_MYCLE

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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:ML0579
ORF Names:B1496_F1_31
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2472476-phosphogluconolactonasePRO_0000090100Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0579.

Structurei

3D structure databases

ProteinModelPortaliQ49700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256283.
KOiK01057.
OMAiGVKWDKW.
OrthoDBiEOG63FW46.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q49700 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSASVEIFSD SKTMVGAAGK RLASTIQSAV AARERALIVL TGGSSGIGLL
60 70 80 90 100
RDLATRGQQI DWSRVHLFWG DERYVPKDDD ERNEKQARVA LLDHIDIPPS
110 120 130 140 150
QVHPMPAGDG EFGNDLEAAA LAYEQLLAAY AAPGYPTPNF DVHLMGMGPE
160 170 180 190 200
GHINSLFPNT VAVRETSRMV VGVRNSPKPP PERITLTLNA IQRSREVWLM
210 220 230 240
VSGTAKADAV AAAMGGAPSA SIPAAGAVGL ETTLWLLDEE AAAKIPG
Length:247
Mass (Da):26,161
Last modified:November 1, 1996 - v1
Checksum:i70FECAA8728FC34E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00013 Genomic DNA. Translation: AAA17114.1.
AL583919 Genomic DNA. Translation: CAC30087.1.
PIRiS72775.
RefSeqiNP_301491.1. NC_002677.1.
WP_010907815.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30087; CAC30087; CAC30087.
GeneIDi910133.
KEGGimle:ML0579.
PATRICi18052122. VBIMycLep78757_1008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00013 Genomic DNA. Translation: AAA17114.1 .
AL583919 Genomic DNA. Translation: CAC30087.1 .
PIRi S72775.
RefSeqi NP_301491.1. NC_002677.1.
WP_010907815.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q49700.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30087 ; CAC30087 ; CAC30087 .
GeneIDi 910133.
KEGGi mle:ML0579.
PATRICi 18052122. VBIMycLep78757_1008.

Organism-specific databases

Lepromai ML0579.

Phylogenomic databases

eggNOGi COG0363.
HOGENOMi HOG000256283.
KOi K01057.
OMAi GVKWDKW.
OrthoDBi EOG63FW46.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00409 .

Family and domain databases

InterProi IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view ]
Pfami PF01182. Glucosamine_iso. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01198. pgl. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry namei6PGL_MYCLE
AccessioniPrimary (citable) accession number: Q49700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3