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Protein

Transmembrane channel-like protein 4

Gene

Tmc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 4
Gene namesi
Name:Tmc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304811. Tmc4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 154154ExtracellularSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 23560CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 33478ExtracellularSequence analysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence analysisAdd
BLAST
Topological domaini356 – 38025CytoplasmicSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Topological domaini402 – 41110ExtracellularSequence analysis
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Topological domaini433 – 46937CytoplasmicSequence analysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence analysisAdd
BLAST
Topological domaini491 – 51727ExtracellularSequence analysisAdd
BLAST
Transmembranei518 – 53821HelicalSequence analysisAdd
BLAST
Topological domaini539 – 5391CytoplasmicSequence analysis
Transmembranei540 – 56021HelicalSequence analysisAdd
BLAST
Topological domaini561 – 57818ExtracellularSequence analysisAdd
BLAST
Transmembranei579 – 59921HelicalSequence analysisAdd
BLAST
Topological domaini600 – 63940CytoplasmicSequence analysisAdd
BLAST
Transmembranei640 – 66021HelicalSequence analysisAdd
BLAST
Topological domaini661 – 69838ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Transmembrane channel-like protein 4PRO_0000289470Add
BLAST

Proteomic databases

PaxDbiQ496Z4.
PRIDEiQ496Z4.

PTM databases

PhosphoSiteiQ496Z4.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIGT. Eukaryota.
ENOG410Y7QP. LUCA.
HOGENOMiHOG000154634.
HOVERGENiHBG108586.
InParanoidiQ496Z4.
PhylomeDBiQ496Z4.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q496Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESPREAWA QFPAWSSSRK ARTGPSLASV LNDLPSAATL RYRGPGVLPW
60 70 80 90 100
GTLDENDDEG RSLQAFAETA QMESQPSREL PWPMQARRAH RKSQAREQVA
110 120 130 140 150
SGSESRAAYW TQQLSRTKGK MKEGFQTIQP WAWTLKKIGG QFGAGTESYF
160 170 180 190 200
SLLRFLLFLN LGASVIEVCM KLIPTWLEGA PPGPPGPNIS SPCGSYIPHT
210 220 230 240 250
QGLVTFPTQL FNLLSGEGYL EWSPLFYGFY PPRSNLAITY LCSVFAIGLI
260 270 280 290 300
YLLFILHRSV SGLKETLLAE SDVLTSYSHR VFSAWNFGLC GDMHVRLRQR
310 320 330 340 350
IILYELQVDL EEAAVRRRAT EQTLGQRVKV WSMRALLNLL VLALLGAAFY
360 370 380 390 400
GIYWATEYTV TLQETPVVQQ TPLLKLLVNY LPSIFISVFN FVLPPAFTFI
410 420 430 440 450
ASLEGYTHSR QIVLILLRTV FLRLASLVFL LFSLWNQITC GGNMEAEECK
460 470 480 490 500
ACGYNYKEIP CWETRLGQEM YKLVLFDLLM GLLVTLLIQF PRKILCGLCP
510 520 530 540 550
GALGRLSGTL EFQVPDEVLG LIYAQTVVWV GSFFCPLLPL INTAKFLILF
560 570 580 590 600
WLKKITLFSI YSPASRTFRA STANFFFPLV LLVGLAISAV PVLYSIFLIP
610 620 630 640 650
PSKLCGPFQG KLSIWAQIPE SIESLPQTAQ NFLYFLGTQA FTVPLLIVSS
660 670 680 690
ILMMYTVALA NCYGRLISEL KRQIETEVQN KVFLAQRAVA LSSRNGVS
Length:698
Mass (Da):78,211
Last modified:September 13, 2005 - v1
Checksum:iF49DEA80E8FBE9E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100657 mRNA. Translation: AAI00658.1.
RefSeqiNP_001029276.1. NM_001034104.1.
UniGeneiRn.138375.

Genome annotation databases

GeneIDi308310.
KEGGirno:308310.
UCSCiRGD:1304811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100657 mRNA. Translation: AAI00658.1.
RefSeqiNP_001029276.1. NM_001034104.1.
UniGeneiRn.138375.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ496Z4.

Proteomic databases

PaxDbiQ496Z4.
PRIDEiQ496Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi308310.
KEGGirno:308310.
UCSCiRGD:1304811. rat.

Organism-specific databases

CTDi147798.
RGDi1304811. Tmc4.

Phylogenomic databases

eggNOGiENOG410IIGT. Eukaryota.
ENOG410Y7QP. LUCA.
HOGENOMiHOG000154634.
HOVERGENiHBG108586.
InParanoidiQ496Z4.
PhylomeDBiQ496Z4.

Miscellaneous databases

PROiQ496Z4.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMC4_RAT
AccessioniPrimary (citable) accession number: Q496Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.